Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product

Journal of Virology

Volumn 72, Issue 1, 1998, Pages 717-725

  Underwood, Mark R ^a   Harvey, Robert J ^a   Stanat, Sylvia C ^a   Hemphill, Mary Lou ^a   Miller, Teresa ^a   Drach, John C ^b   Townsend, Leroy B ^b   Biron, Karen K ^a  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 5,6 DICHLORO 1BETA D RIBOFURANOSYL BENZIMIDAZOLE; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS INHIBITION; HUMAN CYTOMEGALOVIRUS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

EID: 0031985103     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.1.717-725.1998     Document Type: Article

References (48)

1. Addison, C., F. J. Rixon, J. W. Palfreyman, M. O'Hara, and V. G. Preston. 1984. Characterisation of a herpes simplex virus type 1 mutant which has a temperature-sensitive defect in penetration of cells and assembly of capsids. Virology 138:246-259.
2. Addison, C., F. J. Rixon, and V. G. Preston. 1990. Herpes simplex virus type 1 UL28 gene product is important for the formation of mature capsids. J. Gen. Virol. 71:2377-2384.
3. al-Kobaisi, M. F., F. J. Rixon, I. McDougall, and V. G. Preston. 1991. The herpes simplex virus UL33 gene product is required for the assembly of full capsids. Virology 180:380-388.
4. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1994. Current protocols in molecular biology, vol. 1. John Wiley & Sons. Inc., New York, N.Y.
5. L15 gene product. J. Virol. 71:2666-2673.
6. L15 gene encodes two proteins and is required for cleavage of genomic viral DNA. J. Virol. 68:8118-8124.
7. L15, a highly conserved herpes simplex virus 1 gene, effectively replaces the two exons of the wild-type virus. J. Virol. 66:5621-5626.
8. Biron, K. K., and G. B. Elion. 1980. In vitro susceptibility of varicella-zoster virus to acyclovir. Antimicrob. Agents Chemother. 18:443-447.
9. Black, L. W. 1989. DNA packaging in dsDNA bacteriophages. Annu. Rev. Microbiol. 43:267-292.
10. Blackburn, E. H., and J. W. Szostak. 1984. The molecular structure of centromeres and telomeres. Annu. Rev. Biochem. 53:163-194.
11. Booy, F. P., W. W. Newcomb, B. L. Trus, J. C. Brown, T. S. Baker, and A. C. Steven. 1991. Liquid-crystalline, phage-like packing of encapsidated DNA in herpes simplex virus. Cell 64:1007-1015.
12. Britt, W. J., and C. A. Alford (ed.). 1996. Cytomegalovirus, 3rd ed., vol. 2. Lippincott-Raven Publishers, Philadelphia, Pa.
13. Chee, M. S., A. T. Bankier, S. Beck, R. Bohni, C. M. Brown, R. Cerny, T. Horsnell, C. A. I. Hutchison, T. Kouzarides, J. A. Martignetti, E. Preddie, S. C. Satchwell, P. Tomlinson, K. M. Weston, and B. G. Barrel. 1990. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microhiol. Immunol. 154:125-169.
14. Chu, G., D. Vollrath, and R. W. Davis. 1986. Separation of large DNA molecules by contour-clamped homogeneous electric fields. Science 234:1582-1585.
15. Costa, R. H., K. G. Draper, T. J. Kelly, and E. K. Wagner. 1985. An unusual spliced herpes simplex virus type 1 transcript with sequence homology to Epstein-Barr virus DNA. J. Virol. 54:317-328.
16. Davis, M. G., S. C. Kenney, J. Kamine, J. S. Pagano, and E. S. Huang. 1987. Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 84:8642-8646.
17. Davison, A. J. 1992. Channel catfish virus: a new type of herpesvirus. Virology 186:9-14.
18. Dolan, A., M. Arbuckle, and D. J. McGeoch. 1991. Sequence analysis of the splice junction in the transcript of herpes simplex virus type 1 gene UL15. Virus Res. 20:97-1114.
19. Drach, J. C., L. B. Townsend, K. K. Biron, and E. R. Kern. 1992. Selective inhibition of human cytomegalovirus by polyhalogenated benzimidazole ribonucleosides, a new class of antivirals, p. 402. In Program and abstracts of the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
20. Field, A. K., and K. K. Biron. 1994. "The end of innocence" revisited: resistance of herpesviruses to antiviral drugs. Clin. Microbiol. Rev. 7:1-13.
21. Fuchs, R. 1994. Predicting protein function: a versatile tool for the Apple Macintosh. Comput. Appl. Biosci. 10:171-178.
22. Garber, D. A., S. M. Beverley, and D. M. Coen. 1993. Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis. Virology 197:459-462.
23. Genetics Computer Group. 1991. Program manual for the GCG package, 7th ed., Genetics Computer Group, University of Wisconsin, Madison.
24. Hammerschmidt, W., and B. Sugden. 1990. DNA replication of herpesviruses during the lytic phase of their life-cycles. Mol. Biol. Med. 7:45-57.
25. Irmiere, A., and W. Gibson. 1983. Isolation and characterization of a non-infectious virion-like particle released from cells infected with human strains of cytomegalovirus. Virology 130:118-133.
26. Jacobson, M. A. 1994. Current management of cytomegalovirus disease in patients with AIDS. AIDS Res. Hum. Retroviruses 10:917-923.
27. King, J., and S. Casjens. 1974. Catalytic head assembling protein in virus morphogenesis. Nature 251:112-119.
28. Lai, E., B. W. Birren, S. M. Clark, M. I. Simon, and L. Hood. 1989. Pulsed field gel electrophoresis. Biotechniques 7:34-42.
29. Mocarski, E. S. 1996. Cytomegaloviruses and their replication, p. 2447-2492. In B. N. Fields (ed.), Fields virology, 3rd ed., vol. 2. Lippincott-Raven Publishers, Philadelphia, Pa.
30. Mocarski, E. S., A. C. Liu, and R. R. Spaete. 1987. Structure and variability of the a sequence in the genome of human cytomegalovirus (Towne strain). J. Gen. Virol. 68:2223-2230.
31. Morita, M., M. Tasaka, and H. Fujisawa. 1994. Analysis of functional domains of the packaging proteins of bacteriophage T3 by site-directed mutagenesis. J. Mol. Biol. 235:248-259.
32. Polis, M. A., K. M. Spooner, B. F. Baird, J. F. Manischewitz, H. S. Jaffe, P. E. Fisher, J. Falloon, R. T. Davey, Jr., J. A. Kovacs, R. E. Walker, S. M. Whitcup, R. B. Nussenblatt, H. C. Lane, and H. Masur. 1995. Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria. Antimicrob. Agents Chemother. 39:882-886.
33. L15 open reading frame of herpes simplex virus 1. J. Virol. 67:4497-4503.
34. Robson, L., and W. Gibson. 1989. Primate cytomegalovirus assembly protein: genome location and nucleotide sequence. J. Virol. 63:669-676.
35. Saraste, M., P. R. Sibbald, and A. Wittinghofer. 1990. The P-loop - a common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci. 15:430-434.
36. Sehgal, P. B., and I. Tamm. 1980. Benzimidazoles and their nucleosides. Antibiot. Chemother. 27:93-138.
37. Sherman, G., and S. L. Bachenheimer. 1988. Characterization of intranuclear capsids made by ts morphogenic mutants of HSV-1. Virology 163:471-480.
38. L8 subunit of the herpes simplex virus helicase-primase complex is required for efficient primer utilization. J. Virol. 66:4884-4892.
39. Spaete, R., and E. S. Mocarski. 1985. The a sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes. J. Virol. 54:817-824.
40. Sullivan, V., K. K. Biron, C. Talarico, S. C. Stanat, M. Davis, L. M. Pozzi, and D. M. Coen. 1993. A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob. Agents Chemother. 37:19-25.
41. Sullivan, V., C. L. Talarico, S. C. Stanat, M. Davis, D. M. Coen, and K. K. Biron. 1997. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 358:16-164.
42. L28 deletion mutants. J. Virol. 67:3470-3480.
43. Townsend, L. B., R. V. Devivar, S. R. Turk, M. R. Nassiri, and J. C. Drach. 1995. Design, synthesis, and antiviral activity of certain 2,5,6-trihalo-1-(beta-D-ribofuranosyl)benzimidazoles. J. Med. Chem. 38:4098-4103.
44. Watson, J. D. 1972. Origin of concatemeric T7 DNA. Nature New Biol. 239:197-201
45. Weller, S. K., E. P. Carmichael, D. P. Aschman, D. J. Goldstein, and P. A. Schaffer. 1987. Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA. Virology 161:198-210.
46. Yankulov, K., K. Yamashita, R. Roy, J. M. Egly, and D. L. Bentley. 1995. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J. Biol. Chem. 270:23922-23925.
47. L15 gene of herpes simplex virus type 1 reveals the translation of two proteins. J. Virol. 71:2656-2665.
48. Zhang, X., S. Efstathiou, and A. Simmons. 1994. Identification of novel herpes simplex virus replicative intermediates by field inversion gel electrophoresis: implications for viral DNA amplification strategies. Virology 202:530-539.