Reduced SHARPIN and LUBAC formation may contribute to CCl4 - Or acetaminophen-induced liver cirrhosis in mice

International Journal of Molecular Sciences

Volumn 18, Issue 2, 2017, Pages

  Yamamotoya, Takeshi ^a   Nakatsu, Yusuke ^a   Matsunaga, Yasuka ^a   Fukushima, Toshiaki ^b   Yamazaki, Hiroki ^c   Kaneko, Sunao ^d   Fujishiro, Midori ^e   Kikuchi, Takako ^c   Kushiyama, Akifumi ^c   Tokunaga, Fuminori ^f   Asano, Tomoichiro ^a   Sakoda, Hideyuki ^g  

^a HIROSHIMA UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c INSTITUTE FOR ADULT DISEASES   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

CCl4 and APAP induced hepatitis; Fibrosis; Hepatocyte apoptosis; Inflammation; LUBAC

Indexed keywords

ALANINE AMINOTRANSFERASE; CASPASE 3; HOIL 1L INTERACTING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LINEAR UBIQUITIN CHAIN ASSEMBLY COMPLEX; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PARACETAMOL; PEPTIDES AND PROTEINS; SHANK ASSOCIATED RH DOMAIN INTERACTING PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CARBON TETRACHLORIDE; CARRIER PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN BINDING; RNF31 PROTEIN, MOUSE; SIPL1 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOLOGY; INFLAMMATION; LIVER CIRRHOSIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUNEL ASSAY; UBIQUITINATION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; FIBROSIS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; LIVER CELL; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ACETAMINOPHEN; ANIMALS; APOPTOSIS; CARBON TETRACHLORIDE; CARRIER PROTEINS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FIBROSIS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; INFLAMMATION; LIVER CIRRHOSIS; MALE; MICE; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-PROTEIN LIGASES;

EID: 85011990314     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18020326     Document Type: Article

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