CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: A meta-analysis

Human Immunology

Volumn 75, Issue 5, 2014, Pages 414-421

  Lee, Young Ho ^a   Kim, Jae Hoon ^a   Seo, Young Ho ^a   Choi, Sung Jae ^a   Ji, Jong Dae ^a   Song, Gwan Gyu ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; 3' UNTRANSLATED REGION; MICROSATELLITE DNA;

3' UNTRANSLATED REGION; ALLELE; ARTICLE; ASIAN; CROHN DISEASE; ETHNICITY; EUROPEAN AMERICAN; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOTE; HUMAN; INFLAMMATORY BOWEL DISEASE; META ANALYSIS; MICROSATELLITE MARKER; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMATIC REVIEW; ULCERATIVE COLITIS; GENETIC PREDISPOSITION; GENETICS; RISK;

3' UNTRANSLATED REGIONS; ALLELES; COLITIS, ULCERATIVE; CROHN DISEASE; CTLA-4 ANTIGEN; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFLAMMATORY BOWEL DISEASES; MICROSATELLITE REPEATS; ODDS RATIO; POLYMORPHISM, GENETIC;

EID: 84896548089     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2014.02.020     Document Type: Article

References (41)

1. Cho J.H. Inflammatory bowel disease: genetic and epidemiologic considerations. World J Gastroenterol 2008, 14:338-347.
2. Vermeire S., Rutgeerts P. Current status of genetics research in inflammatory bowel disease. Genes Immun 2005, 6:637-645.
3. Greenwald R.J., Latchman Y.E., Sharpe A.H. Negative co-receptors on lymphocytes. Curr Opin Immunol 2002, 14:391-396.
4. Brunner M.C., Chambers C.A., Chan F.K., Hanke J., Winoto A., Allison J.P. CTLA-4-mediated inhibition of early events of T cell proliferation. J Immunol 1999, 162:5813-5820.
5. Repnik K., Potocnik U. CTLA4 CT60 single-nucleotide polymorphism is associated with Slovenian inflammatory bowel disease patients and regulates expression of CTLA4 isoforms. DNA Cell Biol 2010, 29:603-610.
6. Ben Alaya W., Sfar I., Aouadi H., Jendoubi S., Najjar T., Filali A., et al. Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population. Saudi J Gastroenterol 2009, 15:29-34. 10.4103/1319-3767.
7. Zhou F., Xia B., Guo Q.S., Wang Q., Li L., Jiang L., et al. Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis. Zhonghua Nei Ke Za Zhi 2006, 45:478-481.
8. Jiang Y., Xia B. Association between the cytotoxic T lymphocyte antigen-4 gene microsatellite polymorphism and inflammatory bowel diseases in the Chinese. Zhonghua Nei Ke Za Zhi 2004, 43:191-194.
9. Machida H., Tsukamoto K., Wen C.Y., Narumi Y., Shikuwa S., Isomoto H., et al. Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese. World J Gastroenterol 2005, 11:4188-4193.
10. Rueda B., Zhernakova A., Lopez-Nevot M.A., Gomez-Garcia M., Ortega E., Pinero A., et al. CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders. Hum Immunol 2005, 66:321-325. 10.1016/j.humimm.2004.11.005.
11. Xia B., Crusius J.B., Wu J., Zwiers A., van Bodegraven A.A., Pena A.S. CTLA4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease. Scand J Gastroenterol 2002, 37:1296-1300.
12. Hradsky O., Dusatkova P., Lenicek M., Bronsky J., Nevoral J., Vitek L., et al. The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease. BMC Med Genet 2010, 11:91. 10.1186/1471-2350-11-91.
13. Chen Z., Brant S.R., Li C., Shrestha U.K., Jiang T., Zhou F., et al. CTLA4 -1661A/G and 3'UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expression. Genes Immun 2010, 11:573-583.
14. Magyari L., Farago B., Bene J., Horvatovich K., Lakner L., Varga M., et al. No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples. World J Gastroenterol 2007, 13:2205-2208.
15. Jiang Y., Xia B., Jiang L., Lv M., Guo Q., Chen M., et al. Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients. Inflamm Bowel Dis 2006, 12:369-373.
16. Lankarani K.B., Karbasi A., Kalantari T., Yarmohammadi H., Saberi-Firoozi M., Alizadeh-Naeeni M., et al. Analysis of cytotoxic T lymphocyte associated antigen 4 gene polymorphisms in patients with ulcerative colitis. J Gastroenterol Hepatol 2006, 21:449-453.
17. Hou W., Xia B., Yuan A., Li J., Yang Z., Mao L. CTLA-4 gene polymorphisms in Chinese patients with ulcerative colitis. Inflamm Bowel Dis 2005, 11:653-656.
18. Chen Z., Zhou F., Huang S., Jiang T., Chen L., Ge L., et al. Association of cytotoxic T lymphocyte associated antigen-4 gene (rs60872763) polymorphism with Crohn's disease and high levels of serum sCTLA-4 in Crohn's disease. J Gastroenterol Hepatol 2011, 26:924-930.
19. Huang D., Giscombe R., Zhou Y., Pirskanen R., Lefvert A.K. Dinucleotide repeat expansion in the CTLA-4 gene leads to T cell hyper-reactivity via the CD28 pathway in myasthenia gravis. J Neuroimmunol 2000, 105:69-77.
20. Lee Y.H., Rho Y.H., Choi S.J., Ji J.D., Song G.G. Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatol Int 2006, 27:157-161.
21. Nath S.K., Harley J.B., Lee Y.H. Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum Genet 2005, 118:225-234. 10.1007/s00439-005-0044-6.
22. Lee Y.H., Nath S.K. Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Genet 2005, 118:434-443.
23. Lee Y.H., Song G.G. Efficacy and safety of monthly 150 mg oral ibandronate in women with postmenopausal osteoporosis: a systematic review and meta-analysis of randomized controlled trials. Korean J Intern Med 2011, 26:340-347.
24. Egger M., Davey Smith G., Schneider M., Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
25. Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat Med 2002, 21:1539-1558.
26. Egger M., Smith G.D., Phillips A.N. Meta-analysis: principles and procedures. BMJ 1997, 315:1533-1537.
27. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177-188.
28. Chen Z.T., Xia B., Jiang T., Zhou F., Zou K.F., Ge L.Q. CTLA-4 gene polymorphism regulates CTLA-4 mRNA stability and protein level in patients with ulcerative colitis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2010, 27:603-609.
29. Jiang T., Ge L.Q., Chen Z.T., Li C., Zhou F., Luo Y., et al. Effect of cytotoxic T lymphocyte-associated molecule 4 1661 gene polymorphism on its expression and transcription in ulcerative colitis. J Dig Dis 2010, 11:369-375.
30. Luo Y., Xia B., Li C., Chen Z.T., Ge L.Q., Jiang T. Association of cytotoxic T lymphocyte antigen-4 promoter C-658T polymorphism with ulcerative colitis in Chinese. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009, 26:431-434.
31. Magyari L., Melegh B. Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients. Orv Hetil 2009, 150:81-88.
32. Luo Y., Xia B., Li C., Chen Z., Ge L., Jiang T., et al. Cytotoxic T lymphocyte antigen-4 promoter -658CT gene polymorphism is associated with ulcerative colitis in Chinese patients. Int J Colorectal Dis 2009, 24:489-493.
33. Smyth D.J., Howson J.M., Payne F., Maier L.M., Bailey R., Holland K., et al. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. BMC Med Genet 2006, 7:20.
34. Lee C.K., Hong J.S., Cho Y.S., Yoo B., Kim G.S., Moon H.B. Lack of relationship between vitamin D receptor polymorphism and bone erosion in rheumatoid arthritis. J Korean Med Sci 2001, 16:188-192.
35. Huang D., Giscombe R., Zhou Y., Lefvert A.K. Polymorphisms in CTLA-4 but not tumor necrosis factor-alpha or interleukin 1beta genes are associated with Wegener's granulomatosis. J Rheumatol 2000, 27:397-401.
36. Wang X.B., Kakoulidou M., Giscombe R., Qiu Q., Huang D., Pirskanen R., et al. Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence. J Neuroimmunol 2002, 130:224-232.
37. Shaw G., Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986, 46:659-667.
38. Holopainen P.M., Partanen J.A. Technical note: linkage disequilibrium and disease-associated CTLA4 gene polymorphisms. J Immunol 2001, 167:2457-2458.
39. Maurer M., Loserth S., Kolb-Maurer A., Ponath A., Wiese S., Kruse N., et al. A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1 +49) alters T-cell activation. Immunogenetics 2002, 54:1-8.
40. Wang X.B., Zhao X., Giscombe R., Lefvert A.K. A CTLA-4 gene polymorphism at position -318 in the promoter region affects the expression of protein. Genes Immun 2002, 3:233-234.
41. Ueda H., Howson J.M., Esposito L., Heward J., Snook H., Chamberlain G., et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003, 423:506-511.