Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway

Journal of Neuroimmunology

Volumn 305, Issue , 2017, Pages 108-114

  Chen, Jingkao ^a,b,d   Sun, Zhaowei ^a,b   Jin, Minghua ^a   Tu, Yalin ^a,b   Wang, Shengnan ^a,b   Yang, Xiaohong ^a,b   Chen, Qiuhe ^a,b   Zhang, Xiao ^a,b   Han, Yifan ^b,c   Pi, Rongbiao ^a,b,d  

^a SUN YAT SEN UNIVERSITY   (China)

^b International Joint Laboratory (SYSU PolyU HK) of Novel Anti Dementia Drugs of Guangdong   (China)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Advanced glycation end products; Alzheimer's disease; BV2 cells; Neuroinflammation; Rho kinase

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTIGEN; CD16 ANTIGEN; CD206 ANTIGEN; CD32 ANTIGEN; CRYOPYRIN; CYCLOOXYGENASE 2; FASUDIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; RHO KINASE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; BENZAMIDE DERIVATIVE; CALCIUM BINDING PROTEIN; CARDIAC MYOSIN; CYTOKINE; FPS-ZM1; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN 2; PROTEIN KINASE INHIBITOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BV2 CELL LINE; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; MACROPHAGE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PATHOGENESIS; PHENOTYPE; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL POLARITY; CLASSIFICATION; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSFORMED CELL LINE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BENZAMIDES; CALCIUM-BINDING PROTEINS; CARDIAC MYOSINS; CELL LINE, TRANSFORMED; CELL POLARITY; CYCLOOXYGENASE 2; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSYLATION END PRODUCTS, ADVANCED; MICE; MICROFILAMENT PROTEINS; MICROGLIA; MYOSIN LIGHT CHAINS; NF-KAPPA B; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 85012292965     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2017.02.010     Document Type: Article

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