Cytotoxic and Proinflammatory Effects of Metal-Based Nanoparticles on THP-1 Monocytes Characterized by Combined Proteomics Approaches

Journal of Proteome Research

Volumn 16, Issue 2, 2017, Pages 689-697

  Tarasova, Nataliya K ^a   Gallud, Audrey ^a   Ytterberg, A Jimmy ^a   Chernobrovkin, Alexey ^a   Aranzaes, Jaime Ruiz ^b   Astruc, Didier ^b   Antipov, Alexei ^c   Fedutik, Yuri ^c   Fadeel, Bengt ^a   Zubarev, Roman A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INSTITUT DES SCIENCES MOLÉCULAIRES   (France)

^c Plasmachem GmbH   (Germany)

Author keywords

anticancer drugs; copper oxide; gold nanoparticles; inflammation; monocyte assay; Nanomaterials; quantum dots; thermal proteome profiling

Indexed keywords

CADMIUM TELLURIDE NANOPARTICLE; CAMPTOTHECIN; COPPER OXIDE NANOPARTICLE; CREATINE KINASE; DNA TOPOISOMERASE; DOXORUBICIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GOLD NANOPARTICLE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LONG CHAIN FATTY ACID COENZYME A LIGASE; METAL NANOPARTICLE; PROTEIN; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 8 LIKE PROTEIN 2; UNCLASSIFIED DRUG; CADMIUM DERIVATIVE; CADMIUM TELLURIDE; COPPER; CUPRIC OXIDE; CYTOTOXIN; GOLD; LIPOPOLYSACCHARIDE; PROTEOME; TELLURIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; EC50; ENERGY METABOLISM; HEAT; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; MONOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEOMICS; UPREGULATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; METABOLISM;

CADMIUM COMPOUNDS; CAMPTOTHECIN; CELL PROLIFERATION; CELL SURVIVAL; COPPER; CYTOTOXINS; DOXORUBICIN; GOLD; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LIPOPOLYSACCHARIDES; METAL NANOPARTICLES; MONOCYTES; OXIDATIVE STRESS; PROTEOME; PROTEOMICS; TELLURIUM;

EID: 85011681354     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.6b00747     Document Type: Article

References (34)

1. Chang, Y.-N.; Zhang, M.; Xia, L.; Zhang, J.; Xing, G. The toxic effects and mechanisms of CuO and ZnO nanoparticles Materials 2012, 5 (12) 2850-2871 10.3390/ma5122850
2. Ren, G.; Hu, D.; Cheng, E. W. C.; Vargas-Reus, M. a.; Reip, P.; Allaker, R. P. Characterisation of copper oxide nanoparticles for antimicrobial applications Int. J. Antimicrob. Agents 2009, 33 (6) 587-590 10.1016/j.ijantimicag.2008.12.004
3. Jain, S.; Hirst, D. G.; O'Sullivan, J. M. Gold nanoparticles as novel agents for cancer therapy Br. J. Radiol. 2012, 85 (1010) 101-113 10.1259/bjr/59448833
4. Rizvi, S. B.; Ghaderi, S.; Keshtgar, M.; Seifalian, A. M.; Muhammed, M. Semiconductor quantum dots as fluorescent probes for in vitro and in vivo bio-molecular and cellular imaging Nano Rev. 2010, 1, 5161 10.3402/nano.v1i0.5161
5. Bhattacharya, K.; Mukherjee, S. P.; Gallud, A.; Burkert, S. C.; Bistarelli, S.; Bellucci, S.; Bottini, M.; Star, A.; Fadeel, B. Biological interactions of carbon-based nanomaterials: from coronation to degradation Nanomedicine 2016, 12 (2) 333-351 10.1016/j.nano.2015.11.011
6. Chernobrovkin, A.; Marin-Vicente, C.; Visa, N.; Zubarev, R. A. Functional Identification of Target by Expression Proteomics (FITExP) reveals protein targets and highlights mechanisms of action of small molecule drugs Sci. Rep. 2015, 5, 11176 10.1038/srep11176
7. Tarasova, N. K.; Ytterberg, A. J.; Lundberg, K.; Zhang, X.-M.; Harris, R. A.; Zubarev, R. A. Establishing a proteomics-based monocyte assay to assess differential innate immune activation responses J. Proteome Res. 2016, 15 (7) 2337-2345 10.1021/acs.jproteome.6b00422
8. Tsuchiya, S.; Yamabe, M.; Yamaguchi, Y.; Kobayashi, Y.; Konno, T.; Tada, K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1) Int. J. Cancer 1980, 26 (2) 171-176 10.1002/ijc.2910260208
9. Franken, H.; Mathieson, T.; Childs, D.; Sweetman, G. M. A.; Werner, T.; Tögel, I.; Doce, C.; Gade, S.; Bantscheff, M.; Drewes, G.; Reinhard, F. B. M.; Huber, W.; Savitski, M. M. Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry Nat. Protoc. 2015, 10 (10) 1567-1593 10.1038/nprot.2015.101
10. Costa, P. M.; Fadeel, B. Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk Toxicol. Appl. Pharmacol. 2016, 299, 101-111 10.1016/j.taap.2015.12.014
11. Haniu, H.; Matsuda, Y.; Takeuchi, K.; Kim, Y. A.; Hayashi, T.; Endo, M. Proteomics-based safety evaluation of multi-walled carbon nanotubes Toxicol. Appl. Pharmacol. 2010, 242 (3) 256-262 10.1016/j.taap.2009.10.015
12. Yuan, J.; Gao, H.; Sui, J.; Duan, H.; Chen, W. N.; Ching, C. B. Cytotoxicity evaluation of oxidized single-walled carbon nanotubes and graphene oxide on human hepatoma HepG2 cells: An iTRAQ-coupled 2D LC-MS/MS proteome analysis Toxicol. Sci. 2012, 126 (1) 149-161 10.1093/toxsci/kfr332
13. Palomäki, J.; Sund, J.; Vippola, M.; Kinaret, P.; Greco, D.; Savolainen, K.; Puustinen, A.; Alenius, H. A secretomics analysis reveals major differences in the macrophage responses towards different types of carbon nanotubes Nanotoxicology 2015, 9 (6) 719-728 10.3109/17435390.2014.969346
14. Wuister, S. F.; Swart, I.; Van Driel, F.; Hickey, S. G.; de Mello Donega, C. Highly Luminescent Water-Soluble CdTe Quantum Dots Nano Lett. 2003, 3, 503-507 10.1021/nl034054t
15. Mazumder, S.; Dey, R.; Mitra, M. K.; Mukherjee, S.; Das, G. C. Review: Biofunctionalized quantum dots in biology and medicine J. Nanomater. 2009, 2009, 1-17 10.1155/2009/815734
16. Lovrić, J.; Cho, S. J.; Winnik, F. M.; Maysinger, D. Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death Chem. Biol. 2005, 12 (11) 1227-1234 10.1016/j.chembiol.2005.09.008
17. Wang, Z.; Li, N.; Zhao, J.; White, J. C.; Qu, P.; Xing, B. CuO nanoparticle interaction with human epithelial cells: Cellular uptake, location, export, and genotoxicity Chem. Res. Toxicol. 2012, 25 (7) 1512-1521 10.1021/tx3002093
18. Pan, Y.; Neuss, S.; Leifert, A.; Fischler, M.; Wen, F.; Simon, U.; Schmid, G.; Brandau, W.; Jahnen-Dechent, W. Size-dependent cytotoxicity of gold nanoparticles Small 2007, 3 (11) 1941-1949 10.1002/smll.200700378
19. Goodman, C. M.; McCusker, C. D.; Yilmaz, T.; Rotello, V. M. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains Bioconjugate Chem. 2004, 15 (4) 897-900 10.1021/bc049951i
20. Lyutvinskiy, Y.; Yang, H.; Rutishauser, D.; Zubarev, R. a. In silico instrumental response correction improves precision of label-free proteomics and accuracy of proteomics-based predictive models Mol. Cell. Proteomics 2013, 12, 2324-2331 10.1074/mcp.O112.023804
21. Tarasova, N. K.; Ytterberg, A. J.; Lundberg, K.; Zhang, X.-M.; Harris, R. A.; Zubarev, R. A. Proteomics reveals a role for attachment in monocyte differentiation into efficient pro-inflammatory macrophages J. Proteome Res. 2015, 14 (9) 3940-3947 10.1021/acs.jproteome.5b00659
22. Benjamini, Y.; Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing J. R. Stat. Soc. Ser. B 1995, 57 (1) 289-300
23. Cox, J.; Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification Nat. Biotechnol. 2008, 26 (12) 1367-1372 10.1038/nbt.1511
24. Vallhov, H.; Qin, J.; Johansson, S. M.; Ahlborg, N.; Muhammed, M. A.; Scheynius, A.; Gabrielsson, S. The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications Nano Lett. 2006, 6 (8) 1682-1686 10.1021/nl060860z
25. Feliu, N.; Kohonen, P.; Ji, J.; Zhang, Y.; Karlsson, H. L.; Palmberg, L.; Nyström, A.; Fadeel, B. Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells ACS Nano 2015, 9 (1) 146-163 10.1021/nn5061783
26. Pierce, J. W.; Schoenleber, R.; Jesmok, G.; Best, J.; Moore, S. a; Collins, T.; Gerritsen, M. E. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo J. Biol. Chem. 1997, 272 (34) 21096-21103 10.1074/jbc.272.34.21096
27. Sun, H.; Gong, S.; Carmody, R. J.; Hilliard, A.; Li, L.; Sun, J.; Kong, L.; Xu, L.; Hilliard, B.; Hu, S.; Shen, H.; Yang, X.; Chen, Y. H. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis Cell 2008, 133 (3) 415-426 10.1016/j.cell.2008.03.026
28. Sarkar, A.; Ravindran, G.; Krishnamurthy, V.; Campus, K. K. B. G. A brief review on the effect of cadmium toxicity: from cellular to organ level Int. J. Bio-Technology 2013, 3 (1) 17-36
29. Conroy, J.; Byrne, S. J.; Gun'ko, Y. K.; Rakovich, Y. P.; Donegan, J. F.; Davies, A.; Kelleher, D.; Volkov, Y. CdTe nanoparticles display tropism to core histones and histone-rich cell organelles Small 2008, 4 (11) 2006-2015 10.1002/smll.200800088
30. Villiers, C.; Freitas, H.; Couderc, R.; Villiers, M.-B.; Marche, P. Analysis of the toxicity of gold nano particles on the immune system: effect on dendritic cell functions J. Nanopart. Res. 2010, 12 (1) 55-60 10.1007/s11051-009-9692-0
31. Gerber, A.; Bundschuh, M.; Klingelhofer, D.; Groneberg, D. A. Gold nanoparticles: recent aspects for human toxicology J. Occup. Med. Toxicol. 2013, 8 (1) 32 10.1186/1745-6673-8-32
32. Meng, H.; Xing, G.; Sun, B.; Zhao, F.; Lei, H.; Li, W.; Song, Y.; Chen, Z.; Yuan, H.; Wang, X.; Long, J.; Chen, C.; Liang, X.; Zhang, N.; Chai, Z.; Zhao, Y. Potent angiogenesis inhibition by the particulate form of fullerene derivatives ACS Nano 2010, 4 (5) 2773-2783 10.1021/nn100448z
33. Miao, Y.; Xu, J.; Shen, Y.; Chen, L.; Bian, Y.; Hu, Y.; Zhou, W.; Zheng, F.; Man, N.; Shen, Y.; Zhang, Y.; Wang, M.; Wen, L. Nanoparticle as signaling protein mimic: robust structural and functional modulation of CaMKII upon specific binding to fullerene C60 nanocrystals ACS Nano 2014, 8 (6) 6131-6144 10.1021/nn501495a
34. Gallud, A.; Fadeel, B. Keeping it small: towards a molecular definition of nanotoxicology Eur. J. Nanomed. 2015, 7 (3) 143-151 10.1515/ejnm-2015-0020