Nanoemulsion for improving solubility and permeability of vitex agnus-castus extract: Formulation and in vitro evaluation using PAMPA and Caco-2 approaches

Drug Delivery

Volumn 24, Issue 1, 2017, Pages 380-390

  Piazzini, Vieri ^a   Monteforte, Elena ^a   Luceri, Cristina ^a   Bigagli, Elisabetta ^a   Bilia, Anna Rita ^a   Bergonzi, Maria Camilla ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Caco 2; Nanoemulsion; PAMPA; Solubility; Vitex agnus castus L

Indexed keywords

CREMOPHOR; LABRASOL; NANOCARRIER; TRIACETIN; VITEX AGNUS CASTUS EXTRACT; WATER; HERBACEOUS AGENT; NANOPARTICLE;

AQUEOUS SOLUTION; ARTICLE; ARTIFICIAL MEMBRANE; ASSAY; CACO-2 CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DISPERSITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG SCREENING; DRUG SOLUBILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; MEMBRANE TRANSPORT; NANOEMULSION; PARALLEL ARTIFICIAL MEMBRANE PERMEATION ASSAY; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; VALIDATION STUDY; VITEX AGNUS CASTUS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; EMULSION; INTESTINE ABSORPTION; METABOLISM; PARTICLE SIZE; PERMEABILITY; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; SOLUBILITY; VITEX;

CACO-2 CELLS; CELL SURVIVAL; DRUG COMPOUNDING; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; EMULSIONS; HUMANS; INTESTINAL ABSORPTION; MEMBRANES, ARTIFICIAL; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; SOLUBILITY; VITEX;

EID: 85014500359     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717544.2016.1256002     Document Type: Article

References (37)

1. Aditya NP, Shim M, Lee I, et al. (2013). Curcumin and genistein coloaded nanostructured lipid carriers: in vitro digestion and antiprostate cancer activity. J Agric Food Chem 61:1878-83.
2. Akhtar J, Siddiqui H, Badruddeen SF, et al. (2016). Nanoemulsion: for improved oral delivery of repaglinide. Drug Deliv 23:2016-34.
3. Artursson P, Karlsson J. (1991). Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (CACO-2) cells. Biochem Biophys Res Commun 175:880-85.
4. Artursson P, Palm K, Luthman K. (2001). Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 46:27-43.
5. Balimane PV, Han YH, Chong S. (2006). Current industrial practices of assessing permeability and p-glycoprotein interaction. Aaps J 8: E1-13.
6. Berger D, Schaffner W, Schrader E, et al. (2000). Efficacy of Vitex agnus-castus L extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet 264:150-53.
7. Bergonzi MC, Hamdouch R, Mazzacuva F, et al. (2014). Optimization, characterization and in vitro evaluation of curcumin microemulsions. LWT - Food Sci Technol 59:148-55.
8. Bergonzi MC, Isacchi B, Bilia AR. (2013). Octanoyl-6-O-ascorbic acid: an efficient antioxidant with potent solubilising properties the case of active constituents from Saint John’s wort. J Drug Del Sci Technol 23: 505-09.
9. Bermejo M, Avdeef A, Ruiz A, et al. (2004). PAMPA - a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. Eur J Pharm Sci 21: 429-41.
10. Čilek A, Čelebi N, Tirnaksiz F. (2006). Lecithin-based microemulsion of a peptide for oral administration: preparation, characterization, and physical stability of the formulation. Drug Deliv 13:19-24.
11. Chen X, Murawski A, Patel K, et al. (2008). A novel design of artificial membrane for improving the PAMPA model. Pharm Res 25: 1511-20.
12. Esfanjani AF, Jafari SM. (2016). Biopolymer nanoparticles and natural nanocarriers for nano-encapsulation of phenolic compounds. Colloids Surf B Biointerfaces 146:532-43.
13. European Medicines Agency. (2012). EMA Guidelines, 44, 1-23.
14. European Medicines Agency. (2010). Community Herbal Monograph on Vitex agnus-castus L. fructus, EMA/HMPC/144006/2009, Committee on Herbal Medicinal Products (HMPC).
15. European Pharmacopoeia. (2014). 8.0 Ed. 1137 p.
16. Hiremath SP, Soppimath KS, Betageri GV. (2009). Proliposomes of exemestane for improved oral delivery: formulation and in vitro evaluation using PAMPA, Caco-2 and rat intestine. Int J Pharm 380: 96-104.
17. Hoberg E, Orjala J, Meier B, Sticher O. (1999). Diterpenoids from the fruits of Vitex agnus-castus. Phytochemistry 52:1555-58.
18. Hogner C, Sturm S, Seger C, Stuppner H. (2013). Development and validation of a rapid ultra-high performance liquid chromatography diode array detector method for Vitex agnus-castus. J Chromatogr B 927:181-90.
19. Hu L, Yang J, Liu W, Li L. (2011). Preparation and evaluation of ibuprofen-loaded microemulsion for improvement of oral bioavailability. Drug Deliv 18:90-95.
20. Hubatsch I, Ragnarsson EG, Artursson P. (2007). Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers. Nat Protoc 2:2111-19.
21. Iacomino G, Fierro O, D’Auria S, et al. (2013). Structural analysis and Caco-2 cell permeability of the celiac-toxic A-gliadin peptide 31-55. J Agric Food Chem 61:1088-96.
22. Ibrahim N, Ibrahim H, Sabater AM, et al. (2015). Artemisinin nanoformulation suitable for intravenous injection: preparation, characterization and antimalarial activities. Int J Pharm 495:671-79.
23. ICH. (1996). Validation of analytical procedures: methodology-ICH Harmonised Tripartite Guideline.
24. Isacchi B, Bergonzi MC, Iacopi R, et al. (2016). Liposomal formulation to increase stability and prolong antineuropathic and anti-inflammatory activities of verbascoside. Planta Med [Epub ahead of print]. doi: 10.1055/s-0042-106650.
25. Jarry H, Leonhardt S, Gorkow C, Wuttke W. (1994). In vitro prolactin but not LH and FSH release is inhibited by compounds in extract of Agnus castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 102: 448-54.
26. Kansy M, Senner F, Gubernator K. (1998). Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. J Med Chem 41: 1007-10.
27. Kerns EH, Di L, Petusky S, et al. (2004). Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery. J Pharm Sci 93:1440-53.
28. Porter CJH, Pouton CW, Cuine JF, Charman WN. (2008). Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev 60:673-91.
29. Porter CJH, Trevaskis NL, Charman WN. (2007). Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 6:231-48.
30. Proestos C, Sereli D, Komaitis M. (2006). Determination of phenolic compounds in aromatic plants by RP-HPLC and GC-MS. Food Chem 95:44-52.
31. Righeschi C, Coronnello M, Mastrantoni A, et al. (2014). Strategy to provide a useful solution to effective delivery of dihydroartemisinin: development, characterization and in vitro studies of liposomal formulations. Colloids Surf B Biointerfaces 116:121-27.
32. Righeschi C, Bergonzi MC, Isacchi B, et al. (2016). Enhanced curcumin permeability by SLN formulation: the PAMPA approach. LWT - Food Sci Technol 66:475-83.
33. Sandhya KV, Devi GS, Mathew SM. (2008). Liposomal formulations of serratiopeptidase: in vitro studies using PAMPA and Caco-2 models. Mol Pharm 5:92-97.
34. Sermkaew N, Ketjinda W, Boonme P, et al. (2013). Liquid and solid selfmicroemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from a crude extract of Andrographis paniculata. Eur J Pharm Sci 50:459-66.
35. Tenjarla S. (1999). Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst 16: 461-521.
36. Yee S. (1997). In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth. Pharm Res 14:763-66.
37. Zahid H, Rizwani GH, Ishaqe S. (2016). Phytopharmacological review on Vitex agnus-castus: a potential medicinal plant. Chin Herbal Med 8:24-29.