Series "hot topics in paediatric asthma" Edited by K-H. Carlsen, G. Hedlin and A. Bush Number 2 in this Series: Childhood asthma and infection: Virus-induced exacerbations as determinants and modifiers

European Respiratory Journal

Volumn 36, Issue 2, 2010, Pages 438-445

  Xepapadaki, P ^a   Papadopoulos, N G ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Childhood asthma; Exacerbation; Infections; Virus

Indexed keywords

AZITHROMYCIN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLARITHROMYCIN; CORTICOSTEROID; IMMUNOGLOBULIN E ANTIBODY; LEUKOTRIENE RECEPTOR BLOCKING AGENT; TELITHROMYCIN; ANTIOXIDANT;

ASTHMA; CHILD; CHILDHOOD DISEASE; CLINICAL TRIAL; DISEASE EXACERBATION; DRUG EFFICACY; HUMAN; IMMUNE RESPONSE; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; RISK FACTOR; TREATMENT OUTCOME; VIRAL RESPIRATORY TRACT INFECTION; ANIMAL; CHEMISTRY; IMMUNOLOGY; INFLAMMATION; METHODOLOGY; MICROBIOLOGY; MOUSE; PEDIATRICS; PULMONOLOGY; VIRUS INFECTION;

ANIMALS; ANTIOXIDANTS; ASTHMA; CHILD; HUMANS; INFLAMMATION; MICE; PEDIATRICS; PULMONARY MEDICINE; RESPIRATORY TRACT INFECTIONS; VIRUS DISEASES;

EID: 77955601233     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00149009     Document Type: Review

References (113)

1. Simpson A, Custovic A. Prevention of allergic sensitization by environmental control. Curr Allergy Asthma Rep 2009; 9: 363-369.
2. Johnston SL. Overview of virus-induced airway disease. Proc Am Thorac Soc 2005; 2: 150-156.
3. Taylor DR, Bateman ED, Boulet LP, et al. A new perspective on concepts of asthma severity and control. Eur Respir J 2008; 32: 545-554.
4. Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations. Standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009; 180: 59-99.
5. Reddel H, Ware S, Marks G, et al. Differences between asthma exacerbations and poor asthma control. Lancet 1999; 353: 364-369.
6. Sykes A, Seemungal T. Recent advances in exacerbations of asthma. Thorax 2008; 63: 758-760.
7. National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program, Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Full Report 2007. Bethesda, US Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, 2007.
8. Pauwels RA, Lofdahl CG, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 1997; 337: 1405-1411.
9. Chipps BE, Murphy KR. Assessment and treatment of acute asthma in children. J Pediatr 2005; 147: 288-294.
10. Sears MR. Epidemiology of asthma exacerbations. J Allergy Clin Immunol 2008; 122: 662-668.
11. Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995; 310: 1225-1229.
12. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ 1993; 307: 982-986.
13. Murray CS, Poletti G, Kebadze T, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006; 61: 376-382.
14. Bacharier LB, Boner A, Carlsen KH, et al. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy 2008; 63: 5-34.
15. Brand PL, Baraldi E, Bisgaard H, et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008; 32: 1096-1110.
16. Illi S, von Mutius E, Lau S, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006; 368: 763-770.
17. Tan WC. Viruses in asthma exacerbations. Curr Opin Pulm Med 2005; 11: 21-26.
18. Atmar RL, Guy E, Guntupalli KK, et al. Respiratory tract viral infections in inner-city asthmatic adults. Arch Intern Med 1998; 158: 2453-2459.
19. Khetsuriani N, Kazerouni NN, Erdman DD, et al. Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol 2007; 119: 314-321.
20. Johnston NW, Johnston SL, Norman GR, et al. The September epidemic of asthma hospitalization: school children as disease vectors. J Allergy Clin Immunol 2006; 117: 557-562.
21. Almqvist C, Wickman M, Perfetti L, et al. Worsening of asthma in children allergic to cats, after indirect exposure to cat at school. Am J Respir Crit Care Med 2001; 163: 694-698.
22. Pendergraft TB, Stanford RH, Beasley R, et al. Seasonal variation in asthma-related hospital and intensive care unit admissions. J Asthma 2005; 42: 265-271.
23. Bartlett NW, McLean GR, Chang YS, et al. Genetics and epidemiology: asthma and infection. Curr Opin Allergy Clin Immunol 2009; 9: 395-400.
24. Miller BD, Wood BL, Lim J, et al. Depressed children with asthma evidence increased airway resistance: "vagal bias" as a mechanism? J Allergy Clin Immunol 2009; 124: 66-73.e10.
25. Abe T, Tokuda Y, Ohde S, et al. The relationship of short-term air pollution and weather to ED visits for asthma in Japan. Am J Emerg Med 2009; 27: 153-159.
26. Eggleston PA. Complex interactions of pollutant and allergen exposures and their impact on people with asthma. Pediatrics 2009; 123: Suppl. 3, S160-S167.
27. Mohr LB, Luo S, Mathias E, et al. Influence of season and temperature on the relationship of elemental carbon air pollution to pediatric asthma emergency room visits. J Asthma 2008; 45: 936-943.
28. Covar RA, Szefler SJ, Zeiger RS, et al. Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. J Allergy Clin Immunol 2008; 122: 741-747.e4.
29. Dales RE, Cakmak S, Judek S, et al. Tree pollen and hospitalization for asthma in urban Canada. Int Arch Allergy Immunol 2008; 146: 241-247.
30. Heguy L, Garneau M, Goldberg MS, et al. Associations between grass and weed pollen and emergency department visits for asthma among children in Montreal. Environ Res 2008; 106: 203-211.
31. Peden DB. Pollutants and asthma: role of air toxics. Environ Health Perspect 2002; 110: Suppl. 4, 565-568.
32. 2) and the severity of virus-induced asthma in children. Lancet 2003; 361: 1939-1944.
33. Green RM, Custovic A, Sanderson G, et al. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ 2002; 324: 763.
34. Sandberg S, Jarvenpaa S, Penttinen A, et al. Asthma exacerbations in children immediately following stressful life events: a Cox's hierarchical regression. Thorax 2004; 59: 1046-1051.
35. Singh AM, Busse WW. Asthma exacerbations. 2: aetiology. Thorax 2006; 61: 809-816.
36. Matthew J, Pinto Pereira LM, Pappas TE, et al. Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies. Ital J Pediatr 2009; 35: 16.
37. Cheuk DK, Tang IW, Chan KH, et al. Rhinovirus infection in hospitalized children in Hong Kong: a prospective study. Pediatr Infect Dis J 2007; 26: 995-1000.
38. Calvo C, Garcia-Garcia ML, Blanco C, et al. Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain. Pediatr Infect Dis J 2007; 26: 904-908.
39. Xepapadaki P, Papadopoulos NG. Viral infections and allergies. Immunobiology 2007; 212: 453-459.
40. Williams JV, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 2004; 350: 443-450.
41. Foulongne V, Guyon G, Rodiere M, et al. Human metapneumovirus infection in young children hospitalized with respiratory tract disease. Pediatr Infect Dis J 2006; 25: 354-359.
42. Vallet C, Pons-Catalano C, Mandelcwajg A, et al. Human bocavirus: a cause of severe asthma exacerbation in children. J Pediatr 2009; 155: 286-288.
43. Papadopoulos NG. Do rhinoviruses cause pneumonia in children? Paediatr Respir Rev 2004; 5: Suppl. A, S191-S195.
44. Papadopoulos NG, Moustaki M, Tsolia M, et al. Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med 2002; 165: 1285-1289.
45. Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178: 667-672.
46. Lemanske RF Jr, Jackson DJ, Gangnon RE, et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 2005; 116: 571-577.
47. Lee WM, Kiesner C, Pappas T, et al. A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS One 2007; 2: e966.
48. Renwick N, Schweiger B, Kapoor V, et al. A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany. J Infect Dis 2007; 196: 1754-1760.
49. Lau SK, Yip CC, Tsoi HW, et al. Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children. J Clin Microbiol 2007; 45: 3655-3664.
50. Miller EK, Edwards KM, Weinberg GA, et al. A novel group of rhinoviruses is associated with asthma hospitalizations. J Allergy Clin Immunol 2009; 123: 98-104.e1.
51. Linsuwanon P, Payungporn S, Samransamruajkit R, et al. High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease. J Infect 2009; 59: 115-121.
52. Peltola V, Jartti T, Putto-Laurila A, et al. Rhinovirus infections in children: a retrospective and prospective hospital-based study. J Med Virol 2009; 81: 1831-1838.
53. Lau SK, Yip CC, Lin AW, et al. Clinical and molecular epidemiology of human rhinovirus C in children and adults in Hong Kong reveals a possible distinct human rhinovirus C subgroup. J Infect Dis 2009; 200: 1096-1103.
54. Xepapadaki P, Papadopoulos NG. Atypical bacteria and macrolides in asthma. Allergy Asthma Clin Immunol 2008; 4: 111-116.
55. Biscardi S, Lorrot M, Marc E, et al. Mycoplasma pneumoniae and asthma in children. Clin Infect Dis 2004; 38: 1341-1346.
56. Cosentini R, Tarsia P, Canetta C, et al. Severe asthma exacerbation: role of acute Chlamydophila pneumoniae and Mycoplasma pneumoniae infection. Respir Res 2008; 9: 48.
57. Wu Q, Martin RJ, Lafasto S, et al. Toll-like receptor 2 downregulation in established mouse allergic lungs contributes to decreased mycoplasma clearance. Am J Respir Crit Care Med 2008; 177: 720-729.
58. Kraft M, Adler KB, Ingram JL, et al. Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma. Eur Respir J 2008; 31: 43-46.
59. 2LEN and InterAirways document. Allergy 2007; 62: 457-470.
60. Dreschers S, Dumitru CA, Adams C, et al. The cold case: are rhinoviruses perfectly adapted pathogens? Cell Mol Life Sci 2007; 64: 181-191.
61. Papadopoulos NG, Bates PJ, Bardin PG, et al. Rhinoviruses infect the lower airways. J Infect Dis 2000; 181: 1875-1884.
62. Papadopoulos NG, Papi A, Meyer J, et al. Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells. Clin Exp Allergy 2001; 31: 1060-1066.
63. Schroth MK, Grimm E, Frindt P, et al. Rhinovirus replication causes RANTES production in primary bronchial epithelial cells. Am J Respir Cell Mol Biol 1999; 20: 1220-1228.
64. Kelly JT, Busse WW. Host immune responses to rhinovirus: mechanisms in asthma. J Allergy Clin Immunol 2008; 122: 671-682.
65. Xatzipsalti M, Kyrana S, Tsolia M, et al. Rhinovirus viremia in children with respiratory infections. Am J Respir Crit Care Med 2005; 172: 1037-1040.
66. Papadopoulos NG, Papi A, Psarras S, et al. Mechanisms of rhinovirus-induced asthma. Paediatr Respir Rev 2004; 5: 255-260.
67. Wiehler S, Proud D. Interleukin-17A modulates human airway epithelial responses to human rhinovirus infection. Am J Physiol Lung Cell Mol Physiol 2007; 293: L505-L515.
68. Wark PA, Johnston SL, Moric I, et al. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 2002; 19: 68-75.
69. Pizzichini MM, Pizzichini E, Efthimiadis A, et al. Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study. Am J Respir Crit Care Med 1998; 158: 1178-1184.
70. Fraenkel DJ, Bardin PG, Sanderson G, et al. Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med 1995; 151: 879-886.
71. Wark PA, Bucchieri F, Johnston SL, et al. IFN-γ-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol 2007; 120: 586-593.
72. Tuthill TJ, Papadopoulos NG, Jourdan P, et al. Mouse respiratory epithelial cells support efficient replication of human rhinovirus. J Gen Virol 2003; 84: 2829-2836.
73. Bartlett NW, Walton RP, Edwards MR, et al. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med 2008; 14: 199-204.
74. Newcomb DC, Sajjan US, Nagarkar DR, et al. Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice. Am J Respir Crit Care Med 2008; 177: 1111-1121.
75. Johnston SL. Innate immunity in the pathogenesis of virus-induced asthma exacerbations. Proc Am Thorac Soc 2007; 4: 267-270.
76. Takaoka A, Hayakawa S, Yanai H, et al. Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence. Nature 2003; 424: 516-523.
77. Kotenko SV, Gallagher G, Baurin VV, et al. IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 2003; 4: 69-77.
78. Bullens DM, Decraene A, Dilissen E, et al. Type III IFN-λ mRNA expression in sputum of adult and school-aged asthmatics. Clin Exp Allergy 2008; 38: 1459-1467.
79. Wark PA, Johnston SL, Bucchieri F, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201: 937-947.
80. Papadopoulos NG, Stanciu LA, Papi A, et al. A defective type 1 response to rhinovirus in atopic asthma. Thorax 2002; 57: 328-332.
81. Gern JE, Vrtis R, Grindle KA, et al. Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am J Respir Crit Care Med 2000; 162: 2226-2231.
82. Gehlhar K, Bilitewski C, Reinitz-Rademacher K, et al. Impaired virus-induced interferon-α2 release in adult asthmatic patients. Clin Exp Allergy 2006; 36: 331-337.
83. Contoli M, Message SD, Laza-Stanca V, et al. Role of deficient type III interferon-λ production in asthma exacerbations. Nat Med 2006; 12: 1023-1026.
84. Khaitov MR, Laza-Stanca V, Edwards MR, et al. Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells. Allergy 2009; 64: 375-386.
85. Xepapadaki P, Papadopoulos NG, Bossios A, et al. Duration of postviral airway hyperresponsiveness in children with asthma: effect of atopy. J Allergy Clin Immunol 2005; 116: 299-304.
86. Heymann PW, Platts-Mills TA, Johnston SL. Role of viral infections, atopy and antiviral immunity in the etiology of wheezing exacerbations among children and young adults. Pediatr Infect Dis J 2005; 24: S217-S222.
87. Bossios A, Psarras S, Gourgiotis D, et al. Rhinovirus infection induces cytotoxicity and delays wound healing in bronchial epithelial cells. Respir Res 2005; 6: 114.
88. Hansbro NG, Horvat JC, Wark PA, et al. Understanding the mechanisms of viral induced asthma: new therapeutic directions. Pharmacol Ther 2008; 117: 313-353.
89. Bossios A, Gourgiotis D, Skevaki CL, et al. Rhinovirus infection and house dust mite exposure synergize in inducing bronchial epithelial cell interleukin-8 release. Clin Exp Allergy 2008; 38: 1615-1626.
90. Xatzipsalti M, Psarros F, Konstantinou G, et al. Modulation of the epithelial inflammatory response to rhinovirus in an atopic environment. Clin Exp Allergy 2008; 38: 466-472.
91. de Kluijver J, Grunberg K, Sont JK, et al. Rhinovirus infection in nonasthmatic subjects: effects on intrapulmonary airways. Eur Respir J 2002; 20: 274-279.
92. Psarras S, Volonaki E, Skevaki CL, et al. Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses. J Allergy Clin Immunol 2006; 117: 291-297.
93. Skevaki C, Psarras S, Volonaki E, et al. Human rhinovirus induction of fibroblast production by bronchial epithelial cells mediates stroma cell proliferation: association with airway remodelling in asthma. Allergy 2008; 63: Suppl. 88, 59-60.
94. Johnston NW, Mandhane PJ, Dai J, et al. Attenuation of the September epidemic of asthma exacerbations in children: a randomized, controlled trial of montelukast added to usual therapy. Pediatrics 2007; 120: e702-e712.
95. Sorkness CA, Lemanske RF Jr, Mauger DT, et al. Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol 2007; 119: 64-72.
96. Rees PJ. Review: omalizumab reduces exacerbation and steroid use in chronic asthma. Evid Based Med 2007; 12: 11.
97. Papi A, Canonica GW, Maestrelli P, et al. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. N Engl J Med 2007; 356: 2040-2052.
98. 2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct cis-acting elements. J Biol Chem 2007; 282: 15366-15375.
99. Pelaia G, Vatrella A, Cuda G, et al. Molecular mechanisms of corticosteroid actions in chronic inflammatory airway diseases. Life Sci 2003; 72: 1549-1561.
100. Bisgaard H, Hermansen MN, Loland L, et al. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006; 354: 1998-2005.
101. Bisgaard H, Zielen S, Garcia-Garcia ML, et al. Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma. Am J Respir Crit Care Med 2005; 171: 315-322.
102. Robertson CF, Price D, Henry R, et al. Short-course montelukast for intermittent asthma in children: a randomized controlled trial. Am J Respir Crit Care Med 2007; 175: 323-329.
103. Bacharier LB, Phillips BR, Zeiger RS, et al. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol 2008; 122: 1127-1135.e8.
104. Sperber SJ, Levine PA, Sorrentino JV, et al. Ineffectiveness of recombinant interferon-β serine nasal drops for prophylaxis of natural colds. J Infect Dis 1989; 160: 700-705.
105. Farr BM, Gwaltney JM Jr, Adams KF, et al. Intranasal interferon-α2 for prevention of natural rhinovirus colds. Antimicrob Agents Chemother 1984; 26: 31-34.
106. Hayden FG, Herrington DT, Coats TL, et al. Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials. Clin Infect Dis 2003; 36: 1523-1532.
107. Pevear DC, Hayden FG, Demenczuk TM, et al. Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses. Antimicrob Agents Chemother 2005; 49: 4492-4499.
108. Gotfried MH. Macrolides for the treatment of chronic sinusitis, asthma, and COPD. Chest 2004; 125: 52S-60S.
109. Shinkai M, Rubin BK. Macrolides and airway inflammation in children. Paediatr Respir Rev 2005; 6: 227-235.
110. Johnston SL, Martin RJ. Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis? Am J Respir Crit Care Med 2005; 172: 1078-1089.
111. Johnston SL, Blasi F, Black PN, et al. The effect of telithromycin in acute exacerbations of asthma. N Engl J Med 2006; 354: 1589-1600.
112. Little FF. Treating acute asthma with antibiotics - not quite yet. N Engl J Med 2006; 354: 1632-1634.
113. Kneyber MC, van Woensel JB, Uijtendaal E, et al. Azithromycin does not improve disease course in hospitalized infants with respiratory syncytial virus (RSV) lower respiratory tract disease: a randomized equivalence trial. Pediatr Pulmonol 2008; 43: 142-149.