Improved FRET biosensor for the measurement of BCR-ABL activity in chronic myeloid leukemia cells

Cell Structure and Function

Volumn 42, Issue 1, 2017, Pages 15-26

  Horiguchi, Mika ^a   Fujioka, Mari ^a   Kondo, Takeshi ^a   Fujioka, Yoichiro ^a   Li, Xinxin ^a   Horiuchi, Kosui ^a   Satoh, Aya O ^a   Nepal, Prabha ^a   Nishide, Shinya ^a   Nanbo, Asuka ^a   Teshima, Takanori ^a   Ohba, Yusuke ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic myeloid leukemia; Companion diagnostics; F rster resonance energy transfer; Molecular target drug; Tyrosine kinase inhibitor

Indexed keywords

BCR ABL PROTEIN; CRK LIKE PROTEIN; ANTINEOPLASTIC AGENT; NUCLEAR EXPORT SIGNAL; NUCLEAR PROTEIN; PHARMACOLOGICAL BIOMARKER; PROTEIN KINASE INHIBITOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BIOSENSOR; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; INFORMED CONSENT; LIMIT OF QUANTITATION; PATHOGENESIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION; GENETIC PROCEDURES; GENETIC TRANSFECTION; GENETICS; K-562 CELL LINE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; METABOLISM; NUCLEAR EXPORT SIGNAL; PATHOLOGY; PHOSPHORYLATION; PLASMID; PROCEDURES; TRANSGENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; BIOMARKERS, PHARMACOLOGICAL; BIOSENSING TECHNIQUES; FLUORESCENCE RESONANCE ENERGY TRANSFER; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MYELOID CELLS; NUCLEAR EXPORT SIGNALS; NUCLEAR PROTEINS; PHOSPHORYLATION; PLASMIDS; PROTEIN KINASE INHIBITORS; TRANSFECTION; TRANSGENES;

EID: 85011586486     PISSN: 03867196     EISSN: 13473700     Source Type: Journal    
DOI: 10.1247/csf.16019     Document Type: Article

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