Evidence for major genes influencing pulmonary function in the NHLBI Family Heart Study

Genetic Epidemiology

Volumn 19, Issue 1, 2000, Pages 81-94

  Wilk, Jemma B ^a   Djousse, Luc ^a   Arnett, Donna K ^b   Rich, Stephen S ^c   Province, Michael A ^d   Hunt, Steven C ^e   Crapo, Robert O ^f   Higgins, Millicent ^g   Myers, Richard H ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d WASHINGTON UNIVERSITY   (United States)

^e UNIVERSITY OF UTAH   (United States)

^f LDS HOSPITAL   (United States)

^g NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

FEV1; FEV1 FVC ratio; FVC; Segregation analysis

Indexed keywords

ARTICLE; ENVIRONMENTAL FACTOR; FAMILY STUDY; FEMALE; FORCED EXPIRATORY VOLUME; HEREDITY; HUMAN; LUNG FUNCTION; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; RESPIRATORY AIRFLOW; SEGREGATION ANALYSIS;

ANTHROPOMETRY; CHI-SQUARE DISTRIBUTION; FAMILY; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LUNG DISEASES; MALE; MODELS, GENETIC; PHENOTYPE; REGRESSION ANALYSIS; SMOKING; SPIROMETRY; VITAL CAPACITY;

EID: 0033922390     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2272(200007)19:1<81::AID-GEPI6>3.0.CO;2-8     Document Type: Article

References (18)

1. Akaike H. 1974. A new look at the statistical model identification. IEEE Trans Automat Control AC-19:719-23.
2. Atwood LD, Kammerer CM, Mitchell BD. 1993. Exploring the HDL likelihood surface. Genet Epidemiol 10:641-5.
3. Bonney GE. 1984. On the statistical determination of major gene mechanisms in continuous human traits: regressive models. Am J Med Genet 18:731-49.
4. Chen Y, Home SL, Rennie DC, Dosman JA. 1996. Segregation analysis of two lung function indices in a random sample of young families: the Humboldt family study. Genet Epidemiol 13:35-47.
5. Chen Y, Rennie DC, Lockinger LA, Dosman JA. 1997. Major genetic effect on forced vital capacity: the Humboldt family study. Genet Epidemiol 14:63-76.
6. Coultas DB, Hanis CL, Howard CA, Skipper BJ, Samet JM. 1991. Heritability of ventilatory function in smoking and nonsmoking New Mexico Hispanics. Am Rev Respir Dis 144:770-5.
7. DeStefano AL, Cupples LA, Maciel P, Gaspar C, Radvany J, Dawson DM, Sudarsky L, Corwin L, Coutinho P, MacLeod P. 1996. A familial factor independent of CAG repeat length influences age at onset of Machado-Joseph disease. Am J Hum Genet 59:119-27.
8. George VT, Elston RC. 1988. Generalized modulus power transformations. Commun Statist Theory Methods 17:2933-52.
9. Givelber RJ, Couropmitree NN, Gottlieb DJ, Evans JC, Levy D, Myers RH, O'Conner GT. 1998. Segregation analysis of pulmonary function among families in the Framingham study. Am J Respir Crit Care Med 157:1445-51.
10. Higgins M, Province M, Heiss G, Eckfeldt J, Ellison RC, Folsom AR, Rao DC, Sprafka JM, Williams R. 1996. NHLBI family heart study: objectives and design. Am J Epidemiol 143:1219-28.
11. Lewitter FI, Tager IB, McGue M, Tishler PV, Speizer FE. 1984. Genetic and environmental determinants of level of pulmonary function. Am J Epidemiol 120:518-30.
12. National Center for Health Statistics. 1996. Monitoring Health Care in America. Quarterly Fact Sheet, December.
13. Rice T, Despr'es JP, Daw EW, Gagnon J, Borecki IB, P'erusse L, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. 1997. Familial resemblance for abdominal visceral fat: the HERITAGE family study. Int J Obes Relat Metab Disord 21:1024-31.
14. Rybicki BA, Beaty TH, Cohen BH. 1990. Major genetic mechanisms in pulmonary function. J Clin Epidemiol 43:667-75.
15. S.A.G.E. 1997.. Statistical analysis for genetic epidemiology , Release 3.1. Computer program package available from the Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, OH.
16. Sanford AJ, Weir TD, Pare PD. 1997. Genetic risk factors for chronic obstructive pulmonary disease. Eur Respir J 10:1380-91.
17. Tager I, Segal M, Speizer F, Weiss S. 1988. The natural history of forced expiratory volume: effects of cigarette smoking and respiratory symptoms. Am Rev Respir Dis 138:837-49.
18. 1-antitrypsin deficiency: the clinical and physiological features of pulmonary emphysema in subjects homozygous for Pi type Z: a survey by the British Thoracic Association. Br J Dis Chest 77:14-27.