Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study

Alzheimer's and Dementia

Volumn 11, Issue 6, 2015, Pages 587-592

  Lövheim, Hugo ^a   Gilthorpe, Jonathan ^b   Johansson, Anders ^b   Eriksson, Sture ^a,b   Hallmans, Göran ^b   Elgh, Fredrik ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Alzheimer's disease; Dementia; Herpes; Herpes simplex; HSV; Nested case control study

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; VIRUS ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; ALZHEIMER DISEASE; ARTICLE; BLOOD SAMPLING; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HERPES SIMPLEX; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; AGED; BLOOD; IMMUNOLOGY; RISK; SIMPLEXVIRUS; STATISTICAL MODEL;

AGED; ALZHEIMER DISEASE; ANTIBODIES, VIRAL; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HERPES SIMPLEX; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LOGISTIC MODELS; MALE; MIDDLE AGED; RISK; SIMPLEXVIRUS;

EID: 84931573662     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.07.157     Document Type: Article

References (26)

1. J.S. Smith, and N.J. Robinson Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review J Infect Dis 186 Suppl 1 2002 S3 S28
2. E. Lycke, R. Norrby, and B.E. Roos A serological study on mentally ill patients with particular reference to the prevalence of herpes virus infections Br J Psychiatry 124 1974 273 279
3. M.J. Ball Limbic predilection in Alzheimer dementia: is reactivated herpes virus involved? Can J Neurol Sci 9 1982 303 306
4. L. Letenneur, K. Peres, H. Fleury, I. Garrigue, P. Barberger-Gateau, C. Helmer, et al. Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study PLoS ONE 3 2008 e3637
5. H. Lövheim, J. Gilthorpe, R. Adolfsson, L.G. Nilsson, and F. Elgh Reactivated herpes simplex infection increases the risk of Alzheimer's disease Alzheimers Dement 2014 Jul 17. Epub ahead of print.
6. U. Beffert, P. Bertrand, D. Champagne, S. Gauthier, and J. Poirier HSV-1 in brain and risk of Alzheimer's disease Lancet 351 1998 1330 1331
7. S. Itabashi, H. Arai, T. Matsui, S. Higuchi, and H. Sasaki Herpes simplex virus and risk of Alzheimer's disease Lancet 349 1997 1102
8. R.F. Itzhaki, W.R. Lin, D. Shang, G.K. Wilcock, B. Faragher, and G.A. Jamieson Herpes simplex virus type 1 in brain and risk of Alzheimer's disease Lancet 349 1997 241 244
9. W.R. Lin, M.A. Wozniak, R.J. Cooper, G.K. Wilcock, and R.F. Itzhaki Herpes viruses in brain and Alzheimer's disease J Pathol 197 2002 395 402
10. M.A. Wozniak, A.P. Mee, and R.F. Itzhaki Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques J Pathol 217 2009 131 138
11. G. Alvarez, J. Aldudo, M. Alonso, S. Santana, and F. Valdivieso Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells J Neurosci Res 90 2012 1020 1029
12. D.H. Cribbs, B.Y. Azizeh, C.W. Cotman, and F.M. LaFerla Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide Biochemistry 39 2000 5988 5994
13. R. Piacentini, L. Civitelli, C. Ripoli, M.E. Marcocci, G. De Chiara, E. Garaci, et al. HSV-1 promotes Ca2+-mediated APP phosphorylation and Abeta accumulation in rat cortical neurons Neurobiol Aging 32 2011 2323.e13 2323.e26
14. S. Santana, M. Recuero, M.J. Bullido, F. Valdivieso, and J. Aldudo Herpes simplex virus type I induces the accumulation of intracellular beta-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells Neurobiol Aging 33 2012 430.e19 430.e33
15. S.J. Shipley, E.T. Parkin, R.F. Itzhaki, and C.B. Dobson Herpes simplex virus interferes with amyloid precursor protein processing BMC Microbiol 5 2005 48
16. M.A. Wozniak, A.L. Frost, and R.F. Itzhaki Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1 J Alzheimers Dis 16 2009 341 350
17. M.A. Wozniak, R.F. Itzhaki, S.J. Shipley, and C.B. Dobson Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation Neurosci Lett 429 2007 95 100
18. P.S. Bhattacharjee, D.M. Neumann, T.P. Foster, S. Bouhanik, C. Clement, D. Vinay, et al. Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1 Exp Eye Res 87 2008 122 130
19. J.S. Burgos, C. Ramirez, I. Sastre, M.J. Bullido, and F. Valdivieso ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1 Neuroreport 14 2003 1825 1827
20. J.S. Burgos, C. Ramirez, I. Sastre, and F. Valdivieso Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA J Virol 80 2006 5383 5387
21. J.S. Burgos, C. Ramirez, I. Sastre, and F. Valdivieso Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner Aging Cell 6 2007 841 842
22. D.M. Koelle, A. Magaret, T. Warren, G.D. Schellenberg, and A. Wald APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding Sex Transm Infect 86 2010 202 206
23. G. Hallmans, Å. Ågren, G. Johansson, A. Johansson, B. Stegmayr, J.H. Jansson, et al. Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort - evaluation of risk factors and their interactions Scand J Public Health Suppl 61 2003 18 24
24. M.F. Folstein, S.E. Folstein, and P.R. McHugh "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
25. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 2000 American Psychiatric Association Text Revision. Washington, DC
26. P. Juto, and B. Settergren Specific serum IgA, IgG and IgM antibody determination by a modified indirect ELISA-technique in primary and recurrent herpes simplex virus infection J Virol Methods 20 1988 45 55