The automated bioaerosol exposure system: Preclinical platform development and a respiratory dosimetry application with nonhuman primates

Journal of Pharmacological and Toxicological Methods

Volumn 49, Issue 1, 2004, Pages 39-55

  Hartings, Justin M ^a,b   Roy, Chad J ^b  

^a Hartings Consulting Inc   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Automation; Dosimetry; Inhalation; Method; Plethysmography; Primates; Validation

Indexed keywords

STAPHYLOCOCCUS ENTEROTOXIN B; VACCINE;

ACCURACY; AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOMATION; BODY PLETHYSMOGRAPHY; CALCULATION; COMPARATIVE STUDY; DOSIMETRY; EXPERIMENT; EXPOSURE; HOMEOSTASIS; INHALATION; MACACA; MICROPROCESSOR; NONHUMAN; RESPIRATORY FUNCTION; STATISTICAL ANALYSIS;

ANIMALIA; MACACA; MACACA MULATTA; PRIMATES;

EID: 0344737051     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2003.07.001     Document Type: Article

References (61)

1. Allen D.L., Leiter P.A., Tielking R.L., Hoffman W.P., Vidyashanker A.N., van Lier R.B., Wolff R.K. Effects of inhalation exposures to an M1-receptor agonist on ventilation in rhesus monkeys. Drug and Chemical Toxicology. 22:1999;595-611.
2. Allen D.L., Pollard K.R., Hughes B.L., Dorato M.A., Wolff R.K. Use of a head dome system to compare i.v. methacholine-induced bronchoconstriction in conscious vs anesthetized rhesus monkeys. Journal of Applied Toxicology. (1):1995;13-17.
3. Anzueto A., DeLemos R.A., Seidenfeld J., Moore G., Hamil H., Johnson D., Jenkinson S.G. Acute inhalation toxicity of soman and sarin in baboons. Fundamental and Applied Toxicology. 14:1990;676-687.
4. Besch T.K., Ruble D.L., Gibbs P.H., Pitt M.L. Steady-state minute volume determination by body-only plethysmography in juvenile rhesus monkeys. Laboratory Animal Sciences. 46:1996;539-544.
5. Bide R.W., Armour S.J., Yee E. Allometric respiration/body mass data for animals to be used for estimates of inhalation toxicity to young adult humans. Journal of Applied Toxicology. 20:2000;273-290.
6. Bowes S.M., Frank R., Swift D.L. The head dome: A simplified method for human exposures to inhaled air pollutants. American Industrial Hygiene Association Journal. 51:1990;257-260.
7. Byron P.R., Patton J. Drug delivery via the respiratory tract. Journal of Aerosol Medicine. 7:1994;49-75.
8. Cannon W.C., Blanton E.F., McDonald K.E. The flow-past chamber: An improved nose-only exposure system for rodents. American Industrial Hygiene Association Journal. 44:1983;923-928.
9. CDC (United States Department of Health and Human Services) Biosafety in microbiological and biomedical laboratories. 2002;United States Government Printing Office, Washington, DC.
10. Cheng Y., Moss O. Inhalation exposure systems. McCellan R.O., Henderson R.E. Inhalation toxicology. 1997;25-66 Pergamon, New York.
11. Conley J., Yang H., Wilson T., Blasetti K., Ninno V., Schell G., Wong J. Aerosol delivery of liposome-encapsulated ciprofloxacin: Aerosol characterization and efficacy against Francisella tularensis infection in mice. Antimicrobial Agents and Chemotherapy. 41:1997;1288-1292.
12. Dahl A.R., Schlesinger R.B., Heck H.D.A., Medinsky M.A., Lucier G.W. Comparative dosimetry of inhaled materials: Differences among animal species and extrapolation of man. Fundamental and Applied Toxicology. 16:1990;1-13.
13. Decker J.R., Park J.F., Craig D.K. A method for measuring respiratory minute volume parameters of large animals during exposure to aerosols. American Industrial Hygiene Association Journal. 40:1979;567-577.
14. Dorato M.A., Wolff R.K. Inhalation exposure technology, dosimetry, and regulatory issues. Toxicologic Pathology. 19:1991;373-383.
15. Drorbaugh J.E., Fenn W.O. A barometric method for measuring ventilation in newborn infants. Pediatrics. 16:1955;81-87.
16. Dunklin G.W., Puck T.T. The lethal effect of relative humidity on airborne bacteria. Journal of Experimental Medicine. 87:1948;87-101.
17. Ehrlich R., Miller S. Survival of airborne Pasteurella tularensis at different atmospheric temperatures. Applied Microbiology. 25:1973;369-372.
18. Ehrlich R., Miller S., Walker R. Relationship between atmospheric temperature and survival of airborne bacteria. Applied Microbiology. 19:1970;245-249.
19. Franz D.R. Defense against Toxin Weapons. Zajtchuk R., Bellamy R.F. Textbook of military medicine: Part I. Warfare, weaponry, and the casualty: Medical aspects of chemical and biological warfare. 1997;603-619 U.S. Surgeon General Printing Office, Washington, DC.
20. Griffith R.B., Standafer S. Simultaneous mainstream-sidestream smoke exposure system: II. The rats exposure system. Toxicology. 35:1985;13-24.
21. Guyton A.C. Measurement of the respiratory volumes of laboratory animals. American Journal of Physiology. 150:1947;70-77.
22. Hartings, J. M., Roy, C. J., & Liverette, G. M. (2003). Inhalation System, U.S. Patent and Trademark Office, Patent Application #10/364,855.
23. Hassler, C. R., Moutvic, R. R., Freeman, G. B., Morgan, M. M., Vinci, T. M., Rust, S. W., & Lordo, R. A. (1993). Behavioral and toxicologic effects of alfentanil in cynomolgus monkeys following single, short-term inhalation exposure. Edgewood Research Development and Engineering Center Technical Report Number ERDEC-CR-009, U.S. Army Chemical and Biological Defense Agency, unclassified.
24. Henderson D. An apparatus for the study of airborne infection. Journal of Hygiene. 50:1952;53-68.
25. Higuchi M.A., Davies D.W. An ammonia abatement system for whole-body small animal inhalation exposures to acid aerosols. Inhalation Toxicology. 5:1993;333-343.
26. Ivins B.E., Pitt M.L.M., Fellows P.F., Farchaus J.W., Benner G.E., Waag D.M., Little S.F., Anderson G.W., Gibbs P.H., Friedlander A.M. Comparative efficacy of experimental anthrax vaccine candidates against inhalation anthrax in rhesus macaques. Vaccine. 16:1996;1141-1148.
27. Jemski J.V., Phillips G.B. Aerosol challenge of animals. Gay W. Methods of animal experimentation. 1965;274-341 Academic Press, New York.
28. Johnson E., Jaax N., White J., Jahrling P. Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus. International Journal of Experimental Pathology. 76(4):1995;227-236.
29. Kimmel E.C. A small animal plethysmograph/exposure tube for determination of respiratory mechanics during exposure, using a noninvasive method to measure intrapleural pressure. Toxicology Methods. 11:2001;173-188.
30. Ko G., First M., Burge H. Influence of relative humidity on particle size and UV sensitivity of Serratia marcescens and Mycobacterium bovis BCG aerosols. Tubercle and Lung Disease. 80:2000;217-228.
31. Landry T.O., Ramsey J.C., McKenna H.J. Pulmonary physiology and inhalation dosimetry in rats: Development of a method and two examples. Toxicology and Applied Pharmacology. 71(1):1983;72-83.
32. Larson E., Dominik J., Slone T. Aerosol stability and respiratory infectivity of Japanese B encephalitis virus. Infection and Immunity. 30:1980;397-401.
33. Leong K.H., Wang H.C., Stukel J.J., Hopke P.K. An improved constant output nebulizer. American Industrial Hygiene Association Journal. 43(2):1982;136.
34. Le Souef P. The meaning of lung dose. Allergy. 54:1999;93-96.
35. Lowell G.H., Colleton C., Frost D., Kaminski R.W., Hughes M., Hatch J., Hooper C., Estep J., Pitt L., Topper M., Hunt R.E., Baker W., Baze W.B. Immunogenicity and efficacy against lethal aerosol SEB challenge in monkeys by intramuscular and respiratory delivery of proteosome-toxiod vaccines. Infection and Immunity. 64:1996;4686-4693.
36. Malek D.E., Alarie Y. Ergometer within a whole-body plethysmograph to evaluate performance of guinea pigs under toxic atmospheres. Toxicology and Applied Pharmacology. 101:1989;340-355.
37. Martonen T.B., Katz I.M., Musante C.J. A nonhuman primate aerosol deposition model for toxicological and pharmaceutical studies. Inhalation Toxicology. 13:2001;307-324.
38. Mauderly J.L. Respiration of F344 rats in nose-only inhalation exposure tubes. Journal of Applied Toxicology. 6:1986;25-30.
39. McClellan R.O. An introduction to inhalation toxicology. McCellan R.O., Henderson R.E. Inhalation toxicology. 1997;3-21 Pergamon, New York.
40. McDonald R.J., Liggitt H.D., Roche L., Hguyen H.T., Pearlman R., Raabe O.G., Bussey L.B., Gorman C.M. Aerosol delivery of lipid: DNA complexes to lungs of rhesus monkeys. Pharmaceutical Research. 15:1998;671-679.
41. McFarland H.N. Designs and operational characteristics of inhalation exposure equipment - A review. Fundamental and Applied Toxicology. 3:1983;603-613.
42. McMurray D.N. A nonhuman primate model for preclinical testing of new tuberculosis vaccines. Clinical Infectious Diseases. 30:2000;S210-S212.
43. 14C] methyl bromide as influenced by exposure concentration. Toxicology and Applied Pharmacology. 78:1985;215-225.
44. Nerbrink O., Fagerstrom P.-O., Wendel T., Eirefelt S., Kallen A., Marchner H., Dahlback M. A novel dry powder aerosol delivery system for real time measurement of the inhaled dose to large animals (dogs). Aerosol Science and Technology. 27:1997;147-161.
45. O'Shaughnessy P., Hemenway D.R. Computer automation of a dry-dust generating system. Inhalation Toxicology. 6:1994;95-113.
46. O'Shaughnessy P., Hemenway D.R. Characteristics of an aerosol photometer while automatically controlling chamber dilution-air flow rate. Inhalation Toxicology. 12:2000;979-996.
47. Phalen R.F., Mannix R.C., Drew R.T. Inhalation exposure methodology. Environmental Health Perspectives. 56:1984;23-34.
48. Pitt M.L.M. Defense against toxin weapons. Sidell F.R., Takafuji E.T., Franz D.R. Textbook of military medicine, Part I: Warfare, weaponry, and the casualty: Medical aspects of chemical and biological warfare. 1996;U.S. Surgeon General Printing Office, Washington, DC.
49. Pitt M.L.M., Little S.F., Ivins B.E., Barth J., Hewetson J., Gibbs P., Dertzbaugh M., Friedlander A.M. In vitro correlate of immunity in a rabbit model of inhalational anthrax. Vaccine. 19:2001;4768-4773.
50. Raabe O.G., Bennick J.E., Light M.E., Hobbs C.H., Thomas R.L. An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols. Toxicology and Applied Pharmacology. 26:1973;264-273.
51. Reece W.O. Respiration in mammals. Chapter 13, Respiration. Swenson M.J. Dukes' Physiology of Domestic Animals. 1993;245-246 Comstock/Cornell University Press, Ithacam.
52. Roy C.J., Hale M.L., Hartings J.M., Duniho S., Pitt M.L.M. Impact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c mice. Inhalation Toxicology. 15(6):2003;619-638.
53. Roy, C. J., & Hartings, J. M. (2001). Automated inhalation toxicology exposure system. U.S. Patent and Trademark Office, Patent Application #09/919, 741.
54. Roy C.J., Reed D.S., Duniho S., Krieg A.M., DaSilva L. Immunogenicity of inhaled murine CpG oligonucleotides as a mucosal adjuvant in combination with recombinant SEB vaccine. Toxicologist. 66(1):2002;S-737.
55. Salem H. Inhalation toxicology: Research methods, applications, and evaluation. 1987;Dekker, New York.
56. Schlesinger R.B. Comparative deposition of inhaled aerosols in experimental animals and humans: A review. Journal of Toxicology and Environmental Health. 15:1985;197-214.
57. Snipes M.B., Spoo J.W., Brookins L.K., Jones S.E., Mauderly J.L., Orwat T.B., Stiver J.H., Dahl A.R. A method for measuring nasal and lung uptake of inhaled vapor. Fundamental and Applied Toxicology. 16:1991;81-91.
58. Stephenson E.H., Moeller R.B., York C.G., Young H.W. Nose-only versus whole-body aerosol exposure for induction of upper respiratory infections of laboratory mice. American Industrial Hygiene Journal. 49:1988;128-135.
59. Stiles B., Garza A., Ulrich R., Boles J. Mucosal vaccination with recombinantly attenuated staphylococcal enterotoxin B and protection in a murine model. Infection and Immunity. 69:2001;2031-2036.
60. Thorne P.S. Inhalation toxicology models of endotoxin- and bioaerosol-induced inflammation. Toxicology. 2(152):2000;13-23.
61. Wolff R.K., Dorato M.A. Toxicologic testing of inhaled pharmaceutical aerosols. Critical Reviews in Toxicology. 23:1993;343-369.