Genetic abnormalities and patterns of antigenic expression in multiple myeloma

Clinical Cancer Research

Volumn 11, Issue 10, 2005, Pages 3661-3667

  Mateo, Gema ^a,b   Castellanos, Mariana ^a,b   Rasillo, Ana ^b,c   Gutiérrez, Norma C ^a,b   Montalbán, Ma Angeles ^d   Martín, Ma Luisa ^d   Hernández, Jesús Ma ^a,b   López Berges, Ma Consuelo ^a,b   Montejano, Laura ^d   Bladé, Joan ^f   Mateos, Ma Victoria ^a,b   Sureda, Anna ^g   De La Rubia, Javier ^h   Díaz Mediavilla, Joaquín ^e   Pandiella, Atanasio ^b   Lahuerta, Juan José ^d   Orfao, Alberto ^b,c   San Miguel, Jesús F ^a,b  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^b CSIC   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^e HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^f Hospital Clínic   (Spain)

^g Hospital Sant Pau I Santa Creu   (Spain)

^h HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIGEN; CD56 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; STEM CELL FACTOR RECEPTOR;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CHROMOSOME 13Q; CHROMOSOME DELETION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MALE; MULTIPLE MYELOMA; PLASMA CELL; PLOIDY; PRIORITY JOURNAL;

EID: 21044442093     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-1489     Document Type: Article

References (37)

1. Harada H, Kawano MM, Huang N, et al. Phenotypic difference of normal plasma cells from mature myeloma cells. Blood 1993;81:2658-63.
2. Leo R, Boeker M, Peest D, et al. Multiparameter analyses of normal and malignant human plasma cells: CD38++, CD56+, CD54+, clg+ is the common phenotype of myeloma cells. Ann Hematol 1992;64:132-9.
3. Almeida J, Orfao A, Mateo G, et al. Immunophenotypic and DNA content characteristics of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance. Pathol Biol (Paris) 1999;47:119-27.
4. Lemoli RM. C-kit ligand (SCF) in human multiple myeloma cells. Leuk Lymphoma 1996;20:457-64.
5. Ocqueteau M, Orfao A, Garcia-Sanz R, Almeida J, Gonzalez M, San Miguel JF. Expression of the CD117 antigen (c-Kit) on normal and myelomatous plasma cells. Br J Haematol 1996;95:489-93.
6. Ocqueteau M, Orfao A, Almeida J, et al. Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients. Implications for the differential diagnosis between MGUS and multiple myeloma. Am J Pathol 1998;152:1655-65.
7. Sahara N, Ihara M, Ono T, et al. Multiple myeloma expressing CD19(+)CD56(-) phenotype. Am J Hematol 2000;64:311-3.
8. San Miguel JF. Immunophenotypic heterogeneity of multiple myeloma: influence on the biology and clinical course of the disease. Castellano-Leones (Spain) Cooperative Group for the Study of Monoclonal Gammopathies. Br J Haematol 1991;77:185-90.
9. Lin P, Owens R, Tricot G, Wilson CS. Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma. Am J Clin Pathol 2004;121:482-8.
10. Fujii R, Ishikawa H, Mahmoud MS, Asaoku H, Kawano MM. MPC-1-CD49e-immature myeloma cells include CD45+ subpopulations that can proliferate in response to IL-6 in human myelomas. Br J Haematol 1999;105:131-40.
11. Pellat-Deceunynck C, Bataille R. Normal and malignant human plasma cells: proliferation, differentiation, and expansions in relation to CD45 expression. Blood Cells Mol Dis 2004;32:293-301.
12. Brown RD, Pope B, Yuen E, Gibson J, Joshua DE. The expression of T cell related costimulatory molecules in multiple myeloma. Leuk Lymphoma 1998;31:379-84.
13. Pellat-Deceunynck C, Bataille R, Robillard N, et al. Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells. Blood 1994;84:2597-603.
14. Barker HF, Hamilton MS, Ball J, Drew M, Franklin IM. Expression of adhesion molecules LFA-3 and N-CAM on normal and malignant human plasma cells. Br J Haematol 1992;81:331-5.
15. Sahara N, Takeshita A, Shigeno K, et al. Clinicopathological and prognostic characteristics of CD56-negative multiple myeloma. Br J Haematol 2002;117:882-5.
16. Van Riet I, DeWaele M, Remels L, Lacor P, Schots R, Van Camp B. Expression of cytoadhesion molecules (CD56, CD54, CD18 and CD29) by myeloma plasma cells. Br J Haematol 1991;79:421-7.
17. Orfao A, Chillon MC, Bortoluci AM, et al. The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PML-RARα gene rearrangements. Haematologica 1999;84:405-12.
18. Tabernero MD, Bortoluci AM, Alaejos I, et al. Adult precursor B-ALL with BCR/ABL gene rearrangements displays a unique immunophenotype based on the pattern of CD10, CD34, CD13 and CD38 expresssion. Leukemia 2001;15:406-14.
19. De Zen L, Orfao A, Cazzaniga G, et al. Quantitative multiparametric immunophenotyping in acute lymphoblastic leukemia: correlation with specific genotype. I. ETV6/AML1 ALLs identification. Leukemia 2000;14:1225-31.
20. Bergsagel PL, Kuehl WM. Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma. Immunol Rev 2003;194:96-104.
21. Gutierrez NC, Hernandez JM, Garcia JL, et al. Correlation between cytogenetic abnormalities and disease characteristics in multiple myeloma: monosomy of chromosome 13 and structural abnormalities of 11q are associated with a high percentage of S-phase plasma cells. Haematologica 2000;85:1146-52.
22. Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res 2004;64:1546-58.
23. Fonseca R, Debes-Marun CS, Picken EB, et al. The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood 2003;102:2562-7.
24. Smadja NV, Leroux D, Soulier J, et al. Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases. Genes Chromosomes Cancer 2003;38:234-9.
25. Robillard N, Avet-Loiseau H, Garand R, et al. CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma. Blood 2003;102:1070-1.
26. Orfao A, Garcia-Sanz R, Lopez-Berges MC, et al. A new method for the analysis of plasma cell DNA content in multiple myeloma samples using a CD38/propidium iodide double staining technique. Cytometry 1994;17:332-9.
27. San Miguel JF, Garcia-Sanz R, Gonzalez M, Orfao A. DNA cell content studies in multiple myeloma. Leuk Lymphoma 1996;23:33-41.
28. Hernandez JM, Gonzalez MB, Granada I, et al. Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo. Haematologica 2000;85:481-5.
29. Lima M, Teixeira MA, Fonseca S, et al. Immunophenotypic aberrations, DNA content, and cell cycle analysis of plasma cells in patients with myeloma and monoclonal gammopathies. Blood Cells Mol Dis 2000;26:634-45.
30. Rawstron AC, Barrans SL, Blythe D, et al. In multiple myeloma, only a single stage of neoplastic plasma cell differentiation can be identified by VLA-5 and CD45 expression. Br J Haematol 2001;113:794-802.
31. Ruiz-Arguelles GJ, San Miguel JF. Cell surface markers in multiple myeloma. Mayo Clin Proc 1994;69:684-90.
32. Tominaga N. Analysis of surface antigen expression of human immunoglobulin-secreting cells: phenotypic heterogeneity in normal counterparts of myeloma cells. Br J Haematol 1989;73:302-8.
33. Medina F, Segundo C, Campos-Caro A, Gonzalez-Garcia I, Brieva JA. The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression. Blood 2002;99:2154-61.
34. Rasillo A, Tabernero MD, Sanchez ML, et al. Fluorescence in situ hybridization analysis of aneuploidization patterns in monoclonal gammopathy of undetermined significance versus multiple myeloma and plasma cell leukemia. Cancer 2003;97:601-9.
35. Tienhaara A, Pelliniemi TT. Flow cytometric DNA analysis and clinical correlations in multiple myeloma. Am J Clin Pathol 1992;97:322-30.
36. Garcia-Sanz R. Prognostic implications of DNA aneuploidy in 156 untreated multiple myeloma patients. Castelano-Leones (Spain) Cooperative Group for the Study of Monoclonal Gammopathies. Br J Haematol 1995;90:106-12.
37. Avet-Loiseau H, Facon T, Grosbois B, et al. Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood 2002;99:2185-91.