-
1
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
2
-
-
4444344330
-
Etal. EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, etal. EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004; 101: 13306-11.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
-
3
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
-
4
-
-
69949162760
-
Etal. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu Y-L, Thongprasert S, Yang C-H, Chu D-T, Saijo N, etal. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.-L.2
Thongprasert, S.3
Yang, C.-H.4
Chu, D.-T.5
Saijo, N.6
-
5
-
-
84857502654
-
Etal. Erlotinib versus standard chemotherapy as fi rst-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, etal. Erlotinib versus standard chemotherapy as fi rst-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
Vergnenegre, A.4
Massuti, B.5
Felip, E.6
-
6
-
-
84884736973
-
P hase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
Sequist LV, Yang JC-H, Yamamoto N, O’Byrne K, Hirsh V, Mok T, et al. P hase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013;31:3327-34.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.-H.2
Yamamoto, N.3
O’Byrne, K.4
Hirsh, V.5
Mok, T.6
-
7
-
-
84946212527
-
Etal. EGFR kinase domain duplication (EGFR-KDD) is a novel oncogenic driver in lung cancer that is clinically responsive to afatinib
-
Gallant J-N, Sheehan JH, Shaver TM, Bailey M, Lipson D, Chandramohan R, etal. EGFR kinase domain duplication (EGFR-KDD) is a novel oncogenic driver in lung cancer that is clinically responsive to afatinib. Cancer Discov 2015;5:1155-63.
-
(2015)
Cancer Discov
, vol.5
, pp. 1155-1163
-
-
Gallant, J.-N.1
Sheehan, J.H.2
Shaver, T.M.3
Bailey, M.4
Lipson, D.5
Chandramohan, R.6
-
8
-
-
84942511240
-
Durable response to tyrosine kinase inhibitor therapy in a lung cancer patient harboring epidermal growth factor receptor tandem kinase domain duplication
-
Baik CS, Wu D, Smith C, Martins RG, Pritchard CC. Durable response to tyrosine kinase inhibitor therapy in a lung cancer patient harboring epidermal growth factor receptor tandem kinase domain duplication. J Thorac Oncol 2015;10:e97-9.
-
(2015)
J Thorac Oncol
, vol.10
, pp. e97-e99
-
-
Baik, C.S.1
Wu, D.2
Smith, C.3
Martins, R.G.4
Pritchard, C.C.5
-
9
-
-
84887491073
-
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
-
Frampton GM, Fichtenholtz A, Otto GA, Wang K, Downing SR, He J, et al. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol 2013;31:1023-31.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 1023-1031
-
-
Frampton, G.M.1
Fichtenholtz, A.2
Otto, G.A.3
Wang, K.4
Downing, S.R.5
He, J.6
-
10
-
-
57849117384
-
Etal. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
-
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, etal. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-47.
-
(2009)
Eur J Cancer
, vol.45
, pp. 228-247
-
-
Eisenhauer, E.A.1
Therasse, P.2
Bogaerts, J.3
Schwartz, L.H.4
Sargent, D.5
Ford, R.6
-
11
-
-
0001044842
-
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein
-
Daley GQ, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci U S A 1988;85:9312-6.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 9312-9316
-
-
Daley, G.Q.1
Baltimore, D.2
-
12
-
-
0004228474
-
Variants of 3T3 cells lacking mitogenic response to epidermal growth factor
-
Pruss RM, Herschman HR. Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. Proc Natl Acad Sci U S A 1977;74:3918-21.
-
(1977)
Proc Natl Acad Sci U S A
, vol.74
, pp. 3918-3921
-
-
Pruss, R.M.1
Herschman, H.R.2
-
13
-
-
0037429737
-
Epidermal growth factor receptor: Mechanisms of activation and
-
Jorissen RN, Walker F, Pouliot N, Garrett TPJ, Ward CW, Burgess AW. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res 2003;284:31-53.
-
(2003)
Exp Cell Res
, vol.284
, pp. 31-53
-
-
Jorissen, R.N.1
Walker, F.2
Pouliot, N.3
Garrett, T.4
Ward, C.W.5
Burgess, A.W.6
-
14
-
-
67349269541
-
Etal. The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants
-
Chung BM, Dimri M, George M, Reddi AL, Chen G, Band V, etal. The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene 2009;28:1821-32.
-
(2009)
Oncogene
, vol.28
, pp. 1821-1832
-
-
Chung, B.M.1
Dimri, M.2
George, M.3
Reddi, A.L.4
Chen, G.5
Band, V.6
-
15
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 2006;125:1137-49.
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
Cole, P.A.4
Kuriyan, J.5
-
16
-
-
84888646015
-
Tyrosine kinase gene rearrangements in epithelial malignancies
-
Shaw AT, Hsu PP, Awad MM, Engelman JA. Tyrosine kinase gene rearrangements in epithelial malignancies. Nat Rev Cancer 2013;13: 772-87.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 772-787
-
-
Shaw, A.T.1
Hsu, P.P.2
Awad, M.M.3
Engelman, J.A.4
-
17
-
-
3543041245
-
Etal. Crystal structure of a Rad51 fi lament
-
Conway AB, Lynch TW, Zhang Y, Fortin GS, Fung CW, Symington LS, etal. Crystal structure of a Rad51 fi lament. Nat Struct Mol Biol 2004;11:791-6.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 791-796
-
-
Conway, A.B.1
Lynch, T.W.2
Zhang, Y.3
Fortin, G.S.4
Fung, C.W.5
Symington, L.S.6
-
18
-
-
17444403242
-
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
-
Li S, Schmitz KR, Jeffrey PD, Wiltzius JJW, Kussie P, Ferguson KM. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell 2005; 7: 301-11.
-
(2005)
Cancer Cell
, vol.7
, pp. 301-311
-
-
Li, S.1
Schmitz, K.R.2
Jeffrey, P.D.3
Wiltzius, J.4
Kussie, P.5
Ferguson, K.M.6
-
19
-
-
84922373207
-
The landscape of kinase fusions in cancer
-
Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C. The landscape of kinase fusions in cancer. Nat Commun 2014;5:1-10.
-
(2014)
Nat Commun
, vol.5
, pp. 1-10
-
-
Stransky, N.1
Cerami, E.2
Schalm, S.3
Kim, J.L.4
Lengauer, C.5
-
20
-
-
84861760527
-
Differential sensitivity of gliomaversus lung cancer- specific EGFR mutations to EGFR kinase inhibitors
-
Vivanco I, Robins HI, Rohle D, Campos C, Grommes C, Nghiemphu PL, et al. Differential sensitivity of gliomaversus lung cancer- specific EGFR mutations to EGFR kinase inhibitors. Cancer Discov 2012;2:458-71.
-
(2012)
Cancer Discov
, vol.2
, pp. 458-471
-
-
Vivanco, I.1
Robins, H.I.2
Rohle, D.3
Campos, C.4
Grommes, C.5
Nghiemphu, P.L.6
-
21
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
-
Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009; 373: 1525-31.
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
Von Pawel, J.4
Krzakowski, M.5
Ramlau, R.6
-
22
-
-
84888129994
-
Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: A phase 3, open-label, randomised trial
-
Kim ES, Neubauer M, Cohn A, Schwartzberg L, Garbo L, Caton J, et al. Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: a phase 3, open-label, randomised trial. Lancet Oncol 2013; 14: 1326-36.
-
(2013)
Lancet Oncol
, vol.14
, pp. 1326-1336
-
-
Kim, E.S.1
Neubauer, M.2
Cohn, A.3
Schwartzberg, L.4
Garbo, L.5
Caton, J.6
-
23
-
-
84888323979
-
Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization
-
Cho J, Chen L, Sangji N, Okabe T, Yonesaka K, Francis JM, et al. Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization. Cancer Res 2013; 73: 6770-9.
-
(2013)
Cancer Res
, vol.73
, pp. 6770-6779
-
-
Cho, J.1
Chen, L.2
Sangji, N.3
Okabe, T.4
Yonesaka, K.5
Francis, J.M.6
-
24
-
-
84885074034
-
The somatic genomic landscape of glioblastoma
-
Brennan CW, Verhaak RGW, McKenna A, Campos B, Noushmehr H, Salama SR, etal. The somatic genomic landscape of glioblastoma. Cell 2013;155:462-77.
-
(2013)
Cell
, vol.155
, pp. 462-477
-
-
Brennan, C.W.1
Verhaak, R.2
McKenna, A.3
Campos, B.4
Noushmehr, H.5
Salama, S.R.6
-
25
-
-
84255170397
-
Etal. Glioblastoma-derived epidermal growth factor receptor carboxyl- terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies
-
Cho J, Pastorino S, Zeng Q, Xu X, Johnson W, Vandenberg S, etal. Glioblastoma-derived epidermal growth factor receptor carboxyl- terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies. Cancer Res 2011;71:7587-96.
-
(2011)
Cancer Res
, vol.71
, pp. 7587-7596
-
-
Cho, J.1
Pastorino, S.2
Zeng, Q.3
Xu, X.4
Johnson, W.5
Vandenberg, S.6
-
26
-
-
84866410479
-
Etal. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
-
Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, etal. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 2012;150:1107-20.
-
(2012)
Cell
, vol.150
, pp. 1107-1120
-
-
Imielinski, M.1
Berger, A.H.2
Hammerman, P.S.3
Hernandez, B.4
Pugh, T.J.5
Hodis, E.6
-
27
-
-
34547638047
-
Etal. Identifi cation of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, etal. Identifi cation of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-6.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
-
28
-
-
77956905336
-
Isolation and characterization of the core single-stranded DNA- binding domain of purine-rich element binding protein B (Pur β)
-
Rumora AE, Steere AN, Ramsey JE, Knapp AM, Ballif BA, Kelm RJ. Isolation and characterization of the core single-stranded DNA- binding domain of purine-rich element binding protein B (Pur β). Biochem Biophys Res Commun 2010;400:340-5.
-
(2010)
Biochem Biophys Res Commun
, vol.400
, pp. 340-345
-
-
Rumora, A.E.1
Steere, A.N.2
Ramsey, J.E.3
Knapp, A.M.4
Ballif, B.A.5
Kelm, R.J.6
-
29
-
-
49649114605
-
Protein structure modeling with MODELLER
-
Eswar N, Eramian D, Webb B, Shen M-Y, Sali A. Protein structure modeling with MODELLER. Methods Mol Biol 2008;426:145-59.
-
(2008)
Methods Mol Biol
, vol.426
, pp. 145-159
-
-
Eswar, N.1
Eramian, D.2
Webb, B.3
Shen, M.-Y.4
Sali, A.5
-
30
-
-
0031585984
-
Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions
-
Simons KT, Kooperberg C, Huang E, Baker D. Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions. J Mol Biol 1997;268:209-25.
-
(1997)
J Mol Biol
, vol.268
, pp. 209-225
-
-
Simons, K.T.1
Kooperberg, C.2
Huang, E.3
Baker, D.4
|