Cholesterol-Lowering Activity of Tartary Buckwheat Protein

Journal of Agricultural and Food Chemistry

Volumn 65, Issue 9, 2017, Pages 1900-1906

  Zhang, Chengnan ^b   Zhang, Rui ^c   Li, Yuk Man ^b   Liang, Ning ^b   Zhao, Yimin ^b   Zhu, Hanyue ^b   He, Zouyan ^b   Liu, Jianhui ^a   Hao, Wangjun ^b   Jiao, Rui ^c   Ma, Ka Ying ^b   Chen, Zhen Yu ^b  

^a Shatin ^*

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c Jilin Academy of Agricultural Mechanization   (China)

Author keywords

cholesterol; rice protein; Tartary buckwheat protein; wheat protein

Indexed keywords

ALCOHOLS; ANIMALS; CHOLESTEROL; CROPS; FLAVONOIDS; GENE EXPRESSION; LIPIDS; PHENOLS; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ACYL-COA:CHOLESTEROL ACYLTRANSFERASE; ATP BINDING CASSETTE TRANSPORTERS; CHOLESTEROL LOWERING; HYPERCHOLESTEROLEMIA; REAL TIME POLYMERASE CHAIN REACTIONS; RICE PROTEINS; TARTARY BUCKWHEAT; WHEAT PROTEINS;

PROTEINS;

ABC TRANSPORTER; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; HYPOCHOLESTEROLEMIC AGENT; PLANT EXTRACT; PLANT PROTEIN;

ANIMAL; BLOOD; CHEMISTRY; DIET THERAPY; FAGOPYRUM; GENETICS; HAMSTER; HUMAN; HYPERCHOLESTEROLEMIA; INTESTINE; MALE; METABOLISM;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CRICETINAE; FAGOPYRUM; HUMANS; HYPERCHOLESTEROLEMIA; INTESTINES; MALE; PLANT EXTRACTS; PLANT PROTEINS;

EID: 85014734864     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.7b00066     Document Type: Article

References (28)

1. Sharrett, A. R.; Ballantyne, C. M.; Coady, S. A.; Heiss, G.; Sorlie, P. D.; Catellier, D.; Patsch, W. Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions Circulation 2001, 104, 1108-13 10.1161/hc3501.095214
2. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III); National Institutes of Health, 2002; Publication No. 02-5215.
3. He, L. Review on the research status of Tartary buckwheat. In Proceeding from the International Conference Asian Product Development; Corke, H.; Lin, R., Eds.; Science Press: Shanxi, Taiyuan, China, 1998; pp. 197-203.
4. Giménez-Bastida, J. A.; Zieliński, H. Buckwheat as a Functional Food and Its Effects on Health J. Agric. Food Chem. 2015, 63, 7896-913 10.1021/acs.jafc.5b02498
5. Qiu, J.; Liu, Y.; Yue, Y.; Qin, Y.; Li, Z. Dietary Tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial Nutr. Res. (N. Y., NY, U. S.) 2016, 36, 1392-1401 10.1016/j.nutres.2016.11.007
6. Wieslander, G.; Fabjan, N.; Vogrincic, M.; Kreft, I.; Janson, C.; Spetz-Nyström, U.; Vombergar, B.; Tagesson, C.; Leanderson, P.; Norbäck, D. Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs Tohoku J. Exp. Med. 2011, 225, 123-30 10.1620/tjem.225.123
7. He, J.; Klag, M. J.; Whelton, P. K.; Mo, J. P.; Chen, J. Y.; Qian, M. C.; Moo, P. S.; He, G. Q. Oats and buckwheat intakes and cardiovascular disease risk factors in an ethnic minority in China Am. J. Clin. Nutr. 1995, 61, 366-72
8. Son, B. K.; Kim, J. Y.; Lee, S. S. Effect of adlay, buckwheat and barley on lipid metabolism and aorta histopathology in rats fed an obesogenic diet Ann. Nutr. Metab. 2008, 52, 181-7 10.1159/000138121
9. Prestamo, G.; Pedrazuela, A.; Penas, E.; Lasuncion, M. A.; Arroyo, G. Role of buckwheat diet on rats as prebiotic and healthy food Nutr. Res. (N. Y., NY, U. S.) 2003, 23, 803-14 10.1016/S0271-5317(03)00074-5
10. Kayashita, J.; Shimaoka, I.; Nakajoh, M.; Yamazaki, M.; Kato, N. Consumption of buckwheat protein lowers plasma cholesterol and raises fecal neutral sterols in cholesterol-fed rats because of its low digestibility J. Nutr. 1997, 27, 1395-400
11. Tomotake, H.; Yamamoto, N.; Kitabayashi, H.; Kawakami, A.; Kayashita, J.; Ohinata, H.; Karasawa, H.; Kato, N. Preparation of tartary buckwheat protein product and its improving effect on cholesterol metabolism in rats and mice fed cholesterol-enriched diet J. Food Sci. 2007, 72 ( 7 ) S528-33 10.1111/j.1750-3841.2007.00474.x
12. Wang, M.; Liu, J. R.; Gao, J. M.; Parry, J. W.; Wei, Y. M. Antioxidant activity of Tartary buckwheat bran extract and its effect on the lipid profile of hyperlipidemic rats J. Agric. Food Chem. 2009, 57, 5106-12 10.1021/jf900194s
13. Yang, N.; Li, Y. M.; Zhang, K.; Jiao, R.; Ma, K. Y.; Zhang, R.; Ren, G.; Chen, Z. Y. Hypocholesterolemic activity of buckwheat flour is mediated by increasing sterol excretion and down-regulation of intestinal NPC1L1 and ACAT2 J. Funct. Foods 2014, 6, 311-8 10.1016/j.jff.2013.10.020
14. Ziaee, A.; Zamansoltani, F.; Nassiri-Asl, M.; Abbasi, E. Effects of rutin on lipid profile in hypercholesterolaemic rats Basic Clin. Pharmacol. Toxicol. 2009, 104, 253-258 10.1111/j.1742-7843.2008.00368.x
15. Hirche, F.; Schroder, A.; Knoth, B.; Stangl, G. I.; Eder, K. Effect of dietary methionine on plasma and liver cholesterol concentrations in rats and expression of hepatic genes involved in cholesterol metabolism Br. J. Nutr. 2006, 95, 879-888 10.1079/BJN20061729
16. Gudbrandsen, O. A.; Wergedahl, H.; Liaset, B.; Espe, M.; Berge, R. K. Dietary proteins with high isoflavone content or low methionine-glycine and lysine-arginine ratios are hypocholesterolaemic and lower the plasma homocysteine level in male Zucker fa/fa rats Br. J. Nutr. 2005, 94 ( 3 ) 321-30 10.1079/BJN20051496
17. Tomotake, H.; Yamamoto, N.; Yanaka, N.; Ohinata, H.; Yamazaki, R.; Kayashita, J.; Kato, N. High protein buckwheat flour suppresses hypercholesterolemia in rats and gallstone formation in mice by hypercholesterolemic diet and body fat in rats because of its low protein digestibility Nutrition 2006, 22, 166-173 10.1016/j.nut.2005.01.012
18. Chinese Standard GB/T 5009.124-2003. In Method for Determination of Amino Acids in Foods; Standards Press of China: Beijing, China, 2003.
19. Chinese Standard GB/T 18246-2000. In Method for Determination of Amino Acids in Foods; Standards Press of China: Beijing, China, 2000.
20. Steadman, K. J.; Burgoon, M. S.; Lewis, B. A.; Edwardson, S. E.; Obendorf, R. L. Minerals, phytic acid, tannin and rutin in buckwheat seed milling fractions J. Sci. Food Agric. 2001, 81, 1094-1100 10.1002/jsfa.914
21. Fabjan, N.; Rode, J.; Kosÿir, I. J.; Wang, Z.; Zhang, Z.; Kreft, I. Tartary buckwheat (Fagopyrum tataricum Gaertn.) as a source of dietary rutin and quercitrin J. Agric. Food Chem. 2003, 51, 6452-6455 10.1021/jf034543e
22. Huang, W.; Cheang, W. S.; Wang, X.; Lei, L.; Liu, Y.; Ma, K. Y.; Zheng, F.; Huang, Y.; Chen, Z. Y. Capsaicinoids but not their analogue capsinoids lower plasma cholesterol and possess beneficial vascular activity J. Agric. Food Chem. 2014, 62, 8415-20 10.1021/jf502888h
23. Chan, P. T.; Fong, W. P.; Huang, Y.; Ho, W. K. K.; Chen, Z. Y. Jasmine green tea epicatehins are hypolipidemic in hamster (Mesocricetus auratus) fed a high fat diet J. Nutr. 1999, 129, 1094-1101
24. Wang, X.; Guan, L.; Zhao, Y.; Lei, L.; Liu, Y.; Ma, K. Y.; Wang, L.; Man, S. W.; Wang, J.; Huang, Y.; Chen, Z. Y. Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters Atherosclerosis 2015, 242, 77-86 10.1016/j.atherosclerosis.2015.06.046
25. Juzwiak, S.; Wojcicki, J.; Mokrzycki, K.; Marchlewicz, M.; Bialecka, M.; Wenda-Rozewicka, L.; Gawronska-Szklarz, B.; Drozdzik, M. Effect of quercetin on experimental hyperlipidemia and atherosclerosis in rabbits Pharmacol. Rep. 2005, 57, 604-9
26. Lee, K. H.; Park, E.; Lee, H. J.; Kim, M. O.; Cha, Y. J.; Kim, J. M.; Lee, H.; Shin, M. J. Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers Nutr. Res. Pract. 2011, 5, 28-33 10.4162/nrp.2011.5.1.28
27. 14C] quercetin-4′-glucoside in rats Drug Met. Dispos. 2005, 33, 1036-1043 10.1124/dmd.104.002691
28. Metzger, B. T.; Barnes, D. M.; Reed, J. D. Insoluble fraction of buckwheat (Fagopyrum esculentum Moench) protein possessing cholesterol-binding properties that reduce micelle cholesterol solubility and uptake by Caco-2 cells J. Agric. Food Chem. 2007, 55, 6032-3038 10.1021/jf0709496