A STAT6 intronic single-nucleotide polymorphism is associated with clinical malaria in Ghanaian children

Genetics and Epigenetics

Volumn 1, Issue 8, 2016, Pages 7-14

  Amoako Sakyi, Daniel ^a,b   Adukpo, Selorme ^b,c   Kusi, Kwadwo A ^b   Dodoo, Daniel ^b   Ofori, Michael F ^b   Adjei, George O ^d,e   Edoh, Dominic E ^d   Asmah, Richard H ^d   Brown, Charles ^d   Adu, Bright ^b   Obiri Yeboah, Dorcas ^a   Futagbi, Godfred ^d   Abubakari, Sharif Buari ^a   Troye Blomberg, Marita ^f   Akanmori, Bartholomew D ^g   Goka, Bamenla Q ^d   Arko Mensah, John ^d   Gyan, Ben A ^b  

^a UNIVERSITY OF CAPE COAST   (Ghana)

^b University of Ghana   (Ghana)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF GHANA   (Ghana)

^e Centre for Tropical Clinical Pharmacology and Therapeutics   (Ghana)

^f STOCKHOLM UNIVERSITY   (Sweden)

^g WHO REGIONAL OFFICE FOR AFRICA   (Congo)

Author keywords

Ghana; IgE; Intron; Malaria; Rs3024974; SNP; STAT6

Indexed keywords

EID: 85012013203     PISSN: 1179237X     EISSN: None     Source Type: Journal    
DOI: 10.4137/GeG.s38307     Document Type: Article

References (43)

1. Greenwood B, Marsh K, Snow R. Why do some African children develop severe malaria? Parasitol Today. 1991;7(10):277-281.
2. Al-Taiar A, Jaffar S, Assabri A, et al. Who develops severe malaria? Impact of access to healthcare, socio-economic and environmental factors on children in Yemen: a case-control study. Trop Med Int Health. 2008;13(6):762-770.
3. O'Meara WP, Noor A, Gatakaa H, Tsofa B, McKenzie FE, Marsh K. The impact of primary health care on malaria morbidity-defining access by disease burden. Trop Med Int Health. 2009;14(1):29-35.
4. Sonko ST, Jaiteh M, Jafali J, et al. Does socio-economic status explain the differentials in malaria parasite prevalence? Evidence from the Gambia. Malar J. 2014; 13(1):449.
5. Gyan BA, Goka B, Cvetkovic JT, et al. Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children. Clin Exp Immunol. 2004;138(1):145-150.
6. McGuire W, Hill AVS, Allsopp CEM, Greenwood BM, Kwiatkowski D. Variation in the TNF-a promoter region associated with susceptibility to cerebral malaria. Nature. 1994;371(6497):508-511.
7. Maiga B, Dolo A, Touré O, et al. Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali. PLoS One. 2013;8(10): e75675.
8. Cherif M, Amoako-Sakyi D, Dolo A, et al. Distribution of Fc?R gene polymorphisms among two sympatric populations in Mali: differing allele frequencies, associations with malariometric indices and implications for genetic susceptibility to malaria. Malar J. 2016;15:29.
9. Hill AV. The immunogenetics of resistance to malaria. Proc Assoc Am Physicians. 1999;111(4):272-277.
10. Arama C, Maiga B, Dolo A, et al. Ethnic differences in susceptibility to malaria: what have we learned from immuno-epidemiological studies in West Africa? Acta Trop. 2015;146:152-156.
11. Angulo I, Fresno M. Cytokines in the pathogenesis of and protection against malaria. Clin Diagn Lab Immunol. 2002;9(6):1145-1152.
12. Kurtzhals JA, Adabayeri V, Goka BQ, et al. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Lancet. 1998;351(9118):1768-1772.
13. Kandasamy K, Mohan SS, Raju R, et al. NetPath: a public resource of curated signal transduction pathways. Genome Biol. 2010;11(1):R3.
14. Verra F, Luoni G, Calissano C, et al. IL4-589C/T polymorphism and IgE levels in severe malaria. Acta Trop. 2004;90(2):205-209.
15. Tangteerawatana P, Perlmann H, Hayano M, Kalambaheti T, Troye-Blomberg M, Khusmith S. IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria. Malar J. 2009;8(1):1-10.
16. Koukouikila-Koussounda F, Ntoumi F, Ndounga M, Tong HV, Abena A-A, Velavan TP. Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children. Malar J. 2013;12:9.
17. Weidinger S, Klopp N, Wagenpfeil S, et al. Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J Med Genet. 2004;41(9):658-663.
18. Barnes KC, Freidhoff LR, Nickel R, et al. Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy. J Allergy Clin Immunol. 1999; 104(2 pt 1):485-491.
19. Duetsch G, Illig T, Loesgen S, et al. STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sibpair study. Hum Mol Genet. 2002;11(6):613-621.
20. Thawani N, Tam M, Stevenson MM. STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia. Haematologica. 2009;94(2): 195-204.
21. Robson KJH, Weatherall DJ. Malarial anemia and STAT6. Haematologica. 2009; 94(2):157-159.
22. Takeda K, Tanaka T, Shi W, et al. Essential role of Stat6 in IL-4 signalling. Nature. 1996;380(6575):627-630.
23. He H, Isnard A, Kouriba B, et al. A STAT6 gene polymorphism is associated with high infection levels in urinary schistosomiasis. Genes Immun. 2008;9(3): 195-206.
24. Perlmann H, Helmby H, Hagstedt M, et al. IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clin Exp Immunol. 1994;97(2):284-292.
25. Perlmann P, Perlmann H, Flyg BW, et al. Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria. Infect Immun. 1997;65(1):116-121.
26. Bereczky S, Montgomery SM, Troye-Blomberg M, Rooth I, Shaw M-A, Färnert A. Elevated anti-malarial IgE in asymptomatic individuals is associated with reduced risk for subsequent clinical malaria. Int J Parasitol. 2004;34(8):935-942.
27. Duarte J, Deshpande P, Guiyedi V, et al. Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status. Malar J. 2007;6(1):1.
28. Seka-Seka J, Brouh Y, Yapo-Crézoit AC, Atseye NH. The role of serum immunoglobulin E in the pathogenesis of Plasmodium falciparum malaria in Ivorian children. Scand J Immunol. 2004;59(2):228-230.
29. Punnonen J, Aversa G, Cocks BG, et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A. 1993;90(8):3730-3734.
30. Adukpo S, Kusi KA, Ofori MF, et al. High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria. PLoS One. 2013;8(12):e84181.
31. Kusi KA, Gyan BA, Goka BQ, et al. Levels of soluble CD163 and severity of malaria in children in Ghana. Clin Vaccine Immunol. 2008;15(9):1456-1460.
32. Plotly | Make charts and dashboards online. Available at: https://plot.ly/feed/. Accessed March 28, 2016.
33. Salanti G, Amountza G, Ntzani EE, Ioannidis JPA. Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet. 2005;13(7):840-848.
34. Lee W-C. Searching for disease-susceptibility loci by testing for Hardy-Weinberg disequilibrium in a gene bank of affected individuals. Am J Epidemiol. 2003;158(5):397-400.
35. Allison AC. Protection afforded by sickle-cell trait against subtertian malarial infection. Br Med J. 1954;1(4857):290-294.
36. Perlmann P, Perlmann H, ElGhazali G, Blomberg MT. IgE and tumor necrosis factor in malaria infection. Immunol Lett. 1999;65(1-2):29-33.
37. Maeno Y, Perlmann P, Perlmann H, et al. IgE deposition in brain microvessels and on parasitized erythrocytes from cerebral malaria patients. Am J Trop Med Hyg. 2000;63(3-4):128-132.
38. Dehlink E, Baker AH, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One. 2010;5(8):e12204.
39. Harris MB, Chang CC, Berton MT, et al. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol. 1999;19(10): 7264-7275.
40. Akanmori BD, Kurtzhals JA, Goka BQ, et al. Distinct patterns of cytokine regulation in discrete clinical forms of Plasmodium falciparum malaria. Eur Cytokine Netw. 2000;11(1):113-118.
41. Grau GER, Hunt NH. Cytokines and some of their effector mechanisms in cerebral malaria pathogenesis. In: Hommel M, Kremsner PG, eds. Encyclopedia of Malaria. New York, NY: Springer; 2014:1-11.
42. Mackintosh CL, Beeson JG, Marsh K. Clinical features and pathogenesis of severe malaria. Trends Parasitol. 2004;20(12):597-603.
43. Noone C, Parkinson M, Dowling DJ, et al. Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum. Malar J. 2013;12:5. doi:10.1186/1475-2875-12-5.