Inhibition of human cytomegalovirus pUL89 terminase subunit blocks virus replication and genome cleavage

Journal of Virology

Volumn 91, Issue 3, 2017, Pages

  Wang, Yan ^a   Mao, Lili ^a,b   Kankanala, Jayakanth ^a   Wang, Zhengqiang ^a   Geraghty, Robert J ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Human cytomegalovirus; Hydroxypyridonecarboxylic acid; Metal chelation; PUL89 inhibitor; Terminase

Indexed keywords

2 BROMO 5,6 DICHLORO 1BETA DEXTRO RIBOFURANOSYL 1H BENZIMIDAZOLE; ADENOSINE TRIPHOSPHATASE; ANTIVIRUS AGENT; CARBOXYLIC ACID DERIVATIVE; COMPOUND 10K; ENDONUCLEASE; GANCICLOVIR; GENOMIC DNA; HYDROXYPYRIDONECARBOXYLIC ACID; LETERMOVIR; PROTEIN PUL89; RALTEGRAVIR; RIBONUCLEASE H; RIBONUCLEASE INHIBITOR; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE; ENZYME INHIBITOR; PROTEIN BINDING; PROTEIN SUBUNIT; TERMINASE; UL89 PROTEIN, CYTOMEGALOVIRUS; VIRAL PROTEIN; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; EC50; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IC50; LIGAND BINDING; NONHUMAN; PHARMACOPHORE; POLYACRYLAMIDE GEL ELECTROPHORESIS; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; CONFORMATION; CYTOMEGALOVIRUS; DRUG EFFECTS; KINETICS; METABOLISM; MOLECULAR MODEL; PHYSIOLOGY; PROTEIN SUBUNIT;

ANTIVIRAL AGENTS; CELL LINE; CYTOMEGALOVIRUS; DNA, VIRAL; ENDODEOXYRIBONUCLEASES; ENZYME INHIBITORS; GENOME, VIRAL; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN SUBUNITS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 85010876883     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02152-16     Document Type: Article

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