Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model

Neurobiology of Disease

Volumn 96, Issue , 2016, Pages 38-46

  Ciarlone, Stephanie L ^a,b   Grieco, Joseph C ^a,b   D'Agostino, Dominic P ^b   Weeber, Edwin J ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Angelman syndrome; Ketone ester; Metabolism; Motor coordination; Seizure; Synaptic plasticity

Indexed keywords

1,3 BUTANEDIOL ACETOACETATE DIESTER; ANTICONVULSIVE AGENT; ESTER DERIVATIVE; GLUCOSE; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR STIMULATING AGENT; ESTER; KAINIC ACID; KETONE; UBE3A PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

AMINO ACID BRAIN LEVEL; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; EATING HABIT; FEMALE; GLUCOSE BLOOD LEVEL; HAPPY PUPPET SYNDROME; HIPPOCAMPAL CA1 REGION; IN VIVO STUDY; KETOACIDOSIS; KETOGENIC DIET; LOCOMOTION; LONG TERM POTENTIATION; MALE; MOTOR COORDINATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOGNITION; SEIZURE; STATE DEPENDENT LEARNING; SUPPLEMENTATION; WEIGHT REDUCTION; ACTION POTENTIAL; ANIMAL; AUDITORY STIMULATION; BLOOD; COMPLICATION; CONDITIONING; DISEASE MODEL; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; EXPLORATORY BEHAVIOR; GENETICS; HIPPOCAMPUS; MAZE TEST; METABOLISM; PATHOLOGY; PSYCHOMOTOR PERFORMANCE; TRANSGENIC MOUSE;

ACOUSTIC STIMULATION; ACTION POTENTIALS; ANGELMAN SYNDROME; ANIMALS; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; ESTERS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; EXPLORATORY BEHAVIOR; FEMALE; HIPPOCAMPUS; KAINIC ACID; KETONES; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; NEURONAL PLASTICITY; PSYCHOMOTOR PERFORMANCE; SEIZURES; UBIQUITIN-PROTEIN LIGASES;

EID: 84983777921     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2016.08.002     Document Type: Article

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