Effects of chemical modification of ursodeoxycholic acid on TGR5 activation

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 1, 2011, Pages 1-7

  Iguchi, Yusuke ^a   Nishimaki Mogami, Tomoko ^b   Yamaguchi, Masafumi ^a   Teraoka, Fumiteru ^a   Kaneko, Tetsuo ^a   Une, Mizuho ^a  

^a HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Farnesoid X receptor; Metabolic syndrome; Structure activity relationship; TGR5; Ursodeoxycholic acid

Indexed keywords

3ALPHA HYDROXY 7BETA SULFOOXY 5BETA CHOLANOIC ACID; 3ALPHA, 7BETA DIHYDROXY 3BETA METHYL 5BETA CHOLANOIC ACID; 3ALPHA, 7BETA DIHYDROXY 7ALPHA METHYL 5BETA CHOLANOIC ACID; 3ALPHA, 7BETA, 12ALPHA TRIHYDROXY 5BETA CHOLANOIC ACID; 3BETA, 7BETA DIHYDROXY 3ALPHA METHYL 5BETA CHOLANOIC ACID; 3BETA, 7BETA DIHYDROXY 5BETA CHOLANOIC ACID; 3BETA, 7BETA DIHYDROXY 7ALPHA METHYL 5BETA CHOLANOIC ACID; 7ALPHA METHYL TAUROURSODEOXYCHOLIC ACID; 7BETA HYDROXY 3 OXO 5BETA CHOLANOIC ACID; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR; HYDROXYL GROUP; LUCIFERASE; SERYLURSODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID DERIVATIVE; URSODEOXYCHOLYL 4 AMINOBENZOIC ACID; URSODEOXYCHOLYL CYSTEIC ACID; URSODEOXYCHOLYL GLYCINE; URSODEOXYCHOLYL SERINE;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HEK293; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENZYME ASSAY; EPIMERIZATION; HUMAN; HUMAN CELL; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; RECEPTOR UPREGULATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; URSODEOXYCHOLIC ACID;

EID: 78951495765     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1     Document Type: Article

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