Medicinal chemistry profiling of monocyclic 1,2-azaborines

ChemMedChem

Volumn 12, Issue 5, 2017, Pages 358-361

  Zhao, Peng ^a   Nettleton, David O ^b   Karki, Rajeshri G ^b   Zécri, Frédéric J ^b   Liu, Shih Yuan ^a  

^a BOSTON COLLEGE   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Azaborines; BN heterocycle; CDK2 inhibitors; Drug discovery; Solubility

Indexed keywords

CYCLIN DEPENDENT KINASE 2 INHIBITOR; HETEROCYCLIC COMPOUND; MONOCYCLIC 1,2 AZABORINE DERIVATIVE; UNCLASSIFIED DRUG; 1,2-AZABORINE; BORON DERIVATIVE; CYCLIN DEPENDENT KINASE 2; PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MEDICINAL CHEMISTRY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; HALF LIFE TIME; HYDROGEN BOND; MALE; METABOLISM; MOLECULAR DYNAMICS; ORAL DRUG ADMINISTRATION; PROTEIN TERTIARY STRUCTURE; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; BORON COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; CYCLIN-DEPENDENT KINASE 2; HALF-LIFE; HYDROGEN BONDING; MALE; MOLECULAR DYNAMICS SIMULATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 85013377867     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201700047     Document Type: Article

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