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Volumn 90, Issue 1, 2016, Pages 61-72

Immunophenotype of normal vs. myeloma plasma cells: Toward antibody panel specifications for MRD detection in multiple myeloma

Author keywords

antibody panels; EuroFlow; high sensitivity; markers; minimal residual disease; multiple myeloma

Indexed keywords

ANTIGEN; CD19 ANTIGEN; CD20 ANTIGEN; CD200 ANTIGEN; CD22 ANTIGEN; CD229 ANTIGEN; CD27 ANTIGEN; CD28 ANTIGEN; CD307 ANTIGEN; CD319 ANTIGEN; CD33 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; CD81 ANTIGEN; CYTOPLASMIC IMMUNOGLOBULIN; FLUOROCHROME; IMMUNOGLOBULIN; INTERCELLULAR ADHESION MOLECULE 1; STEM CELL FACTOR RECEPTOR; SYNDECAN 1; UNCLASSIFIED DRUG; ANTIBODY; ANTINEOPLASTIC AGENT; LEUKOCYTE ANTIGEN;

EID: 85010982932     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.21265     Document Type: Review
Times cited : (195)

References (75)
  • 1
    • 0036839014 scopus 로고    scopus 로고
    • Flow cytometric disease monitoring in multiple myeloma: The relationship between normal and neoplastic plasma cells predicts outcome after transplantation
    • Rawstron AC, Davies FE, DasGupta R, Ashcroft AJ, Patmore R, Drayson MT, Owen RG, Jack AS, Child JA Morgan GJ. Flow cytometric disease monitoring in multiple myeloma: The relationship between normal and neoplastic plasma cells predicts outcome after transplantation. Blood 2002;100:3095–3100.
    • (2002) Blood , vol.100 , pp. 3095-3100
    • Rawstron, A.C.1    Davies, F.E.2    DasGupta, R.3    Ashcroft, A.J.4    Patmore, R.5    Drayson, M.T.6    Owen, R.G.7    Jack, A.S.8    Child, J.A.9    Morgan, G.J.10
  • 2
    • 0036493775 scopus 로고    scopus 로고
    • Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: A tool for comparing the efficacy of different treatment strategies and predicting outcome
    • San Miguel JF, Almeida J, Mateo G, Blade J, Lopez-Berges C, Caballero D, Hernandez J, Moro MJ, Fernandez-Calvo J, Diaz-Mediavilla J, et al. Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: A tool for comparing the efficacy of different treatment strategies and predicting outcome. Blood 2002;99:1853–1856.
    • (2002) Blood , vol.99 , pp. 1853-1856
    • San Miguel, J.F.1    Almeida, J.2    Mateo, G.3    Blade, J.4    Lopez-Berges, C.5    Caballero, D.6    Hernandez, J.7    Moro, M.J.8    Fernandez-Calvo, J.9    Diaz-Mediavilla, J.10
  • 3
    • 84929347438 scopus 로고    scopus 로고
    • New criteria for response assessment: Role of minimal residual disease in multiple myeloma
    • Paiva B, van Dongen JJ, Orfao A. New criteria for response assessment: Role of minimal residual disease in multiple myeloma. Blood 2015;125:3059–3068.
    • (2015) Blood , vol.125 , pp. 3059-3068
    • Paiva, B.1    van Dongen, J.J.2    Orfao, A.3
  • 5
  • 6
    • 45749097488 scopus 로고    scopus 로고
    • Prognostic value of immunophenotyping in multiple myeloma: A study by the PETHEMA/GEM cooperative study groups on patients uniformly treated with high-dose therapy
    • Mateo G, Montalban MA, Vidriales MB, Lahuerta JJ, Mateos MV, Gutierrez N, Rosinol L, Montejano L, Blade J, Martinez R, et al. Prognostic value of immunophenotyping in multiple myeloma: A study by the PETHEMA/GEM cooperative study groups on patients uniformly treated with high-dose therapy. J Clin Oncol 2008;26:2737–2744.
    • (2008) J Clin Oncol , vol.26 , pp. 2737-2744
    • Mateo, G.1    Montalban, M.A.2    Vidriales, M.B.3    Lahuerta, J.J.4    Mateos, M.V.5    Gutierrez, N.6    Rosinol, L.7    Montejano, L.8    Blade, J.9    Martinez, R.10
  • 12
    • 84923650138 scopus 로고    scopus 로고
    • Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy
    • Mathis S, Chapuis N, Borgeot J, Maynadie M, Fontenay M, Bene MC, Guy J, Bardet V. Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy. Cytometry B Clin Cytom 2015;88:101–109.
    • (2015) Cytometry B Clin Cytom , vol.88 , pp. 101-109
    • Mathis, S.1    Chapuis, N.2    Borgeot, J.3    Maynadie, M.4    Fontenay, M.5    Bene, M.C.6    Guy, J.7    Bardet, V.8
  • 13
    • 84886921631 scopus 로고    scopus 로고
    • Minimal residual disease testing in multiple myeloma by flow cytometry: Major heterogeneity
    • Flanders A, Stetler-Stevenson M, Landgren O. Minimal residual disease testing in multiple myeloma by flow cytometry: Major heterogeneity. Blood 2013;122:1088–1089.
    • (2013) Blood , vol.122 , pp. 1088-1089
    • Flanders, A.1    Stetler-Stevenson, M.2    Landgren, O.3
  • 14
    • 0021272605 scopus 로고
    • Expression of human B cell-associated antigens on leukemias and lymphomas: A model of human B cell differentiation
    • Anderson KC, Bates MP, Slaughenhoupt BL, Pinkus GS, Schlossman SF, Nadler LM. Expression of human B cell-associated antigens on leukemias and lymphomas: A model of human B cell differentiation. Blood 1984;63:1424–1433.
    • (1984) Blood , vol.63 , pp. 1424-1433
    • Anderson, K.C.1    Bates, M.P.2    Slaughenhoupt, B.L.3    Pinkus, G.S.4    Schlossman, S.F.5    Nadler, L.M.6
  • 15
    • 0022636548 scopus 로고
    • Immunological phenotype of neoplasms involving the B cell in the last step of differentiation
    • San Miguel JF, Caballero MD, Gonzalez M, Zola H, Lopez Borrasca A. Immunological phenotype of neoplasms involving the B cell in the last step of differentiation. Br J Haematol 1986;62:75–83.
    • (1986) Br J Haematol , vol.62 , pp. 75-83
    • San Miguel, J.F.1    Caballero, M.D.2    Gonzalez, M.3    Zola, H.4    Lopez Borrasca, A.5
  • 18
    • 46749101051 scopus 로고    scopus 로고
    • Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: Analysis of a series of 432 patients
    • Quijano S, Lopez A, Rasillo A, Barrena S, Luz Sanchez M, Flores J, Fernandez C, Sayagues JM, Osuna CS, Fernandez N, et al. Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: Analysis of a series of 432 patients. Blood 2008;111:5130–5141.
    • (2008) Blood , vol.111 , pp. 5130-5141
    • Quijano, S.1    Lopez, A.2    Rasillo, A.3    Barrena, S.4    Luz Sanchez, M.5    Flores, J.6    Fernandez, C.7    Sayagues, J.M.8    Osuna, C.S.9    Fernandez, N.10
  • 20
    • 1542410055 scopus 로고    scopus 로고
    • Impact of flow cytometry on the diagnosis and characterization of lymphomas, chronic lymphoproliferative disorders and plasma cell neoplasias
    • Braylan RC. Impact of flow cytometry on the diagnosis and characterization of lymphomas, chronic lymphoproliferative disorders and plasma cell neoplasias. Cytometry A 2004;58:57–61.
    • (2004) Cytometry A , vol.58 , pp. 57-61
    • Braylan, R.C.1
  • 21
    • 0025259973 scopus 로고
    • Identification and characterization of plasma cells in normal human bone marrow by high-resolution flow cytometry
    • Terstappen LW, Johnsen S, Segers-Nolten IM, Loken MR. Identification and characterization of plasma cells in normal human bone marrow by high-resolution flow cytometry. Blood 1990;76:1739–1747.
    • (1990) Blood , vol.76 , pp. 1739-1747
    • Terstappen, L.W.1    Johnsen, S.2    Segers-Nolten, I.M.3    Loken, M.R.4
  • 22
    • 0028033750 scopus 로고
    • A new method for the analysis of plasma cell DNA content in multiple myeloma samples using a CD38/propidium iodide double staining technique
    • −33
    • Orfao A, Garcia-Sanz R, Lopez-Berges MC, Belen Vidriales M, Gonzalez M, Caballero MD, San Miguel JF. A new method for the analysis of plasma cell DNA content in multiple myeloma samples using a CD38/propidium iodide double staining technique. Cytometry 1994;17:332−339.
    • (1994) Cytometry , vol.17 , pp. 332-339
    • Orfao, A.1    Garcia-Sanz, R.2    Lopez-Berges, M.C.3    Belen Vidriales, M.4    Gonzalez, M.5    Caballero, M.D.6    San Miguel, J.F.7
  • 26
    • 0037630415 scopus 로고    scopus 로고
    • Heparan sulfate regulates targeting of syndecan-1 to a functional domain on the cell surface
    • Yang Y, Borset M, Langford JK, Sanderson RD. Heparan sulfate regulates targeting of syndecan-1 to a functional domain on the cell surface. J Biol Chem 2003;278:12888–12893.
    • (2003) J Biol Chem , vol.278 , pp. 12888-12893
    • Yang, Y.1    Borset, M.2    Langford, J.K.3    Sanderson, R.D.4
  • 29
    • 84902982435 scopus 로고    scopus 로고
    • Potential role of daratumumab in the treatment of multiple myeloma
    • Khagi Y, Mark TM. Potential role of daratumumab in the treatment of multiple myeloma. Onco Targets Ther 2014;7:1095–1100.
    • (2014) Onco Targets Ther , vol.7 , pp. 1095-1100
    • Khagi, Y.1    Mark, T.M.2
  • 31
  • 34
    • 66149133630 scopus 로고    scopus 로고
    • CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells
    • Tai YT, Soydan E, Song W, Fulciniti M, Kim K, Hong F, Li XF, Burger P, Rumizen MJ, Nahar S, et al. CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells. Blood 2009;113:4309–4318.
    • (2009) Blood , vol.113 , pp. 4309-4318
    • Tai, Y.T.1    Soydan, E.2    Song, W.3    Fulciniti, M.4    Kim, K.5    Hong, F.6    Li, X.F.7    Burger, P.8    Rumizen, M.J.9    Nahar, S.10
  • 36
    • 84884164729 scopus 로고    scopus 로고
    • CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma
    • Veillette A, Guo H. CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma. Crit Rev Oncol Hematol 2013;88:168–177.
    • (2013) Crit Rev Oncol Hematol , vol.88 , pp. 168-177
    • Veillette, A.1    Guo, H.2
  • 38
    • 84938499665 scopus 로고    scopus 로고
    • Utility of CD54, CD229, and CD319 for the identification of plasma cells in patient with clonal plasma cell diseases
    • Bottcher S,, on behalf of the EuroFlow consortium., DOI
    • Pojero F, Flores-Montero J, Sanoja L, Pérez JJ, Puig N, Paiva B, Bottcher S, van Dongen JJM, Orfao A, on behalf of the EuroFlow consortium. Utility of CD54, CD229, and CD319 for the identification of plasma cells in patient with clonal plasma cell diseases. Cytometry B Clin Cytom 2015; DOI 10.1002/cyto.b.21269.
    • (2015) Cytometry B Clin Cytom
    • Pojero, F.1    Flores-Montero, J.2    Sanoja, L.3    Pérez, J.J.4    Puig, N.5    Paiva, B.6    van Dongen, J.J.M.7    Orfao, A.8
  • 40
    • 77953191669 scopus 로고    scopus 로고
    • Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells
    • Caraux A, Klein B, Paiva B, Bret C, Schmitz A, Fuhler GM, Bos NA, Johnsen HE, Orfao A, Perez-Andres M. Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells. Haematologica 2010;95:1016–1020.
    • (2010) Haematologica , vol.95 , pp. 1016-1020
    • Caraux, A.1    Klein, B.2    Paiva, B.3    Bret, C.4    Schmitz, A.5    Fuhler, G.M.6    Bos, N.A.7    Johnsen, H.E.8    Orfao, A.9    Perez-Andres, M.10
  • 42
    • 84897936528 scopus 로고    scopus 로고
    • Immunophenotype of normal and myelomatous plasma-cell subsets
    • Robillard N, Wuilleme S, Moreau P, Bene MC. Immunophenotype of normal and myelomatous plasma-cell subsets. Front Immunol 2014;5:137.
    • (2014) Front Immunol , vol.5 , pp. 137.
    • Robillard, N.1    Wuilleme, S.2    Moreau, P.3    Bene, M.C.4
  • 43
  • 45
    • 84928370932 scopus 로고    scopus 로고
    • Old and new immunophenotypic markers in multiple myeloma for discrimination of responding and relapsing patients: The importance of “normal” residual plasma cell analysis
    • Pojero F, Casuccio A, Parrino MF, Cardinale G, Colonna Romano G, Caruso C, Gervasi F. Old and new immunophenotypic markers in multiple myeloma for discrimination of responding and relapsing patients: The importance of “normal” residual plasma cell analysis. Cytometry B Clin Cytom 2015;88:165–182.
    • (2015) Cytometry B Clin Cytom , vol.88 , pp. 165-182
    • Pojero, F.1    Casuccio, A.2    Parrino, M.F.3    Cardinale, G.4    Colonna Romano, G.5    Caruso, C.6    Gervasi, F.7
  • 50
  • 52
    • 70349130288 scopus 로고    scopus 로고
    • Constitutively lower expressions of CD54 on primary myeloma cells and their different localizations in bone marrow
    • Iqbal MS, Otsuyama K, Shamsasenjan K, Asaoku H, Mahmoud MS, Gondo T, Kawano MM. Constitutively lower expressions of CD54 on primary myeloma cells and their different localizations in bone marrow. Eur J Haematol 2009;83:302–312.
    • (2009) Eur J Haematol , vol.83 , pp. 302-312
    • Iqbal, M.S.1    Otsuyama, K.2    Shamsasenjan, K.3    Asaoku, H.4    Mahmoud, M.S.5    Gondo, T.6    Kawano, M.M.7
  • 54
    • 33845531300 scopus 로고    scopus 로고
    • Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma
    • Ise T, Nagata S, Kreitman RJ, Wilson WH, Wayne AS, Stetler-Stevenson M, Bishop MR, Scheinberg DA, Rassenti L, Kipps TJ, et al. Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma. Leukemia 2007;21:169–174.
    • (2007) Leukemia , vol.21 , pp. 169-174
    • Ise, T.1    Nagata, S.2    Kreitman, R.J.3    Wilson, W.H.4    Wayne, A.S.5    Stetler-Stevenson, M.6    Bishop, M.R.7    Scheinberg, D.A.8    Rassenti, L.9    Kipps, T.J.10
  • 55
    • 1642348370 scopus 로고    scopus 로고
    • Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma
    • Lin P, Owens R, Tricot G, Wilson CS. Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma. Am J Clin Pathol 2004;121:482–488.
    • (2004) Am J Clin Pathol , vol.121 , pp. 482-488
    • Lin, P.1    Owens, R.2    Tricot, G.3    Wilson, C.S.4
  • 56
    • 34447544075 scopus 로고    scopus 로고
    • Optimizing a multicolor immunophenotyping assay
    • Mahnke YD, Roederer M. Optimizing a multicolor immunophenotyping assay. Clin Lab Med 2007;27:469–485.
    • (2007) Clin Lab Med , vol.27 , pp. 469-485
    • Mahnke, Y.D.1    Roederer, M.2
  • 58
    • 59449099316 scopus 로고    scopus 로고
    • Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation
    • Paiva B, Vidriales MB, Cervero J, Mateo G, Perez JJ, Montalban MA, Sureda A, Montejano L, Gutierrez NC, Garcia de Coca A, et al. Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation. Blood 2008;112:4017–4023.
    • (2008) Blood , vol.112 , pp. 4017-4023
    • Paiva, B.1    Vidriales, M.B.2    Cervero, J.3    Mateo, G.4    Perez, J.J.5    Montalban, M.A.6    Sureda, A.7    Montejano, L.8    Gutierrez, N.C.9    Garcia de Coca, A.10
  • 60
  • 61
    • 27144546033 scopus 로고    scopus 로고
    • Minimal residual disease monitoring in multiple myeloma: A comparison between allelic-specific oligonucleotide real-time quantitative polymerase chain reaction and flow cytometry
    • Sarasquete ME, Garcia-Sanz R, Gonzalez D, Martinez J, Mateo G, Martinez P, Ribera JM, Hernandez JM, Lahuerta JJ, Orfao A, et al. Minimal residual disease monitoring in multiple myeloma: A comparison between allelic-specific oligonucleotide real-time quantitative polymerase chain reaction and flow cytometry. Haematologica 2005;90:1365–1372.
    • (2005) Haematologica , vol.90 , pp. 1365-1372
    • Sarasquete, M.E.1    Garcia-Sanz, R.2    Gonzalez, D.3    Martinez, J.4    Mateo, G.5    Martinez, P.6    Ribera, J.M.7    Hernandez, J.M.8    Lahuerta, J.J.9    Orfao, A.10
  • 62
    • 34548141773 scopus 로고    scopus 로고
    • A single-tube six-colour flow cytometry screening assay for the detection of minimal residual disease in myeloma
    • de Tute RM, Jack AS, Child JA Morgan GJ, Owen RG Rawstron AC. A single-tube six-colour flow cytometry screening assay for the detection of minimal residual disease in myeloma. Leukemia 2007;21:2046–2049.
    • (2007) Leukemia , vol.21 , pp. 2046-2049
    • de Tute, R.M.1    Jack, A.S.2    Child, J.A.3    Morgan, G.J.4    Owen, R.G.5    Rawstron, A.C.6
  • 63
    • 70449717409 scopus 로고    scopus 로고
    • Flow cytometric immunophenotyping and minimal residual disease analysis in multiple myeloma
    • Gupta R, Bhaskar A, Kumar L, Sharma A, Jain P. Flow cytometric immunophenotyping and minimal residual disease analysis in multiple myeloma. Am J Clin Pathol 2009;132:728–732.
    • (2009) Am J Clin Pathol , vol.132 , pp. 728-732
    • Gupta, R.1    Bhaskar, A.2    Kumar, L.3    Sharma, A.4    Jain, P.5
  • 66
    • 84883001834 scopus 로고    scopus 로고
    • A single-tube multiparameter seven-colour flow cytometry strategy for the detection of malignant plasma cells in multiple myeloma
    • Robillard N, Bene MC, Moreau P, Wuilleme S. A single-tube multiparameter seven-colour flow cytometry strategy for the detection of malignant plasma cells in multiple myeloma. Blood Cancer J 2013;3:e134.
    • (2013) Blood Cancer J , vol.3
    • Robillard, N.1    Bene, M.C.2    Moreau, P.3    Wuilleme, S.4
  • 67
    • 84906819363 scopus 로고    scopus 로고
    • Front-line transplantation program with lenalidomide, bortezomib, and dexamethasone combination as induction and consolidation followed by lenalidomide maintenance in patients with multiple myeloma: A phase II study by the Intergroupe Francophone du Myelome
    • Roussel M, Lauwers-Cances V, Robillard N, Hulin C, Leleu X, Benboubker L, Marit G, Moreau P, Pegourie B, Caillot D, et al. Front-line transplantation program with lenalidomide, bortezomib, and dexamethasone combination as induction and consolidation followed by lenalidomide maintenance in patients with multiple myeloma: A phase II study by the Intergroupe Francophone du Myelome. J Clin Oncol 2014;32:2712–2717.
    • (2014) J Clin Oncol , vol.32 , pp. 2712-2717
    • Roussel, M.1    Lauwers-Cances, V.2    Robillard, N.3    Hulin, C.4    Leleu, X.5    Benboubker, L.6    Marit, G.7    Moreau, P.8    Pegourie, B.9    Caillot, D.10
  • 68
    • 85011000363 scopus 로고    scopus 로고
    • Automated, highly-sensitive flow cytometry method for standardized detection of minimal residual disease in multiple myeloma
    • Flores-Montero J. Automated, highly-sensitive flow cytometry method for standardized detection of minimal residual disease in multiple myeloma. Manuscript in Preparation.
    • Manuscript in Preparation
    • Flores-Montero, J.1
  • 71
    • 84856086596 scopus 로고    scopus 로고
    • High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma
    • Paiva B, Gutierrez NC, Rosinol L, Vidriales MB, Montalban MA, Martinez-Lopez J, Mateos MV, Cibeira MT, Cordon L, Oriol A, et al. High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma. Blood 2012;119:687–691.
    • (2012) Blood , vol.119 , pp. 687-691
    • Paiva, B.1    Gutierrez, N.C.2    Rosinol, L.3    Vidriales, M.B.4    Montalban, M.A.5    Martinez-Lopez, J.6    Mateos, M.V.7    Cibeira, M.T.8    Cordon, L.9    Oriol, A.10
  • 74
    • 78149465908 scopus 로고    scopus 로고
    • Automated pattern-guided principal component analysis vs. expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: A step forward in the standardization of clinical immunophenotyping
    • Costa ES, Pedreira CE, Barrena S, Lecrevisse Q, Flores J, Quijano S, Almeida J, Del Carmen Garcia-Macias M, Bottcher S, Van Dongen JJ, et al. Automated pattern-guided principal component analysis vs. expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: A step forward in the standardization of clinical immunophenotyping. Leukemia 2010;24:1927–1933.
    • (2010) Leukemia , vol.24 , pp. 1927-1933
    • Costa, E.S.1    Pedreira, C.E.2    Barrena, S.3    Lecrevisse, Q.4    Flores, J.5    Quijano, S.6    Almeida, J.7    Del Carmen Garcia-Macias, M.8    Bottcher, S.9    Van Dongen, J.J.10
  • 75
    • 85010920839 scopus 로고    scopus 로고
    • New Developments in the ESLHO Networks. 3rd ESLHO Symposium. The Nederlands;, p.
    • European scientific foundation of laboratory hemato oncology (ESLHO). New Developments in the ESLHO Networks. 3rd ESLHO Symposium. The Nederlands; 2014. 63 p.
    • (2014) , pp. 63


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