Overexpression of CTHRC1 in Hepatocellular Carcinoma Promotes Tumor Invasion and Predicts Poor Prognosis

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Chen, Yu Ling ^a,b   Wang, Ting Huang ^a,b   Hsu, Hey Chi ^a,b   Yuan, Ray Hwang ^b   Jeng, Yung Ming ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; COLLAGEN TRIPLE HELIX REPEAT CONTAINING 1 PROTEIN; FOCAL ADHESION KINASE; GLYCOPROTEIN; MESSENGER RNA; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; CTHRC1 GENE; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FEMALE; GENE; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MICROARRAY ANALYSIS; PREDICTIVE VALUE; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; TUMOR INVASION; TUMOR VOLUME;

ADULT; AGED; ANTIGENS, CD29; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL MOVEMENT; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING; ODDS RATIO; PROGNOSIS; RHOA GTP-BINDING PROTEIN;

EID: 84880763495     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070324     Document Type: Article

References (26)

1. El-Serag HB, Rudolph KL, (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-7256.
2. Yu MC, Yuan JM, Govindarajan S, Ross RK, (2004) Epidemiology of hepatocellular carcinoma. Can J Gastroenterol 14: 703-709.
3. Schafer DF, Sorrel MF, (1999) Hepatocellular carcinoma. Lancet 353: 1253-1257.
4. Hsu HC, Jeng YM, Mao TL, Chu JS, Lai PL, et al. (2000) β-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 157: 763-770.
5. Hsu HC, Huang AM, Lai PL, Chien WM, Peng SY, et al. (1994) Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma. Hepatology 19: 122-128.
6. Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, et al. (2005) Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res 96: 261-268.
7. LeClair RJ, Durmus T, Wang Q, Pyagay P, Terzic A, et al. (2007) Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. Circ Res 100: 826-833.
8. Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell 15: 23-36.
9. Tang L, Dai DL, Su M, Martinka M, Li G, et al. (2006) Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Clin Cancer Res 12: 3716-3722.
10. Edmonson HA, Steiner PE, (1954) Primary carcinoma of the liver: A study of 100 among 489,000 necropsies. Cancer (Phila.) 7: 462-503.
11. Edge SB (2010) AJCC cancer staging manual (7th ed). New York, NY: Springer.
12. Wang YC, Chen YL, Yuan RH, Pan HW, Yang WC, et al. (2010) Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma. Carcinogenesis 31: 1516-1522.
13. Wessel D, Fugge UI, (1984) A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Analytical Biochemistry 138: 141-143.
14. Sahai E, Marshall CJ, (2002) RHO-GTPases and cancer. Nat Rev Cancer 2: 133-134.
15. Wong CC, Wong CM, Au SL, Ng IO, (2010) RhoGTPases and Rho-effectors in hepatocellular carcinoma metastasis: ROCK N'Rho move it. Liver Int 30: 642-656.
16. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, et al. (1996) The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J 15: 1885-1893.
17. Janssen ME, Kim E, Liu H, Fujimoto LM, Bobkov A, et al. (2006) Three-dimensional structure of vinculin bound to actin filaments. Mol Cell 21: 271-281.
18. Owen JD, Ruest PJ, Fry DW, Hanks SK, (1999) Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol 19: 4806-4818.
19. Burridge K, Turner CE, Romer LH, (1992) Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol 119: 893-903.
20. Zutter MM, Sun H, Santoro SA, (1998) Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors. J. Mammary Gland Biol. Neoplasia 3: 191-200.
21. Jeng YM, Chang CC, Hu FC, Chou HY, Kao HL, et al. (2008) RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma. Hepatology 48: 1118-1127.
22. Dale RM, Sisson BE, Topczewski J, (2009) The emerging role of Wnt/PCP signaling in organ formation. Zebrafish 6: 9-14.
23. Chung S, Kim S, Yoon J, Adler PN, Yim J, (2007) The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. Genetics 176: 891-903.
24. Hotchin NA, Hall A, (1995) The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol 131: 1857-1865.
25. Ridley AJ, Hall A, (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389-399.
26. Park EH, Kim S, Jo JY, Kim SJ, Hwang Y, et al. (2013) Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis 2013 34: 694-702.