A novel nonnucleoside inhibitor specifically targets cytomegalovirus DNA maturation via the UL89 and UL56 gene products

Journal of Virology

Volumn 75, Issue 19, 2001, Pages 9077-9086

  Buerger, I ^a   Reefschlaeger, J ^a   Bender, W ^a   Eckenberg, P ^a   Popp, A ^a   Weber, O ^a   Graeper, S ^a   Klenk, H D ^a   Ruebsamen Waigmann, H ^a   Hallenberger, S ^a  

^a BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5,6 TRICHLORO 1 BETA DEXTRO RIBOFURANOSYLBENZIMIDAZOLE; BAY 35 5014; BAY 36 8888; GENE PRODUCT; PROTEIN UL56; PROTEIN UL89; RNA DIRECTED DNA POLYMERASE INHIBITOR; TOMEGLOVIR; UNCLASSIFIED DRUG; VIRUS DNA;

ARTICLE; CYTOMEGALOVIRUS; DNA CLEAVAGE; DNA SYNTHESIS INHIBITION; ELECTRON MICROSCOPY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SOUTHERN BLOTTING; VIRUS MUTATION; VIRUS RESISTANCE; VIRUS TRANSCRIPTION;

ANIMALS; CELL LINE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; HUMANS; MICE; NAPHTHALENESULFONATES; VIRAL PROTEINS; VIRAL STRUCTURAL PROTEINS; VIRUS ASSEMBLY;

EID: 0034855634     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.19.9077-9086.2001     Document Type: Article

References (58)

1. Cytomegalovirus
2. The herpes simplex virus UL33 gene product is required for the assembly of full capsids
3. Chronic intrauterine and perinatal infections
4. Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region
5. L15 gene product
6. Replication of herpesvirus DNA. IV. Analysis of concatemers
7. A novel terminase activity associated with the DNA packaging protein gp17 of bacteriophage T4
8. Structural analysis of DNA cleaved in vivo by bacteriophage T4 terminase
9. DNA packaging in dsDNA bacteriophages
10. DNA packaging and cutting by phage terminases: Control in phage T4 by a synaptic mechanism
11. Identification of the gene product encoded by ORF UL56 of the human cytomegalovirus genome
12. The gene product of human cytomegalovirus ORF UL56 binds the pac motif and has specific nuclease activity
13. Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: A new approach for construction of HMVC mutants
14. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169
15. Foscarnet: A review of its antiviral activity, pharmacokinetic properties, and therapeutic use in immunocompromised patients with cytomegalovirus retinitis
16. Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments
17. Ganciclovir
18. Channel catfish virus: A new type of herpesvirus
19. Molecular cloning and physical mapping of murine cytomegalovirus DNA
20. Pyrophosphate analogs as inhibitors of DNA polymerases of cytomegalovirus, herpes simplex virus and cellular origin
21. Significance of cytomegalovirus for long-term survival after orthotopic liver transplantation: A prospective derivation and validation cohort analysis
22. "The end of innocence" revisited: Resistance of herpesviruses to antiviral drugs
23. Structure and assembly of the virion
24. The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells
25. Genetic analysis of a clinical isolate of human cytomegalovirus exhibiting resistance against both ganciclovir and cidofovir
26. High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis
27. Selective extraction of polyoma DNA from infected mouse cell cultures
28. Intracellular metabolism of the antiherpes agent (S)-1-hydroxy-2-(phosphonylmethoxy)propyl]cytosine
29. Ocular manifestations of HIV infection
30. Defined large-scale alteration of the human cytomegalovirus genome constructed by cotransfection of overlapping cosmids
31. Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins
32. Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56
33. Replication of herpesvirus DNA. V. The maturation of concatemeric DNA of pseudorabies virus to genome length is related to capsid formation
34. A preclinical and clinical overview of the nucleotide-based antiviral agent cidofovir (HPMPC)
35. The herpes simplex type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion
36. The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments
37. A discontinuous headful packaging model for packaging less than headful length DNA molecules by bacteriophage T4
38. Biochemical characterization of an ATPase activity associated with the large packaging subunit gp17 from bacteriophage T4
39. Inhibition of cellular DNA polymerase α and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine
40. The cause of death in patients with human immunodeficiency virus infection: A clinical and pathological study with emphasis on the role of pulmonary disease
41. The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA
42. Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome
43. Structural and functional domains of the large subunit of the bacteriophage T3 DNA packaging enzyme: Importance of the C-terminal region in prohead binding
44. Bacteriophage λ DNA maturation and DNA packaging
45. Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis
46. Isolation and characterization of herpes simplex virus type 1 mutants defective in the UL6 gene
47. Versatile insertion plasmids for targeted genome manipulations in bacteria: Isolation, deletion, and rescue of the pathogenicity island LEE of the Escherichia coli O157:H7 genome
48. Cloning, overexpression and purification of the terminase proteins gp16 and gp17 of bacteriophage T4. Construction of a defined in vitro DNA packaging system using purified terminase proteins
49. Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients
50. The α sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes
51. Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: Isolation and characterization of two UL28 deletion mutants
52. Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product
53. Herpes simplex virus DNA replication and genome maturation
54. Analysis and mapping of a family of 3′-coterminal transcripts containing coding sequences for human cytomegalovirus open reading frames UL93 through UL99
55. Characterization of 1CP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins
56. Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging
57. Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy