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Volumn 91, Issue 6, 2017, Pages

Human cytomegalovirus (HCMV)-specific CD4+ T cells are polyfunctional and can respond to HCMVinfected dendritic cells in vitro

Author keywords

Ageing; Antiviral; CD4+ T cells; Human cytomegalovirus (HCMV); Polyfunctional

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; GAMMA INTERFERON; GLYCOPROTEIN B; INTERLEUKIN 10; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROTEIN IE1; PROTEIN IE2; PROTEIN PP71; PROTEIN US3; UNCLASSIFIED DRUG; VIRAL PROTEIN; IL10 PROTEIN, HUMAN; VIRUS ANTIGEN;

EID: 85014114674     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02128-16     Document Type: Article
Times cited : (60)

References (71)
  • 1
    • 9644259300 scopus 로고    scopus 로고
    • Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments
    • Gandhi MK, Khanna R. 2004. Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis 4:725-738. https://doi.org/10.1016/S1473-3099(04)01202-2.
    • (2004) Lancet Infect Dis , vol.4 , pp. 725-738
    • Gandhi, M.K.1    Khanna, R.2
  • 2
    • 33745589746 scopus 로고    scopus 로고
    • Latency and reactivation of human cytomegalovirus
    • Sinclair J, Sissons P. 2006. Latency and reactivation of human cytomegalovirus. J Gen Virol 87:1763-1779. https://doi.org/10.1099/vir.0.81891-0.
    • (2006) J Gen Virol , vol.87 , pp. 1763-1779
    • Sinclair, J.1    Sissons, P.2
  • 3
    • 59649121998 scopus 로고    scopus 로고
    • Immunobiology of human cytomegalovirus: from bench to bedside
    • Crough T, Khanna R. 2009. Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 22:76-98. https://doi.org/10.1128/CMR.00034-08.
    • (2009) Clin Microbiol Rev , vol.22 , pp. 76-98
    • Crough, T.1    Khanna, R.2
  • 4
    • 79955017145 scopus 로고    scopus 로고
    • Human cytomegalovirus immunity and immune evasion
    • Jackson S, Mason G, Wills M. 2011. Human cytomegalovirus immunity and immune evasion. Virus Res 157:151-160. https://doi.org/10.1016/j.virusres.2010.10.031.
    • (2011) Virus Res , vol.157 , pp. 151-160
    • Jackson, S.1    Mason, G.2    Wills, M.3
  • 7
    • 0242285681 scopus 로고    scopus 로고
    • Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines
    • Peggs KS, Verfuerth S, Pizzey A, Khan N, Guiver M, Moss PA, Mackinnon S. 2003. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet 362:1375-1377. https://doi.org/10.1016/S0140-6736(03)14634-X.
    • (2003) Lancet , vol.362 , pp. 1375-1377
    • Peggs, K.S.1    Verfuerth, S.2    Pizzey, A.3    Khan, N.4    Guiver, M.5    Moss, P.A.6    Mackinnon, S.7
  • 9
    • 0035872743 scopus 로고    scopus 로고
    • Levels of virus-specific CD4 T cells correlate with cytomegalovirus control and predict virus-induced disease after renal transplantation
    • Sester M, Sester U, Gartner B, Heine G, Girndt M, Mueller-Lantzsch N, Meyerhans A, Kohler H. 2001. Levels of virus-specific CD4 T cells correlate with cytomegalovirus control and predict virus-induced disease after renal transplantation. Transplantation 71:1287-1294. https://doi.org/10.1097/00007890-200105150-00018.
    • (2001) Transplantation , vol.71 , pp. 1287-1294
    • Sester, M.1    Sester, U.2    Gartner, B.3    Heine, G.4    Girndt, M.5    Mueller-Lantzsch, N.6    Meyerhans, A.7    Kohler, H.8
  • 14
    • 84911964048 scopus 로고    scopus 로고
    • Adaptive cellular immunity to human cytomegalovirus
    • Reddehase MJ (ed), Caister Academic Press, Poole, United Kingdom
    • Wills MR, Mason GM, Sissons JGP. 2013. Adaptive cellular immunity to human cytomegalovirus, p 142-172. In Reddehase MJ (ed), Cytomegaloviruses: from molecular pathogenesis to intervention, vol II. Caister Academic Press, Poole, United Kingdom.
    • (2013) Cytomegaloviruses: from molecular pathogenesis to intervention , vol.2 , pp. 142-172
    • Wills, M.R.1    Mason, G.M.2    Sissons, J.G.P.3
  • 15
    • 9244230555 scopus 로고    scopus 로고
    • Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H
    • Elkington R, Shoukry NH, Walker S, Crough T, Fazou C, Kaur A, Walker CM, Khanna R. 2004. Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H. Eur J Immunol 34:3216-3226. https://doi.org/10.1002/eji.200425203.
    • (2004) Eur J Immunol , vol.34 , pp. 3216-3226
    • Elkington, R.1    Shoukry, N.H.2    Walker, S.3    Crough, T.4    Fazou, C.5    Kaur, A.6    Walker, C.M.7    Khanna, R.8
  • 18
    • 0036198286 scopus 로고    scopus 로고
    • Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus
    • Sester M, Sester U, Gartner B, Kubuschok B, Girndt M, Meyerhans A, Kohler H. 2002. Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus. J Virol 76:3748-3755. https://doi.org/10.1128/JVI.76.8.3748-3755.2002.
    • (2002) J Virol , vol.76 , pp. 3748-3755
    • Sester, M.1    Sester, U.2    Gartner, B.3    Kubuschok, B.4    Girndt, M.5    Meyerhans, A.6    Kohler, H.7
  • 23
    • 84938581215 scopus 로고    scopus 로고
    • + T-cell reconstitution following stem cell transplantation through the use of HLA class II-peptide tetramers identifies patients at high risk of recurrent CMV reactivation
    • + T-cell reconstitution following stem cell transplantation through the use of HLA class II-peptide tetramers identifies patients at high risk of recurrent CMV reactivation. Haematologica 100:e318-e322. https://doi.org/10.3324/haematol.2015.123687.
    • (2015) Haematologica , vol.100 , pp. e318-e322
    • Raeiszadeh, M.1    Pachnio, A.2    Begum, J.3    Craddock, C.4    Moss, P.5    Chen, F.E.6
  • 24
    • 6344241638 scopus 로고    scopus 로고
    • + T cell clones specific for human cytomegalovirus are distributed in both CD45RAhigh and CD45ROhigh populations
    • + T cell clones specific for human cytomegalovirus are distributed in both CD45RAhigh and CD45ROhigh populations. J Immunol 173:5843-5851. https://doi.org/10.4049/jimmunol.173.9.5843.
    • (2004) J Immunol , vol.173 , pp. 5843-5851
    • Weekes, M.P.1    Wills, M.R.2    Sissons, J.G.P.3    Carmichael, A.J.4
  • 27
    • 84888331175 scopus 로고    scopus 로고
    • PD-1 analysis on CD28+ CD27+ CD4 T cells allows stimulation-independent assessment of CMV viremic episodes in transplant recipients
    • Dirks J, Tas H, Schmidt T, Kirsch S, Gärtner BC, Sester U, Sester M. 2013. PD-1 analysis on CD28+ CD27+ CD4 T cells allows stimulation-independent assessment of CMV viremic episodes in transplant recipients. Am J Transplant 13:3132-3141. https://doi.org/10.1111/ajt.12480.
    • (2013) Am J Transplant , vol.13 , pp. 3132-3141
    • Dirks, J.1    Tas, H.2    Schmidt, T.3    Kirsch, S.4    Gärtner, B.C.5    Sester, U.6    Sester, M.7
  • 28
    • 84871935156 scopus 로고    scopus 로고
    • Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    • Derhovanessian E, Theeten H, Hähnel K, Van Damme P, Cools N, Pawelec G. 2013. Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine 31:685-690. https://doi.org/10.1016/j.vaccine.2012.11.041.
    • (2013) Vaccine , vol.31 , pp. 685-690
    • Derhovanessian, E.1    Theeten, H.2    Hähnel, K.3    Van Damme, P.4    Cools, N.5    Pawelec, G.6
  • 31
    • 41349108021 scopus 로고    scopus 로고
    • + T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals
    • + T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals. Blood 111:2053-2061. https://doi.org/10.1182/blood-2007-04-079863.
    • (2008) Blood , vol.111 , pp. 2053-2061
    • Crompton, L.1    Khan, N.2    Khanna, R.3    Nayak, L.4    Moss, P.A.H.5
  • 32
    • 84856822945 scopus 로고    scopus 로고
    • Polyfunctional T cells accumulate in large human cytomegalovirusspecific T cell responses
    • Lachmann R, Bajwa M, Vita S, Smith H, Cheek E, Akbar A, Kern F. 2012. Polyfunctional T cells accumulate in large human cytomegalovirusspecific T cell responses. J Virol 86:1001-1009. https://doi.org/10.1128/JVI.00873-11.
    • (2012) J Virol , vol.86 , pp. 1001-1009
    • Lachmann, R.1    Bajwa, M.2    Vita, S.3    Smith, H.4    Cheek, E.5    Akbar, A.6    Kern, F.7
  • 35
    • 84898829909 scopus 로고    scopus 로고
    • Mouse CMV infection delays antibody class switch upon an unrelated virus challenge
    • Marandu TF, Finsterbusch K, Kröger A, Cicin-Šain L. 2014. Mouse CMV infection delays antibody class switch upon an unrelated virus challenge. Exp Gerontol 54:101-108. https://doi.org/10.1016/j.exger.2014.01.017.
    • (2014) Exp Gerontol , vol.54 , pp. 101-108
    • Marandu, T.F.1    Finsterbusch, K.2    Kröger, A.3    Cicin-Šain, L.4
  • 36
    • 58149260267 scopus 로고    scopus 로고
    • The cytolytic enzymes granzyme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression
    • Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, Roederer M, De Rosa SC. 2009. The cytolytic enzymes granzyme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. J Leukoc Biol 85:88-97. https://doi.org/10.1189/jlb.0208107.
    • (2009) J Leukoc Biol , vol.85 , pp. 88-97
    • Chattopadhyay, P.K.1    Betts, M.R.2    Price, D.A.3    Gostick, E.4    Horton, H.5    Roederer, M.6    De Rosa, S.C.7
  • 37
    • 84960375723 scopus 로고    scopus 로고
    • Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review
    • Weltevrede M, Eilers R, de Melker HE, van Baarle D. 2016. Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review. Exp Gerontol 77:87-95. https://doi.org/10.1016/j.exger.2016.02.005.
    • (2016) Exp Gerontol , vol.77 , pp. 87-95
    • Weltevrede, M.1    Eilers, R.2    de Melker, H.E.3    van Baarle, D.4
  • 39
    • 84949235352 scopus 로고    scopus 로고
    • Infection in an aging population
    • Kline KA, Bowdish DME. 2016. Infection in an aging population. Curr Opin Microbiol 29:63-67. https://doi.org/10.1016/j.mib.2015.11.003.
    • (2016) Curr Opin Microbiol , vol.29 , pp. 63-67
    • Kline, K.A.1    Bowdish, D.M.E.2
  • 40
    • 84877806367 scopus 로고    scopus 로고
    • Cytomegalovirus infection is associated with increased mortality in the older population
    • Savva GM, Pachnio A, Kaul B, Morgan K, Huppert FA, Brayne C, Moss PAH, Medical Research Council Cognitive Function and Ageing Study. 2013. Cytomegalovirus infection is associated with increased mortality in the older population. Aging Cell 12:381-387. https://doi.org/10.1111/acel.12059.
    • (2013) Aging Cell , vol.12 , pp. 381-387
    • Savva, G.M.1    Pachnio, A.2    Kaul, B.3    Morgan, K.4    Huppert, F.A.5    Brayne, C.6    Moss, P.A.H.7
  • 41
    • 79951899662 scopus 로고    scopus 로고
    • Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States
    • Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE. 2011. Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS One 6:e16103. https://doi.org/10.1371/journal.pone.0016103.
    • (2011) PLoS One , vol.6
    • Simanek, A.M.1    Dowd, J.B.2    Pawelec, G.3    Melzer, D.4    Dutta, A.5    Aiello, A.E.6
  • 43
    • 84870198003 scopus 로고    scopus 로고
    • Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort
    • Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ. 2012. Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort. J Infect Dis 206:1897-1903. https://doi.org/10.1093/infdis/jis620.
    • (2012) J Infect Dis , vol.206 , pp. 1897-1903
    • Gkrania-Klotsas, E.1    Langenberg, C.2    Sharp, S.J.3    Luben, R.4    Khaw, K.T.5    Wareham, N.J.6
  • 45
    • 84958593673 scopus 로고    scopus 로고
    • Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans
    • Schulz AR, Malzer JN, Domingo C, Jurchott K, Grutzkau A, Babel N, Nienen M, Jelinek T, Niedrig M, Thiel A. 2015. Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans. J Immunol 195:4699-4711. https://doi.org/10.4049/jimmunol.1500598.
    • (2015) J Immunol , vol.195 , pp. 4699-4711
    • Schulz, A.R.1    Malzer, J.N.2    Domingo, C.3    Jurchott, K.4    Grutzkau, A.5    Babel, N.6    Nienen, M.7    Jelinek, T.8    Niedrig, M.9    Thiel, A.10
  • 50
    • 34547773111 scopus 로고    scopus 로고
    • Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells
    • Kannanganat S, Ibegbu C, Chennareddi L, Robinson HL, Amara RR. 2007. Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells. J Virol 81:8468-8476. https://doi.org/10.1128/JVI.00228-07.
    • (2007) J Virol , vol.81 , pp. 8468-8476
    • Kannanganat, S.1    Ibegbu, C.2    Chennareddi, L.3    Robinson, H.L.4    Amara, R.R.5
  • 51
    • 27144557584 scopus 로고    scopus 로고
    • + T cells with diverse cytokine profiles
    • + T cells with diverse cytokine profiles. Nat Med 11:1113-1117. https://doi.org/10.1038/nm1293.
    • (2005) Nat Med , vol.11 , pp. 1113-1117
    • Chattopadhyay, P.K.1    Yu, J.2    Roederer, M.3
  • 53
    • 84867890628 scopus 로고    scopus 로고
    • Diverse immune evasion strategies by human cytomegalovirus
    • Noriega V, Redmann V, Gardner T, Tortorella D. 2012. Diverse immune evasion strategies by human cytomegalovirus. Immunol Res 54: 140-151. https://doi.org/10.1007/s12026-012-8304-8.
    • (2012) Immunol Res , vol.54 , pp. 140-151
    • Noriega, V.1    Redmann, V.2    Gardner, T.3    Tortorella, D.4
  • 55
    • 0028142430 scopus 로고
    • Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA
    • Steimle V, Siegrist CA, Mottet A, Lisowska-Grospierre B, Mach B. 1994. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 265:106-109. https://doi.org/10.1126/science.8016643.
    • (1994) Science , vol.265 , pp. 106-109
    • Steimle, V.1    Siegrist, C.A.2    Mottet, A.3    Lisowska-Grospierre, B.4    Mach, B.5
  • 56
    • 84987784667 scopus 로고    scopus 로고
    • The intimate relationship between human cytomegalovirus and the dendritic cell lineage
    • Sinclair J, Reeves M. 2014. The intimate relationship between human cytomegalovirus and the dendritic cell lineage. Front Microbiol 5:389. https://doi.org/10.3389/fmicb.2014.00389.
    • (2014) Front Microbiol , vol.5 , pp. 389
    • Sinclair, J.1    Reeves, M.2
  • 57
    • 84929960117 scopus 로고    scopus 로고
    • The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?
    • Wills MR, Poole E, Lau B, Krishna B, Sinclair JH. 2015. The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies? Cell Mol Immunol 12:128-138. https://doi.org/10.1038/cmi.2014.75.
    • (2015) Cell Mol Immunol , vol.12 , pp. 128-138
    • Wills, M.R.1    Poole, E.2    Lau, B.3    Krishna, B.4    Sinclair, J.H.5
  • 58
    • 0035062021 scopus 로고    scopus 로고
    • Interleukin-10 and the interleukin-10 receptor
    • Moore KW, de Malefyt R, Coffman RL, O'Garra A. 2001. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683-765. https://doi.org/10.1146/annurev.immunol.19.1.683.
    • (2001) Annu Rev Immunol , vol.19 , pp. 683-765
    • Moore, K.W.1    de Malefyt, R.2    Coffman, R.L.3    O'Garra, A.4
  • 59
    • 84933053127 scopus 로고    scopus 로고
    • Stepping up ELISpot: multilevel analysis in FluoroSpot assays
    • Janetzki S, Rueger M, Dillenbeck T. 2014. Stepping up ELISpot: multilevel analysis in FluoroSpot assays. Cells 3:1102-1115. https://doi.org/10.3390/cells3041102.
    • (2014) Cells , vol.3 , pp. 1102-1115
    • Janetzki, S.1    Rueger, M.2    Dillenbeck, T.3
  • 60
    • 84903529989 scopus 로고    scopus 로고
    • Evaluation of suitable target antigens and immunoassays for high-accuracy immune monitoring of cytomegalovirus and Epstein-Barr virus-specific T cells as targets of interest in immunotherapeutic approaches
    • Tischer S, Dieks D, Sukdolak C, Bunse C, Figueiredo C, Immenschuh S, Borchers S, Stripecke R, Maecker-Kolhoff B, Blasczyk R, Eiz-Vesper B. 2014. Evaluation of suitable target antigens and immunoassays for high-accuracy immune monitoring of cytomegalovirus and Epstein-Barr virus-specific T cells as targets of interest in immunotherapeutic approaches. J Immunol Methods 408:101-113. https://doi.org/10.1016/j.jim.2014.05.011.
    • (2014) J Immunol Methods , vol.408 , pp. 101-113
    • Tischer, S.1    Dieks, D.2    Sukdolak, C.3    Bunse, C.4    Figueiredo, C.5    Immenschuh, S.6    Borchers, S.7    Stripecke, R.8    Maecker-Kolhoff, B.9    Blasczyk, R.10    Eiz-Vesper, B.11
  • 63
    • 0036838715 scopus 로고    scopus 로고
    • Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentation
    • Hegde NR, Tomazin RA, Wisner TW, Dunn C, Boname JM, Lewinsohn DM, Johnson DC. 2002. Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentation. J Virol 76:10929-10941. https://doi.org/10.1128/JVI.76.21.10929-10941.2002.
    • (2002) J Virol , vol.76 , pp. 10929-10941
    • Hegde, N.R.1    Tomazin, R.A.2    Wisner, T.W.3    Dunn, C.4    Boname, J.M.5    Lewinsohn, D.M.6    Johnson, D.C.7
  • 65
    • 0037560152 scopus 로고    scopus 로고
    • Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain
    • Odeberg J, Plachter B, Brandén L, Söderberg-Nauclér C. 2003. Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain. Blood 101: 4870-4877. https://doi.org/10.1182/blood-2002-05-1504.
    • (2003) Blood , vol.101 , pp. 4870-4877
    • Odeberg, J.1    Plachter, B.2    Brandén, L.3    Söderberg-Nauclér, C.4
  • 66
    • 0038421086 scopus 로고    scopus 로고
    • Human cytomegalovirus impairs dendritic cell function: a novel mechanism of human cytomegalovirus immune escape
    • Beck K, Meyer-König U, Weidmann M, Nern C, Hufert FT. 2003. Human cytomegalovirus impairs dendritic cell function: a novel mechanism of human cytomegalovirus immune escape. Eur J Immunol 33:1528-1538. https://doi.org/10.1002/eji.200323612.
    • (2003) Eur J Immunol , vol.33 , pp. 1528-1538
    • Beck, K.1    Meyer-König, U.2    Weidmann, M.3    Nern, C.4    Hufert, F.T.5
  • 67
  • 68
    • 84954113947 scopus 로고    scopus 로고
    • Cytomegalovirus-specific CD4 T cells are cytolytic and mediate vaccine protection
    • Verma S, Weiskopf D, Gupta A, McDonald B, Peters B, Sette A, Benedict CA. 2015. Cytomegalovirus-specific CD4 T cells are cytolytic and mediate vaccine protection. J Virol 90:650-658. https://doi.org/10.1128/JVI.02123-15.
    • (2015) J Virol , vol.90 , pp. 650-658
    • Verma, S.1    Weiskopf, D.2    Gupta, A.3    McDonald, B.4    Peters, B.5    Sette, A.6    Benedict, C.A.7
  • 71
    • 84939566590 scopus 로고    scopus 로고
    • Immunosenescence: implications for response to infection and vaccination in older people
    • Pera A, Campos C, López N, Hassouneh F, Alonso C, Tarazona R, Solana R. 2015. Immunosenescence: implications for response to infection and vaccination in older people. Maturitas 82:50-55. https://doi.org/10.1016/j.maturitas.2015.05.004.
    • (2015) Maturitas , vol.82 , pp. 50-55
    • Pera, A.1    Campos, C.2    López, N.3    Hassouneh, F.4    Alonso, C.5    Tarazona, R.6    Solana, R.7


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