Rescue of peripheral and CNS axon defects in mice lacking NMNAT2

Journal of Neuroscience

Volumn 33, Issue 33, 2013, Pages 13410-13424

  Gilley, Jonathan ^a   Adalbert, Robert ^a   Yu, Gang ^b   Coleman, Michael P ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; GENE SILENCING; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIFESPAN; MALE; MOUSE; NERVE FIBER DEGENERATION; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORACIC SPINAL CORD; WALLERIAN DEGENERATION;

ANIMALS; AXONS; BRAIN; GANGLIA, SPINAL; GENE KNOCKDOWN TECHNIQUES; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NERVE DEGENERATION; NEURITES; NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; SPINAL NERVES; SUPERIOR CERVICAL GANGLION; TRANSPLANTATION CHIMERA;

EID: 84881500396     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1534-13.2013     Document Type: Article

References (31)

1. Adalbert R, Coleman MP (2012) Axon pathology in age-related neurodegenerative disorders. Neuropathol Appl Neurobiol. Advance online publication. Retrieved Oct. 10, 2012. doi:10.1111/j.1365-2990.2012.01308.x.
2. Babetto E, Beirowski B, Russler EV, Milbrandt J, Diantonio A (2013) The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep 3:1422-1429.
3. Berger F, Lau C, Dahlmann M, Ziegler M (2005) Subcellular compartmen-tation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J Biol Chem 280: 36334-36341.
4. Bhattacharya MR, Gerdts J, Naylor SA, Royse EX, Ebstein SY, Sasaki Y, Milbrandt J, DiAntonio A (2012) A model of toxic neuropathy in Drosoph-ila reveals a role for MORN4 in promoting axonal degeneration. J Neurosci 32:5054-5061.
5. Bowers CW, Zigmond RE (1979) Localization of neurons in the rat superior cervical ganglion that project into different postganglionic trunks. J Comp Neurol 185:381-391.
6. + levels. Eur J Neurosci 7:1596-1602.
7. Cai Y, Yu SS, Chen SR, Pi RB, Gao S, Li H, Ye JT, Liu PQ (2012) Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6. FEBS Lett 586:866-874.
8. Coleman MP, Freeman MR (2010) Wallerian degeneration, wld(s), and nmnat. Annu Rev Neurosci 33:245-267.
9. Fang Y, Soares L, Teng X, Geary M, Bonini NM (2012) A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity. Curr Biol 22:590-595.
10. Gilley J, Coleman MP (2010) Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons. PLoS Biol 8:e1000300.
11. Godement P, Vanselow J, Thanos S, Bonhoeffer F (1987) A study in developing visual systems with a new method of staining neurones and their processes in fixed tissue. Development 101:697-713.
12. Hicks AN, Lorenzetti D, Gilley J, Lu B, Andersson KE, Miligan C, Overbeek PA, Oppenheim R, Bishop CE (2012) Nicotinamide mononucleotide adenylyltransferase 2 (nmnat2) regulates axon integrity in the mouse embryo. PloS One 7:e47869.
13. Hsu JY, Stein SA, Xu XM (2006) Development of the corticospinal tract in the mouse spinal cord: a quantitative ultrastructural analysis. Brain Res 1084:16-27.
14. Ljungberg MC, Ali YO, Zhu J, Wu CS, Oka K, Zhai RG, Lu HC (2012) CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet 21:251-267.
15. Lonze BE, Ginty DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605-623.
16. Lonze BE, Riccio A, Cohen S, Ginty DD (2002) Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34:371-385.
17. Mack TG, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, Thomson D, Gillingwater T, Court F, Conforti L, Fernando FS, Tarlton A, An-dressen C, Addicks K, Magni G, Ribchester RR, Perry VH, Coleman MP (2001) Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci 4:1199-1206.
18. Martin P (1990) Tissue patterning in the developing mouse limb. Int J Dev Biol 34:323-336.
19. Mayer PR, Huang N, Dewey CM, Dries DR, Zhang H, Yu G (2010) Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem 285:40387-40396.
20. Milde S, Gilley J, Coleman MP (2013) Subcellular localization determines the stability and axon protective capacity of axon survival factor nmnat2. PLoS Biol 11:e1001539.
21. Oppenheim RW (1991) Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501.
22. Orsomando G, Cialabrini L, Amici A, Mazzola F, Ruggieri S, Conforti L, Janeckova L, Coleman MP, Magni G (2012) Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues. PloS One 7:e53271.
23. Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, AveryMA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, et al. (2012) Dsarm/Sarm1 is required for activa tion of an injury-induced axon death pathway. Science 337:481-484.
24. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD (1993) Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262:695-700.
25. Rodríguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM (2000) High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25:139-140.
26. Sasaki Y, Araki T, Milbrandt J (2006) Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axo-tomy. J Neurosci 26:8484-8491.
27. Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H (2005) Genomewide production of multipurpose alleles for the functional analysisofthe mouse genome. Proc Natl Acad Sci USA 102:7221-7226.
28. Turgeon B, Meloche S (2009) Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases. Physiol Rev 89:1-26.
29. Xiong X, Hao Y, Sun K, Li J, Li X, Mishra B, Soppina P, Wu C, Hume RI, Collins CA (2012) The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol 10:e1001440.
30. Yan T, Feng Y, Zheng J, Ge X, Zhang Y, Wu D, Zhao J, Zhai Q (2010) Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int 56:101-106.
31. Zhai RG, Zhang F, Hiesinger PR, Cao Y, Haueter CM, Bellen HJ (2008) NAD synthase NMNAT acts as a chaperone to protect against neurode-generation. Nature 452:887-891.