BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase 10A (PDE10A) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4453-4461

  Vlasceanu, Alexandru ^b   Jessing, Mikkel ^a   Kilburn, John Paul ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antipsychotics; Borazaronaphthalenes; PDE10A inhibitors

Indexed keywords

2 [4 [1 METHYL 4 (4 PYRIDINYL) 3 PYRAZOLYL]PHENOXYMETHYL]QUINOLINE; 2 [[4 [1 METHYL 4 (PYRIDIN 4 YL) 1H PYRAZOL 3 YL]PHENOXY]METHYL] 1,2 DIHYDROBENZO[E][1,2]AZABORININE; 4 [1 METHYL 3 [4 (NAPHTHALEN 2 YLMETHOXY)PHENYL] 1H PYRAZOL 4 YL]PYRIDINE; BORAZARONAPHTHALENE DERIVATIVE; N METHYL N [4 (NAPHTHALEN 2 YLMETHOXY)PHENYL] 2 (PYRIDIN 3 YL)THIAZOLE 4 CARBOXAMIDE; N METHYL N [4 (NAPHTHALEN 2 YLMETHOXY)PHENYL] 3 PHENYL 1H PYRAZOLE 5 CARBOXAMIDE; N METHYL N [4 (NAPHTHALEN 2 YLMETHOXY)PHENYL] 5 (PYRIDIN 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; N METHYL N [4 (NAPHTHALEN 2 YLMETHOXY)PHENYL]BENZO[D]THIAZOLE 6 CARBOXAMIDE; N METHYL N [4 (NAPHTHALEN 2 YLMETHOXY)PHENYL]ISONICOTINAMIDE; N [4 (BENZO[E][1,2]AZABORININ 2 (1H)YLMETHOXY)PHENYL] N METHYL 2 (PYRIDIN 3 YL)THIAZOLE 4 CARBOXAMIDE; N [4 (BENZO[E][1,2]AZABORININ 2 (1H)YLMETHOXY)PHENYL] N METHYL 3 PHENYL 1H PYRAZOLE 5 CARBOXAMIDE; N [4 (BENZO[E][1,2]AZABORININ 2 (1H)YLMETHOXY)PHENYL] N METHYL 5 (PYRIDIN 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; N [4 (BENZO[E][1,2]AZABORININ 2 (1H)YLMETHOXY)PHENYL] N METHYLBENZO[D]THIAZOLE 6 CARBOXAMIDE; N [4 (BENZO[E][1,2]AZABORININ 2 (1H)YLMETHOXY)PHENYL] N METHYLISONICOTINAMIDE; NAPHTHALENE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG; NEUROLEPTIC AGENT; PDE10A PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; BN CC ISOSTERISM; CHEMICAL PHENOMENA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; ENZYME ACTIVE SITE; HYDROGEN BOND; IN VITRO STUDY; LIPOPHILICITY; MEDICINAL CHEMISTRY; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR DOCKING; SYNTHESIS;

ANTIPSYCHOTIC AGENTS; BINDING SITES; CATALYTIC DOMAIN; HUMANS; MOLECULAR DOCKING SIMULATION; NAPHTHALENES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937816168     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.06.019     Document Type: Article

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