Evaluation of inflammatory and immune responses in long-term cultured human precision-cut lung slices

Human Vaccines and Immunotherapeutics

Volumn 13, Issue 2, 2017, Pages 351-358

  Temann, Angela ^a   Golovina, Tatiana ^a   Neuhaus, Vanessa ^b   Thompson, Carolann ^a   Chichester, Jessica A ^a   Braun, Armin ^b   Yusibov, Vidadi ^a  

^a Fraunhofer USA Inc   (United States)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

immune response; inflammation; LPS; lung; precision cut lung slices

Indexed keywords

CYCLOOXYGENASE 2; INFLUENZA VACCINE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; TETANUS TOXOID; TUMOR NECROSIS FACTOR;

ARTICLE; CALCEIN-AM ASSAY; CELL VIABILITY; CYTOKINE PRODUCTION; DONOR; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFLAMMATION; LUNG SLICE; METABOLIC ACTIVITY ASSAY; LUNG; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PRECLINICAL STUDY; PROCEDURES;

DRUG EVALUATION, PRECLINICAL; HUMANS; LUNG; ORGAN CULTURE TECHNIQUES;

EID: 85014076837     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2017.1264794     Document Type: Article

References (28)

1. Henjakovic M, Martin C, Hoymann HG, Sewald K, Ressmeyer AR, Dassow C, Pohlmann G, Krug N, Uhlig S, Braun A. Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vivo studies. Toxicol Sci 2008; 106:444-53; PMID:18775882; http://dx.doi.org/10.1093/toxsci/kfn178
2. Martin C, Uhlig S, Ullrich V. Cytokine-induced bronchoconstriction in precision-cut lung slices is dependent upon cyclooxygenase-2 and thromboxane receptor activation. Am J Respir Cell Mol Biol 2001; 24:139-45; PMID:11159047; http://dx.doi.org/10.1165/ajrcmb.24.2.3545
3. Ressmeyer AR, Larsson AK, Vollmer E, Dahlen SE, Uhlig S, Martin C. Characterisation of guinea pig precision-cut lung slices:comparison with human tissues. Eur Respir J 2006; 28:603-11; PMID:16737991; http://dx.doi.org/10.1183/09031936.06.00004206
4. Schleputz M, Rieg AD, Seehase S, Spillner J, Perez-Bouza A, Braunschweig T, Schroeder T, Bernau M, Lambermont V, Schlumbohm C, et al. Neurally mediated airway constriction in human and other species:a comparative study using precision-cut lung slices (PCLS). PLoS One 2012; 7:e47344; PMID:23056631; http://dx.doi.org/10.1371/journal.pone.0047344
5. Seehase S, Lauenstein HD, Schlumbohm C, Switalla S, Neuhaus V, Forster C, Fieguth HG, Pfennig O, Fuchs E, Kaup FJ, et al. LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing. PLoS One 2012; 7:e43709; PMID:22952743; http://dx.doi.org/10.1371/journal.pone.0043709
6. Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA, Jr. Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol 2012; 46:132-8; PMID:22298527; http://dx.doi.org/10.1165/rcmb.2010-0276OC
7. Henjakovic M, Sewald K, Switalla S, Kaiser D, Muller M, Veres TZ, Martin C, Uhlig S, Krug N, Braun A. Ex vivo testing of immune responses in precision-cut lung slices. Toxicol Appl Pharmacol 2008; 231:68-76; PMID:18504053; http://dx.doi.org/10.1016/j.taap.2008.04.003
8. Seehase S, Schleputz M, Switalla S, Matz-Rensing K, Kaup FJ, Zoller M, Schlumbohm C, Fuchs E, Lauenstein HD, Winkler C, et al. Bronchoconstriction in nonhuman primates:a species comparison. J Appl Physiol (1985) 2011; 111:791-8; http://dx.doi.org/10.1152/japplphysiol.00162.2011
9. Rieg AD, Rossaint R, Uhlig S, Martin C. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices. PLoS One 2011; 6:e29698; PMID:22216346; http://dx.doi.org/10.1371/journal.pone.0029698
10. Rieg AD, Suleiman S, Perez-Bouza A, Braunschweig T, Spillner JW, Schroder T, Verjans E, Schalte G, Rossaint R, Uhlig S, et al. Milrinone relaxes pulmonary veins in guinea pigs and humans. PLoS One 2014; 9:e87685; PMID:24498166; http://dx.doi.org/10.1371/journal.pone.0087685
11. Cooper PR, Zhang J, Damera G, Hoshi T, Zopf DA, Panettieri RA, Jr. C-027 inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways. Allergy Asthma Proc 2011; 32:359-65; PMID:22195688; http://dx.doi.org/10.2500/aap.2011.32.3460
12. Lauenstein L, Switalla S, Prenzler F, Seehase S, Pfennig O, Forster C, Fieguth H, Braun A, Sewald K. Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS). Toxicol In Vitro 2014; 28:588-99; PMID:24412833; http://dx.doi.org/10.1016/j.tiv.2013.12.016
13. Nassimi M, Schleh C, Lauenstein HD, Hussein R, Hoymann HG, Koch W, Pohlmann G, Krug N, Sewald K, Rittinghausen S, et al. A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung. Eur J Pharm Biopharm 2010; 75:107-16; PMID:20206256; http://dx.doi.org/10.1016/j.ejpb.2010.02.014
14. Paranjpe M, Neuhaus V, Finke JH, Richter C, Gothsch T, Kwade A, Buttgenbach S, Braun A, Muller-Goymann CC. In vitro and ex vivo toxicological testing of sildenafil-loaded solid lipid nanoparticles. Inhal Toxicol 2013; 25:536-43; PMID:23905970; http://dx.doi.org/10.3109/08958378.2013.810315
15. Wu W, Booth JL, Duggan ES, Wu S, Patel KB, Coggeshall KM, Metcalf JP. Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model. Virology 2010; 396:178-88; PMID:19913271; http://dx.doi.org/10.1016/j.virol.2009.10.016
16. Cooper PR, Lamb R, Day ND, Branigan PJ, Kajekar R, San Mateo L, Hornby PJ, Panettieri RA, Jr. TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation. Am J Physiol Lung Cell Mol Physiol 2009; 297:L530-7; PMID:19542247; http://dx.doi.org/10.1152/ajplung.00133.2009
17. Neuhaus V, Schwarz K, Klee A, Seehase S, Forster C, Pfennig O, Jonigk D, Fieguth HG, Koch W, Warnecke G, et al. Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique. PLoS One 2013; 8:e71728.
18. Switalla S, Lauenstein L, Prenzler F, Knothe S, Forster C, Fieguth HG, Pfennig O, Schaumann F, Martin C, Guzman CA, et al. Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices. Toxicol Appl Pharmacol 2010; 246:107-15; PMID:20434477; http://dx.doi.org/10.1016/j.taap.2010.04.010
19. Liberati TA, Randle MR, Toth LA. In vitro lung slices:a powerful approach for assessment of lung pathophysiology. Expert Rev Mol Diagn 2010; 10:501-8; PMID:20465504; http://dx.doi.org/10.1586/erm.10.21
20. Sanderson MJ. Exploring lung physiology in health and disease with lung slices. Pulm Pharmacol Ther 2011; 24:452-65; PMID:21600999; http://dx.doi.org/10.1016/j.pupt.2011.05.001
21. Umachandran M, Ioannides C. Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h. Toxicology 2006; 224:14-21; PMID:16701934; http://dx.doi.org/10.1016/j.tox.2006.03.020
22. Martin TR, Mathison JC, Tobias PS, Leturcq DJ, Moriarty AM, Maunder RJ, Ulevitch RJ. Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs. J Clin Invest 1992; 90:2209-19.
23. Vernooy JH, Dentener MA, van Suylen RJ, Buurman WA, Wouters EF. Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells:no role for tumor necrosis factor-alpha and infiltrating neutrophils. Am J Respir Cell Mol Biol 2001; 24:569-76; PMID:11350826; http://dx.doi.org/10.1165/ajrcmb.24.5.4156
24. Wang HL, Akinci IO, Baker CM, Urich D, Bellmeyer A, Jain M, Chandel NS, Mutlu GM, Budinger GR. The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. J Immunol 2007; 179:1834-41; PMID:17641050; http://dx.doi.org/10.4049/jimmunol.179.3.1834
25. Bingisser R, Stey C, Weller M, Groscurth P, Russi E, Frei K. Apoptosis in human alveolar macrophages is induced by endotoxin and is modulated by cytokines. Am J Respir Cell Mol Biol 1996; 15:64-70; PMID:8679223; http://dx.doi.org/10.1165/ajrcmb.15.1.8679223
26. Hess A, Wang-Lauenstein L, Braun A, Kolle SN, Landsiedel R, Liebsch M, Ma-Hock L, Pirow R, Schneider X, Steinfath M, et al. Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity. Toxicol In Vitro 2016; 32:347-61; PMID:26778741; http://dx.doi.org/10.1016/j.tiv.2016.01.006
27. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, et al. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol 2014; 50:876-81; PMID:24313705; http://dx.doi.org/10.1165/rcmb.2013-0166MA
28. Ebsen M, Mogilevski G, Anhenn O, Maiworm V, Theegarten D, Schwarze J, Morgenroth K. Infection of murine precision cut lung slices (PCLS) with respiratory syncytial virus (RSV) and chlamydophila pneumoniae using the Krumdieck technique. Pathol Res Pract 2002; 198:747-53; PMID:12530578; http://dx.doi.org/10.1078/0344-0338-00331