Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy

Journal of Molecular Cell Biology

Volumn 8, Issue 6, 2016, Pages 530-541

  Zhang, Youhua ^a   Pan, Youdong ^a   Lin, Changdong ^a   Zheng, Yajuan ^a   Sun, Hao ^a   Zhang, Hailong ^a   Wang, Junlei ^a   Yuan, Mengya ^a   Duan, Tao ^b   Du, Qiaoling ^b   Chen, Jianfeng ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Fetal outcome; G protein coupled receptor; Maternal cholestasis; Placental inflammation; Ursodeoxycholic acid

Indexed keywords

ANDROGRAPHOLIDE; BILE ACID; G PROTEIN COUPLED BILE ACID RECEPTOR 1; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; DITERPENE; GPBAR1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG TARGETING; FEMALE; FETUS; FETUS DEATH; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; INFLAMMATION; INTRAHEPATIC CHOLESTASIS; INTRAHEPATIC CHOLESTASIS OF PREGNANCY; LEUKOCYTE; LYMPHOCYTE MIGRATION; NEWBORN; NONHUMAN; PLACENTA DISORDER; PLACENTAL INFLAMMATION; PREGNANCY DISORDER; RAT; SIGNAL TRANSDUCTION; SYNCYTIOTROPHOBLAST; TROPHOBLAST; UPREGULATION; ANIMAL; CELL MOTION; CHOLESTASIS, INTRAHEPATIC; COMPLICATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LYMPHOCYTE; METABOLISM; PATHOLOGY; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; SPRAGUE DAWLEY RAT;

ANIMALS; BILE ACIDS AND SALTS; CELL ADHESION; CELL MOVEMENT; CHOLESTASIS, INTRAHEPATIC; DITERPENES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; LEUKOCYTES; LYMPHOCYTES; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TROPHOBLASTS; URSODEOXYCHOLIC ACID;

EID: 85014568153     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjw025     Document Type: Article

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