Calcium–NFAT transcriptional signalling in T cell activation and T cell exhaustion

Cell Calcium

Volumn 63, Issue , 2017, Pages 66-69

  Hogan, Patrick G ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Activation; Anergy; Exhaustion; Immune response; Lymphocyte; Modulation; NFAT; T cell; Tolerance; Transcription; Unresponsiveness

Indexed keywords

CALCIUM; TRANSCRIPTION FACTOR NFAT;

BINDING SITE; CELL STRESS; GENE EXPRESSION REGULATION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; RNA SEQUENCE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE EXHAUSTION; T LYMPHOCYTE UNRESPONSIVENESS; TRANSCRIPTION REGULATION; ANIMAL; CALCIUM SIGNALING; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE; TRANSCRIPTION INITIATION;

ANIMALS; CALCIUM; CALCIUM SIGNALING; HUMANS; LYMPHOCYTE ACTIVATION; NFATC TRANSCRIPTION FACTORS; T-LYMPHOCYTES; TRANSCRIPTIONAL ACTIVATION;

EID: 85010951281     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2017.01.014     Document Type: Review

References (29)

1. [1] Shaw, J.P., Utz, P.J., Durand, D.B., Toole, J.J., Emmel, E.A., Crabtree, G.R., Identification of a putative regulator of early T cell activation genes. Science 241 (1988), 202–205.
2. [2] Brunvand, M.W., Schmmidt, A., Siebenlist, U., Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene. J. Biol. Chem. 263 (1988), 18904–18910.
3. [3] Miyatake, S., Shlomai, J., Arai, K., Arai, N., Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes— those for GM-CSF, interleukin-4 (IL-4), and IL-5. Mol. Cell. Biol. 11 (1991), 5894–5901.
4. [4] Jain, J., McCaffrey, P.G., Valge-Archer, V.E., Rao, A., Nuclear factor of activated T cells contains Fos and Jun. Nature 356 (1992), 801–804.
5. [5] Northrop, J.P., Ullman, K.S., Crabtree, G.R., Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. J. Biol. Chem. 268 (1993), 2917–2923.
6. [6] Tokumitsu, H., Masuda, E.S., Tsuboi, A., Arai, K., Arai, N., Purification of the 120 kDa component of the human nuclear factor of activated T cells (NF-AT): reconstitution of binding activity to the cis-acting element of the GM-CSF and IL-2 promoter with AP-1. Biochem. Biophys. Res. Commun. 196 (1993), 737–744.
7. [7] McCaffrey, P.G., Luo, C., Kerppola, T.K., Jain, J., Badalian, T.M., Ho, A.M., Burgeon, E., Lane, W.S., Lambert, J.N., Curran, T., Verdine, G.L., Rao, A., Hogan, P.G., Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262 (1993), 750–754.
8. [8] Northrop, J.P., Ho, S.N., Chen, L., Thomas, D.J., Timmerman, L.A., Nolan, G.P., Admon, A., Crabtree, G.R., NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369 (1994), 497–502.
9. [9] Hoey, T., Sun, Y.L., Williamson, K., Xu, X., Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2 (1995), 461–472.
10. [10] Kronke, M., Leonard, W.J., Depper, J.M., Arya, S.K., Wong-Staal, F., Gallo, R.C., Waldmann, T.A., Greene, W.C., Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. U. S. A. 81 (1984), 5214–5218.
11. [11] Schmidt, A., Hennighausen, L., Siebenlist, U., Inducible nuclear factor binding to the κB elements of the human immunodeficiency virus in T cells can be blocked by cyclosporin A in a signal-dependent manner. J. Virol. 64 (1990), 4037–4041.
12. [12] Emmel, E.A., Verweij, C.L., Durand, D.B., Higgins, K.M., Lacy, E., Crabtree, G.R., Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246 (1989), 1617–1620.
13. [13] Liu, J., Albers, M.W., Wandless, T.J., Luan, S., Alberg, D.G., Belshaw, P.J., Cohen, P., MacKintosh, C., Klee, C.B., Schreiber, S.L., Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry 31 (1992), 3896–3901.
14. [14] Shaw, K.T.-Y., Ho, A.M., Raghavan, A., Kim, J., Jain, J., Park, J., Sharma, S., Rao, A., Hogan, P.G., Immunosuppressive drugs prevent a rapid dephosphorylation of the transcription factor NFAT1 in stimulated immune cells. Proc. Natl. Acad. Sci. U. S. A. 92 (1995), 11205–11209.
15. [15] Chen, L., Glover, J.N., Hogan, P.G., Rao, A., Harrison, S.C., Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature 392 (1998), 42–48.
16. [16] Rao, A., Luo, C., Hogan, P.G., Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15 (1997), 707–747.
17. [17] Schwartz, R.H., T cell anergy. Annu. Rev. Immunol. 21 (2003), 305–334.
18. [18] Macian, F., Garcia-Cozar, F., Im, S.H., Horton, H.F., Byrne, M.C., Rao, A., Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109 (2002), 7199–7731.
19. [19] Jenkins, M.K., Pardoll, D.M., Mizuguchi, J., Chused, T.M., Schwartz, R.H., Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc. Natl. Acad. Sci. U. S. A. 84 (1987), 5409–5413.
20. [20] Jenkins, M.K., Chen, C.A., Jung, G., Mueller, D.L., Schwartz, R.H., Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 144 (1990), 16–22.
21. [21] Heissmeyer, V., Macian, F., Im, S.H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y.C., Dustin, M.L., Rao, A., Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 (2004), 255–265.
22. [22] Macian, F., Garcia-Rodriguez, C., Rao, A., Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J. 19 (2000), 4783–4795.
23. + T cells. Immunity 42 (2015), 265–278.
24. [24] Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
25. [25] Topalian, S.L., Drake, C.G., Pardoll, D.M., Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27 (2015), 450–461.
26. + T cell exhaustion during chronic viral infection. Immunity 27 (2007), 670–684.
27. + regulatory T cells controlled by the transcription factor Egr-2. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 13974–13979.
28. + T cell exhaustion versus memory. Immunity 37 (2012), 1130–1144.
29. [29] Wherry, E.J., Kurachi, M., Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol. 15 (2015), 486–499.