Stromal cues regulate the pancreatic cancer epigenome and metabolome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 5, 2017, Pages 1129-1134

  Sherman, Mara H ^a,h   Yu, Ruth T ^a   Tseng, Tiffany W ^a   Sousa, Cristovao M ^b   Liu, Sihao ^a   Truitt, Morgan L ^a   He, Nanhai ^a   Ding, Ning ^a   Liddle, Christopher ^c   Atkins, Annette R ^a   Leblanc, Mathias ^a   Collisson, Eric A ^d   Asara, John M ^e   Kimmelman, Alec C ^b,f   Downes, Michael ^a   Evans, Ronald M ^a,g  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^h OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

BRD2; Cancer metabolism; Histone acetylation; Pancreatic ductal adenocarcinoma; Tumor microenvironment

Indexed keywords

BROMODOMAIN CONTAINING PROTEIN 2; DOXYCYCLINE; HISTONE; PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG; BRD2 PROTEIN, HUMAN; CYTOKINE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TUMOR PROTEIN;

ANIMAL CELL; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE; CELL VIABILITY; CHROMATIN; CONFERENCE PAPER; CONTROL GROUP; CONTROLLED STUDY; DNA REPLICATION; DOWN REGULATION; ENHANCER REGION; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLOME; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RNA SEQUENCE; STROMA; TUMOR MICROENVIRONMENT; UPREGULATION; ACETYLATION; ANTAGONISTS AND INHIBITORS; ENERGY METABOLISM; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HISTONE CODE; METABOLISM; PANCREAS CARCINOMA; PANCREAS TUMOR; PANCREATIC STELLATE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS); STROMA CELL; TUMOR CELL CULTURE;

ACETYLATION; CARCINOMA, PANCREATIC DUCTAL; CYTOKINES; ENERGY METABOLISM; ENHANCER ELEMENTS, GENETIC; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE CODE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; METABOLOME; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; PANCREATIC STELLATE CELLS; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; STROMAL CELLS; TUMOR CELLS, CULTURED; TUMOR MICROENVIRONMENT;

EID: 85011295507     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1620164114     Document Type: Article

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