Laminin γ2 Mediates Wnt5a-Induced Invasion of Gastric Cancer Cells

Gastroenterology

Volumn 137, Issue 1, 2009, Pages

  Yamamoto, Hideki ^a,a   Kitadai, Yasuhiko ^a   Oue, Naohide ^a   Ohdan, Hideki ^a   Yasui, Wataru ^a   Kikuchi, Akira ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; KALININ; LAMININ GAMMA1; LAMININ GAMMA2; MUTANT PROTEIN; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WNT5A PROTEIN; LAMC2 PROTEIN, HUMAN; LAMC2 PROTEIN, MOUSE; LAMININ; MESSENGER RNA; ONCOPROTEIN; TRANSCRIPTION FACTOR AP 1; WNT PROTEIN; WNT5A PROTEIN, HUMAN; WNT5A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CELL ASSAY; CELL INVASION; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KNOCKOUT GENE; L CELL; LIVER METASTASIS; MALE; METASTASIS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; STOMACH CANCER; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; LIVER TUMOR; METABOLISM; METHODOLOGY; MUTATION; NUDE MOUSE; PATHOLOGY; PROMOTER REGION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STOMACH TUMOR; TUMOR CELL LINE; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LAMININ; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MUTATION; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; UP-REGULATION; WNT PROTEINS;

EID: 67649214739     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.02.003     Document Type: Article

References (29)

1. Ohgaki H., and Matsukura N. Stomach cancer (2003), IARC Press, Lyon, France
2. Hohenberger P., and Gretschel S. Gastric cancer. Lancet 362 (2003) 305-315
3. Gupta G.P., and Massague J. Cancer metastasis: building a framework. Cell 127 (2006) 679-695
4. Yokozaki H. Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol Int 50 (2000) 767-777
5. Saitoh T., Mine T., and Katoh M. Frequent up-regulation of WNT5A mRNA in primary gastric cancer. Int J Mol Med 9 (2002) 515-519
6. Kurayoshi M., Oue N., Yamamoto H., et al. Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 66 (2006) 10439-10448
7. Weeraratna A.T., Jiang Y., Hostetter G., et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1 (2002) 279-288
8. Kikuchi A., and Yamamoto H. Tumor formation due to abnormalities in the β-catenin-independent pathway of Wnt signaling. Cancer Sci 99 (2008) 202-208
9. Kurayoshi M., Yamamoto H., Izumi S., et al. Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J 402 (2007) 515-523
10. Hintermann E., and Quaranta V. Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors. Matrix Biol 23 (2004) 75-85
11. Miyazaki K. Laminin-5 (laminin-332): unique biological activity and role in tumor growth and invasion. Cancer Sci 97 (2006) 91-98
12. Fukushima Y., Ohnishi T., Arita N., et al. Integrin α3β1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells. Int J Cancer 76 (1998) 63-72
13. Kariya Y., Tsubota Y., Hirosaki T., et al. Differential regulation of cellular adhesion and migration by recombinant laminin-5 forms with partial deletion or mutation within the G3 domain of α3 chain. J Cell Biochem 88 (2003) 506-520
14. Pyke C., Romer J., Kallunki P., et al. The γ 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers. Am J Pathol 145 (1994) 782-791
15. Koshikawa N., Moriyama K., Takamura H., et al. Overexpression of laminin γ2 chain monomer in invading gastric carcinoma cells. Cancer Res 59 (1999) 5596-5601
16. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol 64 (1965) 31-49
17. Tsuchiya Y., Sato H., Endo Y., et al. Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo. Cancer Res 53 (1993) 1397-1402
18. Fidler I.J. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes Memorial Award Lecture. Cancer Res 50 (1990) 6130-6138
19. Olsen J., Lefebvre O., Fritsch C., et al. Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin γ2-chain gene promoter by hepatocyte growth factor (scatter factor). Biochem J 347 (2000) 407-417
20. Yamanaka H., Moriguchi T., Masuyama N., et al. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep 3 (2002) 69-75
21. Kikuchi A., Yamamoto H., and Kishida S. Multiplicity of the interactions of Wnt proteins and their receptors. Cell Signal 19 (2007) 659-671
22. Hlubek F., Jung A., Kotzor N., et al. Expression of the invasion factor laminin γ2 in colorectal carcinomas is regulated by β-catenin. Cancer Res 61 (2001) 8089-8093
23. Mikels A.J., and Nusse R. Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context. PLoS Biol 4 (2006) 570-582
24. -/- colon carcinoma. Science 275 (1997) 1784-1787
25. Schenk S., Hintermann E., Bilban M., et al. Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. J Cell Biol 161 (2003) 197-209
26. Ogawa T., Tsubota Y., Hashimoto J., et al. The short arm of laminin γ2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin β4 chain. Mol Biol Cell 18 (2007) 1621-1633
27. Atcha F.A., Munguia J.E., Li T.W., et al. A new β-catenin-dependent activation domain in T cell factor. J Biol Chem 278 (2003) 16169-16175
28. Tahara E. Growth factors and oncogenes in human gastrointestinal carcinomas. J Cancer Res Clin Oncol 116 (1990) 121-131
29. Huang C., Rajfur Z., Borchers C., et al. JNK phosphorylates paxillin and regulates cell migration. Nature 424 (2003) 219-223