메뉴 건너뛰기




Volumn 45, Issue , 2017, Pages 52-59

Oncogenic growth factor signaling mediating tumor escape from cellular immunity

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HLA ANTIGEN CLASS 1; PROGRAMMED DEATH 1 LIGAND 1; TUMOR ANTIGEN;

EID: 85012180618     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2017.01.004     Document Type: Review
Times cited : (16)

References (59)
  • 1
    • 33751328082 scopus 로고    scopus 로고
    • ErbB receptors: new insights on mechanisms and biology
    • 1 Linggi, B., Carpenter, G., ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol 16 (2006), 649–656.
    • (2006) Trends Cell Biol , vol.16 , pp. 649-656
    • Linggi, B.1    Carpenter, G.2
  • 2
    • 1242315584 scopus 로고    scopus 로고
    • Signal transduction and oncogenesis by ErbB/HER receptors
    • 2 Marmor, M.D., Skaria, K.B., Yarden, Y., Signal transduction and oncogenesis by ErbB/HER receptors. Int J Radiat Oncol Biol Phys 58 (2004), 903–913.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 903-913
    • Marmor, M.D.1    Skaria, K.B.2    Yarden, Y.3
  • 3
    • 33645130990 scopus 로고    scopus 로고
    • Signaling through ERBB receptors: multiple layers of diversity and control
    • 3 Warren, C.M., Landgraf, R., Signaling through ERBB receptors: multiple layers of diversity and control. Cell Signal 18 (2006), 923–933.
    • (2006) Cell Signal , vol.18 , pp. 923-933
    • Warren, C.M.1    Landgraf, R.2
  • 4
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 4 Hanahan, D., Weinberg, R.A., The hallmarks of cancer. Cell 100 (2000), 57–70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • 5 Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0034638925 scopus 로고    scopus 로고
    • Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
    • 6 Harari, D., Yarden, Y., Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene 19 (2000), 6102–6114.
    • (2000) Oncogene , vol.19 , pp. 6102-6114
    • Harari, D.1    Yarden, Y.2
  • 7
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • 7 Blume-Jensen, P., Hunter, T., Oncogenic kinase signalling. Nature 411 (2001), 355–365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 8
    • 0025194462 scopus 로고
    • Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function
    • 8 Wada, T., Qian, X.L., Greene, M.I., Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function. Cell 61 (1990), 1339–1347.
    • (1990) Cell , vol.61 , pp. 1339-1347
    • Wada, T.1    Qian, X.L.2    Greene, M.I.3
  • 9
    • 84886089551 scopus 로고    scopus 로고
    • The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered
    • 9 Gan, H.K., Cvrljevic, A.N., Johns, T.G., The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J 280 (2013), 5350–5370.
    • (2013) FEBS J , vol.280 , pp. 5350-5370
    • Gan, H.K.1    Cvrljevic, A.N.2    Johns, T.G.3
  • 10
    • 84875950992 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease
    • 10 Ohashi, K., Maruvka, Y.E., Michor, F., Pao, W., Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease. J Clin Oncol 31 (2013), 1070–1080.
    • (2013) J Clin Oncol , vol.31 , pp. 1070-1080
    • Ohashi, K.1    Maruvka, Y.E.2    Michor, F.3    Pao, W.4
  • 11
    • 44449127592 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family: biology driving targeted therapeutics
    • 11 Wieduwilt, M.J., Moasser, M.M., The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci 65 (2008), 1566–1584.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1566-1584
    • Wieduwilt, M.J.1    Moasser, M.M.2
  • 12
    • 0141599428 scopus 로고    scopus 로고
    • Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
    • 12 Stamos, J., Sliwkowski, M.X., Eigenbrot, C., Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J Biol Chem 277 (2002), 46265–46272.
    • (2002) J Biol Chem , vol.277 , pp. 46265-46272
    • Stamos, J.1    Sliwkowski, M.X.2    Eigenbrot, C.3
  • 13
    • 33847406095 scopus 로고    scopus 로고
    • Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
    • 13 Yun, C.H., Boggon, T.J., Li, Y., Woo, M.S., Greulich, H., Meyerson, M., Eck, M.J., Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell 11 (2007), 217–227.
    • (2007) Cancer Cell , vol.11 , pp. 217-227
    • Yun, C.H.1    Boggon, T.J.2    Li, Y.3    Woo, M.S.4    Greulich, H.5    Meyerson, M.6    Eck, M.J.7
  • 15
    • 17644413210 scopus 로고    scopus 로고
    • Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome
    • 15 Meissner, M., Reichert, T.E., Kunkel, M., Gooding, W., Whiteside, T.L., Ferrone, S., Seliger, B., Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome. Clin Cancer Res 11 (2005), 2552–2560.
    • (2005) Clin Cancer Res , vol.11 , pp. 2552-2560
    • Meissner, M.1    Reichert, T.E.2    Kunkel, M.3    Gooding, W.4    Whiteside, T.L.5    Ferrone, S.6    Seliger, B.7
  • 16
    • 33644839506 scopus 로고    scopus 로고
    • Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL
    • 16 Lopez-Albaitero, A., Nayak, J.V., Ogino, T., Machandia, A., Gooding, W., DeLeo, A.B., Ferrone, S., Ferris, R.L., Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL. J Immunol 176 (2006), 3402–3409.
    • (2006) J Immunol , vol.176 , pp. 3402-3409
    • Lopez-Albaitero, A.1    Nayak, J.V.2    Ogino, T.3    Machandia, A.4    Gooding, W.5    DeLeo, A.B.6    Ferrone, S.7    Ferris, R.L.8
  • 17
    • 84874099238 scopus 로고    scopus 로고
    • SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells
    • 17 Leibowitz, M.S., Srivastava, R.M., Andrade Filho, P.A., Egloff, A.M., Wang, L., Seethala, R.R., Ferrone, S., Ferris, R.L., SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells. Clin Cancer Res 19 (2013), 798–808.
    • (2013) Clin Cancer Res , vol.19 , pp. 798-808
    • Leibowitz, M.S.1    Srivastava, R.M.2    Andrade Filho, P.A.3    Egloff, A.M.4    Wang, L.5    Seethala, R.R.6    Ferrone, S.7    Ferris, R.L.8
  • 18
    • 84886949455 scopus 로고    scopus 로고
    • The two sides of HER2/neu: immune escape versus surveillance
    • 18 Seliger, B., Kiessling, R., The two sides of HER2/neu: immune escape versus surveillance. Trends Mol Med 19 (2013), 677–684.
    • (2013) Trends Mol Med , vol.19 , pp. 677-684
    • Seliger, B.1    Kiessling, R.2
  • 19
    • 0142059890 scopus 로고    scopus 로고
    • Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling
    • 19 Agazie, Y.M., Hayman, M.J., Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol Cell Biol 23 (2003), 7875–7886.
    • (2003) Mol Cell Biol , vol.23 , pp. 7875-7886
    • Agazie, Y.M.1    Hayman, M.J.2
  • 20
    • 84885816614 scopus 로고    scopus 로고
    • Vemurafenib enhances MHC induction in BRAFV600E homozygous melanoma cells
    • 20 Sapkota, B., Hill, C.E., Pollack, B.P., Vemurafenib enhances MHC induction in BRAFV600E homozygous melanoma cells. Oncoimmunology, 2, 2013, e22890.
    • (2013) Oncoimmunology , vol.2 , pp. e22890
    • Sapkota, B.1    Hill, C.E.2    Pollack, B.P.3
  • 21
    • 84896702989 scopus 로고    scopus 로고
    • EGFR-mediated tumor immunoescape: the imbalance between phosphorylated STAT1 and phosphorylated STAT3
    • 21 Concha-Benavente, F., Srivastava, R.M., Ferrone, S., Ferris, R.L., EGFR-mediated tumor immunoescape: the imbalance between phosphorylated STAT1 and phosphorylated STAT3. Oncoimmunology, 2, 2013, e27215.
    • (2013) Oncoimmunology , vol.2 , pp. e27215
    • Concha-Benavente, F.1    Srivastava, R.M.2    Ferrone, S.3    Ferris, R.L.4
  • 22
    • 84961992269 scopus 로고    scopus 로고
    • STAT1-induced HLA class I upregulation enhances immunogenicity and clinical response to anti-EGFR mAb cetuximab therapy in HNC patients
    • Authors demostrate that EGFR induces HLA class I downregulation via SHP2-STAT1 suppression, EGFR blockade with cetuximab induced upregulation of IFNγ receptor, STAT1 activation and upregulation of HLA-B/C alleles more than HLA-A alleles. HLA class I upregulation was significantly associated with clincal response to cetuximab in a single agent neo-adjuvant phase II clinical trial.
    • 22• Srivastava, R.M., Trivedi, S., Concha-Benavente, F., Hyun-Bae, J., Wang, L., Seethala, R.R., Branstetter, BFT, Ferrone, S., Ferris, R.L., STAT1-induced HLA class I upregulation enhances immunogenicity and clinical response to anti-EGFR mAb cetuximab therapy in HNC patients. Cancer Immunol Res 3 (2015), 936–945 Authors demostrate that EGFR induces HLA class I downregulation via SHP2-STAT1 suppression, EGFR blockade with cetuximab induced upregulation of IFNγ receptor, STAT1 activation and upregulation of HLA-B/C alleles more than HLA-A alleles. HLA class I upregulation was significantly associated with clincal response to cetuximab in a single agent neo-adjuvant phase II clinical trial.
    • (2015) Cancer Immunol Res , vol.3 , pp. 936-945
    • Srivastava, R.M.1    Trivedi, S.2    Concha-Benavente, F.3    Hyun-Bae, J.4    Wang, L.5    Seethala, R.R.6    Branstetter, B.F.T.7    Ferrone, S.8    Ferris, R.L.9
  • 23
    • 0033827817 scopus 로고    scopus 로고
    • Antigen-processing machinery breakdown and tumor growth
    • 23 Seliger, B., Maeurer, M.J., Ferrone, S., Antigen-processing machinery breakdown and tumor growth. Immunol Today 21 (2000), 455–464.
    • (2000) Immunol Today , vol.21 , pp. 455-464
    • Seliger, B.1    Maeurer, M.J.2    Ferrone, S.3
  • 24
    • 33745813122 scopus 로고    scopus 로고
    • Defective human leukocyte antigen class I-associated antigen presentation caused by a novel beta2-microglobulin loss-of-function in melanoma cells
    • 24 Chang, C.C., Ogino, T., Mullins, D.W., Oliver, J.L., Yamshchikov, G.V., Bandoh, N., Slingluff, C.L. Jr., Ferrone, S., Defective human leukocyte antigen class I-associated antigen presentation caused by a novel beta2-microglobulin loss-of-function in melanoma cells. J Biol Chem 281 (2006), 18763–18773.
    • (2006) J Biol Chem , vol.281 , pp. 18763-18773
    • Chang, C.C.1    Ogino, T.2    Mullins, D.W.3    Oliver, J.L.4    Yamshchikov, G.V.5    Bandoh, N.6    Slingluff, C.L.7    Ferrone, S.8
  • 26
    • 0032213456 scopus 로고    scopus 로고
    • Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors
    • 26 Zaks, T.Z., Rosenberg, S.A., Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors. Cancer Res 58 (1998), 4902–4908.
    • (1998) Cancer Res , vol.58 , pp. 4902-4908
    • Zaks, T.Z.1    Rosenberg, S.A.2
  • 27
    • 0344825125 scopus 로고    scopus 로고
    • Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines
    • 27 Choudhury, A., Charo, J., Parapuram, S.K., Hunt, R.C., Hunt, D.M., Seliger, B., Kiessling, R., Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines. Int J Cancer 108 (2004), 71–77.
    • (2004) Int J Cancer , vol.108 , pp. 71-77
    • Choudhury, A.1    Charo, J.2    Parapuram, S.K.3    Hunt, R.C.4    Hunt, D.M.5    Seliger, B.6    Kiessling, R.7
  • 29
    • 77957256424 scopus 로고    scopus 로고
    • Identification of E2F1 as an important transcription factor for the regulation of tapasin expression
    • 29 Bukur, J., Herrmann, F., Handke, D., Recktenwald, C., Seliger, B., Identification of E2F1 as an important transcription factor for the regulation of tapasin expression. J Biol Chem 285 (2010), 30419–30426.
    • (2010) J Biol Chem , vol.285 , pp. 30419-30426
    • Bukur, J.1    Herrmann, F.2    Handke, D.3    Recktenwald, C.4    Seliger, B.5
  • 36
    • 84908669117 scopus 로고    scopus 로고
    • Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer
    • 36 Kimura, Y., Oki, E., Yoshida, A., Aishima, S., Zaitsu, Y., Ohtsu, H., Ando, K., Ida, S., Saeki, H., Morita, M., et al. Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer. Anticancer Res 34 (2014), 4207–4212.
    • (2014) Anticancer Res , vol.34 , pp. 4207-4212
    • Kimura, Y.1    Oki, E.2    Yoshida, A.3    Aishima, S.4    Zaitsu, Y.5    Ohtsu, H.6    Ando, K.7    Ida, S.8    Saeki, H.9    Morita, M.10
  • 38
    • 84961696245 scopus 로고    scopus 로고
    • Identification of the cell-intrinsic and -extrinsic pathways downstream of EGFR and IFNgamma that induce PD-L1 expression in head and neck cancer
    • Authors identify tumor cell extrinsic (IFNγ mediated) and intrinsic (EGFR mediated) pathways that induce PD-L1 expression. Importantly, these pathways use JAK2/STAT1 as a common signaling pathway for PD-L1 upregulation. This is the first study that reports the signaling pathway that induces PD-L1 expression downstream wild type EGFR. These findings are clinically relevant since EGFR expression in large cohort of head and neck quamous cell carcinoma specimens (TCGA,n = 500) significantly correlated with JAK2 and PD-L1 expression. Specific JAK2 inhibition prevented IFNγ and EGFR induced PD-L1 upregulation.
    • 38• Concha-Benavente, F., Srivastava, R.M., Trivedi, S., Lei, Y., Chandran, U., Seethala, R.R., Freeman, G.J., Ferris, R.L., et al. Identification of the cell-intrinsic and -extrinsic pathways downstream of EGFR and IFNgamma that induce PD-L1 expression in head and neck cancer. Cancer Res 76 (2016), 1031–1043 Authors identify tumor cell extrinsic (IFNγ mediated) and intrinsic (EGFR mediated) pathways that induce PD-L1 expression. Importantly, these pathways use JAK2/STAT1 as a common signaling pathway for PD-L1 upregulation. This is the first study that reports the signaling pathway that induces PD-L1 expression downstream wild type EGFR. These findings are clinically relevant since EGFR expression in large cohort of head and neck quamous cell carcinoma specimens (TCGA,n = 500) significantly correlated with JAK2 and PD-L1 expression. Specific JAK2 inhibition prevented IFNγ and EGFR induced PD-L1 upregulation.
    • (2016) Cancer Res , vol.76 , pp. 1031-1043
    • Concha-Benavente, F.1    Srivastava, R.M.2    Trivedi, S.3    Lei, Y.4    Chandran, U.5    Seethala, R.R.6    Freeman, G.J.7    Ferris, R.L.8
  • 40
    • 84904267255 scopus 로고    scopus 로고
    • Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma
    • 40 McBride, S.M., Rothenberg, S.M., Faquin, W.C., Chan, A.W., Clark, J.R., Ellisen, L.W., Wirth, L.J., Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma. Head Neck 36 (2014), 1181–1188.
    • (2014) Head Neck , vol.36 , pp. 1181-1188
    • McBride, S.M.1    Rothenberg, S.M.2    Faquin, W.C.3    Chan, A.W.4    Clark, J.R.5    Ellisen, L.W.6    Wirth, L.J.7
  • 41
    • 84923197605 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of head and neck squamous cell carcinomas
    • Characterization of 279 head and neck squamous cell carcinoma specimens identified important mutations in different subsets of patients. HPV-positive patients had PIK3CA, TRAF3 loss-of-function mutations. Smokers had TP53, CDKN2A inactivating mutations. Patients with favourable clinical outcomes had activating mutations of HRAS or PIK3CA coupled with inactivating mutations in CASP8, NOTCH1 and TP53. Importantly, this study identifies altered pathways that are elegible for therapeutic targets.
    • 41•• The Cancer Genome Atlas Network, Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517 (2015), 576–582 Characterization of 279 head and neck squamous cell carcinoma specimens identified important mutations in different subsets of patients. HPV-positive patients had PIK3CA, TRAF3 loss-of-function mutations. Smokers had TP53, CDKN2A inactivating mutations. Patients with favourable clinical outcomes had activating mutations of HRAS or PIK3CA coupled with inactivating mutations in CASP8, NOTCH1 and TP53. Importantly, this study identifies altered pathways that are elegible for therapeutic targets.
    • (2015) Nature , vol.517 , pp. 576-582
    • The Cancer Genome Atlas Network1
  • 42
    • 84983216790 scopus 로고    scopus 로고
    • Mutations associated with acquired resistance to PD-1 blockade in melanoma
    • Authors describe critical loss-of-function mutations in the IFNγ receptor pathway that are associated to resistance to anti-PD-1 therapy in melanoma patients. JAK1, JAK2 and B2M inactivating mutations were reported in specimens from patients who relapsed after anti-PD1 therapy with pembrolizumab.
    • 42•• Zaretsky, J.M., Garcia-Diaz, A., Shin, D.S., Escuin-Ordinas, H., Hugo, W., Hu-Lieskovan, S., Torrejon, D.Y., Abril-Rodriguez, G., Sandoval, S., Barthly, L., et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med 375 (2016), 819–829 Authors describe critical loss-of-function mutations in the IFNγ receptor pathway that are associated to resistance to anti-PD-1 therapy in melanoma patients. JAK1, JAK2 and B2M inactivating mutations were reported in specimens from patients who relapsed after anti-PD1 therapy with pembrolizumab.
    • (2016) N Engl J Med , vol.375 , pp. 819-829
    • Zaretsky, J.M.1    Garcia-Diaz, A.2    Shin, D.S.3    Escuin-Ordinas, H.4    Hugo, W.5    Hu-Lieskovan, S.6    Torrejon, D.Y.7    Abril-Rodriguez, G.8    Sandoval, S.9    Barthly, L.10
  • 44
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • Comprehensive review of different checkpoint receptors and ligands expressed in the tumor microenvironment, drugs that have been FDA approved targeting CTLA-4, PD-1, PD-L1, mechanism of tumor resistance to innate and adaptive immunity and candidate combination therapies are discussed.
    • 44• Topalian, S.L., Drake, C.G., Pardoll, D.M., Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27 (2015), 450–461 Comprehensive review of different checkpoint receptors and ligands expressed in the tumor microenvironment, drugs that have been FDA approved targeting CTLA-4, PD-1, PD-L1, mechanism of tumor resistance to innate and adaptive immunity and candidate combination therapies are discussed.
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 49
    • 33947259319 scopus 로고    scopus 로고
    • Immunosuppressive strategies that are mediated by tumor cells
    • 49 Rabinovich, G.A., Gabrilovich, D., Sotomayor, E.M., Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25 (2007), 267–296.
    • (2007) Annu Rev Immunol , vol.25 , pp. 267-296
    • Rabinovich, G.A.1    Gabrilovich, D.2    Sotomayor, E.M.3
  • 52
    • 46749150647 scopus 로고    scopus 로고
    • Her-2/neu-induced cytokine signature in breast cancer
    • 52 Vazquez-Martin, A., Colomer, R., Menendez, J.A., Her-2/neu-induced cytokine signature in breast cancer. Adv Exp Med Biol 617 (2008), 311–319.
    • (2008) Adv Exp Med Biol , vol.617 , pp. 311-319
    • Vazquez-Martin, A.1    Colomer, R.2    Menendez, J.A.3
  • 54
    • 84949778471 scopus 로고    scopus 로고
    • Anti-tumor immunity in head and neck cancer: understanding the evidence, how tumors escape and immunotherapeutic approaches
    • 54 Allen, C.T., Clavijo, P.E., Van Waes, C., Chen, Z., Anti-tumor immunity in head and neck cancer: understanding the evidence, how tumors escape and immunotherapeutic approaches. Cancers (Basel) 7 (2015), 2397–2414.
    • (2015) Cancers (Basel) , vol.7 , pp. 2397-2414
    • Allen, C.T.1    Clavijo, P.E.2    Van Waes, C.3    Chen, Z.4
  • 55
    • 84997503538 scopus 로고    scopus 로고
    • Cetuximab ameliorates suppressive phenotypes of myeloid antigen presenting cells in head and neck cancer patients
    • 55 Li, J., Srivastava, R.M., Ettyreddy, A., Ferris, R.L., Cetuximab ameliorates suppressive phenotypes of myeloid antigen presenting cells in head and neck cancer patients. J Immunother Cancer, 3, 2015, 54.
    • (2015) J Immunother Cancer , vol.3 , pp. 54
    • Li, J.1    Srivastava, R.M.2    Ettyreddy, A.3    Ferris, R.L.4
  • 56
    • 84942170607 scopus 로고    scopus 로고
    • CTLA-4(+) regulatory T cells increased in cetuximab-treated head and neck cancer patients suppress NK cell cytotoxicity and correlate with poor prognosis
    • 56 Jie, H.B., Schuler, P.J., Lee, S.C., Srivastava, R.M., Argiris, A., Ferrone, S., Whiteside, T.L., Ferris, R.L., CTLA-4(+) regulatory T cells increased in cetuximab-treated head and neck cancer patients suppress NK cell cytotoxicity and correlate with poor prognosis. Cancer Res 75 (2015), 2200–2210.
    • (2015) Cancer Res , vol.75 , pp. 2200-2210
    • Jie, H.B.1    Schuler, P.J.2    Lee, S.C.3    Srivastava, R.M.4    Argiris, A.5    Ferrone, S.6    Whiteside, T.L.7    Ferris, R.L.8
  • 58
    • 85012303370 scopus 로고    scopus 로고
    • CD137 stimulation enhances cetuximab-induced natural killer: dendritic cell priming of antitumor T-cell immunity in patients with head and neck cancer
    • 58 Srivastava, R.M., Trivedi, S., Concha-Benavente, F., Gibson, S.P., Reeder, C., Ferrone, S., Ferris, R.L., CD137 stimulation enhances cetuximab-induced natural killer: dendritic cell priming of antitumor T-cell immunity in patients with head and neck cancer. Clin Cancer Res 23 (2017), 707–716.
    • (2017) Clin Cancer Res , vol.23 , pp. 707-716
    • Srivastava, R.M.1    Trivedi, S.2    Concha-Benavente, F.3    Gibson, S.P.4    Reeder, C.5    Ferrone, S.6    Ferris, R.L.7
  • 59
    • 77957783901 scopus 로고    scopus 로고
    • TGFbeta signaling in head and neck squamous cell carcinoma
    • 59 White, R.A., Malkoski, S.P., Wang, X.J., TGFbeta signaling in head and neck squamous cell carcinoma. Oncogene 29 (2010), 5437–5446.
    • (2010) Oncogene , vol.29 , pp. 5437-5446
    • White, R.A.1    Malkoski, S.P.2    Wang, X.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.