Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models

Translational Psychiatry

Volumn 7, Issue 1, 2017, Pages

  Cacciottolo, M ^a   Wang, X ^b   Driscoll, I ^c   Woodward, N ^a   Saffari, A ^d   Reyes, J ^e   Serre, M L ^e   Vizuete, W ^e   Sioutas, C ^d   Morgan, T E ^a   Gatz, M ^a,b   Chui, H C ^b   Shumaker, S A ^f   Resnick, S M ^g   Espeland, M A ^f   Finch, C E ^a,b   Chen, J C ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^d University of Southern California   (United States)

^e University of North Carolina at Chapel Hill   (United States)

^f WAKE FOREST SCHOOL OF MEDICINE   (United States)

^g NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; GLUTAMATE RECEPTOR 1; THIOFLAVINE; AMPA RECEPTOR; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1;

AGED; AGING; AIR POLLUTANT; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ATROPHY; C57BL 6 MOUSE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HIPPOCAMPAL CA1 REGION; HUMAN; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MOUSE; NEURITE; NEURO-2A CELL LINE; NEUROBLASTOMA; NEUROPATHOLOGY; NONHUMAN; PARTICULATE MATTER; PROTEIN PROCESSING; TRANSGENIC MOUSE; WILD TYPE MOUSE; ALZHEIMER DISEASE; ANIMAL; ATROPHY; DEMENTIA; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; METABOLISM; PATHOLOGY; STATISTICS AND NUMERICAL DATA; TUMOR CELL LINE;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOLIPOPROTEIN E4; ATROPHY; CA1 REGION, HIPPOCAMPAL; CELL LINE, TUMOR; CEREBRUM; COGNITIVE DYSFUNCTION; DEMENTIA; ENVIRONMENTAL EXPOSURE; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; IN VITRO TECHNIQUES; MICE; MICE, TRANSGENIC; NEURITES; PARTICULATE MATTER; RECEPTORS, AMPA;

EID: 85012247798     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2016.280     Document Type: Article

References (60)

1. Selkoe DJ. Preventing Alzheimer's disease. Science 2012; 337: 1488-1492.
2. Farrer LA. Expanding the genomic roadmap of Alzheimer's disease. Lancet Neurol 2015; 14: 783-785.
3. Dekosky ST, Gandy S. Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns? JAMA Neurol 2014; 71: 273-275.
4. Karagulian F, Belis CA, Dora CFC, Pruss-Ustun AM, Bonjour S, Adair-Rohani H et al. Contributions to cities' ambient particulate matter (PM): A systematic review of local source contributions at global level. Atmos Environ 2015; 120: 475-483.
5. Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC et al. The Outdoor Air Pollution and Brain Health Workshop. Neurotoxicology 2012; 33: 972-984.
6. Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S et al. Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology. Mol Psychiatry 2011; 16: 987-995, 973.
7. West MJ, Kawas CH, Stewart WF, Rudow GL, Troncoso JC. Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiol Aging 2004; 25: 1205-1212.
8. Morgan TE, Davis DA, Iwata N, Tanner JA, Snyder D, Ning Z et al. Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. Environ Health Perspect 2011; 119: 1003-1009.
9. Durga M, Devasena T, Rajasekar A. Determination of LC and sub-chronic neurotoxicity of diesel exhaust nanoparticles. Environ Toxicol Pharmacol 2015; 40: 615-625.
10. Levesque S, Surace MJ, McDonald J, Block ML. Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease. J Neuroinflamm 2011; 8: 105.
11. Bhatt DP, Puig KL, Gorr MW, Wold LE, Combs CK. A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain. PLoS ONE 2015; 10: e0127102.
12. Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R et al. Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study. Ann Neurol 2015; 78: 466-476.
13. Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M et al. APOE4-specific changes in Abeta accumulation in a new transgenic mouse model of Alzheimer disease. The Journal of biological chemistry 2012; 287: 41774-41786.
14. Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J et al. Intraneuronal betaamyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006; 26: 10129-10140.
15. Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C et al. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiology of aging 2016; 37: 47-57.
16. Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM et al. APOE4 enhances agedependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener 2015; 10: 7.
17. Clougherty JE. A growing role for gender analysis in air pollution epidemiology. Environ Health Perspect 2010; 118: 167-176.
18. Liu R, Young MT, Chen JC, Kaufman JD, Chen H. Ambient Air Pollution Exposures and Risk of Parkinson Disease. Environ Health Perspect 2016; 124: 1759-1765.
19. Boyd-Kimball D, Sultana R, Mohmmad-Abdul H, Butterfield DA. Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta(1-42): Implications for proposed mechanisms of toxicity. J Alzheimers Dis 2004; 6: 515-525.
20. Hick M, Herrmann U, Weyer SW, Mallm JP, Tschape JA, Borgers M et al. Acute function of secreted amyloid precursor protein fragment APPsalpha in synaptic plasticity. Acta Neuropathol 2015; 129: 21-37.
21. Weyer SW, Zagrebelsky M, Herrmann U, Hick M, Ganss L, Gobbert J et al. Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression. Acta Neuropathol Commun 2014; 2: 36.
22. Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004; 291: 2947-2958.
23. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 1987; 48: 314-318.
24. Rapp SR, Espeland MA, Shumaker SA, Henderson VW, Brunner RL, Manson JE et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003; 289: 2663-2672.
25. Christakos G, BP SMB. Temporal GIS: Advanced Functions for Field-based Applications. Springer: New York, 2001.
26. Griffin BA, Anderson GL, Shih RA, Whitsel EA. Use of alternative time scales in Cox proportional hazard models: implications for time-varying environmental exposures. Stat Med 2012; 31: 3320-3327.
27. Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994; 81: 515-526.
28. Liu Q, Babadjouni R, Radwanski R, Cheng H, Patel A, Hodis DM et al. Stroke damage is exacerbated by nano-size particulate matter in a mouse model. PLoS ONE 2016; 11: e0153376.
29. de Olmos JS, Beltramino CA, de Olmos de Lorenzo S. Use of an amino-cupric-silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia, and physical trauma. Neurotoxicol Teratol 1994; 16: 545-561.
30. Environmental Protection Agency (EPA). National Ambient Air Quality Standards for Particulate Matter; Proposed Rule, Vol. 77. Federal Register: Washington, DC, 2012, pp 38890-39055.
31. Whitcomb DJ, Hogg EL, Regan P, Piers T, Narayan P, Whitehead G et al. Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus. Sci Rep 2015; 5: 10934.
32. Ailshire JA, Crimmins EM. Fine particulate matter air pollution and cognitive function among older US adults. Am J Epidemiol 2014; 180: 359-366.
33. Gatto NM, Henderson VW, Hodis HN St, John JA, Lurmann F, Chen JC et al. Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles. Neurotoxicology 2014; 40: 1-7.
34. Tonne C, Elbaz A, Beevers S, Singh-Manoux A. Traffic-related air pollution in relation to cognitive function in older adults. Epidemiology 2014; 25: 674-681.
35. Weuve J, Puett RC, Schwartz J, Yanosky JD, Laden F, Grodstein F. Exposure to particulate air pollution and cognitive decline in older women. Arch Intern Med 2012; 172: 219-227.
36. Wu Y-C, Lin Y-C, Yu H-L, Chen J-H, Chen T-F, Sun Y et al. Association between air pollutants and dementia risk in the elderly. Alzheimers Dement 2015; 1: 220-228.
37. Oudin A, Forsberg B, Adolfsson AN, Lind N, Modig L, Nordin M et al. Traffic-related air pollution and dementia incidence in Northern Sweden: a Longitudinal Study. Environ Health Perspect 2016; 124: 306-312.
38. Kioumourtzoglou MA, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F et al. Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States. Environ Health Perspect 2016; 124: 23-29.
39. Jung CR, Lin YT, Hwang BF. Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. Journal of Alzheimer's disease: JAD 2015; 44: 573-584.
40. Chang KH, Chang MY, Muo CH, Wu TN, Chen CY, Kao CH. Increased risk of dementia in patients exposed to nitrogen dioxide and carbon monoxide: a population-based retrospective cohort study. PLoS ONE 2014; 9: e103078.
41. Kioumourtzoglou MA, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F et al. Long-term PM exposure and neurological hospital admissions in the Northeastern United States. Environ Health Perspect 2015; 124: 23-29.
42. Taylor DH Jr, Fillenbaum GG, Ezell ME. The accuracy of medicare claims data in identifying Alzheimer's disease. J Clin Epidemiol 2002; 55: 929-937.
43. Hayden KM, Farmer KM. Invited commentary: The importance of studying environmental risk factors for dementia. Alzheimers Dement 2015; 1: 268-269.
44. Langa KM. Is the risk of Alzheimer's disease and dementia declining? Alzheimers Res Ther 2015; 7: 34.
45. Barendregt JJ, Veerman JL. Categorical versus continuous risk factors and the calculation of potential impact fractions. J Epidemiol Community Health 2010; 64: 209-212.
46. Kim SH, Knight EM, Saunders EL, Cuevas AK, Popovech M, Chen LC et al. Rapid doubling of Alzheimer's amyloid-beta40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution. F1000Research 2012; 1: 70.
47. Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O et al. Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. Lancet Neurol 2013; 12: 357-367.
48. Squire LR, Zola-Morgan S. The medial temporal lobe memory system. Science 1991; 253: 1380-1386.
49. Jagust W. Vulnerable neural systems and the borderland of brain aging and neurodegeneration. Neuron 2013; 77: 219-234.
50. Allen JL, Oberdorster G, Morris-Schaffer K, Wong C, Klocke C, Sobolewski M et al. Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders. Neurotoxicology 2015. pii: S0161-813X(15)30048-6. doi: 10.1016/j.neuro.2015.12.014.
51. Peterson BS, Rauh VA, Bansal R, Hao X, Toth Z, Nati G et al. Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry 2015; 72: 531-540.
52. Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W et al. A voxel-based morphometry study reveals local brain structural alterations associated with ambient fine particles in older women. Front Hum Neurosci 2016; 10: 495.
53. Braak H, Thal DR, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 2011; 70: 960-969.
54. Zarow C, Vinters HV, Ellis WG, Weiner MW, Mungas D, White L et al. Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia. Ann Neurol 2005; 57: 896-903.
55. Adami HO, Berry SC, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D et al. Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference. Toxicol Sci 2011; 122: 223-234.
56. Matthews JN, Altman DG. Statistics notes. Interaction 2: Compare effect sizes not P values. BMJ 1996; 313: 808.
57. Ward A, Crean S, Mercaldi CJ, Collins JM, Boyd D, Cook MN et al. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology 2012; 38: 1-17.
58. Prince M, Acosta D, Ferri CP, Guerra M, Huang Y, Llibre Rodriguez JJ et al. Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. Lancet 2012; 380: 50-58.
59. Calderon-Garciduenas L, Kavanaugh M, Block M, D'Angiulli A, Delgado-Chavez R, Torres-Jardon R et al. Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults. J Alzheimers Dis 2012; 28: 93-107.
60. Schikowski T, Vossoughi M, Vierkotter A, Schulte T, Teichert T, Sugiri D et al. Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women. Environ Res 2015; 142: 10-16.