메뉴 건너뛰기




Volumn 88, Issue , 2017, Pages 814-822

Receptor tyrosine kinase-like orphan receptor 1 (ROR-1): An emerging target for diagnosis and therapy of chronic lymphocytic leukemia

Author keywords

CLL; Diagnosis; ROR 1; Therapy; Tyrosine kinase

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE INHIBITOR; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1; UNCLASSIFIED DRUG; ROR1 PROTEIN, HUMAN; TUMOR MARKER;

EID: 85012307829     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.01.070     Document Type: Review
Times cited : (23)

References (95)
  • 1
    • 0346058347 scopus 로고    scopus 로고
    • Immunotherapy of malignant diseases Challenges and strategies
    • [1] Ko, E.C., Wang, X., Ferrone, S., Immunotherapy of malignant diseases Challenges and strategies. Int. Arch. Allergy Immunol. 132:4 (2003), 294–309.
    • (2003) Int. Arch. Allergy Immunol. , vol.132 , Issue.4 , pp. 294-309
    • Ko, E.C.1    Wang, X.2    Ferrone, S.3
  • 2
    • 0034066072 scopus 로고    scopus 로고
    • Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis
    • [2] Weinstein, I.B., Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis. Carcinogenesis 21:5 (2000), 857–864.
    • (2000) Carcinogenesis , vol.21 , Issue.5 , pp. 857-864
    • Weinstein, I.B.1
  • 3
    • 84881109637 scopus 로고    scopus 로고
    • The molecular basis of targeting protein kinases in cancer therapeutics
    • [3] Tsai, C.J., Nussinov, R., The molecular basis of targeting protein kinases in cancer therapeutics. Semin. Cancer Biol. 23:August (4) (2013), 235–242.
    • (2013) Semin. Cancer Biol. , vol.23 , Issue.August (4) , pp. 235-242
    • Tsai, C.J.1    Nussinov, R.2
  • 4
    • 84877773278 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: their on-target toxicities as potential indicators of efficacy
    • [4] Shah, D.R., Shah, R.R., Morganroth, J., Tyrosine kinase inhibitors: their on-target toxicities as potential indicators of efficacy. Drug Saf. 36:6 (2013), 413–426.
    • (2013) Drug Saf. , vol.36 , Issue.6 , pp. 413-426
    • Shah, D.R.1    Shah, R.R.2    Morganroth, J.3
  • 5
    • 12944325331 scopus 로고    scopus 로고
    • A listing of human tumor antigens recognized by T cells: March 2004 update
    • [5] Novellino, L.C.C., Parmiani, G., A listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol. Immunother. 54:3 (2005), 187–207.
    • (2005) Cancer Immunol. Immunother. , vol.54 , Issue.3 , pp. 187-207
    • Novellino, L.C.C.1    Parmiani, G.2
  • 6
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • [6] Krause, D.S., Van Etten, R.A., Tyrosine kinases as targets for cancer therapy. N. Engl. J. Med. 353:2 (2005), 172–187.
    • (2005) N. Engl. J. Med. , vol.353 , Issue.2 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 7
    • 0033786922 scopus 로고    scopus 로고
    • Protein tyrosine kinase structure and function
    • [7] Hubbard, S.R., Till, J.H., Protein tyrosine kinase structure and function. Annu. Rev. Biochem. 69 (2000), 373–398.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 373-398
    • Hubbard, S.R.1    Till, J.H.2
  • 8
    • 0036159121 scopus 로고    scopus 로고
    • The Ror receptor tyrosine kinase family
    • [8] Forrester, W.C., The Ror receptor tyrosine kinase family. Cell. Mol. Life Sci. 59:1 (2002), 83–96.
    • (2002) Cell. Mol. Life Sci. , vol.59 , Issue.1 , pp. 83-96
    • Forrester, W.C.1
  • 9
    • 0028146767 scopus 로고
    • A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
    • [9] Nishikawa, R.J.X., Harmon, R.C., et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc. Natl. Acad. Sci. U. S. A. 91:16 (1994), 7727–7731.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , Issue.16 , pp. 7727-7731
    • Nishikawa, R.J.X.1    Harmon, R.C.2
  • 10
    • 0035150912 scopus 로고    scopus 로고
    • The molecular biology of cancer
    • [10] Bertram, J.S., The molecular biology of cancer. Mol. Aspects Med. 21:December (6) (2000), 167–223.
    • (2000) Mol. Aspects Med. , vol.21 , Issue.December (6) , pp. 167-223
    • Bertram, J.S.1
  • 13
    • 0027074850 scopus 로고
    • A novel family of cell surface receptors with tyrosine kinase-like domain
    • [13] Masiakowski, P.C.R., A novel family of cell surface receptors with tyrosine kinase-like domain. J. Biol. Chem. 267 (1992), 26181–26190.
    • (1992) J. Biol. Chem. , vol.267 , pp. 26181-26190
    • Masiakowski, P.C.R.1
  • 14
    • 0033607015 scopus 로고    scopus 로고
    • A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division
    • [14] Forrester, W.C., Dell, M., Perens, E., Garriga, G., A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature 400 (1999), 881–885.
    • (1999) Nature , vol.400 , pp. 881-885
    • Forrester, W.C.1    Dell, M.2    Perens, E.3    Garriga, G.4
  • 16
    • 77954078799 scopus 로고    scopus 로고
    • Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain
    • [16] Tseng, H.-C., Lyu, P.-C., Lin, W-c., Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain. BMC Cell Biol., 11(1), 2010, 48.
    • (2010) BMC Cell Biol. , vol.11 , Issue.1 , pp. 48
    • Tseng, H.-C.1    Lyu, P.-C.2    Lin, W.-C.3
  • 17
    • 84855168544 scopus 로고    scopus 로고
    • Cytoskeleton network and cellular migration modulated by nuclear-localized receptor tyrosine kinase ROR1
    • [17] Tseng, H.-C., Kao, H.-W., Ho, M.-R., Chen, Y.-R., Lin, T.-W., Lyu, P.-C., et al. Cytoskeleton network and cellular migration modulated by nuclear-localized receptor tyrosine kinase ROR1. Anticancer Res. 31:12 (2011), 4239–4249.
    • (2011) Anticancer Res. , vol.31 , Issue.12 , pp. 4239-4249
    • Tseng, H.-C.1    Kao, H.-W.2    Ho, M.-R.3    Chen, Y.-R.4    Lin, T.-W.5    Lyu, P.-C.6
  • 18
    • 54249099446 scopus 로고    scopus 로고
    • Ror receptor tyrosine kinases: orphans no more
    • [18] Green, J.L., Kuntz, S.G., Sternberg, P.W., Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol. 18:11 (2008), 536–544.
    • (2008) Trends Cell Biol. , vol.18 , Issue.11 , pp. 536-544
    • Green, J.L.1    Kuntz, S.G.2    Sternberg, P.W.3
  • 19
    • 79954622199 scopus 로고    scopus 로고
    • Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis
    • [19] Gentile, A., Lazzari, L., Benvenuti, S., Trusolino, L., Comoglio, P.M., Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res. 71:8 (2011), 3132–3141.
    • (2011) Cancer Res. , vol.71 , Issue.8 , pp. 3132-3141
    • Gentile, A.1    Lazzari, L.2    Benvenuti, S.3    Trusolino, L.4    Comoglio, P.M.5
  • 20
    • 84904206209 scopus 로고    scopus 로고
    • ROR1, an embryonic protein with an emerging role in cancer biology
    • [20] Borcherding, N., Kusner, D., Liu, G.-H., Zhang, W., ROR1, an embryonic protein with an emerging role in cancer biology. Protein Cell 5:7 (2014), 496–502.
    • (2014) Protein Cell , vol.5 , Issue.7 , pp. 496-502
    • Borcherding, N.1    Kusner, D.2    Liu, G.-H.3    Zhang, W.4
  • 21
    • 6544275956 scopus 로고    scopus 로고
    • Spatio‐temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system
    • [21] Oishi, I., Takeuchi, S., Hashimoto, R., Nagabukuro, A., Ueda, T., Liu, Z.J., et al. Spatio‐temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 4:1 (1999), 41–56.
    • (1999) Genes Cells , vol.4 , Issue.1 , pp. 41-56
    • Oishi, I.1    Takeuchi, S.2    Hashimoto, R.3    Nagabukuro, A.4    Ueda, T.5    Liu, Z.J.6
  • 22
    • 0027074850 scopus 로고
    • A novel family of cell surface receptors with tyrosine kinase-like domain
    • [22] Masiakowski, P., Carroll, R.D., A novel family of cell surface receptors with tyrosine kinase-like domain. J. Biol. Chem. 267:36 (1992), 26181–26190.
    • (1992) J. Biol. Chem. , vol.267 , Issue.36 , pp. 26181-26190
    • Masiakowski, P.1    Carroll, R.D.2
  • 23
    • 84869049935 scopus 로고    scopus 로고
    • Crosstalk between ROR1 and the pre-B Cell receptor promotes survival of t (1;19) acute lymphoblastic leukemia
    • [23] Bicocca, V.T., Chang, B.H., Masouleh, B.K., Muschen, M., Loriaux, M.M., Druker, B.J., Tyner, J.W., Crosstalk between ROR1 and the pre-B Cell receptor promotes survival of t (1;19) acute lymphoblastic leukemia. Cancer Cell 22 (2012), 656–667.
    • (2012) Cancer Cell , vol.22 , pp. 656-667
    • Bicocca, V.T.1    Chang, B.H.2    Masouleh, B.K.3    Muschen, M.4    Loriaux, M.M.5    Druker, B.J.6    Tyner, J.W.7
  • 24
    • 84863384604 scopus 로고    scopus 로고
    • NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
    • [24] Yamaguchi, T., Yanagisawa, K., Sugiyama, R., Hosono, Y., Shimada, Y., Arima, C., et al. NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell 21:3 (2012), 348–361.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 348-361
    • Yamaguchi, T.1    Yanagisawa, K.2    Sugiyama, R.3    Hosono, Y.4    Shimada, Y.5    Arima, C.6
  • 25
    • 84904326600 scopus 로고    scopus 로고
    • Evolutionary divergence in the catalytic activity of the CAM-1 ROR1 and ROR2 kinase domains
    • [25] Bainbridge, T.W., DeAlmeida, V.I., Izrael-Tomasevic, A., Chalouni, C., Pan, B., Goldsmith, J., et al. Evolutionary divergence in the catalytic activity of the CAM-1 ROR1 and ROR2 kinase domains. PLoS One, 9(7), 2014, e102695.
    • (2014) PLoS One , vol.9 , Issue.7 , pp. e102695
    • Bainbridge, T.W.1    DeAlmeida, V.I.2    Izrael-Tomasevic, A.3    Chalouni, C.4    Pan, B.5    Goldsmith, J.6
  • 26
    • 0034948866 scopus 로고    scopus 로고
    • Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development
    • [26] Matsuda, T., Nomi, M., Ikeya, M., Kani, S., Oishi, I., Terashima, T., et al. Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech. Dev. 105:1 (2001), 153–156.
    • (2001) Mech. Dev. , vol.105 , Issue.1 , pp. 153-156
    • Matsuda, T.1    Nomi, M.2    Ikeya, M.3    Kani, S.4    Oishi, I.5    Terashima, T.6
  • 27
    • 0033607015 scopus 로고    scopus 로고
    • elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division
    • [27] Forrester, W.C., Dell, M., Perens, E., Garriga, G.A.C., elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature 400:6747 (1999), 881–885.
    • (1999) Nature , vol.400 , Issue.6747 , pp. 881-885
    • Forrester, W.C.1    Dell, M.2    Perens, E.3    Garriga, G.A.C.4
  • 28
    • 0344925865 scopus 로고    scopus 로고
    • Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1
    • [28] Kim, C., Forrester, W.C., Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1. Dev. Biol. 264:2 (2003), 376–390.
    • (2003) Dev. Biol. , vol.264 , Issue.2 , pp. 376-390
    • Kim, C.1    Forrester, W.C.2
  • 29
    • 0035947581 scopus 로고    scopus 로고
    • Localization of disulfide bonds in the frizzled module of Ror1 receptor tyrosine kinase
    • [29] Roszmusz, E., Patthy, A., Trexler, M., Patthy, L., Localization of disulfide bonds in the frizzled module of Ror1 receptor tyrosine kinase. J. Biol. Chem. 276:21 (2001), 18485–18490.
    • (2001) J. Biol. Chem. , vol.276 , Issue.21 , pp. 18485-18490
    • Roszmusz, E.1    Patthy, A.2    Trexler, M.3    Patthy, L.4
  • 30
    • 14044263637 scopus 로고    scopus 로고
    • Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2
    • [30] Paganoni, S., Ferreira, A., Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J. Cell Sci. 118:Jaunuary Pt 2 (2005), 433–446.
    • (2005) J. Cell Sci. , vol.118 , Issue.Jaunuary Pt 2 , pp. 433-446
    • Paganoni, S.1    Ferreira, A.2
  • 31
    • 84953240034 scopus 로고    scopus 로고
    • ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
    • [31] Yamaguchi, T., Lu, C., Ida, L., Yanagisawa, K., Usukura, J., Cheng, J., Hotta, N., Shimada, Y., Isomura, H., Suzuki, M., Fujimoto, T., Takahashi, T., ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat. Commun., 7(January), 2016, 10060.
    • (2016) Nat. Commun. , vol.7 , Issue.January , pp. 10060
    • Yamaguchi, T.1    Lu, C.2    Ida, L.3    Yanagisawa, K.4    Usukura, J.5    Cheng, J.6    Hotta, N.7    Shimada, Y.8    Isomura, H.9    Suzuki, M.10    Fujimoto, T.11    Takahashi, T.12
  • 32
    • 0037237125 scopus 로고    scopus 로고
    • Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans
    • [32] Yoda, A., Oishi, I., Minami, Y., Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans. J. Recept. Signal Transduct. 23:1 (2003), 1–15.
    • (2003) J. Recept. Signal Transduct. , vol.23 , Issue.1 , pp. 1-15
    • Yoda, A.1    Oishi, I.2    Minami, Y.3
  • 33
    • 0035192873 scopus 로고    scopus 로고
    • Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases
    • [33] Nomi, M., Oishi, I., Kani, S., Suzuki, H., Matsuda, T., Yoda, A., et al. Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol. Cell. Biol. 21:24 (2001), 8329–8335.
    • (2001) Mol. Cell. Biol. , vol.21 , Issue.24 , pp. 8329-8335
    • Nomi, M.1    Oishi, I.2    Kani, S.3    Suzuki, H.4    Matsuda, T.5    Yoda, A.6
  • 34
    • 0034051682 scopus 로고    scopus 로고
    • Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development
    • [34] DeChiara, T.M., Kimble, R.B., Poueymirou, W.T., Rojas, J., Masiakowski, P., Valenzuela, D.M., et al. Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat. Genet. 24:3 (2000), 271–274.
    • (2000) Nat. Genet. , vol.24 , Issue.3 , pp. 271-274
    • DeChiara, T.M.1    Kimble, R.B.2    Poueymirou, W.T.3    Rojas, J.4    Masiakowski, P.5    Valenzuela, D.M.6
  • 35
    • 6744265274 scopus 로고    scopus 로고
    • Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation
    • [35] Takeuchi, S., Takeda, K., Oishi, I., Nomi, M., Ikeya, M., Itoh, K., et al. Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells 5:1 (2000), 71–78.
    • (2000) Genes Cells , vol.5 , Issue.1 , pp. 71-78
    • Takeuchi, S.1    Takeda, K.2    Oishi, I.3    Nomi, M.4    Ikeya, M.5    Itoh, K.6
  • 36
    • 0034838873 scopus 로고    scopus 로고
    • Simons JP Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development
    • [36] Al-Shawi, R.A.S., Underwood, C., Simons JP Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev. Genes Evol. 211 (2001), 161–171.
    • (2001) Dev. Genes Evol. , vol.211 , pp. 161-171
    • Al-Shawi, R.A.S.1    Underwood, C.2
  • 37
    • 0034948866 scopus 로고    scopus 로고
    • Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development
    • [37] Matsuda, T.N.M., Ikeya, M., Kani, S., Oishi, I., Terashima, T., Takada, S., Minami, Y., Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech. Dev. 105 (2001), 153–156.
    • (2001) Mech. Dev. , vol.105 , pp. 153-156
    • Matsuda, T.N.M.1    Ikeya, M.2    Kani, S.3    Oishi, I.4    Terashima, T.5    Takada, S.6    Minami, Y.7
  • 43
    • 20444419344 scopus 로고    scopus 로고
    • Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
    • [43] MacKeigan, J.P., Murphy, L.O., Blenis, J., Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat. Cell Biol. 7:6 (2005), 591–600.
    • (2005) Nat. Cell Biol. , vol.7 , Issue.6 , pp. 591-600
    • MacKeigan, J.P.1    Murphy, L.O.2    Blenis, J.3
  • 47
    • 80052602132 scopus 로고    scopus 로고
    • Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid leukemias
    • [47] Shabani, M., Asgarian-Omran, H., Hojjat-Farsangi, M., Vossough, P., Sharifian, R.A., Toughe, G.R., et al. Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid leukemias. Avicenna J. Med. Biotechnol. 3:3 (2011), 119–125.
    • (2011) Avicenna J. Med. Biotechnol. , vol.3 , Issue.3 , pp. 119-125
    • Shabani, M.1    Asgarian-Omran, H.2    Hojjat-Farsangi, M.3    Vossough, P.4    Sharifian, R.A.5    Toughe, G.R.6
  • 48
    • 84869166013 scopus 로고    scopus 로고
    • Kipps TJ The onco-embryonic antigen ROR1 is expressed by a variety of human cancers
    • [48] Zhang, S.C.L., Wang-Rodriguez, J., Zhang, L., Cui, B., Frankel, W., Wu, R., Kipps TJ The onco-embryonic antigen ROR1 is expressed by a variety of human cancers. Am. J. Pathol. 181 (2012), 1903–1910.
    • (2012) Am. J. Pathol. , vol.181 , pp. 1903-1910
    • Zhang, S.C.L.1    Wang-Rodriguez, J.2    Zhang, L.3    Cui, B.4    Frankel, W.5    Wu, R.6
  • 49
    • 84927580139 scopus 로고    scopus 로고
    • Anti-ROR1 monoclonal antibodies induce apoptosis in pancreatic cancer cells via the PI3-kinase/AKT/mTOR pathway
    • [49] Daneshmanesh, A.H., Hojjat-Farsangi, M., Moshfegh, A., Mikaelsson, E., Khan, A.S., Österborg, A., et al. Anti-ROR1 monoclonal antibodies induce apoptosis in pancreatic cancer cells via the PI3-kinase/AKT/mTOR pathway. Cancer Res., 74(19 Suppl), 2014, 4770.
    • (2014) Cancer Res. , vol.74 , Issue.19 , pp. 4770
    • Daneshmanesh, A.H.1    Hojjat-Farsangi, M.2    Moshfegh, A.3    Mikaelsson, E.4    Khan, A.S.5    Österborg, A.6
  • 50
    • 85012238028 scopus 로고    scopus 로고
    • Cirmtuzumab vedotin (UC-961ADC3), an anti-ROR1-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for ROR1-positive leukemia and solid tumors
    • [50] Widhopf, G.F., Prussak, C.E., Wu, C.C., Sadarangani, A., Zhang, S., Lao, F., et al. Cirmtuzumab vedotin (UC-961ADC3), an anti-ROR1-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for ROR1-positive leukemia and solid tumors. Blood, 122(21), 2013, 1637-.
    • (2013) Blood , vol.122 , Issue.21 , pp. 1637-
    • Widhopf, G.F.1    Prussak, C.E.2    Wu, C.C.3    Sadarangani, A.4    Zhang, S.5    Lao, F.6
  • 51
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • [51] Frank, D.A., Mahajan, S., Ritz, J., B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J. Clin. Invest., 100(12), 1997, 3140.
    • (1997) J. Clin. Invest. , vol.100 , Issue.12 , pp. 3140
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 52
    • 77955639050 scopus 로고    scopus 로고
    • Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells
    • [52] Li, P., Harris, D., Liu, Z., Liu, J., Keating, M., Estrov, Z., Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells. PLoS One, 5(7), 2010, e11859.
    • (2010) PLoS One , vol.5 , Issue.7 , pp. e11859
    • Li, P.1    Harris, D.2    Liu, Z.3    Liu, J.4    Keating, M.5    Estrov, Z.6
  • 53
    • 84886240815 scopus 로고    scopus 로고
    • The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells
    • [53] Hojjat-Farsangi, M., Khan, A.S., Daneshmanesh, A.H., Moshfegh, A., Sandin, Å., Mansouri, L., et al. The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells. PLoS One, 8(10), 2013, e78339.
    • (2013) PLoS One , vol.8 , Issue.10 , pp. e78339
    • Hojjat-Farsangi, M.1    Khan, A.S.2    Daneshmanesh, A.H.3    Moshfegh, A.4    Sandin, Å.5    Mansouri, L.6
  • 54
    • 36849046794 scopus 로고    scopus 로고
    • Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3β phosphorylation and promotes osteoblast differentiation and bone formation
    • [54] Liu, Y., Ross, J.F., Bodine, P.V., Billiard, J., Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3β phosphorylation and promotes osteoblast differentiation and bone formation. Mol. Endocrinol. 21:12 (2007), 3050–3061.
    • (2007) Mol. Endocrinol. , vol.21 , Issue.12 , pp. 3050-3061
    • Liu, Y.1    Ross, J.F.2    Bodine, P.V.3    Billiard, J.4
  • 55
    • 54249096215 scopus 로고    scopus 로고
    • Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase
    • [55] Liu, Y., Rubin, B., Bodine, P.V., Billiard, J., Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. J. Cell. Biochem. 105:2 (2008), 497–502.
    • (2008) J. Cell. Biochem. , vol.105 , Issue.2 , pp. 497-502
    • Liu, Y.1    Rubin, B.2    Bodine, P.V.3    Billiard, J.4
  • 56
    • 10244267459 scopus 로고    scopus 로고
    • Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2
    • [56] Sammar, M., Stricker, S., Schwabe, G.C., Sieber, C., Hartung, A., Hanke, M., et al. Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2. Genes Cells 9:12 (2004), 1227–1238.
    • (2004) Genes Cells , vol.9 , Issue.12 , pp. 1227-1238
    • Sammar, M.1    Stricker, S.2    Schwabe, G.C.3    Sieber, C.4    Hartung, A.5    Hanke, M.6
  • 57
    • 54949106904 scopus 로고    scopus 로고
    • Mammalian glycosylation in immunity
    • [57] Marth, J.D., Grewal, P.K., Mammalian glycosylation in immunity. Nat. Rev. Immunol. 8:11 (2008), 874–887.
    • (2008) Nat. Rev. Immunol. , vol.8 , Issue.11 , pp. 874-887
    • Marth, J.D.1    Grewal, P.K.2
  • 59
    • 43249130717 scopus 로고    scopus 로고
    • Flow cytometric immunophenotyping for hematologic neoplasms
    • [59] Craig, Fiona E., Foon, Kenneth A., Flow cytometric immunophenotyping for hematologic neoplasms. Blood 111 (2008), 3941–3967.
    • (2008) Blood , vol.111 , pp. 3941-3967
    • Craig, F.E.1    Foon, K.A.2
  • 60
    • 84938074563 scopus 로고    scopus 로고
    • Introduction to a series of reviews on chronic lymphocytic leukemia
    • [60] Byrd, John C., Introduction to a series of reviews on chronic lymphocytic leukemia. Blood, 126, 2015, 427.
    • (2015) Blood , vol.126 , pp. 427
    • Byrd, J.C.1
  • 61
    • 84959454423 scopus 로고    scopus 로고
    • The molecular pathogenesis of chronic lymphocytic leukaemia
    • [61] Fabbri, G., Dalla-Favera, R., The molecular pathogenesis of chronic lymphocytic leukaemia. Nat. Rev. Cancer 16 (2016), 145–162.
    • (2016) Nat. Rev. Cancer , vol.16 , pp. 145-162
    • Fabbri, G.1    Dalla-Favera, R.2
  • 62
    • 80052102768 scopus 로고    scopus 로고
    • Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL)
    • [62] Uhrmacher, S., Schmidt, C., Erdfelder, F., Poll-Wolbeck, S.J., Gehrke, I., Hallek, M., et al. Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL). Leuk. Res. 35:10 (2011), 1360–1366.
    • (2011) Leuk. Res. , vol.35 , Issue.10 , pp. 1360-1366
    • Uhrmacher, S.1    Schmidt, C.2    Erdfelder, F.3    Poll-Wolbeck, S.J.4    Gehrke, I.5    Hallek, M.6
  • 63
    • 84860912693 scopus 로고    scopus 로고
    • Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells
    • [63] Daneshmanesh, A., Hojjat-Farsangi, M., Khan, A., Jeddi-Tehrani, M., Akhondi, M., Bayat, A., et al. Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells. Leukemia 26:6 (2012), 1348–1355.
    • (2012) Leukemia , vol.26 , Issue.6 , pp. 1348-1355
    • Daneshmanesh, A.1    Hojjat-Farsangi, M.2    Khan, A.3    Jeddi-Tehrani, M.4    Akhondi, M.5    Bayat, A.6
  • 64
    • 34247594390 scopus 로고    scopus 로고
    • International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia
    • [64] Rawstron, A., Villamor, N., Ritgen, M., Böttcher, S., Ghia, P., Zehnder, J., et al. International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia 21:5 (2007), 956–964.
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 956-964
    • Rawstron, A.1    Villamor, N.2    Ritgen, M.3    Böttcher, S.4    Ghia, P.5    Zehnder, J.6
  • 65
    • 33747078748 scopus 로고    scopus 로고
    • Fludarabine in chronic lymphocytic leukaemia
    • [65] Elter, T., Hallek, M., Engert, A., Fludarabine in chronic lymphocytic leukaemia. Expert Opin. Pharmacother. 7:12 (2006), 1641–1651.
    • (2006) Expert Opin. Pharmacother. , vol.7 , Issue.12 , pp. 1641-1651
    • Elter, T.1    Hallek, M.2    Engert, A.3
  • 66
    • 84860907341 scopus 로고    scopus 로고
    • Targeting malignant B cells with an immunotoxin against ROR1
    • [66] Baskar, S., Wiestner, A., Wilson, W.H., Pastan, I., Rader, C., Targeting malignant B cells with an immunotoxin against ROR1. MAbs 4:May–June (3) (2012), 349–361.
    • (2012) MAbs , vol.4 , Issue.May–June (3) , pp. 349-361
    • Baskar, S.1    Wiestner, A.2    Wilson, W.H.3    Pastan, I.4    Rader, C.5
  • 67
    • 84927568982 scopus 로고    scopus 로고
    • Preclinical development of ROR1 peptide based vaccine with activity against chronic lymphocytic leukemia in ROR1 transgenic mice
    • [67] Cui, B., Widhopf, G.F., Chen, L., Rassenti, L., Wang, Z., Ma, S., et al. Preclinical development of ROR1 peptide based vaccine with activity against chronic lymphocytic leukemia in ROR1 transgenic mice. Blood, 122(21), 2013, 4174.
    • (2013) Blood , vol.122 , Issue.21 , pp. 4174
    • Cui, B.1    Widhopf, G.F.2    Chen, L.3    Rassenti, L.4    Wang, Z.5    Ma, S.6
  • 68
    • 84883759491 scopus 로고    scopus 로고
    • Active immunotherapy in HER2 overexpressing breast cancer: current status and future perspectives
    • [68] Milani, A., Sangiolo, D., Montemurro, F., Aglietta, M., Valabrega, G., Active immunotherapy in HER2 overexpressing breast cancer: current status and future perspectives. Ann. Oncol. 24:July (7) (2013), 1740–1748.
    • (2013) Ann. Oncol. , vol.24 , Issue.July (7) , pp. 1740-1748
    • Milani, A.1    Sangiolo, D.2    Montemurro, F.3    Aglietta, M.4    Valabrega, G.5
  • 69
    • 38949156617 scopus 로고    scopus 로고
    • Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia
    • [69] Baskar, S., Kwong, K.Y., Hofer, T., Levy, J.M., Kennedy, M.G., Lee, E., et al. Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 14:2 (2008), 396–404.
    • (2008) Clin. Cancer Res. , vol.14 , Issue.2 , pp. 396-404
    • Baskar, S.1    Kwong, K.Y.2    Hofer, T.3    Levy, J.M.4    Kennedy, M.G.5    Lee, E.6
  • 70
    • 84931053950 scopus 로고    scopus 로고
    • Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy
    • 941-5519 (7)
    • [70] Shabani, M., Naseri, J., Shokri, F., Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy. Expert Opin. Ther. Targets 19:July (7) (2015), 941–955 941-5519 (7).
    • (2015) Expert Opin. Ther. Targets , vol.19 , Issue.July (7) , pp. 941-955
    • Shabani, M.1    Naseri, J.2    Shokri, F.3
  • 71
    • 84889848914 scopus 로고    scopus 로고
    • Future prospects of monoclonal antibodies as magic bullets in immunotherapy
    • [71] Maleki, L.A., Baradaran, B., Majidi, J., Mohammadian, M., Shahneh, F.Z., Future prospects of monoclonal antibodies as magic bullets in immunotherapy. Hum. Antibodies 22:1–2 (2013), 9–13.
    • (2013) Hum. Antibodies , vol.22 , Issue.1-2 , pp. 9-13
    • Maleki, L.A.1    Baradaran, B.2    Majidi, J.3    Mohammadian, M.4    Shahneh, F.Z.5
  • 72
    • 84989306634 scopus 로고    scopus 로고
    • Phage display as a promising approach for vaccine development
    • [72] Aghebati-Maleki, L., Bakhshinejad, B., Baradaran, B., et al. Phage display as a promising approach for vaccine development. J. Biomed. Sci., 23, 2016, 66.
    • (2016) J. Biomed. Sci. , vol.23 , pp. 66
    • Aghebati-Maleki, L.1    Bakhshinejad, B.2    Baradaran, B.3
  • 73
    • 79958776633 scopus 로고    scopus 로고
    • Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies
    • [73] Yang, J., Baskar, S., Kwong, K.Y., Kennedy, M.G., Wiestner, A., Rader, C., Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies. PLoS One, 6(6), 2011, e21018.
    • (2011) PLoS One , vol.6 , Issue.6 , pp. e21018
    • Yang, J.1    Baskar, S.2    Kwong, K.Y.3    Kennedy, M.G.4    Wiestner, A.5    Rader, C.6
  • 74
    • 78349232462 scopus 로고    scopus 로고
    • Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases
    • [74] Bae, J.H., Schlessinger, J., Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases. Mol. Cells 29:5 (2010), 443–448.
    • (2010) Mol. Cells , vol.29 , Issue.5 , pp. 443-448
    • Bae, J.H.1    Schlessinger, J.2
  • 75
    • 0035864706 scopus 로고    scopus 로고
    • Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor
    • [75] Khoury, H., Dankort, D.L., Sadekova, S., Naujokas, M.A., Muller, W.J., Park, M., Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor. Oncogene 20:7 (2001), 788–799.
    • (2001) Oncogene , vol.20 , Issue.7 , pp. 788-799
    • Khoury, H.1    Dankort, D.L.2    Sadekova, S.3    Naujokas, M.A.4    Muller, W.J.5    Park, M.6
  • 76
    • 52049116971 scopus 로고    scopus 로고
    • CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation
    • [76] Noble, C., Mercer, K., Hussain, J., Carragher, L., Giblett, S., Hayward, R., et al. CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. Mol. Cell 31:6 (2008), 862–872.
    • (2008) Mol. Cell , vol.31 , Issue.6 , pp. 862-872
    • Noble, C.1    Mercer, K.2    Hussain, J.3    Carragher, L.4    Giblett, S.5    Hayward, R.6
  • 78
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • [78] Kalos, M., Levine, B.L., Porter, D.L., Katz, S., Grupp, S.A., Bagg, A., et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl. Med., 3(95), 2011, 95ra73.
    • (2011) Sci. Transl. Med. , vol.3 , Issue.95 , pp. 95ra73
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3    Katz, S.4    Grupp, S.A.5    Bagg, A.6
  • 79
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells
    • [79] Kochenderfer, J.N., Dudley, M.E., Feldman, S.A., Wilson, W.H., Spaner, D.E., Maric, I., et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells. Blood 119:12 (2012), 2709–2720.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3    Wilson, W.H.4    Spaner, D.E.5    Maric, I.6
  • 80
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
    • [80] Kochenderfer, J.N., Wilson, W.H., Janik, J.E., Dudley, M.E., Stetler-Stevenson, M., Feldman, S.A., et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 116:20 (2010), 4099–4102.
    • (2010) Blood , vol.116 , Issue.20 , pp. 4099-4102
    • Kochenderfer, J.N.1    Wilson, W.H.2    Janik, J.E.3    Dudley, M.E.4    Stetler-Stevenson, M.5    Feldman, S.A.6
  • 81
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • [81] Morgan, R.A., Dudley, M.E., Wunderlich, J.R., Hughes, M.S., Yang, J.C., Sherry, R.M., et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314:5796 (2006), 126–129.
    • (2006) Science , vol.314 , Issue.5796 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3    Hughes, M.S.4    Yang, J.C.5    Sherry, R.M.6
  • 82
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • [82] Porter, D.L., Levine, B.L., Kalos, M., Bagg, A., June, C.H., Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. New Engl. J. Med. 365:8 (2011), 725–733.
    • (2011) New Engl. J. Med. , vol.365 , Issue.8 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 83
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
    • [83] Eshhar, Z., Waks, T., Gross, G., Schindler, D.G., Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc. Natl. Acad. Sci. U. S. A. 90:2 (1993), 720–724.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , Issue.2 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 84
    • 28544448646 scopus 로고    scopus 로고
    • Supernatural T cells: genetic modification of T cells for cancer therapy
    • [84] Kershaw, M.H., Teng, M.W., Smyth, M.J., Darcy, P.K., Supernatural T cells: genetic modification of T cells for cancer therapy. Nat. Rev. Immunol. 5:12 (2005), 928–940.
    • (2005) Nat. Rev. Immunol. , vol.5 , Issue.12 , pp. 928-940
    • Kershaw, M.H.1    Teng, M.W.2    Smyth, M.J.3    Darcy, P.K.4
  • 85
    • 0037264471 scopus 로고    scopus 로고
    • Targeting tumours with genetically enhanced T lymphocytes
    • [85] Sadelain, M., Rivière, I., Brentjens, R., Targeting tumours with genetically enhanced T lymphocytes. Nat. Rev. Cancer 3:1 (2003), 35–45.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.1 , pp. 35-45
    • Sadelain, M.1    Rivière, I.2    Brentjens, R.3
  • 86
    • 84933510694 scopus 로고    scopus 로고
    • CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
    • [86] Maude, Shannon L., Teachey, David T., Porter, David L., Grupp, Stephan A., CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood 125 (2015), 4017–4023.
    • (2015) Blood , vol.125 , pp. 4017-4023
    • Maude, S.L.1    Teachey, D.T.2    Porter, D.L.3    Grupp, S.A.4
  • 87
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • [87] Brentjens, R.J., Rivière, I., Park, J.H., Davila, M.L., Wang, X., Stefanski, J., et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 118:18 (2011), 4817–4828.
    • (2011) Blood , vol.118 , Issue.18 , pp. 4817-4828
    • Brentjens, R.J.1    Rivière, I.2    Park, J.H.3    Davila, M.L.4    Wang, X.5    Stefanski, J.6
  • 88
    • 84879480191 scopus 로고    scopus 로고
    • Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
    • [88] Hudecek, M., Lupo-Stanghellini, M.-T., Kosasih, P.L., Sommermeyer, D., Jensen, M.C., Rader, C., et al. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Clin. Cancer Res. 19:12 (2013), 3153–3164.
    • (2013) Clin. Cancer Res. , vol.19 , Issue.12 , pp. 3153-3164
    • Hudecek, M.1    Lupo-Stanghellini, M.-T.2    Kosasih, P.L.3    Sommermeyer, D.4    Jensen, M.C.5    Rader, C.6
  • 89
    • 0036216405 scopus 로고    scopus 로고
    • (Gleevec) as a paradigm for cancer therapy
    • [89] STI571, B.J.D., (Gleevec) as a paradigm for cancer therapy. Trends Mol. Med 8:4 Suppl (2002), S14–8.
    • (2002) Trends Mol. Med , vol.8 , Issue.4 , pp. S14-8
    • STI571, B.J.D.1
  • 90
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • [90] Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351:Pt 1 (2000), 95–105.
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3
  • 91
    • 84891317257 scopus 로고    scopus 로고
    • Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation
    • [91] Narayanan, R., Yepuru, M., Coss, C.C., et al. Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation. PLoS One, 8(12), 2013, e83380.
    • (2013) PLoS One , vol.8 , Issue.12 , pp. e83380
    • Narayanan, R.1    Yepuru, M.2    Coss, C.C.3
  • 92
    • 84883160397 scopus 로고    scopus 로고
    • Ibrutinib and novel BTK inhibitors in clinical development
    • [92] Akinleye, A., Chen, Y., Mukhi, N., et al. Ibrutinib and novel BTK inhibitors in clinical development. J. Hematol. Oncol., 6, 2013, 59.
    • (2013) J. Hematol. Oncol. , vol.6 , pp. 59
    • Akinleye, A.1    Chen, Y.2    Mukhi, N.3
  • 93
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI- 32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • [93] Ponader, S., Chen, S.S., Buggy, J.J., et al. The Bruton tyrosine kinase inhibitor PCI- 32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 119:5 (2012), 1182–1189.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1182-1189
    • Ponader, S.1    Chen, S.S.2    Buggy, J.J.3
  • 95
    • 84890063283 scopus 로고    scopus 로고
    • Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2
    • [95] O'Connell, M.P., Marchbank, K., Webster, M.R., Valiga, A.A., Kaur, A., Vultur, A., et al. Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. Cancer Discov. 3:12 (2013), 1378–1393.
    • (2013) Cancer Discov. , vol.3 , Issue.12 , pp. 1378-1393
    • O'Connell, M.P.1    Marchbank, K.2    Webster, M.R.3    Valiga, A.A.4    Kaur, A.5    Vultur, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.