Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation

BMC Medical Genomics

Volumn 7, Issue 1, 2014, Pages

  Du, Qiaoling ^a   Pan, Youdong ^b   Zhang, Youhua ^b   Zhang, Hailong ^b   Zheng, Yajuan ^b   Lu, Ling ^b   Wang, Junlei ^b   Duan, Tao ^a   Chen, Jianfeng ^b  

^a Shanghai First Maternity and Infant Health Hospital   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Genome wide; Immune response; Intrahepatic cholestasis of pregnancy; Microarray; Placenta

Indexed keywords

BILE ACID; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR6; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 7 RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; VASCULOTROPIN; VASCULOTROPIN C;

ADULT; ANGIOGENESIS; ARTICLE; BILE ACID BLOOD LEVEL; BILE ACID METABOLISM; BIRTH WEIGHT; CCL25 GENE; CCL3 GENE; CCR4 GENE; CCR6 GENE; CCR9 GENE; CELL INFILTRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CXCL14 GENE; DNA HYBRIDIZATION; DNA MICROARRAY; EGF GENE; EGFR GENE; FEMALE; FGF18 GENE; FGF9 GENE; FLT1 GENE; FZD4 GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INTERACTION; GENE ONTOLOGY; GESTATIONAL AGE; GNA12 GENE; GNA14 GENE; GNAS GENE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IL 7R GENE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRAHEPATIC CHOLESTASIS; INTRAHEPATIC CHOLESTASIS OF PREGNANCY; ITGB3 GENE; MUSCLE CONTRACTION; PATHOGENESIS; PLACENTA; PREGNANT WOMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VEGFC GENE; BLOOD; COMPLICATION; GENETICS; IMMUNOLOGY; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PREGNANCY; PREGNANCY COMPLICATION;

ADULT; BILE ACIDS AND SALTS; CHOLESTASIS, INTRAHEPATIC; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; NEOVASCULARIZATION, PATHOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 84903677197     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/1755-8794-7-42     Document Type: Article

References (38)

1. Intrahepatic cholestasis of pregnancy: a past and present riddle. Arrese M, Reyes H, Ann Hepatol 2006 5 3 202 205
2. Molecular pathogenesis of intrahepatic cholestasis of pregnancy. Arrese M, Macias RI, Briz O, Perez MJ, Marin JJ, Expert Rev Mol Med 2008 10 9
3. Intrahepatic cholestasis of pregnancy in women with a multiple pregnancy: an analysis of risks and pregnancy outcomes. Lausman AY, Al-Yaseen E, Sam D, Nitsch R, Barrett JF, Chan WS, J Obstet Gynaecol Can 2008 30 11 1008 1013
4. Intrahepatic cholestasis of pregnancy-a heterogeneous group of pregnancy-related disorders? Beuers U, Pusl T, Hepatology 2006 43 4 647 649
5. Maternal serum bile acid levels and fetal distress in cholestasis of pregnancy. Laatikainen T, Tulenheimo A, Int J Gynaecol Obstet 1984 22 2 91 94
6. Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. Glantz A, Marschall HU, Mattsson LA, Hepatology 2004 40 2 467 474
7. Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy. Williamson C, Miragoli M, Sheikh Abdul Kadir S, Abu-Hayyeh S, Papacleovoulou G, Geenes V, Gorelik J, Dig Dis 2011 29 1 58 61
8. Biliary bile acid composition of the human fetus in early gestation. Colombo C, Zuliani G, Ronchi M, Breidenstein J, Setchell KD, Pediatr Res 1987 21 2 197 200
9. A placental phenotype for intrahepatic cholestasis of pregnancy. Geenes VL, Lim YH, Bowman N, Tailor H, Dixon PH, Chambers J, Brown L, Wyatt-Ashmead J, Bhakoo K, Williamson C, Placenta 2011 32 12 1026 1032
10. Correlation between fetal and maternal serum bile acid concentrations. Colombo C, Roda A, Roda E, Buscaglia M, Dell'Agnola CA, Filippetti P, Ronchi M, Sereni F, Pediatr Res 1985 19 2 227 231
11. Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis. Laatikainen TJ, Am J Obstet Gynecol 1975 122 7 852 856
12. Maternal cholestasis induces placental oxidative stress and apoptosis. Protective effect of ursodeoxycholic acid. Perez MJ, Macias RI, Marin JJ, Placenta 2006 27 1 34 41
13. Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy. Wikstrom Shemer E, Thorsell M, Ostlund E, Blomgren B, Marschall HU, Placenta 2012 33 11 914 918
14. Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy. Wei J, Wang H, Yang X, Dong M, Wang Z, Arch Gynecol Obstet 2010 281 5 801 810
15. A DNA chip off the aging block. Cristofalo VJ, Nat Med 2000 6 5 507
16. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Smyth GK, Stat Appl Genet Mol Biol 2004 3 3
17. A review of feature selection techniques in bioinformatics. Saeys Y, Inza I, Larranaga P, Bioinformatics 2007 23 19 2507 2517
18. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Benjamini Y, Hochberg Y, Journal of the Royal Statistical Society Series B Methodological 1995 57 1 289 300
19. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Nat Genet 2000 25 1 25 29
20. Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans. Dupuy D, Bertin N, Hidalgo CA, Venkatesan K, Tu D, Lee D, Rosenberg J, Svrzikapa N, Blanc A, Carnec A, Carvunis AR, Pulak R, Shingles J, Reece-Hoyes J, Hunt-Newbury R, Viveiros R, Mohler WA, Tasan M, Roth FP, Le Peuch C, Hope IA, Johnsen R, Moerman DG, Barabasi AL, Baillie D, Vidal M, Nat Biotechnol 2007 25 6 663 668
21. Network modeling links breast cancer susceptibility and centrosome dysfunction. Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, Assmann V, Elshamy WM, Rual JF, Levine D, Rozek LS, Gelman RS, Gunsalus KC, Greenberg RA, Sobhian B, Bertin N, Venkatesan K, Ayivi-Guedehoussou N, Sole X, Hernandez P, Lazaro C, Nathanson KL, Weber BL, Cusick ME, Hill DE, Offit K, et al. Nat Genet 2007 39 11 1338 1349
22. Human gene coexpression landscape: confident network derived from tissue transcriptomic profiles. Prieto C, Risueno A, Fontanillo C, de las Rivas J, PLoS One 2008 3 12 3911
23. Network biology: understanding the cell's functional organization. Barabasi AL, Oltvai ZN, Nat Rev Genet 2004 5 2 101 113
24. Hierarchical organization of modularity in metabolic networks. Ravasz E, Somera AL, Mongru DA, Oltvai ZN, Barabasi AL, Science 2002 297 5586 1551 1555
25. Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. Carlson MR, Zhang B, Fang Z, Mischel PS, Horvath S, Nelson SF, BMC Genomics 2006 7 40
26. Protein complexes and functional modules in molecular networks. Spirin V, Mirny LA, Proc Natl Acad Sci USA 2003 100 21 12123 12128
27. Intrahepatic Cholestasis Of Pregnancy: New Insights Into Its Pathogenesis. Floreani A, Caroli D, Lazzari R, Memmo A, Vidali E, Colavito D, D'Arrigo A, Leon A, Romero R, Gervasi M, J Matern Fetal Neonatal Med 2013 26 1410 1415
28. Peripartum cardiomyopathy, an autoimmune manifestation of allograft rejection? Gleicher N, Elkayam U, Autoimmun Rev 2009 8 5 384 387
29. Why much of the pathophysiology of preeclampsia-eclampsia must be of an autoimmune nature. Gleicher N, Am J Obstet Gynecol 2007 196 1 5 e1-7
30. Gestational dermatosis shortly after implantation associated with parental class II HLA compatibility and maternal immune activation: preliminary report of a prospective case series. Gleicher N, Barad DH, Dermatology 2011 222 3 206 211
31. Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB, J Clin Endocrinol Metab 2002 87 9 4213 4224
32. Inflammation, inflammatory cells and angiogenesis: decisions and indecisions. Noonan DM, De Lerma BA, Vannini N, Mortara L, Albini A, Cancer Metastasis Rev 2008 27 1 31 40
33. FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. White AC, Lavine KJ, Ornitz DM, Development 2007 134 20 3743 3752
34. The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. Hayashi H, Sano H, Seo S, Kume T, J Biol Chem 2008 283 35 23791 23800
35. Vascular changes in the cerebellum of Norrin/Ndph knockout mice correlate with high expression of Norrin and Frizzled-4. Luhmann UF, Neidhardt J, Kloeckener-Gruissem B, Schafer NF, Glaus E, Feil S, Berger W, Eur J Neurosci 2008 27 10 2619 2628
36. Vascular endothelial growth factor C induces angiogenesis in vivo. Cao Y, Linden P, Farnebo J, Cao R, Eriksson A, Kumar V, Qi JH, Claesson-Welsh L, Alitalo K, Proc Natl Acad Sci U S A 1998 95 24 14389 14394
37. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Karkkainen MJ, Petrova TV, Oncogene 2000 19 49 5598 5605
38. Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Sepúlveda WH GC, Cruz MA, Rudolph MI, Eur J Obstet Gynecol Reprod Biol 1991 42 3 5