Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder

Molecular Autism

Volumn 7, Issue 1, 2016, Pages

  Newell, Christopher ^a   Bomhof, Marc R ^b   Reimer, Raylene A ^a,b   Hittel, Dustin S ^a   Rho, Jong M ^a   Shearer, Jane ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Autism spectrum disorder; BTBR mouse; Gut microbiome; Ketogenic diet

Indexed keywords

AKKERMANSIA MUCINIPHILA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BACTERIAL COUNT; BACTEROIDETES; CECUM; CONTROLLED STUDY; ENTEROBACTERIACEAE; FECES ANALYSIS; FIRMICUTES; INTESTINE FLORA; JUVENILE ANIMAL; KETOGENIC DIET; LACTOBACILLUS; MALE; METHANOBREVIBACTER; MOUSE; NONHUMAN; POPULATION ABUNDANCE; PRIORITY JOURNAL; ROSEBURIA; SPECIES COMPOSITION; THERAPY EFFECT; ANIMAL; ANIMAL BEHAVIOR; BACTERIUM; C57BL MOUSE; DISEASE MODEL; FECES; ISOLATION AND PURIFICATION; MICROBIOLOGY; SOCIAL BEHAVIOR;

ANIMALS; AUTISM SPECTRUM DISORDER; BACTERIA; BEHAVIOR, ANIMAL; CECUM; DISEASE MODELS, ANIMAL; FECES; GASTROINTESTINAL MICROBIOME; KETOGENIC DIET; MALE; MICE; MICE, INBRED C57BL; SOCIAL BEHAVIOR;

EID: 84987629405     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/s13229-016-0099-3     Document Type: Article

References (28)

1. De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti DI, Cristofori F, Guerzoni ME, Gobbetti M, Francavilla R. Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS One. 2013;8:e76993.
2. Finegold SM, Dowd SE, Gontcharova V, Liu C, Henley KE, Wolcott RD, Youn E, Summanen PH, Granpeesheh D, Dixon D, Liu M, Molitoris DR, Green JA. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe. 2010;16:444-53.
3. Duda-Chodak A, Tarko T, Satora P, Sroka P. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. Eur J Nutr. 2015;54:325-41.
4. Kamada N, Seo S-U, Chen GY, Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13:321-35.
5. de Theije CGM, Wopereis H, Ramadan M, van Eijndthoven T, Lambert J, Knol J, Garssen J, Kraneveld AD, Oozeer R. Altered gut microbiota and activity in a murine model of autism spectrum disorders. Brain Behav Immun. 2014;37:197-206.
6. Ruskin DN, Svedova J, Cote JL, Sandau U, Rho JM, Kawamura M, Boison D, Masino SA. Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One. 2013;8:e65021.
7. Meyza KZ, Defensor EB, Jensen AL, Corley MJ, Pearson BL, Pobbe RLH, Bolivar VJ, Blanchard DC, Blanchard RJ. The BTBR T+ tf/J mouse model for autism spectrum disorders-in search of biomarkers. Behav Brain Res. 2013;251:25-34.
8. Gano LB, Patel M, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res. 2014;55:2211-28.
9. van De Sande MMH, van Buul VJ, Brouns FJPH. Autism and nutrition: the role of the gut-brain axis. Nutr Res Rev. 2014;27:199-214.
10. Forsythe P, Kunze WA. Voices from within: gut microbes and the CNS. Cell Mol Life Sci. 2013;70:55-69.
11. Keene DE, Suescun MO, Bostwick MG, Chandrashekar V, Bartke A, Kopchick JJ. Puberty is delayed in male growth hormone receptor gene-disrupted mice. J Androl. 2002;23:661-8.
12. McFarlane HG, Kusek GK, Yang M, Phoenix JL, Bolivar VJ, Crawley JN. Autism-like behavioral phenotypes in BTBR T + tf/J mice. Genes Brain Behav. 2008;7:152-63.
13. Bomhof MR, Saha DC, Reid DT, Paul HA, Reimer RA. Combined effects of oligofructose and Bifidobacterium animalis on gut microbiota and glycemia in obese rats. Obesity (Silver Spring). 2014;22:763-71.
14. Stoddard SF, Smith BJ, Hein R, Roller BRK, Schmidt TM. rrnDB: improved tools for interpreting rRNA gene abundance in bacteria and archaea and a new foundation for future development. Nucleic Acids Res. 2014;43(Database issue):D593-8.
15. Klein MS, Newell C, Bomhof MR, Reimer RA, Hittel DS, Rho JM, Vogel HJ, Shearer J. Metabolomic modelling to monitor host responsiveness to gut microbiota manipulation in the BTBR(T + tf/j) mouse. J Proteome Res. 2016;15:1143-50.
16. Scattoni ML, Ricceri L, Crawley JN. Unusual repertoire of vocalizations in adult BTBR T + tf/J mice during three types of social encounters. Genes Brain Behav. 2011;10:44-56.
17. Sekirov I, Russell SL, Antunes LCM, Finlay BB. Gut microbiota in health and disease. Physiol Rev. 2010;90:859-904.
18. Parracho HMRT, Bingham MO, Gibson GR, McCartney AL. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005;54(Pt 10):987-91.
19. Janssen AWF, Kersten S. The role of the gut microbiota in metabolic health. FASEB J. 2015;29:3111-23.
20. Sandler RH, Finegold SM, Bolte ER, Buchanan CP, Maxwell AP, Väisänen ML, Nelson MN, Wexler HM. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol. 2000;15:429-35.
21. Nau R, Sörgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev. 2010;23:858-83.
22. Abdallah Ismail N, Ragab SH, Abd Elbaky A, Shoeib ARS, Alhosary Y, Fekry D. Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults. Arch Med Sci. 2011;7:501-7.
23. Wang L, Conlon MA, Christophersen CT, Sorich MJ, Angley MT. Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders. Biomark Med. 2014;8:331-44.
24. De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Bäckhed F, Mithieux G. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell. 2014;156:84-96.
25. de Magistris L, Familiari V, Pascotto A, Sapone A, Frolli A, Iardino P, Carteni M, De Rosa M, Francavilla R, Riegler G, Militerni R, Bravaccio C. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr. 2010;51:418-24.
26. Corfield AP, Carroll D, Myerscough N, Probert CS. Mucins in the gastrointestinal tract in health and disease. Front Biosci. 2001;6:D1321-57.
27. Ganesh BP, Klopfleisch R, Loh G, Blaut M. Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella typhimurium-infected gnotobiotic mice. PLoS One. 2013;8:e74963.
28. Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015;519:92-6.