Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model

Aerosol Science and Technology

Volumn 40, Issue 1, 2006, Pages 1-16

  Zhang, Zhe ^a   Kleinstreuer, Clement ^b   Kim, Chong S ^c  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEPOSITION; DIFFUSION IN LIQUIDS; DROP FORMATION; TRANSPORT PROPERTIES; TURBULENCE; VAPORIZATION;

FLOW RATE; SALINE DROPLETS; WATER VAPOUR;

VAPORS;

SODIUM CHLORIDE;

AIRFLOW; ARTICLE; CORRELATION ANALYSIS; EVAPORATION; FLOW RATE; GAS TRANSPORT; HUMIDITY; LAMINAR AIRFLOW; PRIORITY JOURNAL; THERMODYNAMICS; TRACHEOBRONCHIAL TREE; TURBULENT FLOW; UPPER RESPIRATORY TRACT; VAPORIZATION; WATER LOSS; WATER VAPOR; WETTABILITY;

EID: 33745630736     PISSN: 02786826     EISSN: 15217388     Source Type: Journal    
DOI: 10.1080/02786820500461154     Document Type: Article

References (59)

1. Adamson, A. W. (1990). Physical Chemistry of Surfaces, 5th edn. Wiley, New York.
2. AEA Technology (2001). CFX-4.4: Solve. CFX International, Oxfordshire, UK.
3. Balásházy, I., Hofmann, W., and Heistracher, T. (1999). Computation of Local Enhancement Factors for the Quantification of Particle Deposition Patterns in Airway Bifurcations, J. Aerosol Sci. 30:185-203.
4. Balásházy, I., Hofmann, W., and Heistracher, T. (2003). Local Particle Deposition Patterns may Play a Key Role in the Development of Lung Cancer, J. Appl. Physiol. 94:1719-1725.
5. Benaissa, A., Gauthier, J. E. D., Bardon M. F., and Laviolette, M. (2002). Modelling Evaporation of Multicomponent Fuel Droplets under Ambient Temperature Conditions, J. Inst. Energy 75:19-26.
6. Berlemont, A., Grancher, M. S., and Gouesbet, G. (1995). Heat and Mass Transfer Coupling between Vaporizing Droplets and Turbulence using a Lagrangian Approach, Int. J. Heat Mass Transfer 38:3023-3034.
7. Broday, D. M., and Georgopoulos, P. G. (2001). Growth and Deposition of Hygroscopic Particulate Matter in the Human Lungs, Aerosol Sci. Technol. 34:144-159.
8. Chen, W. Y., and Horton, D. J. (1977). Heat and Water Loss from the Airways and Exercise-Induced Asthma, Respiration 34:305-313.
9. Cheng, K. H., Cheng, Y. S., Yeh, H. C., and Swift, D. L. (1997). Measurements of Airway Dimensions and Calculation of Mass Transfer Characteristics of the Human Oral Passage, J. Biomechanical Engineering-Trans of the ASME 119:476-482.
10. Cinkotai, F. F. (1971). The Behavior of Sodium Chloride Particles in Moist Air, J. Aerosol Sci. 2:325-329.
11. Clift, R., Grace, J. R., and Weber, M. E. (1978), Bubbles, Drops, and Particles. Academic Press, New York.
12. Comer, J. K., Kleinstreuer, C., Hyun, S., and Kim, C. S. (2000). Aerosol Transport and Deposition in Sequentially Bifurcating Airways, J Biomechanical Engineering - Trans of the ASME 122:152-158.
13. Comer, J. K., Kleinstreuer, C., and Zhang, Z. (2001). Flow Structures and Particle Deposition Patterns in Double Bifurcation Airway Models. Part 1. Air Flow Fields, J Fluid Mechanics 435:25-54.
14. Daviskas, E., Gonda, I., Anderson, S. D. (1990). Mathematical Modeling of Heat and Water Transport in Human Respiratory Tract, J. Appl. Physiol. 69 (1):362-372.
15. Eisner, A. D., Graham, R. C., and Martonen, T. B. (1990). Coupled Mass and Energy Transport Phenomena in Aerosol/Vapor-Laden Gases - I. Theory of the Hygroscopic Aerosol Effects on Temperature and Relative Humidity Patterns of Inspired Air, J. Aerosol Sci. 21:833-848.
16. Ferron, G. A., Haider, B., and Kreyling, W. G. (1985). A Method for the Approximation of the Relative Humidity in The Upper Airways, Bull. Math. Biol. 47:565-589.
17. Ferron, G. A., Kreyling, W. G., and Haider, B. (1988). Inhalation of Salt Aerosol Particles II. Growth and Deposition in the Human Respiratory Tract, J. Aerosol Sci. 19(5):611-631.
18. Ferron, G. A., Oberdörster, G., and Henneberg, R. (1989). Estimation of the Deposition of Aerosolized Drugs in the Human Respiratory Tract due to Hygroscopic Growth, J. Aerosol Med. 2:271-284.
19. Finlay, W. H. (2001). The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. Academic Press, London.
20. Finlay, W. H., and Stapleton, K. W. (1995). The Effect on Regional Lung Deposition of Coupled Heat and Mass Transfer between Hygroscopic Droplets and their Surrounding Phase, J. Aerosol Sci. 26(4):655-670.
21. Finlay, W. H., Stapleton, K. W., Chan, H. K., Zuberbuhler, P., and Gonda, I. (1996). Regional Deposition of Inhaled Hygroscopic Aerosols: In Vivo SPECT Compared with Mathematical Modeling, J. Appl. Physiol. 81:374-383.
22. Gebheart, J., Anselm, A., Ferron, G., Heyder, J., and Stahlhofen, W. (1990). Experimental Data on the Total Deposition of Hygroscopic Particles in the Human Respiratory Tract. In Aerosols: Science, Industry, Health and Environment, edited by S. Masuda and K. Takahashi, pp. 1299-1302, Pergamon Press, Oxford.
23. Gosman, A. D., and Ioannides, E. (1981). Aspects of Computer Simulation of Liquid-Fueled Combustors, J. Energy 7:482-490.
24. Hanna, L. M., and Scherer, P. (1986). A Theoretical Model of Localized Heat and Water Transport in the Human Respiratory Tract, J. Biomech. Eng. 108:19-27.
25. Hickey, A. J., and Martonen, T. B. (1991). Behavior of Hygroscopic Pharmaceutical Aerosols and the influence of Hydrophobic Additives, Pharm. Res. 10:1-7.
26. Hinds, W. C. (1993). Physical and chemical changes in the particulate phase. In Aerosol Measurements, Pronciples, techniques and Applications. edited by K. Willeke and P. A. Baron, Van Nostrand Reinhold, New York.
27. Ingenito, E. P., Solway, J., McFadden Jr., E. R., Pichurko, B. M., Cravalho, E. G., and Drazen, J. M. (1986). Finite Difference Analysis of Respiratory Heat Transfer, J. Appl. Physiol. 61:2252-2259.
28. Johnson, C. E., Linderoth Jr., L. S., and Nuckols, M. L. (1977). An Analysis of Sensible Respiratory Heat Exchange during Inspiration under Environmental Condition of Deep Diving, J Biomechanical Engineering -Trans of the ASME 99:45-53.
29. Kim, J., Moin, P., and Moser, R. D. (1987). Turbulence Statistics in Fully Developed Channel Flow at Low Reynolds Number, J. Fluid Mechanics 177:133-166.
30. Kleinstreuer, C., and Zhang, Z. (2003). Laminar-to-Turbulent Fluid-Particle Flows in a Human Airway Model, Int. J. Multiphase Flow 29:271-289.
31. Longest, P. W., and Kleinstreuer, C. (2004). Interacting Effects of Uniform Flow, Plane Shear, and Near-Wall Proximity on the Heat and Mass Transfer of Respiratory Aerosols, Int. J. Heat and Mass Transfer 47:4745-4759.
32. Longest, P. W., Kleinstreuer, C., and Buchanan, J. R. (2004). Efficient Computation of Micro-Particle Dynamics Including Wall Effect, Computers & Fluids. 33:577-601.
33. MacInnes, J. M., and Bracco, F. V. (1992). Stochastic Particle Dispersion Modeling and The Tracer-Particle Limit, Physics of Fluids 4:2809-2824.
34. Matida, E. A., Nishino, K., and Torii, K. (2000). Statistical Simulation of Particle Deposition on the Wall from Turbulent Dispersed Pipe Flow, Int. J. Heat and Fluid Flow. 21:389-402.
35. Matida, E. A., Finlay, W. H., Lange, C. F., and Grgic, B. (2004). Improving Numerical Simulations of Particle Deposition in an Idealized Mouth-Throat, J. Aerosol Sci. 35:1-19.
36. McFadden, E. R., Pichurko, B. M., Bowman, H. F., Ingenito, E., Burns, S., Dowling, N., and Solway, J. (1985). Thermal Mapping of the Airways in Humans, J. Applied Physiol. 58:564-570.
37. Morrow, P. E. (1986). Factors Determining Hygroscopic Aerosol Deposition in Airways, Physiol. Rev. 66:330-376.
38. Naftali, S., Schroter, R. C., Shiner, R. J., and Elad, D. (1998). Transport Phenomena in the Human Nasal Cavity: A Computational Model, Annals of Biomedical Engineer. 26:831-839.
39. Nuckols, M. L. (1981). Heat and Water Transfer in the Human Respiratory System at Hyperbaric Conditions, PhD thesis, Duke University, Durham, NC.
40. Peng, C., Chow A. H. L., and Chan, C. K. (2000). Study of the Hygroscopic Properties of Selected Pharmaceutical Aerosols Using Single Particle Levitation, Pharmaceutical Research 17:1104-1109.
41. Schuen, J. S., Chen, L. D., and Faeth, G. M. (1983). Evaluation of a Stochastic Model of Particle Dispersion in a Turbulent Round Jet, AICHE J. 29:167-170.
42. Shepard, D. (1968). A Two-dimensional Interpolation Function for Irregularly-Spaced Data, Proc. 23rd National Conference ACM. ACM, 517-524.
43. Smolik, J., Dzumbova, L., Schwarz, J., and Kulmala, M. (2001). Evaporation of Ventilated Water Droplet: Connection between Heat and Mass Transfer, J. Aerosol Sci. 32:739-748.
44. Tawhai, M. H., and Hunter, P. J. (2004). Modeling Water Vapor and Heat Transfer in the Normal and the Intubated Airways, Annals of Biomedical Engineer. 32:609-622.
45. Vargaftik, N. B. (1975). Tables on Thermophysical Properties of Liquids and Gases, 2nd Ed., Washington, DC: Hemisphere.
46. Vesala, T., Kulmala, M., Rudolf, R., Vrtala, A., and Wagner, P. (1997). Models for Condensational Growth and Evaporation of Binary Aerosol Particles, J. Aerosol Sci. 28:565.
47. Wang, Y., and James, P. W. (1999). On the Effect of Anisotropy on the Turbulent Dispersion and Deposition of Small Particles, Int. J. Multiphase Flow, 25:551-558.
48. Weibel, E. R. (1963). Morphometry of the Human Lung, Academic Press, New York.
49. Wilcox, D. C. (1998). Turbulence Modeling for CFD (Second Edition), DCW Industries, Inc., LA Canada, CA.
50. Williams, R., Rankin, N., Smith, T., Galler, D., and Seakins, P. (1996). Relationship between the Humidity and Temperature of Inspired Gas and the Function of the Airway Mucosa, Crit. Care Med. 24:1920-1929.
51. Zhang, Z., and Kleinstreuer, C. (2001). Effect of Particle Inlet Distributions on Deposition in a Triple Bifurcation Lung Airway Model, J. Aerosol Medicine 14:13-29.
52. Zhang, Z., and Kleinstreuer, C. (2002). Transient Airflow Structures and Particle Transport in a Sequentially Branching Lung Airway Model, Physics of Fluids 14:862-880.
53. Zhang, Z., and Kleinstreuer, C. (2003a). Low Reynolds Number Turbulent Flows in Locally Constricted Conduits: A Comparison Study, AIAA Journal 41:831-840.
54. Zhang, Z., and Kleinstreuer, C (2003b). Species Heat and Mass Transfer in a Human Upper Airway Model, Int. J. Heat and Mass Transfer 46:4755-4768.
55. Zhang, Z., and Kleinstreuer, C (2004). Airflow Structures and Nano-Particle Deposition in a Human Upper Airway Model, J. Computational Phys. 198:178-210.
56. Zhang, Z., Kleinstreuer, C., Donohue, J. F., and Kim, C. S. (2005a). Comparison of Micro- and Nano-Size Particle Depositions in a Human Upper Airway Model, J. Aerosol Sci. 36:211-233.
57. Zhang, Z., Kleinstreuer, C., and Kim, C. S. (2002a). Cyclic Micron-Size Particle Inhalation and Deposition in a Triple Bifurcation Lung Airway Model. J. Aerosol Sci. 33:257-281.
58. Zhang, Z., Kleinstreuer, C., and Kim, C. S. (2002b). Aerosol Deposition Efficiencies and Upstream Release Positions for Different Inhalation Modes in an Upper Bronchial Airway Model, Aerosol Sci. Technol. 36:828-844.
59. Zhang, Z., Kleinstreuer, C., and Kim, C. S. (2005b). Isotonic and Hypertonic Saline Droplet Deposition in a Human Upper Airway Model, J. Aerosol Med. submitted for publication.