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Volumn 18, Issue 2, 2017, Pages

Metabolomic fingerprinting in the comprehensive study of liver changes associated with onion supplementation in hypercholesterolemic Wistar rats

Author keywords

CE MS; Functional food; GC MS; Hypercholesterolemia; LC MS; Mass spectrometry; Metabolome; Non alcoholic fatty liver disease (NAFLD); Non targeted metabolomics

Indexed keywords

ACYLCARNITINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARNITINE; CATALASE; CHOLESTEROL; GLUTATHIONE PEROXIDASE; PALMITOYLCARNITINE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL LIPASE; TRIACYLGLYCEROL;

EID: 85013814026     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18020267     Document Type: Article
Times cited : (35)

References (51)
  • 1
    • 84902532053 scopus 로고    scopus 로고
    • Cholesterol-induced non-alcoholic fatty liver disease and atherosclerosis aggravated by systemic inflammation
    • Kim, E.J.; Kim, B.H.; Seo, H.S.; Lee, Y.J.; Kim, H.H.; Son, H.H.; Choi, M.H. Cholesterol-induced non-alcoholic fatty liver disease and atherosclerosis aggravated by systemic inflammation. PLoS ONE 2014, 9, e97841. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Kim, E.J.1    Kim, B.H.2    Seo, H.S.3    Lee, Y.J.4    Kim, H.H.5    Son, H.H.6    Choi, M.H.7
  • 2
    • 84982161549 scopus 로고    scopus 로고
    • The natural course of non-alcoholic fatty liver disease
    • Bertot, L.C.; Adams, L.A. The natural course of non-alcoholic fatty liver disease. Int. J. Mol. Sci. 2016, 17. [CrossRef]
    • (2016) Int. J. Mol. Sci. , vol.17
    • Bertot, L.C.1    Adams, L.A.2
  • 4
    • 84869213871 scopus 로고    scopus 로고
    • Phenotyping the effect of diet on non-alcoholic fatty liver disease
    • De Wit, N.J.; Afman, L.A.; Mensink, M.; Muller, M. Phenotyping the effect of diet on non-alcoholic fatty liver disease. J. Hepatol. 2012, 57, 1370–1373. [CrossRef] [PubMed]
    • (2012) J. Hepatol , vol.57 , pp. 1370-1373
    • De Wit, N.J.1    Afman, L.A.2    Mensink, M.3    Muller, M.4
  • 5
    • 84949009777 scopus 로고    scopus 로고
    • Natural antioxidants for non-alcoholic fatty liver disease: Molecular targets and clinical perspectives
    • Salomone, F.; Godos, J.; Zelber-Sagi, S. Natural antioxidants for non-alcoholic fatty liver disease: Molecular targets and clinical perspectives. Liver Int. 2016, 36, 5–20. [CrossRef] [PubMed]
    • (2016) Liver Int , vol.36 , pp. 5-20
    • Salomone, F.1    Godos, J.2    Zelber-Sagi, S.3
  • 7
    • 0033994860 scopus 로고    scopus 로고
    • Garlic and onions: Their effect on eicosanoid metabolism and its clinical relevance
    • Ali, M.; Thomson, M.; Afzal, M. Garlic and onions: Their effect on eicosanoid metabolism and its clinical relevance. Prostaglandins Leukot. Essent. Fat. Acids 2000, 62, 55–73. [CrossRef] [PubMed]
    • (2000) Prostaglandins Leukot. Essent. Fat. Acids , vol.62 , pp. 55-73
    • Ali, M.1    Thomson, M.2    Afzal, M.3
  • 8
    • 84857187511 scopus 로고    scopus 로고
    • An evaluation of the hypoglycemic, antioxidant and hepatoprotective potentials of onion (Allium cepa L.) on alloxan-induced diabetic rabbits
    • Ogunmodede, O.S.; Saalu, L.C.; Ogunlade, B.; Akunna, G.G.; Oyewopo, A.O. An evaluation of the hypoglycemic, antioxidant and hepatoprotective potentials of onion (Allium cepa L.) on alloxan-induced diabetic rabbits. Int. J. Pharm. 2012, 8, 21–29.
    • (2012) Int. J. Pharm , vol.8 , pp. 21-29
    • Ogunmodede, O.S.1    Saalu, L.C.2    Ogunlade, B.3    Akunna, G.G.4    Oyewopo, A.O.5
  • 9
    • 67650495835 scopus 로고    scopus 로고
    • Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats
    • Obioha, U.E.; Suru, S.M.; Ola-Mudathir, K.F.; Faremi, T.Y. Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats. Biol. Trace Elem. Res. 2009, 129, 143–156. [CrossRef] [PubMed]
    • (2009) Biol. Trace Elem. Res , vol.129 , pp. 143-156
    • Obioha, U.E.1    Suru, S.M.2    Ola-Mudathir, K.F.3    Faremi, T.Y.4
  • 10
    • 84979210660 scopus 로고    scopus 로고
    • The effects of onion consumption on treatment of metabolic, histologic, and inflammatory features of nonalcoholic fatty liver disease
    • Emamat, H.; Foroughi, F.; Eini-Zinab, H.; Taghizadeh, M.; Rismanchi, M.; Hekmatdoost, A. The effects of onion consumption on treatment of metabolic, histologic, and inflammatory features of nonalcoholic fatty liver disease. J. Diabetes Metab. Disord. 2016, 15. [CrossRef] [PubMed]
    • (2016) J. Diabetes Metab. Disord. , vol.15
    • Emamat, H.1    Foroughi, F.2    Eini-Zinab, H.3    Taghizadeh, M.4    Rismanchi, M.5    Hekmatdoost, A.6
  • 14
    • 84905442962 scopus 로고    scopus 로고
    • Analytical protocols based on LC-MS, GC-MS and CE-MS for nontargeted metabolomics of biological tissues
    • Naz, S.; dos Santos, D.C.M.; Garcia, A.; Barbas, C. Analytical protocols based on LC-MS, GC-MS and CE-MS for nontargeted metabolomics of biological tissues. Bioanalysis 2014, 6, 1657–1677. [CrossRef] [PubMed]
    • (2014) Bioanalysis , vol.6 , pp. 1657-1677
    • Naz, S.1    Dos Santos, D.C.M.2    Garcia, A.3    Barbas, C.4
  • 15
    • 84884414039 scopus 로고    scopus 로고
    • The metabolomic window into hepatobiliary disease
    • Beyoglu, D.; Idle, J.R. The metabolomic window into hepatobiliary disease. J. Hepatol. 2013, 59, 842–858. [CrossRef] [PubMed]
    • (2013) J. Hepatol , vol.59 , pp. 842-858
    • Beyoglu, D.1    Idle, J.R.2
  • 17
    • 84928558967 scopus 로고    scopus 로고
    • High-cholesterol diet enriched with onion affects endothelium-dependent relaxation and NADPH oxidase activity in mesenteric microvessels from Wistar rats
    • González-Peña, D.; Angulo, J.; Vallejo, S.; Colina-Coca, C.; de Ancos, B.; Sánchez-Ferrer, C.F.; Peiró, C.; Sánchez-Moreno, C. High-cholesterol diet enriched with onion affects endothelium-dependent relaxation and NADPH oxidase activity in mesenteric microvessels from Wistar rats. Nutr. Metab. 2014, 11, 57. [CrossRef] [PubMed]
    • (2014) Nutr. Metab , vol.11 , pp. 57
    • González-Peña, D.1    Angulo, J.2    Vallejo, S.3    Colina-Coca, C.4    De Ancos, B.5    Sánchez-Ferrer, C.F.6    Peiró, C.7    Sánchez-Moreno, C.8
  • 18
    • 84946402891 scopus 로고    scopus 로고
    • Evaluation of onion as a functional ingredient in the prevention of metabolic impairments associated to diet-induced hypercholesterolaemia using a multiplatform approach based on LC-MS, CE-MS and GC-MS
    • González-Peña, D.; Dudzik, D.; Colina-Coca, C.; de Ancos, B.; García, A.; Barbas, C.; Sánchez-Moreno, C. Evaluation of onion as a functional ingredient in the prevention of metabolic impairments associated to diet-induced hypercholesterolaemia using a multiplatform approach based on LC-MS, CE-MS and GC-MS. J. Funct. Foods 2015, 19 Pt. A, 363–375. [CrossRef]
    • (2015) J. Funct. Foods , vol.19 , pp. 363-375
    • González-Peña, D.1    Dudzik, D.2    Colina-Coca, C.3    De Ancos, B.4    García, A.5    Barbas, C.6    Sánchez-Moreno, C.7
  • 19
    • 85006415513 scopus 로고    scopus 로고
    • New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
    • González-Peña, D.; Checa, A.; de Ancos, B.; Wheelock, C.E.; Sánchez-Moreno, C. New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia. Redox Biol. 2017, 11, 205–212. [CrossRef] [PubMed]
    • (2017) Redox Biol , vol.11 , pp. 205-212
    • González-Peña, D.1    Checa, A.2    De Ancos, B.3    Wheelock, C.E.4    Sánchez-Moreno, C.5
  • 20
    • 79961211515 scopus 로고    scopus 로고
    • Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model
    • Gorden, D.L.; Ivanova, P.T.; Myers, D.S.; McIntyre, J.O.; VanSaun, M.N.; Wright, J.K.; Matrisian, L.M.; Brown, H.A. Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. PLoS ONE 2011, 6, e22775. [CrossRef] [PubMed]
    • (2011) Plos ONE , vol.6
    • Gorden, D.L.1    Ivanova, P.T.2    Myers, D.S.3    McIntyre, J.O.4    Vansaun, M.N.5    Wright, J.K.6    Matrisian, L.M.7    Brown, H.A.8
  • 24
  • 26
    • 77957143970 scopus 로고    scopus 로고
    • Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis
    • Lee, J.H.; Kim, G.H. Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis. J. Food Sci. 2010, 75, H212–H217. [CrossRef] [PubMed]
    • (2010) J. Food Sci , vol.75 , pp. H212-H217
    • Lee, J.H.1    Kim, G.H.2
  • 27
    • 84937871165 scopus 로고    scopus 로고
    • Quercetin protects mouse liver against CCL4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway
    • Ma, J.Q.; Li, Z.; Xie, W.R.; Liu, C.M.; Liu, S.S. Quercetin protects mouse liver against CCL4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway. Int. Immunopharmacol. 2015, 28, 531–539. [CrossRef] [PubMed]
    • (2015) Int. Immunopharmacol , vol.28 , pp. 531-539
    • Ma, J.Q.1    Li, Z.2    Xie, W.R.3    Liu, C.M.4    Liu, S.S.5
  • 28
    • 84921902154 scopus 로고    scopus 로고
    • Onion (Allium cepa L.) peel extract has anti-platelet effects in rat platelets
    • Ro, J.Y.; Ryu, J.H.; Park, H.J.; Cho, H.J. Onion (Allium cepa L.) peel extract has anti-platelet effects in rat platelets. Springerplus 2015, 4. [CrossRef] [PubMed]
    • (2015) Springerplus , pp. 4
    • Ro, J.Y.1    Ryu, J.H.2    Park, H.J.3    Cho, H.J.4
  • 29
    • 84872089657 scopus 로고    scopus 로고
    • Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes
    • Jung, C.H.; Cho, I.; Ahn, J.; Jeon, T.I.; Ha, T.Y. Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. Phytother. Res. 2013, 27, 139–143. [CrossRef] [PubMed]
    • (2013) Phytother. Res , vol.27 , pp. 139-143
    • Jung, C.H.1    Cho, I.2    Ahn, J.3    Jeon, T.I.4    Ha, T.Y.5
  • 30
    • 84958122868 scopus 로고    scopus 로고
    • D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling
    • D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling. Hepatol. Res. 2016, 46, 225–238. [CrossRef] [PubMed]
    • (2016) Hepatol. Res , vol.46 , pp. 225-238
    • Wang, L.L.1    Zhang, Z.C.2    Hassan, W.3    Li, Y.4    Liu, J.5    Shang, J.6
  • 31
    • 43049097221 scopus 로고    scopus 로고
    • The influence of quercetin on fatty-acid content in selected organs of rats on diets with fresh and oxidized fat
    • Regulska-Ilow, B.; Ilow, R. The influence of quercetin on fatty-acid content in selected organs of rats on diets with fresh and oxidized fat. Adv. Clin. Exp. Med. 2008, 17, 15–26.
    • (2008) Adv. Clin. Exp. Med. , vol.17 , pp. 15-26
    • Regulska-Ilow, B.1    Ilow, R.2
  • 32
    • 77955825504 scopus 로고    scopus 로고
    • Short-chain 3-hydroxyacyl-coa dehydrogenase is a negative regulator of insulin secretion in response to fuel and non-fuel stimuli in ins832/13 β-cells
    • Pepin, E.; Guay, C.; Delghingaro-Augusto, V.; Joly, E.; Madiraju, S.R.; Prentki, M. Short-chain 3-hydroxyacyl-coa dehydrogenase is a negative regulator of insulin secretion in response to fuel and non-fuel stimuli in ins832/13 β-cells. J. Diabetes 2010, 2, 157–167. [CrossRef] [PubMed]
    • (2010) J. Diabetes , vol.2 , pp. 157-167
    • Pepin, E.1    Guay, C.2    Delghingaro-Augusto, V.3    Joly, E.4    Madiraju, S.R.5    Prentki, M.6
  • 35
    • 84962860710 scopus 로고    scopus 로고
    • Effects of arginine supplementation on amino acid profiles in blood and tissues in fed and overnight-fasted rats
    • Holecek, M.; Sispera, L. Effects of arginine supplementation on amino acid profiles in blood and tissues in fed and overnight-fasted rats. Nutrients 2016, 8, 206. [CrossRef] [PubMed]
    • (2016) Nutrients , vol.8 , pp. 206
    • Holecek, M.1    Sispera, L.2
  • 36
    • 84858072223 scopus 로고    scopus 로고
    • Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression
    • Corbin, K.D.; Zeisel, S.H. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr. Opin. Gastroenterol. 2012, 28, 159–165. [CrossRef] [PubMed]
    • (2012) Curr. Opin. Gastroenterol , vol.28 , pp. 159-165
    • Corbin, K.D.1    Zeisel, S.H.2
  • 37
    • 84871783795 scopus 로고    scopus 로고
    • Method based on GC-MS to study the influence of tricarboxylic acid cycle metabolites on cardiovascular risk factors
    • Calderón-Santiago, M.; Priego-Capote, F.; Galache-Osuna, J.G.; Luque de Castro, M.D. Method based on GC-MS to study the influence of tricarboxylic acid cycle metabolites on cardiovascular risk factors. J. Pharm. Biomed. Anal. 2013, 74, 178–185. [CrossRef] [PubMed]
    • (2013) J. Pharm. Biomed. Anal , vol.74 , pp. 178-185
    • Calderón-Santiago, M.1    Priego-Capote, F.2    Galache-Osuna, J.G.3    Luque De Castro, M.D.4
  • 39
    • 84921627420 scopus 로고    scopus 로고
    • Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats
    • Johari, N.Z.; Ismail, I.S.; Sulaiman, M.R.; Abas, F.; Shaari, K. Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats. Int. J. Appl. Res. Nat. Prod. 2015, 8, 1–11.
    • (2015) Int. J. Appl. Res. Nat. Prod. , vol.8 , pp. 1-11
    • Johari, N.Z.1    Ismail, I.S.2    Sulaiman, M.R.3    Abas, F.4    Shaari, K.5
  • 40
    • 0031771058 scopus 로고    scopus 로고
    • ′ -O-β-glucoside by human volunteers after the consumption of onions
    • ′ -O-β-glucoside by human volunteers after the consumption of onions. Free Radic. Res. 1998, 29, 257–269. [CrossRef] [PubMed]
    • (1998) Free Radic. Res , vol.29 , pp. 257-269
    • Aziz, A.A.1    Edwards, C.A.2    Lean, M.E.3    Crozier, A.4
  • 41
    • 0031750552 scopus 로고    scopus 로고
    • Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake
    • De Vries, J.H.; Hollman, P.C.; Meyboom, S.; Buysman, M.N.; Zock, P.L.; van Staveren, W.A.; Katan, M.B. Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake. Am. J. Clin. Nutr. 1998, 68, 60–65. [PubMed]
    • (1998) Am. J. Clin. Nutr. , vol.68 , pp. 60-65
    • De Vries, J.H.1    Hollman, P.C.2    Meyboom, S.3    Buysman, M.N.4    Zock, P.L.5    Van Staveren, W.A.6    Katan, M.B.7
  • 42
    • 0034073446 scopus 로고    scopus 로고
    • Prediction of dietary flavonol consumption from fasting plasma concentration or urinary excretion
    • Noroozi, M.; Burns, J.; Crozier, A.; Kelly, I.E.; Lean, M.E. Prediction of dietary flavonol consumption from fasting plasma concentration or urinary excretion. Eur. J. Clin. Nutr. 2000, 54, 143–149. [CrossRef] [PubMed]
    • (2000) Eur. J. Clin. Nutr , vol.54 , pp. 143-149
    • Noroozi, M.1    Burns, J.2    Crozier, A.3    Kelly, I.E.4    Lean, M.E.5
  • 43
    • 84929471035 scopus 로고    scopus 로고
    • Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: A randomized, single-blinded, cross-over study
    • Shi, Y.; Williamson, G. Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: A randomized, single-blinded, cross-over study. Food Funct. 2015, 6, 1443–1448. [CrossRef] [PubMed]
    • (2015) Food Funct , vol.6 , pp. 1443-1448
    • Shi, Y.1    Williamson, G.2
  • 44
    • 33746698897 scopus 로고    scopus 로고
    • Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
    • Mullen, W.; Edwards, C.A.; Crozier, A. Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br. J. Nutr. 2006, 96, 107–116. [CrossRef] [PubMed]
    • (2006) Br. J. Nutr , vol.96 , pp. 107-116
    • Mullen, W.1    Edwards, C.A.2    Crozier, A.3
  • 45
    • 34247240004 scopus 로고    scopus 로고
    • Onion flesh and onion peel enhance antioxidant status in aged rats
    • Park, J.; Kim, J.; Kim, M.K. Onion flesh and onion peel enhance antioxidant status in aged rats. J. Nutr. Sci. Vitaminol. 2007, 53, 21–29. [CrossRef] [PubMed]
    • (2007) J. Nutr. Sci. Vitaminol , vol.53 , pp. 21-29
    • Park, J.1    Kim, J.2    Kim, M.K.3
  • 46
    • 34247260351 scopus 로고    scopus 로고
    • Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats
    • Azuma, K.; Minami, Y.; Ippoushi, K.; Terao, J. Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats. J. Clin. Biochem. Nutr. 2007, 40, 131–140. [CrossRef] [PubMed]
    • (2007) J. Clin. Biochem. Nutr , vol.40 , pp. 131-140
    • Azuma, K.1    Minami, Y.2    Ippoushi, K.3    Terao, J.4
  • 47
    • 84888437732 scopus 로고    scopus 로고
    • Common onion (Allium cepa) extract reverses cadmium-induced organ toxicity and dyslipidaemia via redox alteration in rats
    • Ige, S.F.; Akhigbe, R.E. Common onion (Allium cepa) extract reverses cadmium-induced organ toxicity and dyslipidaemia via redox alteration in rats. Pathophysiology 2013, 20, 269–274. [CrossRef] [PubMed]
    • (2013) Pathophysiology , vol.20 , pp. 269-274
    • Ige, S.F.1    Akhigbe, R.E.2
  • 48
    • 0030912476 scopus 로고    scopus 로고
    • Components of the AIN-93 diets as improvements in the AIN-76A diet
    • Reeves, P.G. Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr. 1997, 127, 838s–841s. [PubMed]
    • (1997) J. Nutr. , vol.127 , pp. 838s-841s
    • Reeves, P.G.1
  • 49
    • 84888365206 scopus 로고    scopus 로고
    • Multiplatform analytical methodology for metabolic fingerprinting of lung tissue
    • Naz, S.; García, A.; Barbas, C. Multiplatform analytical methodology for metabolic fingerprinting of lung tissue. Anal. Chem. 2013, 85, 10941–10948. [CrossRef] [PubMed]
    • (2013) Anal. Chem , vol.85 , pp. 10941-10948
    • Naz, S.1    García, A.2    Barbas, C.3
  • 50
    • 84979865433 scopus 로고    scopus 로고
    • MetaboAnalyst 3.0—Making metabolomics more meaningful
    • Xia, J.; Sinelnikov, I.V.; Han, B.; Wishart, D.S. MetaboAnalyst 3.0—Making metabolomics more meaningful. Nucleic Acids Res. 2015, 43, W251–W257. [CrossRef] [PubMed]
    • (2015) Nucleic Acids Res , vol.43 , pp. W251-W257
    • Xia, J.1    Sinelnikov, I.V.2    Han, B.3    Wishart, D.S.4


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