CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 10, 2015, Pages 12793-12801

  Yang, Xiao Mei ^a   You, Hai Yan ^a   Li, Qing ^a   Ma, Hong ^a   Wang, Ya Hui ^a   Zhang, Yan Li ^a   Zhu, Lei ^a   Nie, Hui Zhen ^a   Qin, Wen Xin ^a   Zhang, Zhi Gang ^a   Li, Jun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Colorectal cancer; CTHRC1; Extracellular matrix; Metastasis

Indexed keywords

BETA CATENIN; CTHRC1 PROTEIN, HUMAN; SCLEROPROTEIN; WNT PROTEIN;

CELL MOTION; CELL PROLIFERATION; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR INVASION;

BETA CATENIN; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 85013141928     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Qiao L, Wong B. Role of Notch signaling in colorectal cancer. Carcinogenesis 2009; 30: 1979-1986.
2. Ki DH, Jeung HC, Park CH, Kang SH, Lee GY, Lee WS, Kim NK, Chung HC, Rha SY. Whole genome analysis for liver metastasis gene signatures in colorectal cancer. Int J Cancer 2007; 121: 2005-12.
3. Albini A, Mirisola V, Pfeffer U. Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior. Cancer Metastasis Rev 2008; 27: 75-83.
4. Yang JD, Nakamura I, Roberts LR. The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin Cancer Biol 2011; 21: 35-43.
5. Yamamoto H, Kitadai Y, Yamamoto H, Oue N, Ohdan H, Yasui W, Kikuchi A. Laminin gamma 2 mediates wnt5a-induced invasion of gastric cancer cells. Gastroenterology 2009; 137: 242-52.
6. Zhao J, Dong L, Lu B, Wu G, Xu D, Chen J, Li K, Tong X, Dai J, Yao S, Wu M, Guo Y. Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis. Gastroenterology 2008; 135: 956-968.
7. Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, Friesel RE, Lindner V. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res 2005; 96: 261-268.
8. LeClair R, Lindner V. The role of collagen triple helix repeat containing1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med 2007; 17: 202-205.
9. Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004; 6: 17-32.
10. West RB, Nuyten DS, Subramanian S, Nielsen TO, Corless CL, Rubin BP, Montgomery K, Zhu S, Patel R, Hernandez-Boussard T, Goldblum JR, Brown PO, van de Vijver M, van de Rijn M. Determination of stromal signatures in breast carcinoma. PLoS Biol 2005; 3: e187
11. Tang L, Dai DL, Su M, Martinka M, Li G, Zhou Y. Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Clin Cancer Res 2006; 12: 3716-3722.
12. Chen YL, Wang TH, Hsu HC, Yuan RH, Jeng YM. Overexpression of CTHRC1 in hepatocellular carcinoma promotes tumor invasion and predicts poor prognosis. PLoS One 2013; 8: e70324.
13. Gu L, Liu L, Zhong L, Bai Y, Sui H, Wei X, Zhang W, Huang P, Gao D, Kong Y, Lou G. Cthrc1 overexpression is an independent prognostic marker in gastric cancer. Hum Pathol 2014; 45: 1031-8.
14. Liu X, Liu B, Cui Y, Wang F, Sun H, Lv F. Collagen triple helix repeat containing 1 (Cthrc1) is an independently prognostic biomarker of non-small cell lung cancers with cigarette smoke. Tumour Biol 2014; 35: 11677-83.
15. Ma MZ, Zhuang C, Yang XM, Zhang ZZ, Ma H, Zhang WM, You H, Qin W, Gu J, Yang S, Cao H, Zhang ZG. CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt/PCP-Rho signaling. Neoplasia 2014; 16: 265-78.
16. Kim HC, Kim YS, Oh HW, Kim K, Oh SS, Kim JT, Kim BY, Lee SJ, Choe YK, Kim DH, Kim SH, Chae SW, Kim KD, Lee HG. Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells. Oncotarget 2014; 5: 519-29.
17. Ip W, Wellman-Labadie O, Tang L, Su M, Yu R, Dutz J, Wang Y, Huang S, Zhang X, Huang C, Zhou Y. Collagen triple helix repeat containing 1 promotes melanoma cell adhesion and survival. J Cutan Med Surg 2011; 15: 103-10.
18. Kharaishvili G, Cizkova M, Bouchalova K, Mgebrishvili G, Kolar Z, Bouchal J. Collagen triple helix repeat containing 1 protein, periostin and versican in primary and metastatic breast cancer: an immunohistochemical study. J Clin Pathol 2011; 64: 977-82.
19. Skeen VR, Paterson I, Paraskeva C and Williams AC. TGF-β1 signalling, connecting aberrant inflammation and colorectal tumorigenesis. Current Pharmaceutical Design 2012; 18: 3874-3888.
20. Katoh M. WNT/PCP signaling pathway and human cancer (review). Oncol Rep 2005; 14: 1583-8.
21. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20: 781-810.
22. Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Development Cell 2008; 15: 23-26.