A gut-vascular barrier controls the systemic dissemination of bacteria

Science

Volumn 350, Issue 6262, 2015, Pages 830-834

  Spadoni, Ilaria ^a   Zagato, Elena ^a   Bertocchi, Alice ^a   Paolinelli, Roberta ^b   Hot, Edina ^a   Di Sabatino, Antonio ^c   Caprioli, Flavio ^d   Bottiglieri, Luca ^a   Oldani, Amanda ^b   Viale, Giuseppe ^a   Penna, Giuseppe ^a   Dejana, Elisabetta ^b,d,e   Rescigno, Maria ^a,d  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; AMINOTRANSFERASE; BACTERIAL ANTIGEN; TYPE III SECRETION SYSTEM;

ANTIGEN; BACTERIUM; IMMUNE RESPONSE; PATHOGENICITY; RODENT; SERUM;

ANIMAL EXPERIMENT; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; ENDOTHELIUM CELL; GUT VASCULAR BARRIER; HUMAN; INTESTINE FLORA; INTESTINE FUNCTION; LIVER INJURY; MOLECULAR SIZE; MOUSE; NONHUMAN; PATHOGENICITY ISLAND; PERMEABILITY BARRIER; PORTAL VEIN; PRIORITY JOURNAL; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; TYPE III SECRETION SYSTEM; ANIMAL; BLOOD; C57BL MOUSE; CAPILLARY PERMEABILITY; GENETICS; GENOMIC ISLAND; ILEUM; IMMUNOLOGY; INTESTINE; INTESTINE MUCOSA; LIVER; METABOLISM; MICROBIOLOGY; MICROFLORA; PATHOGENICITY; SALMONELLOSIS; SIGNAL TRANSDUCTION; SPLEEN; VASCULARIZATION; WNT SIGNALING PATHWAY;

MUS; SALMONELLA TYPHIMURIUM;

ANIMALS; ANTIGENS, BACTERIAL; BETA CATENIN; CAPILLARY PERMEABILITY; CELIAC DISEASE; GENOMIC ISLANDS; HUMANS; ILEUM; INTESTINAL MUCOSA; INTESTINES; LIVER; MICE; MICE, INBRED C57BL; MICROBIOTA; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; SPLEEN; TRANSAMINASES; TYPE III SECRETION SYSTEMS; WNT SIGNALING PATHWAY;

EID: 84946926173     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad0135     Document Type: Article

References (20)

1. T. Worbs et al., J. Exp. Med. 203, 519-527 (2006).
2. A. Goubier et al., Immunity 29, 464-475 (2008).
3. M. L. Balmer et al., Sci. Transl. Med. 6, 237ra66 (2014).
4. A. J. Macpherson, T. Uhr, Science 303, 1662-1665 (2004).
5. A. J. Macpherson, K. Smith, J. Exp. Med. 203, 497-500 (2006).
6. M. E. Ohl, S. I. Miller, Annu. Rev. Med. 52, 259-274 (2001).
7. H. C. Müller-Redetzky, N. Suttorp, M. Witzenrath, Cell Tissue Res. 355, 657-673 (2014).
8. R. Daneman, M. Rescigno, Immunity 31, 722-735 (2009).
9. S. Y. Yuan, R. R. Rigor, Regulation of Endothelial Barrier Function (Morgan & Claypoole Life Sciences, San Rafael, CA, 2010).
10. H. Fujita et al., Mol. Biol. Cell 19, 1912-1921 (2008).
11. R. Hallmann, D. N. Mayer, E. L. Berg, R. Broermann, E. C. Butcher, Dev. Dyn. 202, 325-332 (1995).
12. S. Liebner et al., J. Cell Biol. 183, 409-417 (2008).
13. Y. Wang et al., Cell 151, 1332-1344 (2012).
14. Y. Zhou et al., J. Clin. Invest. 124, 3825-3846 (2014).
15. C. H. Lim et al., PLOS Pathog. 10, e1004270 (2014).
16. B. Engelhardt, S. Liebner, Cell Tissue Res. 355, 687-699 (2014).
17. Q. G. Dong et al., Arterioscler. Thromb. Vasc. Biol. 17, 1599-1604 (1997).
18. E. H. Jho et al., Mol. Cell. Biol. 22, 1172-1183 (2002).
19. P. K. Mishra, J. M. Teale, PLOS Negl. Trop. Dis. 7, e2099 (2013).
20. L. Kannan et al., Proc. Natl. Acad. Sci. U.S.A. 110, 14348-14353 (2013).