Thymic Determinants of γδ T Cell Differentiation

Trends in Immunology

Volumn 38, Issue 5, 2017, Pages 336-344

  Muñoz Ruiz, Miguel ^a   Sumaria, Nital ^b   Pennington, Daniel J ^b   Silva Santos, Bruno ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

IFN ; IL 17; T cell development; TCR; Thymus; T cells

Indexed keywords

T LYMPHOCYTE RECEPTOR; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR;

CELL FATE; EFFECTOR CELL; GAMMA DELTA T LYMPHOCYTE; GENETIC TRANSCRIPTION; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS; ANIMAL; BIOLOGICAL MODEL; CELL DIFFERENTIATION; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; CELL DIFFERENTIATION; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 85014606837     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2017.01.007     Document Type: Review

References (72)

1. 1 Kreslavsky, T., et al. αβ versus γδ fate choice: counting the T-cell lineages at the branch point. Immunol. Rev. 238 (2010), 169–181.
2. 2 Terrence, K., et al. Premature expression of T cell receptor (TCR) αβ suppresses TCRγδ gene rearrangement but permits development of γδ lineage T cells. J. Exp. Med. 192 (2000), 537–548.
3. 3 Bruno, L., et al. The αβ T cell receptor can replace the γδ receptor in the development of γδ lineage cells. Immunity 5 (1996), 343–352.
4. 4 Buer, J., et al. Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 185 (1997), 1541–1547.
5. 5 Kang, J., et al. Evidence that γδ versus αβ T cell fate determination is initiated independently of T cell receptor signaling. J. Exp. Med. 193 (2001), 689–698.
6. 6 Melichar, H.J., et al. Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13. Science 315 (2007), 230–233.
7. + γδ T cells in a spontaneous Sox13-mutant CD45.1 congenic mouse substrain provides protection from dermatitis. Nat. Immunol. 14 (2013), 584–592.
8. 8 Haks, M.C., et al. Attenuation of γδTCR signaling efficiently diverts thymocytes to the αβ lineage. Immunity 22 (2005), 595–606.
9. 9 Hayes, S.M., TCR signal strength influences αβ/γδlineage fate. Immunity 22 (2005), 583–593.
10. 10 Lauritsen, J.P., et al. Marked induction of the helix-loop-helix protein Id3 promotes the γδ T cell fate and renders their functional maturation Notch independent. Immunity 31 (2009), 565–575.
11. 11 Lee, S.Y., et al. Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. Immunity 41 (2014), 934–946.
12. 12 Ciofani, M., Zuniga-Pflucker, J.C., Determining γδ versus αβ T cell development. Nat. Rev. Immunol. 10 (2010), 657–663.
13. 13 Ribot, J.C., et al. CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17-producing γδ T cell subsets. Nat. Immunol. 10 (2009), 427–436.
14. 14 Schmolka, N., et al. Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat. Immunol. 14 (2013), 1093–1100.
15. 15 Coffey, F., et al. The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification. J. Exp. Med. 211 (2014), 329–334.
16. 16 Fahl, S.P., et al. Origins of γδ T cell effector subsets: a riddle wrapped in an enigma. J. Immunol. 193 (2014), 4289–4294.
17. 17 Zarin, P., et al. γδ T-cell differentiation and effector function programming, TCR signal strength, when and how much?. Cell. Immunol. 296 (2015), 70–75.
18. 18 Jensen, K.D., et al. Thymic selection determines γδ T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon γ. Immunity 29 (2008), 90–100.
19. 19 Turchinovich, G., Hayday, A.C., Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells. Immunity 35 (2011), 59–68.
20. 20 Prinz, I., et al. Functional development of γδ T cells. Eur. J. Immunol. 43 (2013), 1988–1994.
21. 21 Chien, Y.H., et al. The natural and the inducible: interleukin (IL)-17-producing γδ T cells. Trends Immunol. 34 (2013), 151–154.
22. 22 Wencker, M., et al. Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nat. Immunol. 15 (2014), 80–87.
23. 23 Munoz-Ruiz, M., et al. TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nat. Immunol. 17 (2016), 721–727.
24. 24 Kreslavsky, T., et al. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 12453–12458.
25. 25 Pereira, P., et al. Critical role of TCR specificity in the development of Vγ1Vδ6.3 + innate NKTγδ cells. J. Immunol. 191 (2013), 1716–1723.
26. 26 Malhotra, N., et al. A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity 38 (2013), 681–693.
27. 27 Odumade, O.A., et al. Kruppel-like factor 2 regulates trafficking and homeostasis of γδ T cells. J. Immunol. 184 (2010), 6060–6066.
28. 28 Jordan, M.S., et al. Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 28 (2008), 359–369.
29. 29 Fuller, D.M., et al. A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity. Immunol. Res. 49 (2011), 97–108.
30. 30 Felices, M., et al. Tec kinase Itk in γδT cells is pivotal for controlling IgE production in vivo. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 8308–8313.
31. 31 Blanco, R., et al. Conformational changes in the T cell receptor differentially determine T cell subset development in mice. Sci. Signal., 7, 2014, ra115.
32. 32 Hwang, S., et al. TCR ITAM multiplicity is required for the generation of follicular helper T-cells. Nat. Commun., 6, 2015, 6982.
33. 33 Mahtani-Patching, J., et al. PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization. Sci. Signal., 4, 2011, ra47.
34. 34 Szabo, S.J., et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000), 655–669.
35. H17 differentiation. Nature 460 (2009), 405–409.
36. 36 Ciofani, M., et al. A validated regulatory network for Th17 cell specification. Cell 151 (2012), 289–303.
37. 37 Wei, G., et al. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35 (2011), 299–311.
38. 38 Yang, X.O., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. Immunity 28 (2008), 29–39.
39. 39 Serre, K., Silva-Santos, B., Molecular mechanisms of differentiation of murine proinflammatory γδ T cell subsets. Front. Immunol., 4, 2013, 431.
40. 40 Barros-Martins, J., et al. Effector γδ T cell differentiation relies on master but not auxiliary Th cell transcription factors. J. Immunol. 196 (2016), 3642–3652.
41. 41 Raifer, H., et al. Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22. Eur. J. Immunol. 42 (2012), 3189–3201.
42. 42 Narayan, K., et al. Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nat. Immunol. 13 (2012), 511–518.
43. 43 Seiler, M.P., et al. Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nat. Immunol. 13 (2012), 264–271.
44. 44 Xi, H., et al. Interplay between RORγt, Egr3, and E proteins controls proliferation in response to pre-TCR signals. Immunity 24 (2006), 813–826.
45. 45 Haas, J.D., et al. CCR6 and NK1.1 distinguish between IL-17A and IFN-γ-producing γδ effector T cells. Eur. J. Immunol. 39 (2009), 3488–3497.
46. 46 Park, K., et al. TCR-mediated ThPOK induction promotes development of mature (CD24-) γδ thymocytes. EMBO J. 29 (2010), 2329–2341.
47. 47 Alonzo, E.S., et al. Development of promyelocytic zinc finger and ThPOK-expressing innate γδ T cells is controlled by strength of TCR signaling and Id3. J. Immunol. 184 (2010), 1268–1279.
48. 48 Staal, F.J., et al. WNT signaling in the immune system: WNT is spreading its wings. Nat. Rev. Immunol. 8 (2008), 581–593.
49. 49 Shibata, K., et al. Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. Blood 118 (2011), 586–593.
50. 50 Weber, B.N., et al. A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476 (2011), 63–68.
51. 51 Germar, K., et al. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 20060–20065.
52. 52 Diefenbach, A., et al. Development, differentiation, and diversity of innate lymphoid cells. Immunity 41 (2014), 354–365.
53. 53 Eberl, G., et al. Innate lymphoid cells: a new paradigm in immunology. Science, 348, 2015, aaa6566.
54. 54 Kaye, J., ILC development: TCF-1 reporting in. Nat. Immunol. 16 (2015), 1011–1012.
55. 55 Constantinides, M.G., A committed precursor to innate lymphoid cells. Nature 508 (2014), 397–401.
56. + γδ T cells. J. Immunol. 195 (2015), 4273–4281.
57. 57 Haas, J.D., et al. Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. Immunity 37 (2012), 48–59.
58. 58 Kang, J., Malhotra, N., Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors. Annu. Rev. Immunol. 33 (2015), 505–538.
59. 59 Vermijlen, D., Prinz, I., Ontogeny of innate T lymphocytes – some innate lymphocytes are more innate than others. Front. Immunol., 5, 2014, 486.
60. 60 Vivier, E., et al. The evolution of innate lymphoid cells. Nat. Immunol. 17 (2016), 790–794.
61. 61 De Obaldia, M.E., Bhandoola, A., Transcriptional regulation of innate and adaptive lymphocyte lineages. Annu. Rev. Immunol. 33 (2015), 607–642.
62. 62 Sutton, C.E., et al. IL-17-producing γδ T cells and innate lymphoid cells. Eur. J. Immunol. 42 (2012), 2221–2231.
63. 63 Michel, M.L., et al. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 17549–17554.
64. 64 Chien, Y.H., et al. γδ T cells: first line of defense and beyond. Annu. Rev. Immunol. 32 (2014), 121–155.
65. 65 Zeng, X., et al. γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity 37 (2012), 524–534.
66. 66 Di Marco Barros, R., et al. Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments. Cell, 167, 2016 203–218. e217.
67. 67 Lalor, S.J., McLoughlin, R.M., Memory γδ T cells-newly appreciated protagonists in infection and immunity. Trends Immunol. 37 (2016), 690–702.
68. 68 Lombes, A., et al. Adaptive Immune-like γ/δ T lymphocytes share many common features with their α/β T cell counterparts. J. Immunol. 195 (2015), 1449–1458.
69. + T cells with enhanced protective function. Immunity 40 (2014), 747–757.
70. 70 Silva-Santos, B., et al. γδ T cells in cancer. Nat. Rev. Immunol. 15 (2015), 683–691.
71. 71 Vantourout, P., Hayday, A., Six-of-the-best: unique contributions of γδ T cells to immunology. Nat. Rev. Immunol. 13 (2013), 88–100.
72. 72 Heilig, J.S., Tonegawa, S., Diversity of murine γ genes and expression in fetal and adult T lymphocytes. Nature 322 (1986), 836–840.