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Volumn 30, Issue 2, 2017, Pages 187-192

New insights into the mechanisms of the ketogenic diet

Author keywords

epigenetics; epileptogenesis; ketones; metabolism; seizure suppression

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; AMPA RECEPTOR; ANTICONVULSIVE AGENT; DECANOIC ACID; KETONE BODY; LACTATE DEHYDROGENASE; MEDIUM CHAIN FATTY ACID; MEDIUM CHAIN TRIACYLGLYCEROL; NEUROTROPHIC FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; POLYUNSATURATED FATTY ACID; DECANOIC ACID DERIVATIVE;

EID: 85011697849     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0000000000000432     Document Type: Review
Times cited : (187)

References (50)
  • 1
    • 78149405081 scopus 로고    scopus 로고
    • Ketosis and the ketogenic diet, 2010: Advances in treating epilepsy and other disorders
    • Freeman JM, Kossoff EH. Ketosis and the ketogenic diet, 2010: advances in treating epilepsy and other disorders. Adv Pediatr 2010; 57:315-329.
    • (2010) Adv Pediatr , vol.57 , pp. 315-329
    • Freeman, J.M.1    Kossoff, E.H.2
  • 2
    • 84866022656 scopus 로고    scopus 로고
    • The ketogenic diet as a treatment paradigm for diverse neurological disorders
    • Stafstrom CE, Rho JM. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol 2012; 3:59.
    • (2012) Front Pharmacol , vol.3 , pp. 59
    • Stafstrom, C.E.1    Rho, J.M.2
  • 3
    • 84899051589 scopus 로고    scopus 로고
    • Risk of seizure recurrence after achieving initial seizure freedom on the ketogenic diet
    • Taub KS, Kessler SK, Bergqvist AG. Risk of seizure recurrence after achieving initial seizure freedom on the ketogenic diet. Epilepsia 2014; 55:579-583.
    • (2014) Epilepsia , vol.55 , pp. 579-583
    • Taub, K.S.1    Kessler, S.K.2    Bergqvist, A.G.3
  • 4
    • 84938718749 scopus 로고    scopus 로고
    • How does the ketogenic diet induce anti-seizure effects?
    • Rho JM. How does the ketogenic diet induce anti-seizure effects? Neurosci Lett 2015; 637:4-10.
    • (2015) Neurosci Lett , vol.637 , pp. 4-10
    • Rho, J.M.1
  • 5
    • 84869095296 scopus 로고    scopus 로고
    • Mechanisms of ketogenic diet action
    • Noebels JL, Avoli M, Rogawski MA, et al., editors. 4th ed Bethesda (MD), USA: National Center for Biotechnology Information (US)
    • Masino SA, Rho JM. Mechanisms of ketogenic diet action. In: Noebels JL, Avoli M, Rogawski MA, et al., editors. Jaspers basic mechanisms of the epilepsies, 4th ed Bethesda (MD), USA: National Center for Biotechnology Information (US); 2012.
    • (2012) Jaspers Basic Mechanisms of the Epilepsies
    • Masino, S.A.1    Rho, J.M.2
  • 6
    • 84871718480 scopus 로고    scopus 로고
    • The ketogenic diet: Metabolic influences on brain excitability and epilepsy
    • Lutas A, Yellen G. The ketogenic diet: metabolic influences on brain excitability and epilepsy. Trends Neurosci 2013; 36:32-40.
    • (2013) Trends Neurosci , vol.36 , pp. 32-40
    • Lutas, A.1    Yellen, G.2
  • 7
    • 84989842395 scopus 로고    scopus 로고
    • A prospective study on changes in blood levels of cholecystokinin-8 and leptin in patients with refractory epilepsy treated with the ketogenic diet
    • Lambrechts DA, Brandt-Wouters E, Verschuure P, et al. A prospective study on changes in blood levels of cholecystokinin-8 and leptin in patients with refractory epilepsy treated with the ketogenic diet. Epilepsy Res 2016; 127:87-92.
    • (2016) Epilepsy Res , vol.127 , pp. 87-92
    • Lambrechts, D.A.1    Brandt-Wouters, E.2    Verschuure, P.3
  • 8
    • 84944751908 scopus 로고    scopus 로고
    • Efficacy of the ketogenic diet for the treatment of refractory childhood epilepsy: Cerebrospinal fluid neurotransmitters and amino acid levels
    • Sariego-Jamardo A, Garcia-Cazorla A, Artuch R, et al. Efficacy of the ketogenic diet for the treatment of refractory childhood epilepsy: cerebrospinal fluid neurotransmitters and amino acid levels. Pediatr Neurol 2015; 53: 422-426.
    • (2015) Pediatr Neurol , vol.53 , pp. 422-426
    • Sariego-Jamardo, A.1    Garcia-Cazorla, A.2    Artuch, R.3
  • 9
    • 84948745029 scopus 로고    scopus 로고
    • Variants in KCNJ11 and BAD do not predict response to ketogenic dietary therapies for epilepsy
    • Schoeler NE, Leu C, White J, et al. Variants in KCNJ11 and BAD do not predict response to ketogenic dietary therapies for epilepsy. Epilepsy Res 2015; 118:22-28.
    • (2015) Epilepsy Res , vol.118 , pp. 22-28
    • Schoeler, N.E.1    Leu, C.2    White, J.3
  • 10
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite b-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite b-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 2015; 21:263-269.
    • (2015) Nat Med , vol.21 , pp. 263-269
    • Youm, Y.H.1    Nguyen, K.Y.2    Grant, R.W.3
  • 11
    • 84901325457 scopus 로고    scopus 로고
    • The b-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
    • Rahman M, Muhammad S, Khan MA, et al. The b-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat Commun 2014; 5:3944.
    • (2014) Nat Commun , vol.5 , pp. 3944
    • Rahman, M.1    Muhammad, S.2    Khan, M.A.3
  • 12
    • 84939190356 scopus 로고    scopus 로고
    • Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices
    • Valente-Silva P, Lemos C, Kofalvi A, et al. Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices. NMR Biomed 2015; 28:1111-1116.
    • (2015) NMR Biomed , vol.28 , pp. 1111-1116
    • Valente-Silva, P.1    Lemos, C.2    Kofalvi, A.3
  • 13
    • 84921472344 scopus 로고    scopus 로고
    • Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain
    • Zhang Y, Zhang S, Marin-Valencia I, Puchowicz MA. Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain. J Neurochem 2015; 132:301-312.
    • (2015) J Neurochem , vol.132 , pp. 301-312
    • Zhang, Y.1    Zhang, S.2    Marin-Valencia, I.3    Puchowicz, M.A.4
  • 14
    • 84964305217 scopus 로고    scopus 로고
    • Valproate effect on ketosis in children under ketogenic diet
    • Spilioti M, Pavlou E, Gogou M, et al. Valproate effect on ketosis in children under ketogenic diet. Eur J Paediatr Neurol 2016; 20:555-559.
    • (2016) Eur J Paediatr Neurol , vol.20 , pp. 555-559
    • Spilioti, M.1    Pavlou, E.2    Gogou, M.3
  • 15
    • 84958741342 scopus 로고    scopus 로고
    • B-Hydroxybutyrate supports synaptic vesicle cycling but reduces endocytosis and exocytosis in rat brain synaptosomes
    • Hrynevich SV, Waseem TV, Hebert A, et al. b-Hydroxybutyrate supports synaptic vesicle cycling but reduces endocytosis and exocytosis in rat brain synaptosomes. Neurochem Int 2016; 93:73-81.
    • (2016) Neurochem Int , vol.93 , pp. 73-81
    • Hrynevich, S.V.1    Waseem, T.V.2    Hebert, A.3
  • 16
    • 84938099390 scopus 로고    scopus 로고
    • Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure
    • Viggiano A, Pilla R, Arnold P, et al. Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure. Brain Res 2015; 1618:50-54.
    • (2015) Brain Res , vol.1618 , pp. 50-54
    • Viggiano, A.1    Pilla, R.2    Arnold, P.3
  • 17
    • 84983777921 scopus 로고    scopus 로고
    • Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model
    • Ciarlone SL, Grieco JC, D'Agostino DP, Weeber EJ. Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model. Neurobiol Dis 2016; 96:38-46.
    • (2016) Neurobiol Dis , vol.96 , pp. 38-46
    • Ciarlone, S.L.1    Grieco, J.C.2    D'Agostino, D.P.3    Weeber, E.J.4
  • 18
    • 84875235362 scopus 로고    scopus 로고
    • Seizure control by ketogenic dietassociated medium chain fatty acids
    • Chang P, Terbach N, Plant N, et al. Seizure control by ketogenic dietassociated medium chain fatty acids. Neuropharmacology 2013; 69:105-114.
    • (2013) Neuropharmacology , vol.69 , pp. 105-114
    • Chang, P.1    Terbach, N.2    Plant, N.3
  • 19
    • 84873411637 scopus 로고    scopus 로고
    • Heptanoate as a neural fuel: Energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain
    • Marin-Valencia I, Good LB, Ma Q, et al. Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain. J Cereb Blood Flow Metab 2013; 33:175-182.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 175-182
    • Marin-Valencia, I.1    Good, L.B.2    Ma, Q.3
  • 20
    • 84908007846 scopus 로고    scopus 로고
    • Triheptanoin for glucose transporter type i deficiency (G1D): Modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement
    • Pascual JM, Liu P, Mao D, et al. Triheptanoin for glucose transporter type I deficiency (G1D): modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement. JAMA Neurol 2014; 71:1255-1265.
    • (2014) JAMA Neurol , vol.71 , pp. 1255-1265
    • Pascual, J.M.1    Liu, P.2    Mao, D.3
  • 21
    • 84919762194 scopus 로고    scopus 로고
    • Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency
    • Chang P, Zuckermann AM, Williams S, et al. Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. J Pharmacol Exp Ther 2015; 352:43-52.
    • (2015) J Pharmacol Exp Ther , vol.352 , pp. 43-52
    • Chang, P.1    Zuckermann, A.M.2    Williams, S.3
  • 22
    • 85014644089 scopus 로고    scopus 로고
    • Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function
    • [Epub ahead of print]
    • Tan KN, Carrasco-Pozo C, McDonald TS, et al. Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function. J Cereb Blood Flow Metab 2016. [Epub ahead of print]
    • (2016) J Cereb Blood Flow Metab
    • Tan, K.N.1    Carrasco-Pozo, C.2    McDonald, T.S.3
  • 23
    • 84963765159 scopus 로고    scopus 로고
    • The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex i deficient Leigh syndrome
    • Kanabus M, Fassone E, Hughes SD, et al. The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome. J Inherit Metab Dis 2016; 39:415-426.
    • (2016) J Inherit Metab Dis , vol.39 , pp. 415-426
    • Kanabus, M.1    Fassone, E.2    Hughes, S.D.3
  • 24
    • 84899410824 scopus 로고    scopus 로고
    • The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex i activity in neuronal cells
    • Hughes SD, Kanabus M, Anderson G, et al. The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells. J Neurochem 2014; 129:426-433.
    • (2014) J Neurochem , vol.129 , pp. 426-433
    • Hughes, S.D.1    Kanabus, M.2    Anderson, G.3
  • 25
    • 84966372836 scopus 로고    scopus 로고
    • Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems
    • Thevenet J, De Marchi U, Domingo JS, et al. Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems. FASEB J 2016; 30:1913-1926.
    • (2016) FASEB J , vol.30 , pp. 1913-1926
    • Thevenet, J.1    De Marchi, U.2    Domingo, J.S.3
  • 26
    • 84949255141 scopus 로고    scopus 로고
    • Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? the new hypothesis of action
    • Maciejak P, Szyndler J, Turzynska D, et al. Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action. Neuroscience 2016; 313:130-148.
    • (2016) Neuroscience , vol.313 , pp. 130-148
    • Maciejak, P.1    Szyndler, J.2    Turzynska, D.3
  • 27
    • 84977079443 scopus 로고    scopus 로고
    • Seizure control by decanoic acid through direct AMPA receptor inhibition
    • Chang P, Augustin K, Boddum K, et al. Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain 2016; 139:431-443.
    • (2016) Brain , vol.139 , pp. 431-443
    • Chang, P.1    Augustin, K.2    Boddum, K.3
  • 28
    • 84956717094 scopus 로고    scopus 로고
    • The molecular basis of polyunsaturated fatty acid interactions with the shaker voltage-gated potassium channel
    • Yazdi S, Stein M, Elinder F, et al. The molecular basis of polyunsaturated fatty acid interactions with the shaker voltage-gated potassium channel. PLoS Comput Biol 2016; 12:e1004704.
    • (2016) PLoS Comput Biol , vol.12 , pp. e1004704
    • Yazdi, S.1    Stein, M.2    Elinder, F.3
  • 29
    • 85015852174 scopus 로고    scopus 로고
    • Ketogenic diet, but not polyunsaturated fatty acid diet, reduces spontaneous seizures in juvenile rats with kainic acid-induced epilepsy
    • Dustin SM, Stafstrom CE. Ketogenic diet, but not polyunsaturated fatty acid diet, reduces spontaneous seizures in juvenile rats with kainic acid-induced epilepsy. J Epilepsy Res 2016; 6:1-7.
    • (2016) J Epilepsy Res , vol.6 , pp. 1-7
    • Dustin, S.M.1    Stafstrom, C.E.2
  • 30
    • 84936846247 scopus 로고    scopus 로고
    • Ketogenic diet exhibits antiinflammatory properties
    • Dupuis N, Curatolo N, Benoist JF, Auvin S. Ketogenic diet exhibits antiinflammatory properties. Epilepsia 2015; 56:e95-e98.
    • (2015) Epilepsia , vol.56 , pp. e95-e98
    • Dupuis, N.1    Curatolo, N.2    Benoist, J.F.3    Auvin, S.4
  • 31
    • 84908158825 scopus 로고    scopus 로고
    • Hepatic IRE1a regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARalpha axis signalling
    • Shao M, Shan B, Liu Y, et al. Hepatic IRE1a regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARalpha axis signalling. Nat Commun 2014; 5:3528.
    • (2014) Nat Commun , vol.5 , pp. 3528
    • Shao, M.1    Shan, B.2    Liu, Y.3
  • 32
    • 84901322478 scopus 로고    scopus 로고
    • In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv 1.1a knockout mice
    • Simeone TA, Samson KK, Matthews SA, Simeone KA. In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv 1.1a knockout mice. Epilepsia 2014; 55:e44-e49.
    • (2014) Epilepsia , vol.55 , pp. e44-e49
    • Simeone, T.A.1    Samson, K.K.2    Matthews, S.A.3    Simeone, K.A.4
  • 33
    • 84995394885 scopus 로고    scopus 로고
    • Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy
    • Simeone TA, Matthews SA, Samson KK, Simeone KA. Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy. Exp Neurol 2017; 287:54-64.
    • (2017) Exp Neurol , vol.287 , pp. 54-64
    • Simeone, T.A.1    Matthews, S.A.2    Samson, K.K.3    Simeone, K.A.4
  • 34
    • 84861440823 scopus 로고    scopus 로고
    • BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures
    • Gimenez-Cassina A, Martinez-Francois JR, Fisher JK, et al. BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures. Neuron 2012; 74:719-730.
    • (2012) Neuron , vol.74 , pp. 719-730
    • Gimenez-Cassina, A.1    Martinez-Francois, J.R.2    Fisher, J.K.3
  • 35
    • 84929991757 scopus 로고    scopus 로고
    • Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels
    • Kim DY, Abdelwahab MG, Lee SH, et al. Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels. PLoS One 2015; 10:e0119316.
    • (2015) PLoS One , vol.10 , pp. e0119316
    • Kim, D.Y.1    Abdelwahab, M.G.2    Lee, S.H.3
  • 36
    • 84914706500 scopus 로고    scopus 로고
    • Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels
    • Lutas A, Birnbaumer L, YellenG.Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci 2014; 34:16336-16347.
    • (2014) J Neurosci , vol.34 , pp. 16336-16347
    • Lutas, A.1    Birnbaumer, L.2    Yellen, G.3
  • 37
    • 84964587682 scopus 로고    scopus 로고
    • Effect of dietary fat and the circadian clock on the expression of brain-derived neurotrophic factor (BDNF)
    • Genzer Y, Dadon M, Burg C, et al. Effect of dietary fat and the circadian clock on the expression of brain-derived neurotrophic factor (BDNF). Mol Cell Endocrinol 2016; 430:49-55.
    • (2016) Mol Cell Endocrinol , vol.430 , pp. 49-55
    • Genzer, Y.1    Dadon, M.2    Burg, C.3
  • 38
    • 84876786978 scopus 로고    scopus 로고
    • Brain changes in BDNF and S100B induced by ketogenic diets in Wistar rats
    • Vizuete AF, de Souza DF, Guerra MC, et al. Brain changes in BDNF and S100B induced by ketogenic diets in Wistar rats. Life Sci 2013; 92:923-928.
    • (2013) Life Sci , vol.92 , pp. 923-928
    • Vizuete, A.F.1    De Souza, D.F.2    Guerra, M.C.3
  • 39
    • 84946475986 scopus 로고    scopus 로고
    • The ketogenic diet compensates for AGC1 deficiency and improves myelination
    • Dahlin M, Martin DA, Hedlund Z, et al. The ketogenic diet compensates for AGC1 deficiency and improves myelination. Epilepsia 2015; 56:e176-e181.
    • (2015) Epilepsia , vol.56 , pp. e176-e181
    • Dahlin, M.1    Martin, D.A.2    Hedlund, Z.3
  • 40
    • 85002714982 scopus 로고    scopus 로고
    • Altered glycolysis and mitochondrial respiration in a zebrafish model of Dravet syndrome
    • ENEURO.0008-16.2016
    • Kumar MG, Rowley S, Fulton R, et al. Altered glycolysis and mitochondrial respiration in a zebrafish model of Dravet syndrome. eNeuro 2016; 3. (2):ENEURO.0008-16.2016.
    • (2016) ENeuro , vol.3 , Issue.2
    • Kumar, M.G.1    Rowley, S.2    Fulton, R.3
  • 41
    • 84933181448 scopus 로고    scopus 로고
    • Ketone bodies mediate antiseizure effects through mitochondrial permeability transition
    • Kim DY, Simeone KA, Simeone TA, et al. Ketone bodies mediate antiseizure effects through mitochondrial permeability transition. Ann Neurol 2015; 78:77-87.
    • (2015) Ann Neurol , vol.78 , pp. 77-87
    • Kim, D.Y.1    Simeone, K.A.2    Simeone, T.A.3
  • 42
    • 84911059062 scopus 로고    scopus 로고
    • Catabolism of (2E)-4-hydroxy-2-nonenal via v-and v-1-oxidation stimulated by ketogenic diet
    • Jin Z, Berthiaume JM, Li Q, et al. Catabolism of (2E)-4-hydroxy-2-nonenal via v-and v-1-oxidation stimulated by ketogenic diet. J Biol Chem 2014; 289:32327-32338.
    • (2014) J Biol Chem , vol.289 , pp. 32327-32338
    • Jin, Z.1    Berthiaume, J.M.2    Li, Q.3
  • 43
    • 84907015381 scopus 로고    scopus 로고
    • FGF21 is an endocrine signal of protein restriction
    • Laeger T, Henagan TM, Albarado DC, et al. FGF21 is an endocrine signal of protein restriction. J Clin Invest 2014; 124:3913-3922.
    • (2014) J Clin Invest , vol.124 , pp. 3913-3922
    • Laeger, T.1    Henagan, T.M.2    Albarado, D.C.3
  • 44
    • 84925334416 scopus 로고    scopus 로고
    • Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy
    • Sada N, Lee S, Katsu T, et al. Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science 2015; 347:1362-1367.
    • (2015) Science , vol.347 , pp. 1362-1367
    • Sada, N.1    Lee, S.2    Katsu, T.3
  • 45
    • 84984984358 scopus 로고    scopus 로고
    • Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy
    • Simeone KA, Matthews SA, Rho JM, Simeone TA. Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. Epilepsia 2016; 57:e178-e182.
    • (2016) Epilepsia , vol.57 , pp. e178-e182
    • Simeone, K.A.1    Matthews, S.A.2    Rho, J.M.3    Simeone, T.A.4
  • 46
    • 84888168918 scopus 로고    scopus 로고
    • Deep sequencing reveals increased DNA methylation in chronic rat epilepsy
    • Kobow K, Kaspi A, Harikrishnan KN, et al. Deep sequencing reveals increased DNA methylation in chronic rat epilepsy. Acta Neuropathol 2013; 126:741-756.
    • (2013) Acta Neuropathol , vol.126 , pp. 741-756
    • Kobow, K.1    Kaspi, A.2    Harikrishnan, K.N.3
  • 47
    • 84940021980 scopus 로고    scopus 로고
    • Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats
    • Lusardi TA, Akula KK, Coffman SQ, et al. Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. Neuropharmacology 2015; 99:500-509.
    • (2015) Neuropharmacology , vol.99 , pp. 500-509
    • Lusardi, T.A.1    Akula, K.K.2    Coffman, S.Q.3
  • 48
    • 79959957820 scopus 로고    scopus 로고
    • A ketogenic diet suppresses seizures in mice through adenosine A1 receptors
    • Masino SA, Li T, Theofilas P, et al. A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. J Clin Inv 2011; 121:2679-2683.
    • (2011) J Clin Inv , vol.121 , pp. 2679-2683
    • Masino, S.A.1    Li, T.2    Theofilas, P.3
  • 49
    • 84879710932 scopus 로고    scopus 로고
    • Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis
    • Williams-Karnesky RL, Sandau US, Lusardi TA, et al. Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Inv 2013; 123:3552-3563.
    • (2013) J Clin Inv , vol.123 , pp. 3552-3563
    • Williams-Karnesky, R.L.1    Sandau, U.S.2    Lusardi, T.A.3
  • 50
    • 84987629405 scopus 로고    scopus 로고
    • Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder
    • Newell C, Bomhof MR, Reimer RA, et al. Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder. Mol Autism 2016; 7:37.
    • (2016) Mol Autism , vol.7 , pp. 37
    • Newell, C.1    Bomhof, M.R.2    Reimer, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.