Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

Journal of Immunology

Volumn 198, Issue 4, 2017, Pages 1616-1626

  Wonderlich, Elizabeth R ^a,b   Swan, Zachary D ^a,b   Bissel, Stephanie J ^c   Hartman, Amy L ^a,b   Carney, Jonathan P ^c   O'Malley, Katherine J ^a,c   Obadan, Adebimpe O ^d   Santos, Jefferson ^d   Walker, Reagan ^a   Sturgeon, Timothy J ^a   Frye, Lonnie J ^c   Maiello, Pauline ^c   Scanga, Charles A ^c   Bowling, Jennifer D ^a,b   Bouwer, Anthea L ^a,b   Duangkhae, Parichat A ^a,b   Wiley, Clayton A ^c   Flynn, Joanne L ^c   Wang, Jieru ^c   Cole, Kelly S ^a,c   Perez, Daniel R ^d   Reed, Douglas S ^a,c   Barratt Boyes, Simon M ^a,b,c   more..

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AEROSOL; CYTOKINE;

ADULT RESPIRATORY DISTRESS SYNDROME; AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVIAN INFLUENZA (H5N1); CELL TRANSFER; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; FATALITY; FEMALE; FULMINANT PNEUMONIA; IMAGE ANALYSIS; IMMUNE RESPONSE; LUNG ALVEOLUS MACROPHAGE; MACACA FASCICULARIS; MOLECULAR IMAGING; MOLECULAR PATHOLOGY; NONHUMAN; PARTICLE SIZE; PNEUMONIA; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TARGET CELL; VIRUS IDENTIFICATION; VIRUS REPLICATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DISEASE MODEL; IMMUNOLOGY; INFLUENZA A VIRUS (H5N1); INNATE IMMUNITY; LUNG; LUNG ALVEOLUS; LUNG ALVEOLUS EPITHELIUM CELL; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VIROLOGY; VIRUS PNEUMONIA;

AEROSOLS; ALVEOLAR EPITHELIAL CELLS; ANIMALS; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; INFLUENZA A VIRUS, H5N1 SUBTYPE; LUNG; MACACA FASCICULARIS; MACROPHAGES, ALVEOLAR; ORTHOMYXOVIRIDAE INFECTIONS; PNEUMONIA, VIRAL; PULMONARY ALVEOLI; RESPIRATORY DISTRESS SYNDROME, ADULT; VIRUS REPLICATION;

EID: 85014658865     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1601770     Document Type: Article

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