PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis

Journal of Cell Science

Volumn 130, Issue 3, 2017, Pages 602-613

  Ihara, Shinji ^a,b   Nakayama, Sohei ^a   Murakami, Yoshiko ^c   Suzuki, Emiko ^a,b   Asakawa, Masayo ^a   Kinoshita, Taroh ^c   Sawa, Hitoshi ^a,b  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Endoplasmic reticulum; GPI; MCAHS1 patients; PIGN; Protein aggregation

Indexed keywords

ALANINE; ARGININE; CD59 ANTIGEN; COLLAGEN TYPE 4; EMB 9 PROTEIN; ETHANOLAMINE PHOSPHOTRANSFERASE; GLYCOSYLPHOSPHATIDYLINOSITOL; GREEN FLUORESCENT PROTEIN; HISTIDINE; L SELECTIN; OS156 PROTEIN; PIGN PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ETHANOLAMINE PHOSPHATE TRANSFERASE 1, HUMAN; PHOSPHOTRANSFERASE; PROTEIN AGGREGATE;

AMINO ACID SEQUENCE; ARTICLE; BASEMENT MEMBRANE; CAENORHABDITIS ELEGANS; CELL ORGANELLE; CELLULAR DISTRIBUTION; CHROMOSOME 1; CONGENITAL MALFORMATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; CROSS LINKING; DELETION MUTANT; DEVELOPMENTAL DISORDER; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME ACTIVITY; EPILEPSY; FLOW CYTOMETRY; FLUORESCENCE; GENE INACTIVATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; LARVAL DEVELOPMENT; LIPOGENESIS; MISSENSE MUTATION; MULTIPLE CONGENITAL SEIZURE RELATED SYNDROME 1; MUSCLE HYPOTONIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN QUALITY; QUALITY CONTROL; SEIZURE; TRANSIENT TRANSFECTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; WHOLE GENOME SEQUENCING; WILD TYPE; ANIMAL; CHEMISTRY; CONSERVED SEQUENCE; CYTOLOGY; GENETICS; HEK293 CELL LINE; INTRACELLULAR MEMBRANE; INTRACELLULAR SPACE; METABOLISM; MOLECULAR EVOLUTION; MUTATION; SEQUENCE HOMOLOGY; ULTRASTRUCTURE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CONSERVED SEQUENCE; ENDOPLASMIC RETICULUM; EVOLUTION, MOLECULAR; GLYCOSYLPHOSPHATIDYLINOSITOLS; HEK293 CELLS; HUMANS; INTRACELLULAR MEMBRANES; INTRACELLULAR SPACE; MUTATION; PHOSPHOTRANSFERASES; PROTEIN AGGREGATES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 85012014137     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.196717     Document Type: Article

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