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Volumn 24, Issue 6, 2009, Pages 532-538

Pathophysiology of Abdominal aortic aneurysm relevant to improvements in patients' management

Author keywords

Abdominal aortic aneurysm; Biomarker; Functional imaging; Medication

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BIOLOGICAL MARKER; CROMOGLYCATE DISODIUM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXYCYCLINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MATRIX METALLOPROTEINASE; ROXITHROMYCIN; TRANILAST;

EID: 74249085173     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e328330c2d3     Document Type: Review
Times cited : (56)

References (78)
  • 1
    • 33751198051 scopus 로고    scopus 로고
    • Abdominal aortic aneurysm: Pathogenesis and implications for management
    • DOI 10.1161/01.ATV.0000245819.32762.cb, PII 0004360520061200000006
    • Golledge J, Muller J, Daugherty A, Norman P. Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol 2006; 26:2605-2613. (Pubitemid 44777272)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.12 , pp. 2605-2613
    • Golledge, J.1    Muller, J.2    Daugherty, A.3    Norman, P.4
  • 2
    • 0003839366 scopus 로고    scopus 로고
    • Population Health Division. Sydney: NSW Department of Health. Available at. Accessed 14/12/07
    • Population Health Division. The health of the people of New South Wales - Report of the Chief Health Officer. Sydney: NSW Department of Health. Available at: http://www.health.nsw.gov.au/public-health/chorep/cvd/cvd-aa.htm. Accessed 14/12/07.
    • The Health of the People of New South Wales - Report of the Chief Health Officer
  • 3
    • 74249100319 scopus 로고    scopus 로고
    • National vital statistics reports. Hyattsville, MD: National Center for Health Statistics. Viewed at on 15/9/07
    • Miniño A, Heron M, Smith B, Kochanek K. Deaths: final data for1999. National vital statistics reports. Hyattsville, MD: National Center for Health Statistics. Viewed at http://www.cdc.gov/nchs/data/statab/lcwk9.pdf on 15/9/07.
    • Deaths: Final Data for1999
    • Miniño, A.1    Heron, M.2    Smith, B.3    Kochanek, K.4
  • 4
    • 34250726580 scopus 로고    scopus 로고
    • Endovascular aortic aneurysm repair in patients with the highest risk and in-hospital mortality in the United States
    • Timaran CH, Veith FJ, Rosero EB, et al. Endovascular aortic aneurysm repair in patients with the highest risk and in-hospital mortality in the United States. Arch Surg 2007; 142:520-524.
    • (2007) Arch Surg , vol.142 , pp. 520-524
    • Timaran, C.H.1    Veith, F.J.2    Rosero, E.B.3
  • 5
    • 33846539200 scopus 로고    scopus 로고
    • The outcome of endovascular repair of small abdominal aortic aneurysms
    • Golledge J, Parr A, Boult M, et al. The outcome of endovascular repair of small abdominal aortic aneurysms. Ann Surg 2007; 245:326-333.
    • (2007) Ann Surg , vol.245 , pp. 326-333
    • Golledge, J.1    Parr, A.2    Boult, M.3
  • 6
    • 84993746135 scopus 로고    scopus 로고
    • Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): Randomised controlled trial
    • EVAR trial participants
    • EVAR trial participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet 2005; 365:2179-2186.
    • (2005) Lancet , vol.365 , pp. 2179-2186
  • 7
    • 34548426860 scopus 로고    scopus 로고
    • Lost to follow-up: A potential underappreciated limitation of endovascular aneurysm repair
    • Jones WB, Taylor SM, Kalbaugh CA, et al. Lost to follow-up: a potential underappreciated limitation of endovascular aneurysm repair. J Vasc Surg 2007; 46:434-440.
    • (2007) J Vasc Surg , vol.46 , pp. 434-440
    • Jones, W.B.1    Taylor, S.M.2    Kalbaugh, C.A.3
  • 8
    • 38349185886 scopus 로고    scopus 로고
    • Modelling the long-term costeffectiveness of endovascular or open repair for abdominal aortic aneurysm
    • Based on data from the EVAR 1 trial endovascular AAA repair was estimated to cost £3800 more per case than open repair
    • Epstein DM, Sculpher MJ, Manca A, et al. Modelling the long-term costeffectiveness of endovascular or open repair for abdominal aortic aneurysm. Br J Surg 2008; 95:183-190. Based on data from the EVAR 1 trial endovascular AAA repair was estimated to cost £3800 more per case than open repair.
    • (2008) Br J Surg , vol.95 , pp. 183-190
    • Epstein, D.M.1    Sculpher, M.J.2    Manca, A.3
  • 9
    • 13244286632 scopus 로고    scopus 로고
    • Screening for abdominal aortic aneurysm: A best-evidence systematic review for the US preventive services task force
    • Fleming C, Whitlock EP, Bell TL, Lederle FA. Screening for abdominal aortic aneurysm: a best-evidence systematic review for the US Preventive Services Task Force. Ann Int Med 2005; 142:203-211.
    • (2005) Ann Int Med , vol.142 , pp. 203-211
    • Fleming, C.1    Whitlock, E.P.2    Bell, T.L.3    Lederle, F.A.4
  • 10
    • 58149265250 scopus 로고    scopus 로고
    • Circulating markers of abdominal aortic aneurysm presence and progression
    • This recent review summarizes currently identified circulating markers associated with AAA presence
    • Golledge J, Tsao PS, Dalman RL, Norman PE. Circulating markers of abdominal aortic aneurysm presence and progression. Circulation 2008; 118:2382-2392. This recent review summarizes currently identified circulating markers associated with AAA presence.
    • (2008) Circulation , vol.118 , pp. 2382-2392
    • Golledge, J.1    Tsao, P.S.2    Dalman, R.L.3    Norman, P.E.4
  • 11
    • 48049115070 scopus 로고    scopus 로고
    • Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions
    • This study suggests a potential mechanism underlying the relative protection from AAA presence and progression in diabetics
    • Golledge J, Karan M, Moran CS, et al. Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions. Eur Heart J 2008; 29:665-672. This study suggests a potential mechanism underlying the relative protection from AAA presence and progression in diabetics.
    • (2008) Eur Heart J , vol.29 , pp. 665-672
    • Golledge, J.1    Karan, M.2    Moran, C.S.3
  • 12
    • 34548419640 scopus 로고    scopus 로고
    • Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms
    • Lenk GM, Tromp G, Weinsheimer S, et al. Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms. BMC Genomics 2007; 8:237.
    • (2007) BMC Genomics , vol.8 , pp. 237
    • Lenk, G.M.1    Tromp, G.2    Weinsheimer, S.3
  • 13
    • 59649094037 scopus 로고    scopus 로고
    • Proteomic identification of differentially expressed proteins in aortic wall of patients with ruptured and nonruptured abdominal aortic aneurysms
    • This study carries out a proteomic assessment of proteins extracted from biopsies of ruptured and intact AAA. They identified relative up-regulation of peroxiredoxin-2 and down-regulation of vitronectin
    • Urbonavicius S, Lindholt JS, Vorum H, et al. Proteomic identification of differentially expressed proteins in aortic wall of patients with ruptured and nonruptured abdominal aortic aneurysms. J Vasc Surg 2009; 49:455-463. This study carries out a proteomic assessment of proteins extracted from biopsies of ruptured and intact AAA. They identified relative up-regulation of peroxiredoxin-2 and down-regulation of vitronectin.
    • (2009) J Vasc Surg , vol.49 , pp. 455-463
    • Urbonavicius, S.1    Lindholt, J.S.2    Vorum, H.3
  • 14
    • 38649091662 scopus 로고    scopus 로고
    • The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    • This is the largest study of a genetic site associated with AAA with replication in multiple cohorts suggesting the association of a site on chromosome 9 with AAA
    • Helgadottir A, Thorleifsson G, Magnusson KP, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008; 40:217-224. This is the largest study of a genetic site associated with AAA with replication in multiple cohorts suggesting the association of a site on chromosome 9 with AAA.
    • (2008) Nat Genet , vol.40 , pp. 217-224
    • Helgadottir, A.1    Thorleifsson, G.2    Magnusson, K.P.3
  • 15
    • 60749104192 scopus 로고    scopus 로고
    • Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have a impact on aneurysmal expansion
    • Thompson AR, Golledge J, Cooper AJ, et al. Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have a impact on aneurysmal expansion. Eur J Hum Gen 2009; 17:391-394.
    • (2009) Eur J Hum Gen , vol.17 , pp. 391-394
    • Thompson, A.R.1    Golledge, J.2    Cooper, A.J.3
  • 16
    • 38049186595 scopus 로고    scopus 로고
    • Aortic aneurysms: An immune disease with a strong genetic component
    • Kuivaniemi H, Platsoucas CD, Tilson MD 3rd. Aortic aneurysms: an immune disease with a strong genetic component. Circulation 2008; 117:242-252.
    • (2008) Circulation , vol.117 , pp. 242-252
    • Kuivaniemi, H.1    Platsoucas, C.D.2    Tilson Iii, M.D.3
  • 17
    • 36849084039 scopus 로고    scopus 로고
    • Candidate gene association studies in abdominal aortic aneurysm disease: A review and metaanalysis
    • This summary analysis reports an association of genetic polymorphisms in a number of genes including angiotensin-converting enzyme and methyl tetrahydrofolate reductase with AAA
    • Thompson AR, Drenos F, Hafez H, Humphries SE. Candidate gene association studies in abdominal aortic aneurysm disease: a review and metaanalysis. Eur J Vasc Endovasc Surg 2008; 35:19-30. This summary analysis reports an association of genetic polymorphisms in a number of genes including angiotensin-converting enzyme and methyl tetrahydrofolate reductase with AAA.
    • (2008) Eur J Vasc Endovasc Surg , vol.35 , pp. 19-30
    • Thompson, A.R.1    Drenos, F.2    Hafez, H.3    Humphries, S.E.4
  • 18
    • 51549108089 scopus 로고    scopus 로고
    • Genome wide association studies: Identifying the genes that determine the risk of abdominal aortic aneurysm
    • Aneurysm Consortium., This editorial outlines a current Welcome Trust funded genome wide association study for AAA
    • Aneurysm Consortium. Genome wide association studies: identifying the genes that determine the risk of abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2008; 36:395-396. This editorial outlines a current Welcome Trust funded genome wide association study for AAA.
    • (2008) Eur J Vasc Endovasc Surg , vol.36 , pp. 395-396
  • 19
    • 0036582392 scopus 로고    scopus 로고
    • Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA)
    • Sakalihasan N, Van Damme H, Gomez P, et al. Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA). Eur J Vasc Endovasc Surg 2002; 23:431-436.
    • (2002) Eur J Vasc Endovasc Surg , vol.23 , pp. 431-436
    • Sakalihasan, N.1    Van Damme, H.2    Gomez, P.3
  • 20
    • 3042739940 scopus 로고    scopus 로고
    • Contribution of PET scanning to the evaluation of abdominal aortic aneurysm
    • Sakalihasan N, Hustinx R, Limet R. Contribution of PET scanning to the evaluation of abdominal aortic aneurysm. Semin Vasc Surg 2004; 17:144-153.
    • (2004) Semin Vasc Surg , vol.17 , pp. 144-153
    • Sakalihasan, N.1    Hustinx, R.2    Limet, R.3
  • 21
    • 47249164675 scopus 로고    scopus 로고
    • Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms
    • This study reports the first correlation between FDG uptake and histological changes within human AAA
    • Reeps C, Essler M, Pelisek J, et al. Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J Vasc Surg 2008; 48:417-423. This study reports the first correlation between FDG uptake and histological changes within human AAA.
    • (2008) J Vasc Surg , vol.48 , pp. 417-423
    • Reeps, C.1    Essler, M.2    Pelisek, J.3
  • 22
    • 49449114513 scopus 로고    scopus 로고
    • In vivo imaging of abdominal aortic aneurysms: Increased FDG uptake suggests inflammation in the aneurysm wall
    • Truijers M, Kurvers HA, Bredie SJ, et al. In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall. J Endovasc Ther 2008; 15:462-467.
    • (2008) J Endovasc Ther , vol.15 , pp. 462-467
    • Truijers, M.1    Kurvers, H.A.2    Bredie, S.J.3
  • 23
    • 33747393705 scopus 로고    scopus 로고
    • 99mTc-annexin-V functional imaging of luminal thrombus activity in abdominal aortic aneurysms
    • Sarda-Mantel L, Coutard M, Rouzet F, et al. 99mTc-annexin-V functional imaging of luminal thrombus activity in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2006; 26:2153-2159.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2153-2159
    • Sarda-Mantel, L.1    Coutard, M.2    Rouzet, F.3
  • 24
    • 0041384102 scopus 로고    scopus 로고
    • Smokers' relative risk for aortic aneurysm compared with other smoking-related diseases: A systematic review
    • Lederle FA, Nelson DB, Joseph AM. Smokers' relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review. J Vasc Surg 2003; 38:329-334.
    • (2003) J Vasc Surg , vol.38 , pp. 329-334
    • Lederle, F.A.1    Nelson, D.B.2    Joseph, A.M.3
  • 25
    • 41949095013 scopus 로고    scopus 로고
    • Medical management of small abdominal aortic aneurysms
    • Baxter BT, Terrin MC, Dalman RL. Medical management of small abdominal aortic aneurysms. Circulation 2008; 117:1883-1889.
    • (2008) Circulation , vol.117 , pp. 1883-1889
    • Baxter, B.T.1    Terrin, M.C.2    Dalman, R.L.3
  • 26
    • 0035488854 scopus 로고    scopus 로고
    • Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: A randomized, double-blind, placebo-controlled pilot study
    • Mosorin M, Juvonen J, Biancari F, et al. Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study. J Vasc Surg 2001; 34:606-610.
    • (2001) J Vasc Surg , vol.34 , pp. 606-610
    • Mosorin, M.1    Juvonen, J.2    Biancari, F.3
  • 27
    • 0034827044 scopus 로고    scopus 로고
    • Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion
    • Vammen S, Lindholt JS, Ostergaard L, et al. Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion. Br J Surg 2001; 88:1066-1072.
    • (2001) Br J Surg , vol.88 , pp. 1066-1072
    • Vammen, S.1    Lindholt, J.S.2    Ostergaard, L.3
  • 28
    • 49749138519 scopus 로고    scopus 로고
    • A randomized, placebocontrolled trial of doxycycline after endoluminal aneurysm repair
    • This is the first medication trial in combination with endovascular AAA repair
    • Hackmann AE, Rubin BG, Sanchez LA, et al. A randomized, placebocontrolled trial of doxycycline after endoluminal aneurysm repair. J Vasc Surg 2008; 48:519-526. This is the first medication trial in combination with endovascular AAA repair.
    • (2008) J Vasc Surg , vol.48 , pp. 519-526
    • Hackmann, A.E.1    Rubin, B.G.2    Sanchez, L.A.3
  • 29
    • 40749153991 scopus 로고    scopus 로고
    • Effect of statins on proteolytic activity in the wall of abdominal aortic aneurysms
    • This study reports reduced MMP-9, cathepsin H and cathepsin L in aortic biopsies from patients receiving statins
    • Abisi S, Burnand KG, Humphries J, et al. Effect of statins on proteolytic activity in the wall of abdominal aortic aneurysms. Br J Surg 2008; 95:333-337. This study reports reduced MMP-9, cathepsin H and cathepsin L in aortic biopsies from patients receiving statins.
    • (2008) Br J Surg , vol.95 , pp. 333-337
    • Abisi, S.1    Burnand, K.G.2    Humphries, J.3
  • 30
    • 11144276528 scopus 로고    scopus 로고
    • Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice
    • Steinmetz EF, Buckley C, Shames ML, et al. Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice. Ann Surg 2005; 241:92-101.
    • (2005) Ann Surg , vol.241 , pp. 92-101
    • Steinmetz, E.F.1    Buckley, C.2    Shames, M.L.3
  • 31
    • 30544440956 scopus 로고    scopus 로고
    • Simvastatin suppresses experimental aortic aneurysm expansion
    • Kalyanasundaram A, Elmore JR, Manazer JR, et al. Simvastatin suppresses experimental aortic aneurysm expansion. J Vasc Surg 2006; 43:117-124.
    • (2006) J Vasc Surg , vol.43 , pp. 117-124
    • Kalyanasundaram, A.1    Elmore, J.R.2    Manazer, J.R.3
  • 32
    • 57649200495 scopus 로고    scopus 로고
    • Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration
    • This is the latest of a series of publications suggesting statins reduce AAA formation in rodent models
    • Shiraya S, Miyake T, Aoki M, et al. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Atherosclerosis 2009; 202:34-40. This is the latest of a series of publications suggesting statins reduce AAA formation in rodent models.
    • (2009) Atherosclerosis , vol.202 , pp. 34-40
    • Shiraya, S.1    Miyake, T.2    Aoki, M.3
  • 33
    • 31344433148 scopus 로고    scopus 로고
    • Mortality and size of abdominal aortic aneurysm at long-term follow-up of patients not treated surgically and treated with and without statins
    • Sukhija R, Aronow WS, Sandhu R, et al. Mortality and size of abdominal aortic aneurysm at long-term follow-up of patients not treated surgically and treated with and without statins. Am J Cardiol 2006; 97:279-280.
    • (2006) Am J Cardiol , vol.97 , pp. 279-280
    • Sukhija, R.1    Aronow, W.S.2    Sandhu, R.3
  • 34
    • 33744902627 scopus 로고    scopus 로고
    • Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth
    • Schouten O, van Laanen JH, Boersma E, et al. Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth. Eur J Vasc Endovasc Surg 2006; 32:21-26.
    • (2006) Eur J Vasc Endovasc Surg , vol.32 , pp. 21-26
    • Schouten, O.1    Van Laanen, J.H.2    Boersma, E.3
  • 35
    • 44349115500 scopus 로고    scopus 로고
    • SMART study group. Growth predictors and prognosis of small abdominal aortic aneurysms
    • This study is one of three cohort investigations reporting an association between statin prescription and reduced small AAA progression
    • Schlösser FJ, TangelderMJ, Verhagen HJ, et al., SMART study group. Growth predictors and prognosis of small abdominal aortic aneurysms. J Vasc Surg 2008; 47:1127-1133. This study is one of three cohort investigations reporting an association between statin prescription and reduced small AAA progression.
    • (2008) J Vasc Surg , vol.47 , pp. 1127-1133
    • Schlösser, F.J.1    Tangelder, M.J.2    Verhagen, H.J.3
  • 36
    • 52049104502 scopus 로고    scopus 로고
    • The role of the renin-angiotensin system in aortic aneurysmal diseases
    • Lu H, Rateri DL, Cassis LA, Daugherty A. The role of the renin-angiotensin system in aortic aneurysmal diseases. Curr Hypertens Rep 2008; 10:99-106.
    • (2008) Curr Hypertens Rep , vol.10 , pp. 99-106
    • Lu, H.1    Rateri, D.L.2    Cassis, L.A.3    Daugherty, A.4
  • 37
    • 0034129997 scopus 로고    scopus 로고
    • Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice
    • Daugherty A, Manning MW, Cassis LA. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 2000; 105:1605-1612.
    • (2000) J Clin Invest , vol.105 , pp. 1605-1612
    • Daugherty, A.1    Manning, M.W.2    Cassis, L.A.3
  • 38
    • 19044382607 scopus 로고    scopus 로고
    • Increased local angiotensin II formation in aneurysmal aorta
    • Nishimoto M, Takai S, Fukumoto H, et al. Increased local angiotensin II formation in aneurysmal aorta. Life Sci 2002; 71:2195-2205.
    • (2002) Life Sci , vol.71 , pp. 2195-2205
    • Nishimoto, M.1    Takai, S.2    Fukumoto, H.3
  • 39
    • 0036867198 scopus 로고    scopus 로고
    • Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta
    • Tsunemi K, Takai S, Nishimoto M, et al. Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta. Hypertens Res 2002; 25:817-822.
    • (2002) Hypertens Res , vol.25 , pp. 817-822
    • Tsunemi, K.1    Takai, S.2    Nishimoto, M.3
  • 40
    • 42249103284 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts
    • This study is the first to show association between a genetic polymorphism in angiotensin II type 1 receptor and AAA in three distinct populations
    • Jones GT, Thompson AR, van Bockxmeer FM, et al. Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arterioscler Thromb Vasc Biol 2008; 28:764-770. This study is the first to show association between a genetic polymorphism in angiotensin II type 1 receptor and AAA in three distinct populations.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 764-770
    • Jones, G.T.1    Thompson, A.R.2    Van Bockxmeer, F.M.3
  • 41
    • 0036781239 scopus 로고    scopus 로고
    • An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents beta-aminopropionitrile monofumarate-induced aortic dissection in rats
    • Nagashima H, Uto K, Sakomura Y, et al. An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents beta-aminopropionitrile monofumarate-induced aortic dissection in rats. J Vasc Surg 2002; 36:818-823.
    • (2002) J Vasc Surg , vol.36 , pp. 818-823
    • Nagashima, H.1    Uto, K.2    Sakomura, Y.3
  • 42
    • 0035348484 scopus 로고    scopus 로고
    • Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors
    • Liao S, Miralles M, Kelley BJ, et al. Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors. J Vasc Surg 2001; 33:1057-1064.
    • (2001) J Vasc Surg , vol.33 , pp. 1057-1064
    • Liao, S.1    Miralles, M.2    Kelley, B.J.3
  • 43
    • 59849112584 scopus 로고    scopus 로고
    • Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation
    • This study demonstrated that telmisartan inhibits elastase-induced AAA formation in rats
    • Kaschina E, Schrader F, Sommerfeld M, et al. Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation. J Hypertens 2008; 26:2361-2373. This study demonstrated that telmisartan inhibits elastase-induced AAA formation in rats.
    • (2008) J Hypertens , vol.26 , pp. 2361-2373
    • Kaschina, E.1    Schrader, F.2    Sommerfeld, M.3
  • 44
    • 33747108061 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors and aortic rupture: A population-based case-control study
    • Hackam DG, Thiruchelvam D, Redelmeier DA. Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet 2006; 368:659-665.
    • (2006) Lancet , vol.368 , pp. 659-665
    • Hackam, D.G.1    Thiruchelvam, D.2    Redelmeier, D.A.3
  • 45
    • 34948849376 scopus 로고    scopus 로고
    • Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: A randomized controlled trial
    • Ahimastos AA, Aggarwal A, D'Orsa KM, et al. Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial. J Am Med Assoc 2007; 298:1539-1547.
    • (2007) J Am Med Assoc , vol.298 , pp. 1539-1547
    • Ahimastos, A.A.1    Aggarwal, A.2    D'Orsa, K.M.3
  • 46
    • 45949092534 scopus 로고    scopus 로고
    • Angiotensin II blockade and aorticroot dilation in Marfan's syndrome
    • Brooke BS, Habashi JP, Judge DP, et al. Angiotensin II blockade and aorticroot dilation in Marfan's syndrome. N Engl J Med 2008; 358:2787-2795.
    • (2008) N Engl J Med , vol.358 , pp. 2787-2795
    • Brooke, B.S.1    Habashi, J.P.2    Judge, D.P.3
  • 47
    • 47649122992 scopus 로고    scopus 로고
    • Allergy and the cardiovascular system
    • Triggiani M, Patella V, Staiano RI, et al. Allergy and the cardiovascular system. Clin Exp Immunol 2008; 153 (Suppl 1):7-11.
    • (2008) Clin Exp Immunol , vol.153 , Issue.SUPPL 1 , pp. 7-11
    • Triggiani, M.1    Patella, V.2    Staiano, R.I.3
  • 48
    • 36048932955 scopus 로고    scopus 로고
    • Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    • Sun J, Sukhova GK, Yang M, et al. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest 2007; 117:3359-3368.
    • (2007) J Clin Invest , vol.117 , pp. 3359-3368
    • Sun, J.1    Sukhova, G.K.2    Yang, M.3
  • 49
    • 44949085653 scopus 로고    scopus 로고
    • Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm
    • These two studies suggest that mast cells are involved in AAA formation in rodent models and that mast cell stabilization protects from AAA development
    • Tsuruda T, Kato J, Hatakeyama K, et al. Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm. Circ Res 2008; 102:1368-1377. These two studies suggest that mast cells are involved in AAA formation in rodent models and that mast cell stabilization protects from AAA development.
    • (2008) Circ Res , vol.102 , pp. 1368-1377
    • Tsuruda, T.1    Kato, J.2    Hatakeyama, K.3
  • 50
    • 0030845183 scopus 로고    scopus 로고
    • Dog mast cell alphachymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain
    • Fang KC, Raymond WW, Blount JL, Caughey GH. Dog mast cell alphachymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain. J Biol Chem 1997; 272:25628-25635.
    • (1997) J Biol Chem , vol.272 , pp. 25628-25635
    • Fang, K.C.1    Raymond, W.W.2    Blount, J.L.3    Caughey, G.H.4
  • 51
    • 37249007305 scopus 로고    scopus 로고
    • Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm
    • Furubayashi K, Takai S, Jin D, et al. Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm. Clin Chim Acta 2008; 388:214-216.
    • (2008) Clin Chim Acta , vol.388 , pp. 214-216
    • Furubayashi, K.1    Takai, S.2    Jin, D.3
  • 52
    • 67349109176 scopus 로고    scopus 로고
    • Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice
    • This study reports that chymase inhibition reduces AAA development in a rodent model of AAA
    • Inoue N, Muramatsu M, Jin D, et al. Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice. Atherosclerosis 2009; 359-364. This study reports that chymase inhibition reduces AAA development in a rodent model of AAA.
    • (2009) Atherosclerosis , pp. 359-364
    • Inoue, N.1    Muramatsu, M.2    Jin, D.3
  • 53
    • 34249052530 scopus 로고    scopus 로고
    • The significance of chymase in the progression of abdominal aortic aneurysms in dogs
    • Furubayashi K, Takai S, Jin D, et al. The significance of chymase in the progression of abdominal aortic aneurysms in dogs. Hypertens Res 2007; 30:349-357.
    • (2007) Hypertens Res , vol.30 , pp. 349-357
    • Furubayashi, K.1    Takai, S.2    Jin, D.3
  • 54
    • 29944434304 scopus 로고    scopus 로고
    • Effect of tranilast on matrix metalloproteinase production from neutrophils in-vitro
    • Shimizu T, Kanai K, Kyo Y, et al. Effect of tranilast on matrix metalloproteinase production from neutrophils in-vitro. J Pharm Pharmacol 2006; 58:91-99.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 91-99
    • Shimizu, T.1    Kanai, K.2    Kyo, Y.3
  • 55
    • 22144489860 scopus 로고    scopus 로고
    • Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation
    • Eliason JL, Hannawa KK, Ailawadi G, et al. Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation 2005; 112: 232-240.
    • (2005) Circulation , vol.112 , pp. 232-240
    • Eliason, J.L.1    Hannawa, K.K.2    Ailawadi, G.3
  • 56
    • 43749122341 scopus 로고    scopus 로고
    • Tranilast, an orally active antiallergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but downregulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages
    • Pae HO, Jeong SO, Koo BS, et al. Tranilast, an orally active antiallergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but downregulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages. Biochem Biophys Res Commun 2008; 371:361-365.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 361-365
    • Pae, H.O.1    Jeong, S.O.2    Koo, B.S.3
  • 57
    • 2542466164 scopus 로고    scopus 로고
    • Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats
    • Kagitani S, Ueno H, Hirade S, et al. Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats. J Hypertens 2004; 22:1007-1015.
    • (2004) J Hypertens , vol.22 , pp. 1007-1015
    • Kagitani, S.1    Ueno, H.2    Hirade, S.3
  • 58
    • 0032055716 scopus 로고    scopus 로고
    • Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries
    • Ward MR, Sasahara T, Agrotis A, et al. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Atherosclerosis 1998; 137:267-275.
    • (1998) Atherosclerosis , vol.137 , pp. 267-275
    • Ward, M.R.1    Sasahara, T.2    Agrotis, A.3
  • 59
    • 0029983254 scopus 로고    scopus 로고
    • Tranilast antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells
    • DOI 10.1016/0021-9150(95)05709-9
    • Miyazawa K, Fukuyama J, Misawa K, et al. Tranilast antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells. Atherosclerosis 1996; 121:167-173. (Pubitemid 26125973)
    • (1996) Atherosclerosis , vol.121 , Issue.2 , pp. 167-173
    • Miyazawa, K.1    Fukuyama, J.2    Misawa, K.3    Hamano, S.4    Ujiie, A.5
  • 60
    • 0035930840 scopus 로고    scopus 로고
    • Tranilast inhibits transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation
    • Saiura A, Sata M, Hirata Y, et al. Tranilast inhibits transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation. Eur J Pharmacol 2001; 433:163-168.
    • (2001) Eur J Pharmacol , vol.433 , pp. 163-168
    • Saiura, A.1    Sata, M.2    Hirata, Y.3
  • 61
    • 0033596688 scopus 로고    scopus 로고
    • Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast
    • Matsumura T, Kugiyama K, Sugiyama S, et al. Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast. Circulation 1999; 99:919-924.
    • (1999) Circulation , vol.99 , pp. 919-924
    • Matsumura, T.1    Kugiyama, K.2    Sugiyama, S.3
  • 62
    • 1342281660 scopus 로고    scopus 로고
    • Vascular chymase: Pathophysiological role and therapeutic potential of inhibition
    • Doggrell SA, Wanstall JC. Vascular chymase: pathophysiological role and therapeutic potential of inhibition. Cardiovasc Res 2004; 61:653-662.
    • (2004) Cardiovasc Res , vol.61 , pp. 653-662
    • Doggrell, S.A.1    Wanstall, J.C.2
  • 63
    • 0037015262 scopus 로고    scopus 로고
    • Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial
    • Holmes DR Jr, Savage M, LaBlanche JM, et al. Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial. Circulation 2002; 106:1243-1245.
    • (2002) Circulation , vol.106 , pp. 1243-1245
    • Holmes Jr., D.R.1    Savage, M.2    Lablanche, J.M.3
  • 64
    • 0035571572 scopus 로고    scopus 로고
    • Mast cell chymase inhibits smooth muscle cell growth and collagen expression in vitro: Transforming growth factor-beta1-dependent and-independent effects
    • Wang Y, Shiota N, Leskinen MJ, et al. Mast cell chymase inhibits smooth muscle cell growth and collagen expression in vitro: transforming growth factor-beta1-dependent and-independent effects. Arterioscler Thromb Vasc Biol 2001; 21:1928-1933.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1928-1933
    • Wang, Y.1    Shiota, N.2    Leskinen, M.J.3
  • 65
    • 46049099576 scopus 로고    scopus 로고
    • Acute aortic dissection
    • Golledge J, Eagle KA. Acute aortic dissection. Lancet 2008; 372:55-66.
    • (2008) Lancet , vol.372 , pp. 55-66
    • Golledge, J.1    Eagle, K.A.2
  • 66
    • 0037324287 scopus 로고    scopus 로고
    • Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions
    • Leskinen MJ, Lindstedt KA, Wang Y, Kovanen PT. Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions. Arterioscler Thromb Vasc Biol 2003; 23:238-243.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 238-243
    • Leskinen, M.J.1    Lindstedt, K.A.2    Wang, Y.3    Kovanen, P.T.4
  • 67
    • 49049114477 scopus 로고    scopus 로고
    • Measurement and determinants of infrarenal aortic thrombus volume
    • Golledge J, Wolanski P, Parr A, Buttner P. Measurement and determinants of infrarenal aortic thrombus volume. Eur Radiol 2008; 18:1987-1994.
    • (2008) Eur Radiol , vol.18 , pp. 1987-1994
    • Golledge, J.1    Wolanski, P.2    Parr, A.3    Buttner, P.4
  • 68
    • 34248547514 scopus 로고    scopus 로고
    • Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms
    • Houard X, Rouzet F, Touat Z, et al. Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms. J Pathol 2007; 212:20-28.
    • (2007) J Pathol , vol.212 , pp. 20-28
    • Houard, X.1    Rouzet, F.2    Touat, Z.3
  • 69
    • 18344371443 scopus 로고    scopus 로고
    • Size and location of thrombus in intact and ruptured abdominal aortic aneurysms
    • Hans SS, Jareunpoon O, Balasubramaniam M, Zelenock GB. Size and location of thrombus in intact and ruptured abdominal aortic aneurysms. J Vasc Surg 2005; 41:584-588.
    • (2005) J Vasc Surg , vol.41 , pp. 584-588
    • Hans, S.S.1    Jareunpoon, O.2    Balasubramaniam, M.3    Zelenock, G.B.4
  • 70
    • 63849210317 scopus 로고    scopus 로고
    • Intraluminal thrombus and risk of rupture in patient specific abdominal aortic aneurysm: FSI modelling
    • Bluestein D, Dumont K, De Beule M, et al. Intraluminal thrombus and risk of rupture in patient specific abdominal aortic aneurysm: FSI modelling. Comput Methods Biomech Biomed Engin 2009; 12:73-81.
    • (2009) Comput Methods Biomech Biomed Engin , vol.12 , pp. 73-81
    • Bluestein, D.1    Dumont, K.2    De Beule, M.3
  • 71
    • 45549094567 scopus 로고    scopus 로고
    • Failure properties of intraluminal thrombus in abdominal aortic aneurysm under static and pulsating mechanical loads
    • Gasser TC, GörgïlïG, Folkesson M, Swedenborg J. Failure properties of intraluminal thrombus in abdominal aortic aneurysm under static and pulsating mechanical loads. J Vasc Surg 2008; 48:179-188.
    • (2008) J Vasc Surg , vol.48 , pp. 179-188
    • Gasser, T.C.1    Görgïlï, G.2    Folkesson, M.3    Swedenborg, J.4
  • 72
    • 61349183737 scopus 로고    scopus 로고
    • Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurismal model
    • This study reports that a competitive antagonist of ADP platelet activation reduced AAA development at 42 days in a rat transplant model. This effect was associated with a reduction in intraluminal thrombus, platelets, neutrophils and MMP-9 staining
    • Dai J, Louedec L, Philippe M, et al. Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurismal model. J Vasc Surg 2009; 49:719-727. This study reports that a competitive antagonist of ADP platelet activation reduced AAA development at 42 days in a rat transplant model. This effect was associated with a reduction in intraluminal thrombus, platelets, neutrophils and MMP-9 staining.
    • (2009) J Vasc Surg , vol.49 , pp. 719-727
    • Dai, J.1    Louedec, L.2    Philippe, M.3
  • 73
    • 33644654595 scopus 로고    scopus 로고
    • Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution
    • Touat Z, Ollivier V, Dai J, et al. Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution. Am J Pathol 2006; 168:1022-1030.
    • (2006) Am J Pathol , vol.168 , pp. 1022-1030
    • Touat, Z.1    Ollivier, V.2    Dai, J.3
  • 74
    • 49649107046 scopus 로고    scopus 로고
    • Low-dose aspirin may prevent growth and later surgical repair of medium-sized abdominal aortic aneurysms
    • This study reported the association of aspirin prescription with reduced small AAA progression.
    • Lindholt JS, Sorensen HT, Michel JB, et al. Low-dose aspirin may prevent growth and later surgical repair of medium-sized abdominal aortic aneurysms. Vasc Endovascular Surg 2008; 42:329-334. This study reported the association of aspirin prescription with reduced small AAA progression.
    • (2008) Vasc Endovascular Surg , vol.42 , pp. 329-334
    • Lindholt, J.S.1    Sorensen, H.T.2    Michel, J.B.3
  • 75
    • 55849094397 scopus 로고    scopus 로고
    • Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
    • Chun HJ, Ali ZA, Kojima Y, et al. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest 2008; 118:3343-3354.
    • (2008) J Clin Invest , vol.118 , pp. 3343-3354
    • Chun, H.J.1    Ali, Z.A.2    Kojima, Y.3
  • 76
    • 38549097656 scopus 로고    scopus 로고
    • Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice
    • Qian HS,GuJM, Liu P, et al. Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice. Gene Ther 2008; 15:224-232.
    • (2008) Gene Ther , vol.15 , pp. 224-232
    • Qian, H.S.1    Gu, J.M.2    Liu, P.3
  • 77
    • 28644445776 scopus 로고    scopus 로고
    • Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
    • Yoshimura K, Aoki H, Ikeda Y, et al. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med 2005; 11:1330-1338.
    • (2005) Nat Med , vol.11 , pp. 1330-1338
    • Yoshimura, K.1    Aoki, H.2    Ikeda, Y.3
  • 78
    • 36048977283 scopus 로고    scopus 로고
    • Obesity, adipokines, and abdominal aortic aneurysm: Health inMen study
    • Golledge J, Clancy P, Jamrozik K, Norman PE. Obesity, adipokines, and abdominal aortic aneurysm: Health inMen study. Circulation 2007; 116:2275-2279.
    • (2007) Circulation , vol.116 , pp. 2275-2279
    • Golledge, J.1    Clancy, P.2    Jamrozik, K.3    Norman, P.E.4


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