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Volumn 7, Issue , 2017, Pages

Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; GELATINASE A; PROTEINASE ACTIVATED RECEPTOR 2; SMAD2 PROTEIN; SMAD3 PROTEIN; THROMBIN;

EID: 85013374214     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep43079     Document Type: Article
Times cited : (32)

References (48)
  • 1
    • 74249085173 scopus 로고    scopus 로고
    • Pathophysiology of abdominal aortic aneurysm relevant to improvements in patients' management
    • Golledge, J. & Norman, P. E. Pathophysiology of abdominal aortic aneurysm relevant to improvements in patients' management. Curr. Opin. Cardiol. 24, 532-538 (2009).
    • (2009) Curr. Opin. Cardiol. , vol.24 , pp. 532-538
    • Golledge, J.1    Norman, P.E.2
  • 2
    • 79551716449 scopus 로고    scopus 로고
    • Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm
    • Golledge, J., Muller, R., Clancy, P., McCann, M. & Norman, P. E. Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm. Eur. Heart J. 32, 354-364 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 354-364
    • Golledge, J.1    Muller, R.2    Clancy, P.3    McCann, M.4    Norman, P.E.5
  • 3
    • 13244265861 scopus 로고    scopus 로고
    • Coagulation factor Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes: Implications in acute myocardial infarction
    • Busch, G. et al. Coagulation factor Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes: implications in acute myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 25, 461-466 (2005).
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 461-466
    • Busch, G.1
  • 4
    • 84870497680 scopus 로고    scopus 로고
    • The Interface between inflammation and coagulation in cardiovascular disease
    • Demetz, G. & Ott, I. The Interface between Inflammation and Coagulation in Cardiovascular Disease. Int. J. Inflam. 2012, 860301 (2012).
    • (2012) Int. J. Inflam. , vol.2012 , pp. 860301
    • Demetz, G.1    Ott, I.2
  • 5
    • 49049114477 scopus 로고    scopus 로고
    • Measurement and determinants of infrarenal aortic thrombus volume
    • Golledge, J., Wolanski, P., Parr, A. & Buttner, P. Measurement and determinants of infrarenal aortic thrombus volume. Eur. Radiol. 18, 1987-1994 (2008).
    • (2008) Eur. Radiol. , vol.18 , pp. 1987-1994
    • Golledge, J.1    Wolanski, P.2    Parr, A.3    Buttner, P.4
  • 6
    • 78650520739 scopus 로고    scopus 로고
    • Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms
    • Parr, A. et al. Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms. J. Vasc. Surg. 53, 28-35 (2011).
    • (2011) J. Vasc. Surg. , vol.53 , pp. 28-35
    • Parr, A.1
  • 7
    • 70349303279 scopus 로고    scopus 로고
    • Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B-4 as a major chemotactic factor released from the intraluminal thrombus
    • Houard, X., Ollivier, V., Louedec, L., Michel, J. B. & Back, M. Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B-4 as a major chemotactic factor released from the intraluminal thrombus. Faseb Journal 23, 1376-1383 (2009).
    • (2009) Faseb Journal , vol.23 , pp. 1376-1383
    • Houard, X.1    Ollivier, V.2    Louedec, L.3    Michel, J.B.4    Back, M.5
  • 8
    • 33644654595 scopus 로고    scopus 로고
    • Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution
    • Touat, Z. et al. Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution. Amer. J. Pathol. 168, 1022-1030 (2006).
    • (2006) Amer. J. Pathol. , vol.168 , pp. 1022-1030
    • Touat, Z.1
  • 9
    • 80053283855 scopus 로고    scopus 로고
    • Protease activity in the multi-layered intra-luminal thrombus of abdominal aortic aneurysms
    • Folkesson, M., Silveira, A., Eriksson, P. & Swedenborg, J. Protease activity in the multi-layered intra-luminal thrombus of abdominal aortic aneurysms. Atherosclerosis 218, 294-299 (2011).
    • (2011) Atherosclerosis , vol.218 , pp. 294-299
    • Folkesson, M.1    Silveira, A.2    Eriksson, P.3    Swedenborg, J.4
  • 10
    • 79960647787 scopus 로고    scopus 로고
    • Recent progress in anticoagulant therapy: Oral direct inhibitors of thrombin and factor Xa
    • Bauer, K. A. Recent progress in anticoagulant therapy: oral direct inhibitors of thrombin and factor Xa. J. Thromb. Haemost. 9 Suppl 1, 12-19 (2011).
    • (2011) J. Thromb. Haemost. , vol.9 , pp. 12-19
    • Bauer, K.A.1
  • 11
    • 84893462504 scopus 로고    scopus 로고
    • Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells
    • Bohm, A. et al. Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. Cardiovasc. Res. 99, 505-513 (2013).
    • (2013) Cardiovasc. Res. , vol.99 , pp. 505-513
    • Bohm, A.1
  • 12
    • 77956646450 scopus 로고    scopus 로고
    • Early atherosclerosis exhibits an enhanced procoagulant state
    • Borissoff, J. I. et al. Early atherosclerosis exhibits an enhanced procoagulant state. Circulation 122, 821-830 (2010).
    • (2010) Circulation , vol.122 , pp. 821-830
    • Borissoff, J.I.1
  • 13
    • 84873592215 scopus 로고    scopus 로고
    • Genetic and pharmacological modifications of thrombin formation in apolipoprotein E-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner
    • Borissoff, J. I. et al. Genetic and pharmacological modifications of thrombin formation in apolipoprotein E-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner. PLoS One 8, e55784 (2013).
    • (2013) PLoS One 8, e55784
    • Borissoff, J.I.1
  • 14
    • 84941686619 scopus 로고    scopus 로고
    • Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice
    • Preusch, M. R. et al. Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice. Drug Des. Devel. Ther. 9, 5203-5211 (2015).
    • (2015) Drug Des. Devel. Ther. , vol.9 , pp. 5203-5211
    • Preusch, M.R.1
  • 15
    • 84867614348 scopus 로고    scopus 로고
    • The effects of direct thrombin inhibition with dabigatran on plaque formation and endothelial function in apolipoprotein E-deficient mice
    • Lee, I. O., Kratz, M. T., Schirmer, S. H., Baumhakel, M. & Bohm, M. The effects of direct thrombin inhibition with dabigatran on plaque formation and endothelial function in apolipoprotein E-deficient mice. J. Pharmacol. Exp. Ther. 343, 253-257 (2012).
    • (2012) J. Pharmacol. Exp. Ther. , vol.343 , pp. 253-257
    • Lee, I.O.1    Kratz, M.T.2    Schirmer, S.H.3    Baumhakel, M.4    Bohm, M.5
  • 16
    • 84867997746 scopus 로고    scopus 로고
    • The beneficial effects of a direct thrombin inhibitor, dabigatran etexilate, on the development and stability of atherosclerotic lesions in apolipoprotein E-deficient mice: Dabigatran etexilate and atherosclerosis
    • Kadoglou, N. P. et al. The beneficial effects of a direct thrombin inhibitor, dabigatran etexilate, on the development and stability of atherosclerotic lesions in apolipoprotein E-deficient mice: dabigatran etexilate and atherosclerosis. Cardiovasc. Drugs. Ther. 26, 367-374 (2012).
    • (2012) Cardiovasc. Drugs. Ther. , vol.26 , pp. 367-374
    • Kadoglou, N.P.1
  • 17
    • 84900598078 scopus 로고    scopus 로고
    • Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice
    • Pingel, S. et al. Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice. Arch. Med. Sci. 10, 154-160 (2014).
    • (2014) Arch. Med. Sci. , vol.10 , pp. 154-160
    • Pingel, S.1
  • 18
    • 80052663235 scopus 로고    scopus 로고
    • Evaluation of plaque stability of advanced atherosclerotic lesions in apo E-deficient mice after treatment with the oral factor Xa inhibitor rivaroxaban
    • Zhou, Q. et al. Evaluation of plaque stability of advanced atherosclerotic lesions in apo E-deficient mice after treatment with the oral factor Xa inhibitor rivaroxaban. Mediators Inflamm. 2011, 432080 (2011).
    • (2011) Mediators Inflamm. , vol.2011 , pp. 432080
    • Zhou, Q.1
  • 19
    • 84944810903 scopus 로고    scopus 로고
    • Effects of the factor Xa inhibitor, fondaparinux, on the stability of atherosclerotic lesions in apolipoprotein E-deficient mice
    • Zou, P. et al. Effects of the factor Xa inhibitor, fondaparinux, on the stability of atherosclerotic lesions in apolipoprotein E-deficient mice. Circ J. 79, 2499-2508 (2015).
    • (2015) Circ J. , vol.79 , pp. 2499-2508
    • Zou, P.1
  • 20
    • 84859698558 scopus 로고    scopus 로고
    • The roles of thrombin and protease-activated receptors in inflammation
    • Ma, L. & Dorling, A. The roles of thrombin and protease-activated receptors in inflammation. Semin. Immunopathol. 34, 63-72 (2012).
    • (2012) Semin. Immunopathol. , vol.34 , pp. 63-72
    • Ma, L.1    Dorling, A.2
  • 21
    • 78649752975 scopus 로고    scopus 로고
    • Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis
    • McEachron, T. A., Pawlinski, R., Richards, K. L., Church, F. C. & Mackman, N. Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood 116, 5037-5044 (2010).
    • (2010) Blood , vol.116 , pp. 5037-5044
    • McEachron, T.A.1    Pawlinski, R.2    Richards, K.L.3    Church, F.C.4    Mackman, N.5
  • 22
    • 84963831198 scopus 로고    scopus 로고
    • Thrombin-mediated direct activation of proteinase-activated receptor-2: Another target for thrombin signaling
    • Mihara, K. et al. Thrombin-mediated direct activation of proteinase-activated receptor-2: another target for thrombin signaling. Mol. Pharmacol. 89, 606-614 (2016).
    • (2016) Mol. Pharmacol. , vol.89 , pp. 606-614
    • Mihara, K.1
  • 23
    • 77951553013 scopus 로고    scopus 로고
    • Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas
    • Aman, M., Hirano, M., Kanaide, H. & Hirano, K. Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas. J. Vasc. Res. 47, 494-506 (2010).
    • (2010) J. Vasc. Res. , vol.47 , pp. 494-506
    • Aman, M.1    Hirano, M.2    Kanaide, H.3    Hirano, K.4
  • 24
    • 0032929826 scopus 로고    scopus 로고
    • Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery
    • Damiano, B. P., D'andrea, M. R., De Garavilla, L., Cheung, W. M. & Andrade-Gordon, P. Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery. Thromb. Haemost. 81, 808-814 (1999).
    • (1999) Thromb. Haemost. , vol.81 , pp. 808-814
    • Damiano, B.P.1    D'Andrea, M.R.2    De Garavilla, L.3    Cheung, W.M.4    Andrade-Gordon, P.5
  • 25
    • 33751181465 scopus 로고    scopus 로고
    • Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury
    • Fukunaga, R. et al. Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury. Am. J. Physiol. Heart Circ. Physiol. 291, H2388-H2395 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , pp. H2388-H2395
    • Fukunaga, R.1
  • 26
    • 80053589747 scopus 로고    scopus 로고
    • Redox regulation of human protease-activated receptor-2 by activated factor X
    • Jobi, K. et al. Redox regulation of human protease-activated receptor-2 by activated factor X. Free Radic. Biol. Med. 51, 1758-1764 (2011).
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 1758-1764
    • Jobi, K.1
  • 27
    • 78649795584 scopus 로고    scopus 로고
    • Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-beta-independent process
    • Rodrigues Diez, R. et al. Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-beta-independent process. PLoS One 5, e14145 (2010).
    • (2010) PLoS One , vol.5 , pp. e14145
    • Rodrigues Diez, R.1
  • 28
    • 0345599885 scopus 로고    scopus 로고
    • Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall
    • Kazi, M. et al. Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall. J. Vasc. Surg. 38, 1283-1292 (2003).
    • (2003) J. Vasc. Surg. , vol.38 , pp. 1283-1292
    • Kazi, M.1
  • 29
    • 84863758479 scopus 로고    scopus 로고
    • Selected clotting factors in blood of patients with abdominal aortic aneurysms
    • Kotschy, M. et al. Selected clotting factors in blood of patients with abdominal aortic aneurysms. Kardiol. Pol. 70, 574-579 (2012).
    • (2012) Kardiol. Pol. , vol.70 , pp. 574-579
    • Kotschy, M.1
  • 30
    • 0034129997 scopus 로고    scopus 로고
    • Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice
    • Daugherty, A., Manning, M. W. & Cassis, L. A. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J. Clin. Invest. 105, 1605-1612 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1605-1612
    • Daugherty, A.1    Manning, M.W.2    Cassis, L.A.3
  • 31
    • 0042691721 scopus 로고    scopus 로고
    • Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin-II infused, apolipoprotein E-deficient mice
    • Saraff, K., Babamusta, F., Cassis, L. A. & Daugherty, A. Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin-II infused, apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23, 1621-1626 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1621-1626
    • Saraff, K.1    Babamusta, F.2    Cassis, L.A.3    Daugherty, A.4
  • 32
    • 0034641723 scopus 로고    scopus 로고
    • Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin
    • Shriver, Z. et al. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin. Proc. Natl. Acad. Sci. USA 97, 10365-10370 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10365-10370
    • Shriver, Z.1
  • 33
    • 0043123406 scopus 로고    scopus 로고
    • Fondaparinux: A synthetic selective factor-Xa inhibitor
    • Wong, N. N. Fondaparinux: a synthetic selective factor-Xa inhibitor. Heart Dis. 5, 295-302 (2003).
    • (2003) Heart Dis. , vol.5 , pp. 295-302
    • Wong, N.N.1
  • 34
    • 34447522035 scopus 로고    scopus 로고
    • In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
    • Wienen, W., Stassen, J. M., Priepke, H., Ries, U. J. & Hauel, N. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate. Thromb. Haemost. 98, 155-162 (2007).
    • (2007) Thromb. Haemost. , vol.98 , pp. 155-162
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3    Ries, U.J.4    Hauel, N.5
  • 35
    • 33646449061 scopus 로고    scopus 로고
    • Inflammation and cellular immune responses in abdominal aortic aneurysms
    • Shimizu, K., Mitchell, R. N. & Libby, P. Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 26, 987-994 (2006).
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 987-994
    • Shimizu, K.1    Mitchell, R.N.2    Libby, P.3
  • 36
    • 76649122801 scopus 로고    scopus 로고
    • TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin IIinfused mice
    • Wang, Y. et al. TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin IIinfused mice. J. Clin. Invest. 120, 422-432 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 422-432
    • Wang, Y.1
  • 37
    • 84875370348 scopus 로고    scopus 로고
    • Everolimus limits aortic aneurysm in the apolipoprotein E-deficient mouse by downregulating C-C chemokine receptor 2 positive monocytes
    • Moran, C. S. et al. Everolimus limits aortic aneurysm in the apolipoprotein E-deficient mouse by downregulating C-C chemokine receptor 2 positive monocytes. Arterioscler. Thromb. Vasc. Biol. 33, 814-821 (2013).
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , pp. 814-821
    • Moran, C.S.1
  • 38
    • 84922070169 scopus 로고    scopus 로고
    • A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse
    • Krishna, S. M. et al. A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 35, 389-398 (2015).
    • (2015) Arterioscler. Thromb. Vasc. Biol. , vol.35 , pp. 389-398
    • Krishna, S.M.1
  • 39
    • 0035881168 scopus 로고    scopus 로고
    • FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834
    • Mclean, K., Schirm, S., Johns, A., Morser, J. & Light, D. R. FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834. Thromb. Res. 103, 281-297 (2001).
    • (2001) Thromb. Res. , vol.103 , pp. 281-297
    • Mclean, K.1    Schirm, S.2    Johns, A.3    Morser, J.4    Light, D.R.5
  • 40
    • 84863229975 scopus 로고    scopus 로고
    • Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombin
    • Rana, S., Yang, L., Hassanian, S. M. & Rezaie, A. R. Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombin. J. Cell Biochem. 113, 977-984 (2012).
    • (2012) J. Cell Biochem. , vol.113 , pp. 977-984
    • Rana, S.1    Yang, L.2    Hassanian, S.M.3    Rezaie, A.R.4
  • 41
    • 84861527612 scopus 로고    scopus 로고
    • Osteoprotegerin is associated with aneurysm diameter and proteolysis in abdominal aortic aneurysm disease
    • Koole, D. et al. Osteoprotegerin is associated with aneurysm diameter and proteolysis in abdominal aortic aneurysm disease. Arterioscler. Thromb. Vasc. Biol. 32, 1497-1504 (2012).
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 1497-1504
    • Koole, D.1
  • 42
    • 0031044735 scopus 로고    scopus 로고
    • Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms
    • López-Candales, A. et al. Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am. J. Pathol. 150, 993-1007 (1997).
    • (1997) Am. J. Pathol. , vol.150 , pp. 993-1007
    • López-Candales, A.1
  • 43
    • 20544446895 scopus 로고    scopus 로고
    • Association of osteoprotegerin with human abdominal aortic aneurysm progression
    • Moran, C. S. et al. Association of osteoprotegerin with human abdominal aortic aneurysm progression. Circulation 111, 3119-3125 (2005).
    • (2005) Circulation , vol.111 , pp. 3119-3125
    • Moran, C.S.1
  • 44
    • 84918570321 scopus 로고    scopus 로고
    • Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and rupture in the apolipoprotein E-knockout mouse
    • Moran, C. S., Jose, R. J., Biros, E. & Golledge, J. Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and rupture in the apolipoprotein E-knockout mouse. Arterioscler. Thromb. Vasc. Biol. 34, 2609-2616 (2014).
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 2609-2616
    • Moran, C.S.1    Jose, R.J.2    Biros, E.3    Golledge, J.4
  • 45
    • 0036733629 scopus 로고    scopus 로고
    • Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
    • Longo, G. M. et al. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J. Clin. Invest. 110, 625-632 (2012).
    • (2012) J. Clin. Invest. , vol.110 , pp. 625-632
    • Longo, G.M.1
  • 46
    • 84864148446 scopus 로고    scopus 로고
    • Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model
    • Krishna, S. M. et al. Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. Am. J. Pathol. 181, 706-718 (2012).
    • (2012) Am. J. Pathol. , vol.181 , pp. 706-718
    • Krishna, S.M.1
  • 47
    • 84897560702 scopus 로고    scopus 로고
    • Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein e deficient mouse model
    • Seto, S. W., Krishna, S. M., Moran, C. S., Liu, D. & Golledge, J. Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein E deficient mouse model. Clin. Sci. (Lond). 127, 123-134 (2014).
    • (2014) Clin. Sci. (Lond). , vol.127 , pp. 123-134
    • Seto, S.W.1    Krishna, S.M.2    Moran, C.S.3    Liu, D.4    Golledge, J.5
  • 48
    • 84858698938 scopus 로고    scopus 로고
    • Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm
    • Biros, E., Walker, P. J., Nataatmadja, M., West, M. & Golledge, J. Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm. Atherosclerosis 221, 383-386 (2012).
    • (2012) Atherosclerosis , vol.221 , pp. 383-386
    • Biros, E.1    Walker, P.J.2    Nataatmadja, M.3    West, M.4    Golledge, J.5


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