Reactivated herpes simplex infection increases the risk of Alzheimer's disease

Alzheimer's and Dementia

Volumn 11, Issue 6, 2015, Pages 593-599

  Lövheim, Hugo ^a   Gilthorpe, Jonathan ^b   Adolfsson, Rolf ^b   Nilsson, Lars Göran ^a,c   Elgh, Fredrik ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Alzheimer's disease; Cohort study; Dementia; Herpes; Herpes simplex; HSV

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VIRUS ANTIBODY;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; COHORT ANALYSIS; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HAZARD RATIO; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROSPECTIVE STUDY; REINFECTION; RISK ASSESSMENT; RISK FACTOR; STATISTICAL ANALYSIS; VERY ELDERLY; BLOOD; HERPES SIMPLEX VIRUS 1; IMMUNOLOGY; INCIDENCE; KAPLAN MEIER METHOD; PHYSIOLOGY; RISK; VIROLOGY; VIRUS ACTIVATION;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODIES, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INCIDENCE; KAPLAN-MEIER ESTIMATE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK; VIRUS ACTIVATION;

EID: 84931569620     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.04.522     Document Type: Article

References (35)

1. M.J. Ball Limbic predilection in Alzheimer dementia: is reactivated herpes virus involved? Can J Neurol Sci 9 1982 303 306
2. M.J. Ball, W.J. Lukiw, E.M. Kammerman, and J.M. Hill Intracerebral propagation of Alzheimer's disease: strengthening evidence of a herpes simplex virus etiology Alzheimers Dement 9 2013 169 175
3. R.F. Itzhaki, and M.A. Wozniak Herpes simplex virus type 1 in Alzheimer's disease: the enemy within J Alzheimers Dis 13 2008 393 405
4. U. Beffert, P. Bertrand, D. Champagne, S. Gauthier, and J. Poirier HSV-1 in brain and risk of Alzheimer's disease Lancet 351 1998 1330 1331
5. S. Itabashi, H. Arai, T. Matsui, S. Higuchi, and H. Sasaki Herpes simplex virus and risk of Alzheimer's disease Lancet 349 1997 1102
6. R.F. Itzhaki, W.R. Lin, D. Shang, G.K. Wilcock, B. Faragher, and G.A. Jamieson Herpes simplex virus type 1 in brain and risk of Alzheimer's disease Lancet 349 1997 241 244
7. W.R. Lin, M.A. Wozniak, R.J. Cooper, G.K. Wilcock, and R.F. Itzhaki Herpes viruses in brain and Alzheimer's disease J Pathol 197 2002 395 402
8. M.A. Wozniak, A.P. Mee, and R.F. Itzhaki Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques J Pathol 217 2009 131 138
9. G. Alvarez, J. Aldudo, M. Alonso, S. Santana, and F. Valdivieso Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells J Neurosci Res 90 2012 1020 1029
10. D.H. Cribbs, B.Y. Azizeh, C.W. Cotman, and F.M. LaFerla Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide Biochemistry 39 2000 5988 5994
11. R. Piacentini, L. Civitelli, C. Ripoli, M.E. Marcocci, G. De Chiara, E. Garaci, et al. HSV-1 promotes Ca2+-mediated APP phosphorylation and Abeta accumulation in rat cortical neurons Neurobiol Aging 32 2011 2323.e13 2323.e26
12. S. Santana, M. Recuero, M.J. Bullido, F. Valdivieso, and J. Aldudo Herpes simplex virus type I induces the accumulation of intracellular beta-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells Neurobiol Aging 33 2012 430.e19 430.e33
13. S.J. Shipley, E.T. Parkin, R.F. Itzhaki, and C.B. Dobson Herpes simplex virus interferes with amyloid precursor protein processing BMC Microbiol 5 2005 48
14. M.A. Wozniak, A.L. Frost, and R.F. Itzhaki Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1 J Alzheimers Dis 16 2009 341 350
15. M.A. Wozniak, R.F. Itzhaki, S.J. Shipley, and C.B. Dobson Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation Neurosci Lett 429 2007 95 100
16. J.M. Hill, Y. Zhao, C. Clement, D.M. Neumann, and W.J. Lukiw HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling Neuroreport 20 2009 1500 1505
17. P.S. Bhattacharjee, D.M. Neumann, T.P. Foster, S. Bouhanik, C. Clement, D. Vinay, et al. Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1 Exp Eye Res 87 2008 122 130
18. J.S. Burgos, C. Ramirez, I. Sastre, M.J. Bullido, and F. Valdivieso ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1 Neuroreport 14 2003 1825 1827
19. J.S. Burgos, C. Ramirez, I. Sastre, and F. Valdivieso Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA J Virol 80 2006 5383 5387
20. J.S. Burgos, C. Ramirez, I. Sastre, and F. Valdivieso Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner Aging Cell 6 2007 841 842
21. D.M. Koelle, A. Magaret, T. Warren, G.D. Schellenberg, and A. Wald APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding Sex Transm Infect 86 2010 202 206
22. L. Letenneur, K. Peres, H. Fleury, I. Garrigue, P. Barberger-Gateau, C. Helmer, et al. Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study PLoS ONE 3 2008 e3637
23. L.G. Nilsson, L. Backman, K. Erngrund, L. Nyberg, R. Adolfsson, G. Bucht, et al. The Betula prospective cohort study: memory, health and aging Aging Neuropsychol C 4 1997 1 32
24. S. Katz, A.B. Ford, R.W. Moskowitz, B.A. Jackson, and M.W. Jaffe Studies of illness in the aged. the index of Adl: a standardized measure of biological and psychosocial function JAMA 185 1963 914 919
25. M.F. Folstein, S.E. Folstein, and P.R. McHugh Mini-Mental State". A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
26. A. Sundstrom, P. Marklund, L.G. Nilsson, M. Cruts, R. Adolfsson, C. Van Broeckhoven, et al. APOE influences on neuropsychological function after mild head injury: within-person comparisons Neurology 62 2004 1963 1966
27. G.M. McKhann, D.S. Knopman, H. Chertkow, B.T. Hyman, C.R. Jack Jr., C.H. Kawas, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 2011 263 269
28. P. Juto, and B. Settergren Specific serum IgA, IgG and IgM antibody determination by a modified indirect ELISA-technique in primary and recurrent herpes simplex virus infection J Virol Methods 20 1988 45 55
29. N. Kobayashi, T. Nagata, S. Shinagawa, N. Oka, K. Shimada, A. Shimizu, et al. Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease Biochem Biophys Res Commun 430 2013 907 911
30. A.E. Aiello, M. Haan, L. Blythe, K. Moore, J.M. Gonzalez, and W. Jagust The influence of latent viral infection on rate of cognitive decline over 4 years J Am Geriatr Soc 54 2006 1046 1054
31. C. Feart, C. Helmer, H. Fleury, Y. Bejot, K. Ritchie, P. Amouyel, et al. Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels PLoS One 6 2011 e29480
32. J. Saldanha, R. Sutton, A. Gannicliffe, B. Farragher, and R. Itzhaki Detection of HSV1 DNA by in situ hybridisation in human brain after immunosuppression J Neurol Neurosurg Psychiatry 49 1986 613 619
33. F. Licastro, I. Carbone, M. Ianni, and E. Porcellini Gene signature in Alzheimer's disease and environmental factors: the virus chronicle J Alzheimers Dis 27 2011 809 817
34. C.J. Carter APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle Neurosci Lett 483 2010 96 100
35. M.A. Wozniak, S.J. Shipley, M. Combrinck, G.K. Wilcock, and R. Itzhaki Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients J Med Virol 75 2005 300 306