IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages E1196-E1204

  Choi, Jin Huk ^a   Wang, Kuan Wen ^a   Zhang, Duanwu ^a   Zhan, Xiaowei ^a   Wang, Tao ^a   Bu, Chun Hui ^a   Behrendt, Cassie L ^a   Zeng, Ming ^a   Wang, Ying ^a   Misawa, Takuma ^a   Li, Xiaohong ^a   Tang, Miao ^a   Zhan, Xiaoming ^a   Scott, Lindsay ^a   Hildebrand, Sara ^a   Murray, Anne R ^a   Moresco, Eva Marie Y ^a   Hooper, Lora V ^a   Beutler, Bruce ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

53BP1; Class switch recombination; IgD; Microbiota; Toll like receptor

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; MYELOID DIFFERENTIATION FACTOR 88; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1; CYTIDINE DEAMINASE; MYD88 PROTEIN, MOUSE; TRP53BP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA DAMAGE RESPONSE; FEMALE; GENE REARRANGEMENT; IMMUNOGLOBULIN PRODUCTION; LYMPHOID TISSUE; MALE; MICROFLORA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN SECRETION; ANIMAL; C57BL MOUSE; DEFICIENCY; DNA END JOINING REPAIR; GENETIC RECOMBINATION; GENETICS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MUCOSA;

ANIMALS; CYTIDINE DEAMINASE; DNA END-JOINING REPAIR; FEMALE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN D; LYMPHOID TISSUE; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROBIOTA; MUCOUS MEMBRANE; MYELOID DIFFERENTIATION FACTOR 88; RECOMBINATION, GENETIC; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1;

EID: 85012977529     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1621258114     Document Type: Article

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