NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo

Current Biology

Volumn 27, Issue 6, 2017, Pages 784-794

  Di Stefano, Michele ^a,b   Loreto, Andrea ^a,c   Orsomando, Giuseppe ^d   Mori, Valerio ^d   Zamporlini, Federica ^d   Hulse, Richard P ^e   Webster, Jamie ^a   Donaldson, Lucy F ^a   Gering, Martin ^a   Raffaelli, Nadia ^d   Coleman, Michael P ^c,f   Gilley, Jonathan ^c,f   Conforti, Laura ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^f BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

axon degeneration; NAD; neurodegeneration; NMN; NMN deamidase; NMNAT; NMNAT2; SARM1; Wallerian degeneration; WLDs

Indexed keywords

AMIDASE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NICOTINAMIDENUCLEOTIDE AMIDASE; NMNAT2 PROTEIN, MOUSE;

ANIMAL; AXON; DEFICIENCY; GENETICS; METABOLISM; MOUSE; NERVE DEGENERATION; PATHOLOGY; TRANSGENIC MOUSE; WALLERIAN DEGENERATION;

AMIDOHYDROLASES; ANIMALS; AXONS; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE; WALLERIAN DEGENERATION;

EID: 85014075571     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2017.01.070     Document Type: Article

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