Decreased HHV-6 IgG in Alzheimer's disease

Frontiers in Neurology

Volumn 8, Issue FEB, 2017, Pages

  Westman, Gabriel ^a   Blomberg, Jonas ^a   Yun, Zhibing ^b   Lannfelt, Lars ^c   Ingelsson, Martin ^c   Eriksson, Britt Marie ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Alzheimer's disease; Herpesvirus; HHV 6; IgG; Immunoassay; Multiplex

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; HERPES SIMPLEX ANTIBODY; HERPES ZOSTER IMMUNOGLOBULIN; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS DNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; HUMORAL IMMUNITY; IMMUNOASSAY; IMMUNOREACTIVITY; MALE; MIDDLE AGED; MULTIPLEX IMMUNOASSAY; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; SEROPREVALENCE; VERY ELDERLY; VIRUS REACTIVATION;

EID: 85014171424     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2017.00040     Document Type: Article

References (31)

1. Marshall BJ, McGechie DB, Rogers PA, Glancy RJ. Pyloric Campylobacter infection and gastroduodenal disease. Med J Aust (1985) 142(8):439-44.
2. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol (1999) 189(1):12-9. doi: 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
3. Ahlfors K. IgG antibodies to cytomegalovirus in a normal urban Swedish population. Scand J Infect Dis (1984) 16(4):335-7. doi:10.3109/00365548409073957
4. Kangro HO, Osman HK, Lau YL, Heath RB, Yeung CY, Ng MH. Seroprevalence of antibodies to human herpesviruses in England and Hong Kong. J Med Virol (1994) 43(1):91-6. doi:10.1002/jmv.1890430117
5. Pebody RG, Andrews N, Brown D, Gopal R, De Melker H, François G, et al. The seroepidemiology of herpes simplex virus type 1 and 2 in Europe. Sex Transm Infect (2004) 80(3):185-91. doi:10.1136/sti.2003.005850
6. Svahn A, Berggren J, Parke A, Storsaeter J, Thorstensson R, Linde A. Changes in seroprevalence to four herpesviruses over 30 years in Swedish children aged 9-12 years. J Clin Virol (2006) 37(2):118-23. doi:10.1016/j.jcv.2006.07.012
7. Gordon B, Selnes OA, Hart J Jr, Hanley DF, Whitley RJ. Long-term cognitive sequelae of acyclovir-treated herpes simplex encephalitis. Arch Neurol (1990) 47(6):646-7. doi:10.1001/archneur.1990.00530060054017
8. Lin WR, Wozniak MA, Cooper RJ, Wilcock GK, Itzhaki RF. Herpesviruses in brain and Alzheimer's disease. J Pathol (2002) 197(3):395-402. doi:10.1002/path.1127
9. Gilden D, Cohrs RJ, Mahalingam R, Nagel MA. Neurological disease produced by varicella zoster virus reactivation without rash. Curr Top Microbiol Immunol (2010) 342:243-53. doi:10.1007/82_2009_3
10. Mannonen L, Herrgard E, Valmari P, Rautiainen P, Uotila K, Aine MR, et al. Primary human herpesvirus-6 infection in the central nervous system can cause severe disease. Pediatr Neurol (2007) 37(3):186-91. doi:10.1016/j.pediatrneurol.2007.05.011
11. van Den Pol AN, Mocarski E, Saederup N, Vieira J, Meier TJ. Cytomegalovirus cell tropism, replication, and gene transfer in brain. J Neurosci (1999) 19(24):10948-65.
12. Sosa-Ortiz AL, Acosta-Castillo I, Prince MJ. Epidemiology of dementias and Alzheimer's disease. Arch Med Res (2012) 43(8):600-8. doi:10.1016/j.arcmed.2012.11.003
13. Letenneur L, Peres K, Fleury H, Garrigue I, Barberger-Gateau P, Helmer C, et al. Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study. PLoS One (2008) 3(11):e3637. doi:10.1371/journal.pone.0003637
14. Lovheim H, Gilthorpe J, Adolfsson R, Nilsson LG, Elgh F. Reactivated herpes simplex infection increases the risk of Alzheimer's disease. Alzheimers Dement (2015) 11(6):593-9. doi:10.1016/j.jalz.2014.04.522
15. Lovheim H, Gilthorpe J, Johansson A, Eriksson S, Hallmans G, Elgh F. Herpes simplex infection and the risk of Alzheimer's disease - a nested case-control study. Alzheimers Dement (2015) 11(6):587-92. doi:10.1016/j.jalz.2014.07.157
16. Strandberg TE, Pitkala K, Eerola J, Tilvis R, Tienari PJ. Interaction of herpesviridae, APOE gene, and education in cognitive impairment. Neurobiol Aging (2005) 26(7):1001-4. doi:10.1016/j.neurobiolaging.2004.09.008
17. Strandberg TE, Pitkala KH, Linnavuori KH, Tilvis RS. Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases. Stroke (2003) 34(9):2126-31. doi:10.1161/01.STR.0000086754.32238.DA
18. Lurain NS, Hanson BA, Martinson J, Leurgans SE, Landay AL, Bennett DA, et al. Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease. J Infect Dis (2013) 208(4):564-72. doi:10.1093/infdis/jit210
19. Aiello AE, Haan M, Blythe L, Moore K, Gonzalez JM, Jagust W. The influence of latent viral infection on rate of cognitive decline over 4 years. J Am Geriatr Soc (2006) 54(7):1046-54. doi:10.1111/j.1532-5415.2006.00796.x
20. Westman G, Lidehall AK, Magnusson P, Ingelsson M, Kilander L, Lannfelt L, et al. Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease. PLoS One (2013) 8(10):e77921. doi:10.1371/journal.pone.0077921
21. Westman G, Berglund D, Widen J, Ingelsson M, Korsgren O, Lannfelt L, et al. Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease. PLoS One (2014) 9(5):e96779. doi:10.1371/journal.pone.0096779
22. Elfaitouri A, Herrmann B, Bolin-Wiener A, Wang Y, Gottfries CG, Zachrisson O, et al. Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis. PLoS One (2013) 8(11):e81155. doi:10.1371/journal.pone.0081155
23. Akerstrom B, Brodin T, Reis K, Bjorck L. Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodies. J Immunol (1985) 135(4):2589-92.
24. Westfall PH, Young SS. Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment. New York, NY: John Wiley & Sons (1993).
25. Carbone I, Lazzarotto T, Ianni M, Porcellini E, Forti P, Masliah E, et al. Herpes virus in Alzheimer's disease: relation to progression of the disease. Neurobiol Aging (2013) 35(1):122-9. doi:10.1016/j.neurobiolaging.2013.06.024
26. Agostini S, Mancuso R, Baglio F, Cabinio M, Hernis A, Guerini FR, et al. Lack of evidence for a role of HHV-6 in the pathogenesis of Alzheimer's disease. J Alzheimers Dis (2015) 49(1):229-35. doi:10.3233/JAD-150464
27. Blasko I, Marx F, Steiner E, Hartmann T, Grubeck-Loebenstein B. TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J (1999) 13(1):63-8.
28. Tate J, Ward G. Interferences in immunoassay. Clin Biochem Rev (2004) 25(2):105-20.
29. Dias D, Van Doren J, Schlottmann S, Kelly S, Puchalski D, Ruiz W, et al. Optimization and validation of a multiplexed Luminex assay to quantify antibodies to neutralizing epitopes on human papillomaviruses 6, 11, 16, and 18. Clin Diagn Lab Immunol (2005) 12(8):959-69. doi:10.1128/CDLI.12.8.959-969.2005
30. Edson CM, Hosler BA, Respess RA, Waters DJ, Thorley-Lawson DA. Cross-reactivity between herpes simplex virus glycoprotein B and a 63,000-dalton varicella-zoster virus envelope glycoprotein. J Virol (1985) 56(1):333-6.
31. Lang D, Vornhagen R, Rothe M, Hinderer W, Sonneborn HH, Plachter B. Cross-reactivity of Epstein-Barr virus-specific immunoglobulin M antibodies with cytomegalovirus antigens containing glycine homopolymers. Clin Diagn Lab Immunol (2001) 8(4):747-56. doi:10.1128/CDLI.8.4.747-756.2001