αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell - Related features

Neurology: Neuroimmunology and NeuroInflammation

Volumn 2, Issue 4, 2015, Pages

  Held, Kathrin ^a   Bhonsle Deeng, Latika ^a   Siewert, Katherina ^a   Sato, Wakiro ^a   Beltrán, Eduardo ^a   Schmidt, Stephan ^b   Rühl, Geraldine ^a   Ng, Judy K M ^a   Engerer, Peter ^c   Moser, Markus ^d   Klinkert, Wolfgang E F ^e   Babbe, Holger ^f   Misgeld, Thomas ^c,g,h   Wekerle, Hartmut ^e,g   Laplaud, David Axel ⁱ   Hohlfeld, Reinhard ^a,g   Dornmair, Klaus ^a,g  

^a UNIVERSITY OF MUNICH   (Germany)

^b Chefarzt der Medizinischen Klinik   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^f HARVARD MEDICAL SCHOOL   (United States)

^g Germany 3 Munich Cluster for Systems Neurology   (Germany)

^h Munich Center for Integrated Protein Science   (Germany)

ⁱ Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; BLOOD; BRAIN DAMAGE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CEREBROSPINAL FLUID; COMPLEMENTARITY DETERMINING REGION; FOLLOW UP; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; MALE; MUCOSAL ASSOCIATED INVARIANT T CELL; MULTIPLE SCLEROSIS; MULTIPLEX POLYMERASE CHAIN REACTION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PYROSEQUENCING; T LYMPHOCYTE SUBPOPULATION;

EID: 84962499880     PISSN: None     EISSN: 23327812     Source Type: Journal    
DOI: 10.1212/NXI.0000000000000107     Document Type: Article

References (32)

1. Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 2009; 9:393-407.
2. Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23:683-747.
3. Hohlfeld R, Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci USA 2004; 101(suppl 2):14599-14606.
4. Hauser SL, Bhan AK, Gilles F, Kemp M., Kerr C, Weiner HL. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann Neurol 1986; 19:578-587.
5. Babbe H, Roers A, Waisman A., et al. Clonal expansions of CD8(1) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 2000; 192:393-404.
6. Skulina C, Schmidt S, Dornmair K., et al. Multiple sclerosis: brain-infiltrating CD81 T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci USA 2004; 101:2428-2433.
7. Junker A, Ivanidze J, Malotka J., et al. Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 2007; 130:2789-2799.
8. Friese MA, Fugger L. Pathogenic CD8(1) T cells in multiple sclerosis. Ann Neurol 2009; 66:132-141.
9. Saxena A, Martin-Blondel G, Mars L.T., Liblau RS. Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis. FEBS Lett 2011; 585:3758-3763.
10. Montes M, Zhang X, Berthelot L., et al. Oligoclonal myelinreactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. Clin Immunol 2009; 130:133-144.
11. Seitz S, Schneider CK, Malotka J, et al Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues. Proc Natl Acad Sci USA 2006; 103:12057-12062.
12. Tilloy F, Treiner E, Park S.H., et al. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med 1999; 189:1907-1921.
13. Martin E, Treiner E, Duban L., et al. Stepwise development of MAIT cells in mouse and human. PLoS Biol 2009; 7:e54.
14. Gold MC, Cerri S, Smyk-Pearson S, et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol 2010; 8:e1000407.
15. Reantragoon R, Corbett AJ, Sakala I.G., et al. Antigenloaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. J Exp Med 2013; 210:2305-2320.
16. Lepore M, Kalinichenko A, Colone A., et al. Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRb repertoire. Nat Commun 2014; 5:3866.
17. Treiner E, Duban L, Bahram S., et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 2003; 422:164-169.
18. Le Bourhis L., Martin E, Peguillet I., et al. Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol 2010; 11:701-708.
19. Gold MC, McLaren JE, Reistetter J.A., et al. MR1restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. J Exp Med 2014; 211:1601-1610.
20. Arden B, Clark SP, Kabelitz D, Mak TW Human T-cell receptor variable gene segment families. Immunogenetics 1995; 42:455-500.
21. Kim SM, Bhonsle L, Besgen P., et al. Analysis of the paired TCR α- and β-chains of single human T cells. PloS One 2012; 7:e37338.
22. Alamyar E, Giudicelli V, Li S., Duroux P, Lefranc MP. IMGT/HighV-QUEST: the IMGT(R) web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing. Immunome Res 2012; 8:26.
23. Fergusson JR, Fleming VM, Klenerman P. CD161expressing human T cells. Front Immunol 2011; 2:36.
24. Illés Z., Shimamura M, Newcombe J., Oka N, Yamamura T. Accumulation of Valpha7.2-Jalpha33 invariant T cells in human autoimmune inflammatory lesions in the nervous system. Int Immunol 2004; 16:223-230.
25. Annibali V, Ristori G, Angelini D.F., et al. CD161(high) CD81T cells bear pathogenetic potential in multiple sclerosis. Brain 2011; 134:542-554.
26. Miyazaki Y, Miyake S, Chiba A., Lantz O, Yamamura T. Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis. Int Immunol 2011; 23:529-535.
27. Abrahamsson SV, Angelini DF, Dubinsky A.N., et al. Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis. Brain 2013; 136: 2888-2903.
28. Willing A, Leach OA, Ufer F, et al CD8(1) MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis. Eur J Immunol 2014; 44:3119-3128.
29. Dusseaux M, Martin E, Serriari N., et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 2011; 117: 1250-1259.
30. Wekerle H, Berer K, Krishnamoorthy G. Remote controltriggering of brain autoimmune disease in the gut. Curr Opin Immunol 2013; 25:683-689.
31. Kjer-Nielsen L., Patel O, Corbett A.J., et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 2012; 491:717-723.
32. Patel O, Kjer-Nielsen L, Le Nours J, et al. Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun 2013; 4:2142.